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Heavy ion micro-beam study of single-event transient(SET) in Si Ge heterjunction bipolar transistor

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Science China(Information Sciences) 2017年第12期60卷 120-122页

作者： Jinxin zhang Hongxia GUO Fengqi zhang Chaohui HE Pei LI Yunyi YAN Hui WANG linxia zhang School of Aerospace Science and Technology Xidian University Xinjiang Technical Institute of Physics & Chemistry Chinese Academy of Sciences Northwest Institution of Nuclear Technology School of Energy and Power Engineering Xi'an Jiaotong University

Silicon-germainum heterojunction bipolar transistor(Si Ge HBT)has been demonstrated to be suitable in extreme environment because of its superior temperature characteristics which can operate from 43 K to 400 K[1].In addition,outstanding hardness to both total ionizing dose(TID)radiation and displacement damage make Si Ge HBT technology particularly attractive for space

关键词： Si Heavy ion micro-beam study of single-event transient Ge HBT SET

Study on growing thick AlGaN layer on c-plane sapphire substrate and free-standing GaN substrate

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Science China(Physics,Mechanics & Astronomy) 2012年第12期55卷 2383-2388页

作者： WANG DangHui ZHOU Hao zhang JinCheng XU ShengRui zhang linxia MENG FanNa AI Shan HAO Yue State Key Lab.of Fundamental Science on Wide Band-Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi'an 710071China School of Materials Science and Engineering of Xi'an ShiYou University Xi'an 710065China

In this study,the thick AlGaN epilayers have been grown on the c-plane sapphire substrate and the free-standing GaN substrate using low-temperature AlN nucleation layers by low-pressure metal-organic chemical vapor deposition(LPMOCVD).High resolution X-ray diffraction(HRXRD),atom force microscopy(AFM),scanning electron microscopy(SEM),photoluminescence(PL) and Raman scattering measurements have been employed to study the crystal quality,threading dislocation density,surface morphology,optical properties and phonon properties of thick AlGaN *** results indicate that AlGaN epifilms crystal quality can be improved greatly when grown on the free-standing GaN *** calculated the threading dislocation density and found that thick AlGaN epifilm grown on the free-standing GaN substrate is much lower in total threading dislocation density than that grown on the sapphire substrate,although the surface morphology is rougher than that of sapphire substrate.

关键词： metal-organic chemical vapor deposition crystal quality surface morphology AlN nucleation layer

CD160 is essential for the development of memory CD8+T cells

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CD160 is essential for the development of memory CD8+T cells

第十四届全国免疫学学术大会

作者： linxia zhang chen zhao xiaoyan zhang jianqing xu Fudan University 上海市公共卫生临床中心

Understanding the mechanism regulating the development of memory CD8T cells is paramount to improve the formulation of vaccine and T-cell based *** we found that CD160 is vital for the development and differentiation of memory CD8T *** acute lymphocytic choriomeningitis virus infection,the loss of CD160 skewed the diffe rentiation of CD8+T cells towards short-lived effector T cells,leading to failure of the development of central,effective and tissue-resident memory CD8+T cells and consequently diminished capacity to protect from subsequent viral *** further identified that CD160 deficiency resulted in up-regulation of Akt/mTOR signaling ***,the administration of rapamycin,a mTOR kinase inhibitor,was able to rescue the memory CD8T cell development in CD160 knockout ***,our studies discovered that CD160 is an essential regulator of memory CD8T cell development by acting on Akt-mTOR signaling pathway.

关键词： CD160 Memory CD8+T cells Tissue-resident memory CD8+T cells mTOR

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压缩感知在光学成像领域的应用

光学学报 2020年第1期40卷 92-117页

作者：柯钧张临夏周群北京理工大学光电学院北京100081

早期压缩感知在光学成像领域的应用主要集中在空域压缩成像。近年来,更多的空域压缩成像采用阵列式探测器取代单元探测器采集测量值。同时,压缩成像的研究也从二维空间拓展到三维测距、高速成像、多光谱成像、关联成像和全息成像等方向... 详细信息

