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金融市场环境下货币政策工具调控效力的影响探究

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金融发展评论 2018年第10期 6-12页

作者：崔琳熠中国银行投资银行与资产管理部

新金融市场环境下,非银行金融机构业务激增,民间借贷规模扩张,在促进我国金融不断发展、金融创新产品推陈出新的同时,也对金融监管带来挑战。在新金融市场环境下,常规货币工具的实效性值得关注,央行提出的创新性货币工具的可操作性也被... 详细信息

新金融市场环境下,非银行金融机构业务激增,民间借贷规模扩张,在促进我国金融不断发展、金融创新产品推陈出新的同时,也对金融监管带来挑战。在新金融市场环境下,常规货币工具的实效性值得关注,央行提出的创新性货币工具的可操作性也被广泛讨论。信贷规模膨胀、金融衍生品使用乱象等是否及如何影响中央银行的货币工具的调控力,创新性货币工具对实现宏观政策指引又是否有可实施性值得研究。

关键词：货币政策传导渠道货币政策创新性货币工具影子银行

《身边的奥秘》科教片的多元化节目表现手段分析

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教育信息技术 2009年第3期 55-56页

作者：张学波崔林毅华南师范大学教育信息技术学院

通过对系列科教片《身边的奥秘》的分析，发现其多元化节目表现手段是以精致的画面增强科教片的欣赏性，以准确的解说词增强科教片的思想性，以真实的同期声增强科教片的现场感，以美妙的音乐音响增强科教片的艺术性，以多媒体的特技增... 详细信息

通过对系列科教片《身边的奥秘》的分析，发现其多元化节目表现手段是以精致的画面增强科教片的欣赏性，以准确的解说词增强科教片的思想性，以真实的同期声增强科教片的现场感，以美妙的音乐音响增强科教片的艺术性，以多媒体的特技增强科教片的震撼力。

关键词：科教片节目创作表现手段

Spatial and temporal variabilities of rainstorms over China under climate change

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Journal of Geographical Sciences 2021年第4期31卷 479-496页

作者： HUANG Chang ZHANG Shiqiang DONG Linyao WANG Zucheng LI linyi cui Luming Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest UniversityXi'an 710127China Institute of Earth Surface System and Hazards Northwest UniversityXi'an 710127China College of Urban and Environmental Sciences Northwest UniversityXi'an 710127China Changjiang River Scientific Research Institute Wuhan 430010China State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration Institute for Peat&Mire ResearchNortheast Normal UniversityChangchun 130021China School of Remote Sensing and Information Engineering Wuhan UniversityWuhan 430070China

Rainstorms are one of the extreme rainfall events that cause serious disasters,such as urban flooding and mountain *** studies have used rain gauge observations to analyze rainstorm events,but relevant information is usually missing in gauge-sparse ***-derived precipitation datasets serve as excellent supplements or substitutes for the gauge *** developing a grid-based rainstorm-identification tool,we used the Tropical Rainfall Measurement Mission(TRMM)Multi-satellite Precipitation Analysis(TMPA)time series product to reveal the spatial and temporal variabilities of rainstorms over China during 1998–*** patterns of both increasing and decreasing rainstorm occurrences were detected,with no spatially uniform trend being observed across the whole *** was an increase in the area being affected by rainstorms during the 20-year period,with rainstorm centers shifting along the southwest–northeast *** occurrence was found to be correlated with local total *** comparing rainstorm occurrence with climate variables such as the El Ni?o-Southern Oscillation and Pacific Decadal Oscillation,we also found that climate change was likely to be the primary reason for rainstorm occurrence in *** study complements previous studies that used gauge observations by providing a better understanding of the spatiotemporal dynamics of China’s rainstorms.

关键词： climate change extreme precipitation meteorology rainfall satellite precipitation data

Comparison on Clinical Characteristics of Multifocal Choroiditis and Punctate Inner Choroidopathy

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Eye Science 2011年第3期26卷 161-165页

作者： Zhaomeng Shen linyi Zhang Zhiguo Li Xian Zhang Hongbo cui Lihuili Hospital of Ningbo Ningbo 315040 China

