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Effectiveness of massage therapy on post-operative outcomes among patients undergoing cardiac surgery:A systematic review

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International Journal of Nursing Sciences 2015年第3期2卷 304-312页

作者： C.Ramesh Vasudev Baburaya Pai Nitin Patil Baby S.Nayak Anice george linu sara george Elsa Sanatombi Devi Manipal College of Nursing Manipal UniversityManipalIndia Kasturba Medical College Manipal UniversityManipalIndia

The incidence and prevalence of cardiovascular disease(CVD)are increasing rapidly in developing *** patients with CVD do not respond to medical treatment and have to undergo cardiac *** highly stressful experience results in increased levels of anxiety for *** objective of this review was to evaluate the efficacy of massage therapy on postoperative outcomes among patients undergoing cardiac surgery.A comprehensive literature search was made on PubMed-Medline,CINAHL,Science Direct,Scopus,Web of Science and the Cochrane library databases for original research articles published between 2000 and *** articles that reported the efficacy of massage therapy in patients undergoing cardiac surgery were *** Cochrane data extraction form was used to extract data.A total of 297 studies were identified in the literature ***,only seven studies were eligible for *** the seven studies,six studies demonstrated the effects of massage therapy on improving postoperative outcomes of patients,while one study found no evidence of *** the methods varied considerably,most of the studies included in this review reported positive ***,there is some evidence that massage therapy can lead to positive postoperative *** of the effectiveness of massage therapy in patients undergoing cardiac surgery remains *** research is needed to provide a strong evidence base for the use of massage therapy to improve post-operative outcomes and recovery among cardiac surgery patients.

关键词： Anxiety Heart surgery Massage Pain Post-operative period

An Efficient 3D CNN Framework with Attention Mechanisms for Alzheimer’s Disease Classification

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Computer Systems Science & Engineering 2023年第11期47卷 2097-2118页

作者： Athena george Bejoy Abraham Neetha george linu Shine Sivakumar Ramachandran Department of Electronics and Communication Engineering College of EngineeringTrivandrum695016India Department of Computer Science and Engineering College of Engineering MuttatharaTrivandrum695008India Department of Electronics and Communication Rajeev Gandhi Institute of TechnologyKottayam686501India Department of Electronics and Communication Engineering Government Engineering CollegeWayanad670644India

Neurodegeneration is the gradual deterioration and eventual death of brain cells,leading to progressive loss of structure and function of neurons in the brain and nervous *** disorders,such as Alzheimer’s,Huntington’s,Parkinson’s,amyotrophic lateral sclerosis,multiple system atrophy,and multiple sclerosis,are characterized by progressive deterioration of brain function,resulting in symptoms such as memory impairment,movement difficulties,and cognitive *** diagnosis of these conditions is crucial to slowing down cell degeneration and reducing the severity of the *** resonance imaging(MRI)is widely used by neurologists for diagnosing brain *** majority of the research in this field focuses on processing the 2D images extracted from the 3D MRI volumetric scans for disease *** might result in losing the volumetric information obtained from the whole brain *** address this problem,a novel 3D-CNN architecture with an attention mechanism is proposed to classify whole-brain MRI images for Alzheimer’s disease(AD)*** 3D-CNN model uses channel and spatial attention mechanisms to extract relevant features and improve accuracy in identifying brain dysfunctions by focusing on specific regions of the *** pipeline takes pre-processed MRI volumetric scans as input,and the 3D-CNN model leverages both channel and spatial attention mechanisms to extract precise feature representations of the input MRI volume for accurate *** present study utilizes the publicly available Alzheimer’s disease Neuroimaging Initiative(ADNI)dataset,which has three image classes:Mild Cognitive Impairment(MCI),Cognitive Normal(CN),and AD *** proposed approach achieves an overall accuracy of 79%when classifying three classes and an average accuracy of 87%when identifying AD and the other two *** findings reveal that 3D-CNN models with an attention mechanism exhibit significantly higher classi

关键词： 3D CNN alzheimer’s disease attention mechanism classification

INF-γ and IL-2 Profile as Therapeutic Markers in Tuberculosis Patients at the Jamot Hospital of Yaounde-Cameroon

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Journal of Tuberculosis Research 2024年第2期12卷 119-128页

