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基于STM的外语慕课学习者满意度及影响因素分析

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中国外语 2024年第4期21卷 58-68页

作者：杨林伟胡杰辉烟台大学电子科技大学

学习者满意度是外语慕课持续发展的关键要素。本研究基于外语慕课学习者的评论数据,通过词频统计与结构主题模型(STM),研究了学习者满意度的现状及其影响因素;采用可视化分析,挖掘学习者关注的主题类型及相关关系,进而考察课程类型与教... 详细信息

学习者满意度是外语慕课持续发展的关键要素。本研究基于外语慕课学习者的评论数据,通过词频统计与结构主题模型(STM),研究了学习者满意度的现状及其影响因素;采用可视化分析,挖掘学习者关注的主题类型及相关关系,进而考察课程类型与教师团队规模等外部协变量对满意度的调节效应。结果显示,学习者重点关注的负面主题有考试、评估和技术等问题,学习者学习期望以及教师教学风格是影响学习者满意度的主要因素;显著的正面主题有知识性和学术性,二者是外语慕课质量提升的关键抓手。同时,课程类型和教师团队规模与外语慕课知识性和学术性之间存在交互效应。上述结果对提升外语慕课质量和建设一流本科课程具有重要参考意义。

关键词：外语慕课课程评论学习者满意度结构主题模型

Coupled Effects of Heat and Moisture of Early-Age Concrete

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Fluid Dynamics & Materials Processing 2021年第4期17卷 845-857页

作者： yang Wang Hanxi Wang linwei yang Li Qian School of Urban Construction and Transportation Hefei UniversityHefei230601China School of Electronic Science and Applied Physics Hefei University of TechnologyHefei230601China

In order to analyze the coupled influence of temperature and humidity on early-age concrete(including cement and copper tailings),a mathematical model is introduced on the basis of the Krstulovic-Dabic hydration reaction kinetic *** such a framework,the influence of hydration-released heat and water consumption are also taken into *** results provided by such a model are verified by means of experiments and related sensor *** research results show that this model can adequately predict the internal temperature and the humidity temporal evolution laws.

关键词： Composite cementitious materials cement hydration micro-structure diffusion coefficient coupled of heat and moisture

Three modes of a direct-current plasma jet operated underwater to degrade methylene blue

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Plasma Science and Technology 2017年第11期19卷 75-81页

作者： Xuechen LI Biao WANG Pengying JIA linwei yang Yaru LI Jingdi CHU College of Physics Science and Technology Hebei UniversityBaoding 071002People's Republic of China Key Laboratory of Photo-Electronics Information Materials of Hebei Province Baoding 071002People's Republic of China

A direct-current air plasma jet operated underwater presents three stable modes including an intermittently-pulsed discharge, a periodically-pulsed discharge and a continuous discharge with increasing the power voltage. The three discharge modes have different appearances for the plasma plumes. Moreover, gap voltage-current characteristics indicate that the continuous discharge is in a normal glow regime. Spectral lines from reactive species（OH, N2, N2^＋, Hα,and O） have been revealed in the emission spectrum of the plasma jet operated *** intensities emitted from OH radical and oxygen atom increase with increasing the power voltage or the gas flow rate, indicating that reactive species are abundant. These reactive species cause the degradation of the methylene blue dye in solution. Effects of the experimental parameters such as the power voltage, the gas flow rate and the treatment time are investigated on the degradation efficiency. Results indicate that the degradation efficiency increases with increasing the power voltage, the gas flow rate or the treatment time. Compared with degradation in the intermittently-pulsed mode or the periodically-pulsed one, it is more efficient in the continuous mode, reaching 98% after 21 min treatment.

关键词： plasma jet direct current glow discharge plasma degradation methylene blue

Research on Mechanical Product Development based on CAD Software

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International Journal of Technology Management 2013年第1期 40-42页

作者： Funa Li linwei yang Ying Zeng Faculty of Art and Media Kunming University of Science and Technology KunmingYunnan650501 China City College Kunming University of Science and Technology KunmingYunnan650501 China

This paper introduces analysis the development process of CAD technology, application of the AutoCAD software in engineering field and teaching as well as the significance of the development of two times the. This paper analyzes in detail the development of common language, and the use of Visual BASIC development and application of software based on AutoCAD. The author elaborates the software interlace design and method calls AutoCAD in VB. Finally, the design and implementation of a programming language re-development system based on AutoCAD is concerned. The test results show that the developed AutoCAD two development system has good practical value.