Purpose:To compare the differences in the clinical characteristics of multifocal choroiditis(MFC) and punctate inner choriodopathy(PIC).Methods:A cross-sectional study,consisting of 22 cases(37 eyes) with MFC and 11 cases(18 eyes) with PIC,was carried *** indexes were measured and analysed to compare the differences in clinical characteristics of the subjects between two groups,including BCVA,avergae age,sex composition,presence of intraocular inflammation,choroidal neovascularization(CNV),and intraocular inflammation complications,such as cataract,cystoid macular edema(CME) and epiretinal membrane(ERM).Results:The avergae age of the MFC and PIC patients were(48.1±13.9) years and(32.1±10.2) years with a significant difference(P=0.043).CNV occurred more frequently in patients with PIC(PIC,55.6%;MFC,21.6%;P=0.016) compared with those with *** patients had a higher frequency of intraocular inflammation complications,such as,cataract(27.0%),CME(35.1%),ERM(5.4%).PIC patients presented none of these *** subjects presented with more visual impairments than PIC *** 51.4% of MFC patients had visual impairments and 22.2% of PIC patients had BCVA < 0.3(P=0.047).Conclusion:Both MFC and PIC are categorized into the umbrella term of "white spot syndromes".Although sharing similar ocular expressions,they present with different clinical *** with PIC had a higher frequency of CNV but a lower frequency of structural complications caused by intraocular inflammation and lower frequency of visual impairments compared with MFC counterparts.

关键词：临床特点脉络膜内蒙古特征和炎症反应视力障碍 MFC PIC

A novel de novo mutation of ACTG1 in two sporadic non-syndromic hearing loss cases

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Science China(Life Sciences) 2018年第6期61卷 729-732页

作者： Hongyang Wang Jing Guan Lan Lan Lan Yu linyi Xie Xu Liu Ju Yang cui Zhao Dayong Wang Qiuju Wang Chinese PLA Institute of Otolaryngology Chinese PLA General Hospital Medical School of Chinese PLA Beijing 100853 China Beijing Centre for Physical and Chemical Analysis Beijing 100089 China

Dear Editor,Actins are a family of essential cytoskeletal proteins involved in nearly all cellular processes（Lambrechts et al.,2004）.Of the six human genes that encode actins,only ACTG1and ACTB are ubiquitously ***1（OMIM#604717）,which is linked to the DFNA20/26 locus,wasidentified in autosomal dominant, non-syndromic hearing loss （NSHL） cases （Baek et al., 2012; Liu et al., 2008; Park et al., 2013; Yuan et al., 2016）. In addition, some ACTG1 （OMIM #614583） mutations are associated with Baraitser-Winter syndrome, which is characterized by developmental delay, facial dysmorphologies, brain malformations, colobomas, and variable hearing loss （Riviere et al., 2012）.

关键词： A novel de novo mutation of ACTG1 in two sporadic non-syndromic hearing loss cases

A Novel Homozygous Missense Mutation and A Compound Heterozygous Frameshift Mutations of PDZD7 Gene Identified in Two Chinese Families with Nonsyndromic Hearing Loss.

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A Novel Homozygous Missense Mutation and A Compound Heterozy...

An in-situ generated composite solid-state electrolyte towards high-voltage lithium metal batteries

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会医学遗传医师分会第一届全国学术会议暨2016年浙江省医学遗传学年会

作者： Guan Jing Wang Dayong Wang Hongyang Xie linyi Yang Ju Zhao cui Lan Lan Yin Zifang Wang Qiuju Department of Otolaryngology-Head and Neck Surgery Chinese PLA Institute of Otolaryngology Chinese PL A General Hospital

Objective To investigate the genetic etiology of two non-consanguineous Chinese families with a utosomal recessive non-syndromic hearing loss(ARNSHL). Method Two Chinese ARNSHL families with two affected siblings were recruited in this study. Th e families were analyzed for exons, splicing sites and immediate flanking intron sequences by tar geted region capture and high throughput sequencing. Furthermore, 1751 normal Chinese individ uals served as controls and 122 Chinese families segregating apparent ARNSHL, who have been previously excluded common deafness genes, were ascertained for screening candidate mutation s. Result We identified a novel homozygous missense mutation(***66 Leu) and novel compound heterozygous frameshift mutations(***56 fs Ter24 and ***403 fs Ter36) in the both families. W e screened 1751 normal Chinese individuals and 122 unrelated Chinese families segregating app arent ARNSHL failed to detect the three confirmatory mutations. Conclusion We report novel biallelic mutations in PDZD, which is the first study to identify PDZD7 as the ARNSHL-associated gene in Chinese population. Our finding could expand the pathoge nic spectrum and strengthens the role of PDZD7 biallelic mutations cause ARNSHL.