作者： Alexandra Emmanuelle Membangbi Jacky Njiki-Bikoï Esther Del-Florence Moni Ndedi Donatien Serge Mbaga Elsa Nguiffo Makue André Chris Mikangue Mbongue Koko-Ta Ladiff Sharonne Martha Mesembe Justin Olivier Essindi Aïcha Ngoutane Arnaud Franck Elang Sabine Aimée Touangnou-Chamda george Ikomey Mondinde Eric Walter Perfura-Yone Marie Joseph Nkodo Mindimi sara Honorine Riwom Essama Department of Microbiology The University of Yaound 1 Yaound Cameroon Center for the Study and Control of Communicable Diseases (CSCCD) Yaound Cameroon The Institute for Medical Research and Medicinal Plants Studies Yaound Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaound I Yaound Cameroon The Pneumology Department Jamot Hospital of Yaound Yaound Cameroon

Background: Tuberculosis (TB) is one of the top lethal infectious diseases worldwide. In recent years, interferon-γ (INF-γ) release assays (IGRAs) have been established as routine tests for diagnosing TB infection. However, produced INF-γ assessment cannot permit to distinguish active ATB from latent TB infection (LTBI), especially in TB epidemic areas. In addition to IFN-γ, interleukin-2 (IL-2), secreted by activated T cells, is involved in immune response against Mycobacterium tuberculosis. This could be involved in the follow up of treatment response. The aim of our study was to determine IFN-γ and IL2 cytokines profiles of patients under antituberculosis treatment. Materials and Methods: A six months’ cross-sectional study was conducted at the Jamot Hospital of Yaoundé, from May to August 2021. Sociodemographic and clinical data as well as 5 mL of blood were collected from each participant. INF-γ and IL-2 were determined using indirect Enzyme linked Immuno-Sorbent Assay (ELISA) according to the manufacturer’s recommendations and spectrum exam in combination with radiography and GeneXpert were used as standard. P-values Results: The results showed that men were more infected 14/61 (31.8%) with a high presence in active and resistant TB groups. The mean age was 41.3 ± 13.1 years with a 95% CI = [38.2 - 44.7], the age group with the highest infection rate was ranged between 31 and 40 years. The IL-2 and INF-γ means were respectively 327.6 ± 160.6 pg/mL and 26.6 ± 13.0 pg/mL in ATB patients, 251.1 ± 30.9 pg/mL and 21.4 ± 9.2 pg/mL in patients with resistant tuberculosis, while it was 149.3 ± 93.3 pg/mL and 17.9 ± 9.4 pg/mL in cured patients, 15.1 ± 8.4 pg/mL and 5.3 ± 2.6 pg/mL in participants presumed healthy (p γ and IL-2rates were observed between the different groups. Conclusion: Monitoring the serum levels of INF-γ and IL-2 would be useful for the follow-up of anti-tuberculosis patients, particularly in the both cytokines association case.

关键词： Tuberculosis Antituberculosis Treatment INF-γ IL-2 ELISA

Circulating CD14＋ monocytes in patients with aortic stenosis

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Journal of Geriatric Cardiology 2016年第1期13卷 81-87页

作者： sara Shimoni Valery Meledin Iris Bar Jacob Fabricant Gera Gandelman Jacob george Heart Institute Kaplan Medical Center Rehovot Israel

BackgroundCalcific aortic stenosis （AS） is an active process sharing similarities with atherosclerosis and chronic inflammation. The pathophysiology of AS is notable for three cardinal components： inflammation, fibrosis and calcification. Monocytes play a role in each of these processes. The role of circulating monocytes in AS is not clear. The aim of the present study was to study an association between cir-culating apoptotic and non apoptotic CD14＋ monocytes and AS *** assessed the number of CD14＋ monocytes and apoptotic monocytes in 54 patients with significant AS （aortic valve area 0.74 ± 0.27 cm2） and compared them to 33 patients with similar risk factors and no valvular disease. The level of CD14＋ monocytes and apoptotic monocytes was assessed by flow *** was no difference in the risk factor profile and known coronary or peripheral vascular diseases between patients with AS and ***-tients with AS exhibited increased numbers of CD14＋ monocytes as compared to controls （9.9% ± 4.9%vs. 7.7% ± 3.9%,P= 0.03）. CD14＋ monocyte number was related to age and the presence and severity of AS. In patients with AS, both CD14＋ monocytes and apoptotic mono-cytes were inversely related to aortic valve *** with significant AS have increased number of circulating CD14＋ monocytes and there is an inverse correlation between monocyte count and aortic valve area. These findings may suggest that inflammation is operative not only in early valve injury phase, but also at later developed stages such as calcification when AS is severe.