关键词： AutoCAD Visual BASIC re-development program design

Improving the value of molecular testing:current status and opportunities in colorectal cancer precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 21-28页

作者： Haiyun Li linwei Guo Chenchen Wang Xin Hu Ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Precision Cancer Medical Center Affiliated with Fudan University Shanghai Cancer Center Shanghai 201315China

Colorectal cancer(CRC)is the second leading cause of cancer-related deaths *** radical resection with adjuvant chemotherapy remains the primary treatment choice for CRC,but the 5-year postoperative survival rate is only approximately 60%,and approximately one-third of patients with CRC experience recurrence within 2 years of ***,the transformation of high-throughput sequencing has accelerated the development of precision *** example,KRAS mutations indicate resistance to anti-epidermal growth factor receptor(EGFR)-targeted therapies in ***,molecular-guided individualized therapy has brought new promise in major clinical areas and challenges,such as novel biomarkers predicting sensitivity and resistance to immunotherapy for microsatellite stable(MSS)CRC.

关键词： cancer chemotherapy colorectal

Channel-bias-controlled reconfigurable silicon nanowire transistors via an asymmetric electrode contact strategy

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Chip 2024年第3期3卷 8-14页

作者： Wentao Qian Junzhuan Wang Jun Xu linwei Yu School of Electronic Science and Engineering/National Laboratory of Solid-State Microstructures Nanjing UniversityNanjing 210093China

Reconfigurable field-effect transistors(R-FETs)that can dynamically reconfigure the transistor polarity,from n-type to p-type channel or vice versa,represent a promising new approach to reduce the logic complexity and granularity of programmable *** R-FETs have been successfully demonstrated upon silicon nanowire(SiNW)channels,a pair of extra program gates is still needed to control the source/drain(S/D)*** this work,we propose a rather simple single gate R-FET structure with an asymmetric S/D electrode contact,where the FET channel polarity can be altered by changing the sign of channel bias V_(ds).These R-FETs were fabricated upon an orderly array of planar SiNW channels,grown via in-plane solid-liquid-solid mechanism,and contacted by Ti/Al and Pt/Au at the S/D electrodes,***,this channel-bias-controlled R-FET strategy has been successfully testified and implemented upon both p-typedoped(with indium dopants)or n-type-doped(phosphorus)SiNW channels,whereas the R-FET prototypes demonstrate an impressive high I_(on/off) ratio of>10^(6) and a steep subthreshold swing of 79 mV/*** results indicate a rather simple,compact and generic enough R-FET strategy for the construction of a new generation of SiNW-based programmable and low-power electronics.

关键词： Catalytic Si nanowires Asymmetric electrodes Reconfigure transistor

Synthetic auxotrophs accelerate cell factory development through growth-coupled models

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 73-87页

作者： Liangpo Li linwei Yu Xinxiao Sun Qipeng Yuan Xiaolin Shen Jia Wang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

The engineering of microbial cell factories for the production of high-value chemicals from renewable resources presents several challenges,including the optimization of key enzymes,pathway fluxes and metabolic *** these challenges involves the development of synthetic auxotrophs,a strategy that links cell growth with enzyme properties or biosynthetic *** linkage allows for the improvement of enzyme properties by in vivo directed enzyme evolution,the enhancement of metabolic pathway fluxes under growth pressure,and remodeling of metabolic networks through directed strain *** advantage of employing synthetic auxotrophs lies in the power of growth-coupled selection,which is not only high-throughput but also labor-saving,greatly simplifying the development of both strains and *** auxotrophs play a pivotal role in advancing microbial cell factories,offering benefits from enzyme optimization to the manipulation of metabolic networks within single ***,this strategy extends to coculture systems,enabling collaboration within microbial *** review highlights the recently developed applications of synthetic auxotrophs as microbial cell factories,and discusses future perspectives,aiming to provide a practical guide for growth-coupled models to produce value-added chemicals as part of a sustainable biorefinery.