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Science China Chemistry 2022年第5期65卷 934-942页

作者： Qinglei Wang Tiantian Dong Qian Zhou Zili cui Xuehui Shangguan Chenglong Lu Zhaolin Lv Kai Chen Lang Huang Huanrui Zhang Guanglei cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266100China School of Materials Science and Engineering Linyi UniversityLinyi 276000China School of Materials Science and Engineering Ocean University of ChinaQingdao 266042China

The solid-state electrolyte(SSE) has promising applications in next-generation lithium(Li) metal batteries(LMBs) because of its significantly enhanced safety and more compatible interface characteristics than flammable traditional liquid ***,only a few attempts have achieved high-performance high-voltage LMBs,which is attributed to the fact that both high ionic conductivity and good compatibility with electrodes can hardly be achieved ***,a composite solid-state electrolyte(CSE) based on star-shaped siloxane-based polymer electrolyte coupled with Li_(6.75)La_(3)Zr_(1.75)Ta_(0.25)O_(12)(LLZTO)ceramic fillers is designed and prepared through a facile in-situ polymerization *** obtained CSE exhibits high ionic conductivity(i.e.,1.68 × 10^(-4) S cm^(-1) at a temperature of 60 ℃),superior anodic stability,and high Li-ion transference number(i.e.,0.53) because of the multifunctional synergistic effect of the polymer electrolyte with LLZTO ceramic ***,the as-developed CSE shows excellent compatibility with Li *** a result,the as-developed CSE enables the development of long-life 4.4-V-class solid-state LMBs with a Li CoO_(2) cathode,with 79.7% capacity retention and 99.74% average Coulombic efficiency after 500 cycles at a 0.5 C *** analysis of cycled batteries confirms that such superior battery performance can be mainly ascribed to the formation of a compatible electrode/electrolyte ***,excellent safety features can be observed in LiCoO_(2)/Li pouch *** work provides an important guide for the rational design of SSEs for high-voltage LMBs.

关键词： composite solid-state electrolyte in-situ lithium metal batteries high-voltage

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Monolithically integrated CoP nanowire array： An on/off switch for effective on-demand hydrogen generation via hydrolysis of NaBH4 and NH3BH3

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Nano Research 2017年第2期10卷 595-604页

作者： Liang cui Yuanhong Xu Li Niu Wenrong Yang Jingquan Liu Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers College of Chemistry and Chemical Engineering Linyi University Linyi 276005 China College of Materials Science and Engineering Qingdao University Qingdao 266071 China School of Life and Environmental Sciences Deakin University Geelong 3217 VIC Australia

The issues of hydrogen generation and storage have hindered the widespread use and commercialization of hydrogen fuel cell vehicles. It is thus highly attractive, but the design and development of highly active non-noble-metal catalysts for on-demand hydrogen release from alkaline NaBH4 solution under mild conditions remains a key challenge. Herein, we describe the use of CoP nanowire array integrated on a Ti mesh （CoP NA/Ti） as a three-dimensional （3D） monolithic catalyst for efficient hydrolytic dehydrogenation of NaBH4 in basic solutions. The CoP NAFFi works as an on/off switch for on-demand hydrogen generation at a rate of 6,500 mL/（min.g） and a low activation energy of 41 kJ/mol. It is highly robust for repeated usage after recycling, without sacrificing catalytic performance. Remarkably, this catalyst also performs efficiently for the hydrolysis of NH3BH3.

关键词： monolithic catalyst CoP nanowire array on/off switch hydrolytic dehydrogenation borohydrides

Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment

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Science China(Life Sciences) 2015年第9期58卷 829-838页

作者： XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE linyi ZHAO cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu Department of Otolaryngology-Head and Neck Surgery Chinese PLA Institute of Otolaryngology Chinese PLA General Hospital Center for Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong University National Research Center for Assisted Reproductive Technology and Reproductive Genetics BGI-Shenzhen Department of Ultrasonography Chinese PLA General Hospital Department of Obstetrics and Gynecology Chinese PLA General Hospital The Key laboratory for Reproductive Endocrinology of Ministry of Education

A couple with a proband child of GJB2 （encoding the gap junction protein connexin 26）-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a cus- tomized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagno- sis （PGD）, noninvasive prenatal testing （NIPT）, and noninvasive prenatal diagnosis （N1PD） into the strategy. Auditory and ge- netic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2c.235delC heterozygous embryo resulted in a sin- gleton pregnancy. At the 13th week of gestation, genomic DNA （gDNA） from the trio family and cell-free DNA （cfDNA） from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by inva- sire procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing im- pairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders.

关键词： preimplantation genetic diagnosis(PGD) noninvasive prenatal testing(NIPT) noninvasive prenatal diagnosis(NIPD) GJB2(encoding the