关键词： Aortic stenosis Inflammation Monocytes

Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification

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世界骨科杂志：英文版 2017年第5期8卷 400-411页

作者： David A george Lorenzo Drago sara Scarponi Enrico Gallazzi Fares S Haddad Carlo L Romano Department of Trauma and Orthopaedics University College London Hospitals Microbiological Laboratory Orthopaedic Re-search Institute Galeazzi Centre for Reconstructive Surgery and Osteoarticular Infections Orthopaedic Research Institute Galeazzi

AIM To undertook a systematic review to determine factors that increase a patient's risk of developing lower limb periprosthetic joint infections(PJI).METHODS This systematic review included full-text studies that reviewed risk factors of developing either a hip or knee PJI following a primary arthroplasty published from January 1998 to November 2016. A variety of keywords were used to identify studies through international databases referencing hip arthroplasty, knee arthroplasty, infection, and risk factors. Studies were only included if they included greater than 20 patients in their study cohort, and there was clear documentation of the statistical parameter used; specifically P-value, hazard ratio, relative risk, or/and odds ratio(OR). Furthermore a quality assessment criteria for the individual studies was undertaken to evaluate the presence of record and reporting bias. RESULTS Twenty-seven original studies reviewing risk factors relating to primary total hip and knee arthroplasty infections were included. Four studies(14.8%) reviewed PJI of the hip, 3(11.21%) of the knee, and 20(74.1%) reviewed both joints. Nineteen studies(70.4%) were retrospective and 8(29.6%) prospective. Record bias was identified in the majority of studies(66.7%). The definition of PJI varied amongst the studies but there was a general consensus to define infection by previously validated methods. The most significant risks were the use of preoperative high dose steroids(OR = 21.0, 95%CI: 3.5-127.2, P < 0.001), a BMI above 50(OR = 18.3, P < 0.001), tobacco use(OR = 12.76, 95%CI: 2.47-66.16, P= 0.017), body mass index below 20(OR = 6.00, 95%CI: 1.2-30.9, P = 0.033), diabetes(OR = 5.47, 95%CI: 1.77-16.97, P = 0.003), and coronary artery disease(OR = 5.10, 95%CI: 1.3-19.8, P = 0.017).CONCLUSION We have highlighted the need for the provider to optimise modifiable risk factors, and develop strategies to limit the impact of non-modifiable factors.

关键词： Periprosthetic joint infection Risk factor Predictive Hip arthroplasty Knee arthroplasty

Metal Salts Assisted Enzyme-Based Extraction of Stevioside from the Leaves of <i>Stevia rebaudiana</i>Bertoni

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Advances in Bioscience and Biotechnology 2015年第12期6卷 734-743页

作者： A. Bhaskar Rao sara A. george Sateesh Alavala H. M. Meshram K. Chandra Shekar Medicinal Chemistry and Pharmacology Division CSIR-Indian Institute of Chemical Technology Hyderabad India

Stevioside, extracted from the leaves of Stevia rebaudiana Bertoni, is a natural, high intensity, lowcaloric sweetener with wide therapeutic activities. Conventional stevioside extraction methodologies involve the use of non-green solvents, supercritical fluids, microwaves, etc., however, all these processes are expensive, time-consuming and eco-unfriendly. Therefore an alternative process is desired for the isolation of stevioside. In this study, a novel enzyme-mediated extraction (EME) method has been developed. The dry stevia leaves were pre-treated with hydrolytic enzymes aided by transition metal salts (FeCl3). This was followed by pressurized hot water extraction (PHWE) to release stevioside. The crude extract was purified and clarified through multi-stage membrane filtration. The results confirm that metal salt-assisted cellulase pre-treatment enhanced the yield of stevioside to 72%, with 98% purity, which was higher in comparison to existing methods. Thus, the methodology developed establishes a simple, “green”, enzyme-mediated process for the efficient isolation of stevioside under economical and eco-friendly conditions.

关键词： Stevia rebaudiana Enzyme-Based Extraction Membrane Filtration Stevioside Natural Sweetener

From Hit to Lead:Design and Synthesis of Dihydro-pyrimidones as NNRTIs with Improved Drug Resistance Properties——A Modular Focused Library Design Approach

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From Hit to Lead:Design and Synthesis of Dihydro-pyrimidones...