早期压缩感知在光学成像领域的应用主要集中在空域压缩成像。近年来,更多的空域压缩成像采用阵列式探测器取代单元探测器采集测量值。同时,压缩成像的研究也从二维空间拓展到三维测距、高速成像、多光谱成像、关联成像和全息成像等方向。本文针对空域高分辨率压缩成像、压缩感知测距和时域高速压缩成像进行详细分析,结合空域压缩成像总结了测量矩阵设计的研究进展,讨论研究中遇到的困难以及未来可能发展的机遇,并对压缩感知在多光谱、关联成像、和全息成像中的应用研究进行了讨论。此外,本文也总结了近几年深度学习技术在各应用方向上对系统目标恢复性能的改善。

关键词：成像系统计算成像压缩感知红外成像三维成像高速相机深度学习

Hsa-miR-31 governs T-cell homeostasis in HIV protection via IFN-γ-Stat1-T-bet axis

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Hsa-miR-31 governs T-cell homeostasis in HIV protection via ...

乙型肝病毒性肝炎患者发展成肝癌的临床演变特征研究

第十四届全国免疫学学术大会

作者： Lingyan Zhu Meiqi Feng linxia zhang Chen Zhao Xiaoyan zhang Jianqing Xu 上海市(复旦附属)公共卫生临床中心

It remains poorly defined whether any human miRNAs play protective roles during HIV ***,focusing on a unique cohort of HIV-infected former blood donors,we identified miR-31(hsa-miR-31) by comparative miRNA profiling as the only miRNA inversely correlating with disease *** further validated this association in two prospective cohort *** conservation during evolution,hsa-miR-31,unlike its mouse counterpart(mmu-miR-31),was downregulated in human T cell upon *** ex vivo studies showed that inhibiting miR-31 in naive CD4T cells promoted a transcriptional profile with activation *** with this skewing effect,miR-31 inhibition led to remarkably increased susceptibility to HIV *** suppressive nature of miR-31 in CD4T cell activation was pinpointed to its ability to decrease T-bet,the key molecule governing IFN-γ production and activation of CD4T cells,by directly targeting the upstream STAT1 transcriptional factor for downregulation,thus blunting Th1 *** results firmly established miR-31 as a clinically useful biomarker for prediction of HIV disease progression and,by demonstrating its importance in tuning the activation of CD4T cells,implicated that miR-31 may play critical roles in other physiological contexts where the CD4T cell homeostasis needs to be deliberately controlled.

关键词： HIV CD4+T cells miR-31 STAT1 T-bet

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中华流行病学杂志 1993年第6期14卷 334-337页

作者：张玲霞王永怡解放军三〇二医院 100039 北京

采用统计学方法对３８例乙型肝炎患者发展成肝癌的临床演变特点进行临床流行病学研究。发现患乙型病毒性肝炎的，特别是男患者，血清ＡＬＴ和Ｂｉｌ波动反复或持续异常４年以上；血清蛋白数质量趋向恶化：Ａ／Ｇ＜１．５、白蛋白＜３．... 详细信息

采用统计学方法对３８例乙型肝炎患者发展成肝癌的临床演变特点进行临床流行病学研究。发现患乙型病毒性肝炎的，特别是男患者，血清ＡＬＴ和Ｂｉｌ波动反复或持续异常４年以上；血清蛋白数质量趋向恶化：Ａ／Ｇ＜１．５、白蛋白＜３．５ｇ／Ｌ、蛋白电泳中γ球蛋白＞２４％：血小板计数＜５万／ｍｍ＾３：血沉持续＞２０ｍｍ／ｈ：γ－ＧＴ／ＡＬＴ＞１．５：ＡＫＰ＞１７０μ／Ｌ：βＦＰ＞２０ｎｇ／ｍｌ后仍逐步增高。

关键词：乙型肝炎肝肿瘤临床

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一种新型双半球形胶囊机器人

机械工程学报 2017年第15期53卷 110-118页

作者：张永顺周华涛张林霞杨慧远大连理工大学精密与特种加工教育部重点实验室大连116024

为了实现食管、胃部和结肠等非结构宽裕环境内的介入诊疗作业,提出一种主被动模态双半球胶囊机器人,通过空间万向旋转磁场可控制两种模态相互转换,机器人采用被动模态实现"悬停"调姿,采用主动模态实现滚动行走。研究双半球胶囊机器人主... 详细信息