关键词： synthetic auxotrophs growth-coupled directed enzyme evolution pathway flux directed strain evolution coculture

Myosin Va‑dependent Transport of NMDA Receptors in Hippocampal Neurons

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Neuroscience Bulletin 2024年第8期40卷 1053-1075页

作者： Ru Gong linwei Qin Linlin Chen Ning Wang Yifei Bao Wei Lu Ministry of Education(MOE)Key Laboratory of Developmental Genes and Human Disease School of Life Science and TechnologySoutheast UniversityNanjing 210096China Department of Neurosurgery State Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai 200032China Department of Neurobiology Nanjing Medical UniversityNanjing 210096China Co‑innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

N-methyl-D-aspartate receptor(NMDAR)trafficking is a key process in the regulation of synaptic efficacy and brain ***,the molecular mechanism underlying the surface transport of NMDARs is largely *** we identified myosin Va(MyoVa)as the specific motor protein that traffics NMDARs in hippocampal *** found that MyoVa associates with NMDARs through its cargo binding *** association was increased during NMDAR surface *** of MyoVa suppressed NMDAR *** further demonstrated that Ca^(2+)/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ)regulates NMDAR transport through its direct interaction with ***,MyoVa employed Rab11 family-interacting protein 3(Rab11/FIP3)as the adaptor proteins to couple themselves with NMDARs during their ***,the knockdown of FIP3 impairs hippocampal ***,we conclude that in hippocampal neurons,MyoVa conducts active transport of NMDARs in a CaMKII-dependent manner.

关键词： Myosin Va NMDA receptor CaMKⅡ Transport Memory

A layered multifunctional framework based on polyacrylonitrile and MOF derivatives for stable lithium metal anode

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Journal of Energy Chemistry 2024年第6期93卷 282-288,I0007页

作者： Fanfan Liu Peng Zuo Jing Li Pengcheng Shi Yu Shao linwei Chen Yihong Tan Tao Ma Engineering Research Center of High-frequency Soft Magnetic Materials and Ceramic Powder Materials of Anhui Province School of Chemistry and Material EngineeringChaohu UniversityHefei 238024AnhuiChina Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Anhui University of Chinese MedicineHefei 230012AnhuiChina School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006GuangdongChina Jiujiang DeFu Technology Co. Ltd.Jiujiang 332000JiangxiChina

Composite Li metal anodes based on three-dimensional(3D) porous frameworks have been considered as an effective material for achieving stable Li metal batteries with high energy ***,uneven Li deposition behavior still occurs at the top of 3D frameworks owing to the local accumulation of Li *** promote uniform Li deposition without top dendrite growth,herein,a layered multifunctional framework based on oxidation-treated polyacrylonitrile(OPAN) and metal-organic framework(MOF) derivatives was proposed for rationally regulating the distribution of Li ions flux,nucleation sites,and electrical *** from these merits,the OPAN/carbon nano fiber-MOF(CMOF) composite framework demonstrated a reversible Li plating/stripping behavior for 500 cycles with a stable Coulombic efficiency of around 99.0% at the current density of 2 mA/cm~***,such a Li composite anode exhibited a superior cycle lifespan of over 1300 h under a low polarized voltage of 18 mV in symmetrical *** the Li composite anode was paired with LiFePO_(4)(LFP) cathode,the obtained full cell exhibited a stable cycling over 500 ***,the COMSOL Multiphysics simulation was conducted to reveal the effects on homogeneous Li ions distribution derived from the above-mentioned OPAN/CMOF framework and electrical insulation/conduction *** electrochemical and simulated results shed light on the difficulties of designing stable and safe Li metal anode via optimizing the 3D frameworks.

关键词： Lithium metal anode Layered multifunctional framework Ions flux redistribution Electrical insulation/conduction structure Uniform Li deposition