Accuracy Comparison of 4D Computed Tomography (4DCT) and 4D Cone Beam Computed Tomography (4DCBCT)

中国化学会第二十五届学术年会

作者： george Burton sara Thrall george Freeman Webb Andrews Benjamin Schwartz Elsie Diaz Jerry Jeffery Edward Garvey Bob Nolte Kirk Weaver Ralph Rivero GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 .

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第3期6卷 323-335页

作者： Tzu-Cheng Lee Stephen R. Bowen sara St. James george A. Sandison Paul E. Kinahan Matthew J. Nyflot Department of Bioengineering University of Washington Seattle WA USA Department of Radiation Oncology University of Washington Seattle WA USA Department of Radiology University of Washington Seattle WA USA

The ability of respiratory-correlated fan beam CT (4DCT) and respiratory-correlated cone beam CT (4DCBCT) to accurately estimate tumor volume is critical to accurate dosimetry and treatment verification for lung stereotactic body radiation therapy (SBRT) and other motion-managed therapies. However, it is known that 4DCT and 4DCBCT differ in aspects of image acquisition and reconstruction that may lead to discrepancies between the two modalities. To evaluate quantitative differences between 4DCT and 4DCBCT imaging under respiratory motion, we performed a phantom study in the ground truth setting. A programmable respiratory motion phantom was used to simulate the 1D S-I position of a known-size lesion. Ten sinusoidal and twenty patient-specific breathing waveforms were applied to drive lesion motion during the 4DCT and 4DCBCT acquisitions. The difference in lesion volume acquired between the two imaging modalities was as high as 34.4% and 18.4% for sinusoidal and patient-specific breathing motions, respectively. When compared to the true volume, 4DCT measurement often underestimated the lesion size whereas 4DCBCT overestimated the lesion volume in most of the cases. 4DCBCT gave more accurate recovery of the volume than 4DCT for most settings tested in this study. These findings may be helpful for improving the definition of internal target and planning target volume margins, and extracting quantitative information from on-board treatment verification imaging.

关键词： 4DCT 4DCBCT Verification Imaging Respiratory Motion Phantom

Unraveling quad fever:Severe hyperthermia after traumatic cervical spinal cord injury

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Chinese Journal of Traumatology 2023年第1期26卷 27-32页

作者： Carlton C.L.Watson Dooniya Shaikh Jody C.DiGiacomo Aaron C.Brown Raina Wallace Shridevi Singh Lisa Szydziaka sara Cardozo-Stolberg LD.george Angus Department of Surgery Nassau University Medical CenterEast MeadowNY1155USA American University of the Caribbean School of Medicine Pembroke PinesFL33027USA

Purpose:There are many infectious and inflammatory causes for elevated core-body temperatures,though they rarely pass 40℃(104℉).The term"quad fever"is used for extreme hyperpyrexia in the setting of acute cervical spinal cord injuries(SCIs).The traditional methods of treating hyperpyrexia are often ineffective and reported morbidity and mortality rates approach 100%.This study aims to identify the incidence of elevated temperatures in SCIs at our institution and assess the effectiveness of using a non-invasive dry water temperature management system as a treatment modality with ***:A retrospective analysis of acute SCI patients requiring surgical intensive care unit admission who experienced fevers≥40℃(104℉)were compared to patients with maximum temperatures<40℃.Patients≥18 years old who sustained an acute traumatic SCI were included in this *** who expired in the emergency department;had a SCI without radiologic abnormality;had neuropraxia;were admitted to any location other than the surgical intensive care unit;or had positive blood cultures were *** 9.4 was used to conduct statistical ***:Over the 9-year study period,35 patients were admitted to the surgical intensive care unit with a verified *** patients experienced maximum temperatures of≥40℃.Six of those patients were treated with the dry water temperature management system with an overall mortality of 57.1%in this *** mortality rate for the 28 patients who experienced a maximum temperature of≤40℃was 21.4%(p=0.16).Conclusion:The diagnosis of quad fever should be considered in patients with cervical SCI in the presence of *** this study,there was no significant difference in mortality between quad fever patients treated with a dry water temperature management system versus SCI patients without quad *** early use of a dry water temperature management system appears to decrease the mortality rate of quad fever.

关键词： Spinal cord injuries Fever Quadriplegia Therapeutic hypothermia