为了实现食管、胃部和结肠等非结构宽裕环境内的介入诊疗作业,提出一种主被动模态双半球胶囊机器人,通过空间万向旋转磁场可控制两种模态相互转换,机器人采用被动模态实现"悬停"调姿,采用主动模态实现滚动行走。研究双半球胶囊机器人主被动模态转换机理,推导被动模态下"悬停"姿态调整力学模型与主动模态下滚动力学模型,确定胶囊"悬停"调姿稳定性条件,试验表明该双半球胶囊机器人可实现定点"悬停"调姿下的全景观察与沿弯曲环境滚动行走。双重作业模态分离关键技术的突破为构成集窥视、诊疗为一体的胶囊机器人系统,实现胃肠非结构宽裕环境内遍历检查与医疗作业奠定了基础。

关键词：主被动双半球胶囊双重模态转换机理悬停调姿滚动行走

Seeking "protective" and "harmful" immune genes during chronic HIV-1 infection by transcriptome analysis

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Journal of Bio-X Research 2018年第2期1卷 79-88页

作者： Lingyan Zhu Chao Qiu Chenli Qiu Ying Wang Yuan Dong linxia zhang Weihui Fu Jun Wei Xiaoyan zhang Jianqing Xu Shanghai Public Health Clinical Center&Institutes of Biomedical Sciences Key Laboratory of Medical Molecular Virology of MOE/MOHFudan University Shanghai Municipal Center for Disease Control&Prevention Shanghai Yuncheng Center for Disease Control and Prevention YunchengShanxi ProvinceChina

Human immunodeficiency virus(HIV)-infected individuals exhibit remarkable transcriptomic *** analyses of antiretroviral therapy(ART)-free chronically infected HIV-1 patients with different clinical outcomes are likely to aid the development of vaccine and immune ***,we performed microarray analyses on whole-blood derived RNA from 89 ART-free HIV-1-infected individuals from 2 *** differentially expressed genes were analyzed between long-term non-progressors,viremic non-progressors and typical progressors,and between elite controllers and non-elite controllers among the long-term *** genes related to T-cell growth,proliferation and differentiation and antiapoptosis were upregulated,whereas interferon-stimulated genes and inflammatory genes were significantly downregulated in long-term non-progressors and viremic *** observations above were further confirmed in the set of 261 genes that correlated with disease progression during a 5-year follow-up,which included 51 genes significantly associated with slower disease progression,and 210 genes associated with aggressive disease ***,our data suggest that it is vital to maintain the homeostasis of the immune system when mounting antiviral immune *** therapeutics able to reconstruct immune homeostasis are likely to be required for immune reconstitution in the context of ART,such as the administration of interleukin-7,healthy allogenic CD4^(+)T cells(providing CD4^(+)T-cell growth factors),or Tregs.

关键词： disease progression elite controller HIV-1 immune protection long-term non-progressor

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高效氯氟氰菊酯对大鳞副泥鳅急性毒性和生理毒性的影响

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四川动物 2013年第4期32卷 560-562,567页

作者：张林霞夏晓华河南师范大学生命科学学院河南新乡453007

为了估测高效氯氟氰菊酯对水生生物毒性的大小,以大鳞副泥鳅作为受试动物,研究不同浓度的高效氯氟氰菊酯对其急性毒性和生理毒性的影响。结果表明:高效氯氟氰菊酯对大鳞副泥鳅24h、48h、96h的半数致死浓度(LC50)分别为25.93μg/L、17.28... 详细信息

为了估测高效氯氟氰菊酯对水生生物毒性的大小,以大鳞副泥鳅作为受试动物,研究不同浓度的高效氯氟氰菊酯对其急性毒性和生理毒性的影响。结果表明:高效氯氟氰菊酯对大鳞副泥鳅24h、48h、96h的半数致死浓度(LC50)分别为25.93μg/L、17.28μg/L、14.11μg/L,安全浓度为2.30μg/L。低浓度高效氯氟氰菊酯对大鳞副泥鳅肝脏谷丙转氨酶(GPT)和谷草转氨酶(GOT)起诱导作用,高浓度对其起抑制作用,试验组与对照组存在显著或极显著差异。研究表明,高效氯氟氰菊酯对大鳞副泥鳅有较强的毒性。

关键词：高效氯氟氰菊酯大鳞副泥鳅急性毒性谷丙转氨酶谷草转氨酶