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Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi cai Long Qiu Zhenying Diao lintao cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

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Indocyanine Green Nanoparticles for Theranostic Applications

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Nano-Micro Letters 2013年第3期5卷 145-150页

作者： Zonghai Sheng Dehong Hu Miaomiao Xue Meng He Ping Gong lintao cai Guangdong Key Laboratory of Nanomedicine CAS Key Laboratory of Health Informatics Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences

Theranostics is a concept that integrated imaging and therapy. As an emerging field, it embraces multiple techniques to arrive at an individualized treatment purpose. Indocyanine green(ICG) is a near infrared dye that has been approved by Food and Drug Administration(FDA) in USA for the use in indicator-dilution studies in humans. ICG nanoparticles(NPs) have attracted much attention for its potential applications in cancer theranostics. This review focuses on the preparation, application of ICG NPs for in vivo imaging(fluorescent imaging and photoacoustic imaging) and therapeutics(photothermal therapy, photodynamic therapy and photoacoustic therapy), and future directions based on recent developments in these areas. It is hoped that this review might provide new impetus to understand ICG NPs for cancer theranostics.

关键词： Indocyanine green(ICG) Nanoparticles Theranostics Cancer

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Cryomicroneedle delivery of nanogold-engineered Rhodospirillum rubrum for photochemical transformation and tumor optical biotherapy

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Bioactive Materials 2024年第7期37卷 505-516页

作者： Qingxia Shi Ting Yin Cuiping Zeng Hong Pan Ze Chen Lin Wang Bo Wang Mingbin Zheng lintao cai Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen518055China Guangdong Key Laboratory for Research and Development of Natural Drugs Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan523808China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen518055China National Clinical Research Center for Infectious Disease Shenzhen Third People’s HospitalThe Second Affiliated HospitalSouthern University of Science and TechnologyShenzhen518112China Sino-Euro Center of Biomedicine and Health Shenzhen518024China

Tumor metabolite regulation is intricately linked to cancer *** lactate is a characteristic metabolite of the tumor microenvironment(TME),it supports tumor progression and drives *** this study,we presented a strategy for antitumor therapy by developing a nanogold-engineered Rhodospirillum rubrum(R.r-Au)that consumed lactate and produced hydrogen for optical *** leveraged a cryogenic micromolding approach to construct a transdermal therapeutic cryomicroneedles(CryoMNs)patch integrated with R.r-Au to efficiently deliver living bacterial *** long-term storage studies revealed that the viability of R.r-Au in CryoMNs remained above 90%.We found that the CryoMNs patch was mechanically strong and could be inserted into mouse *** addition,it rapidly dissolved after administering bacterial drugs and did not produce *** laser irradiation,R.r-Au effectively enhanced electron transfer through Au NPs actuation into the photosynthetic system of *** and enlarged lactate consumption and hydrogen production,thus leading to an improved tumor immune *** study demonstrated the potential of CryoMNs-R.r-Au patch as a minimally invasive in situ delivery approach for living bacterial *** research opens up new avenues for nanoengineering bacteria to transform tumor metabolites into effective substances for tumor optical biotherapy.

关键词： Cryomicroneedles Photosynthetic bacteria Lactate depletion Hydrogen generation Optical biotherapy

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Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

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Nano Research 2022年第5期15卷 4224-4232页

作者： Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu Lanlan Liu Ze Chen Hui Ran Qingxia Shi Hong Pan Aiqing Ma lintao cai Guangdong Key Laboratory for Research and Development of Natural Drugs Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China

Sonodynamic therapy(SDT)has aroused considerable momentum in cancer therapy due to its abilities of deep penetration,low toxicity,and noninvasion,while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT ***,we developed a 4T1 cancer cell-macrophage hybrid membrane(HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor(HPPH)-loaded albumin nanoparticles(PHNPs).The experimental results proved that the HM-coated biomimetic NPs(PHNPs@HM)could express the characteristic membrane proteins of both cancer cells and macrophages,remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune ***,as a novel sonosensitizer,HPPH could generate amount of reactive oxygen species(ROS)under ultrasound(US)irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell *** study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency.

关键词： biomimetic materials sonodynamic therapy hybrid cell membrane photochlor sonosensitizer noninvasive treatment

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Optical characteristics and environmental pollutants detection of porous silicon microcavities

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Science China Chemistry 2011年第8期54卷 1348-1356页

作者： HUANG JianFeng, LI Sha, CHEN QingWei & cai lintao CAS Key Laboratory of Health Informatics Shenzhen Key Laboratory of Cancer Nanotechnology Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China CAS Key Laboratory of Health Informatics Shenzhen Key Laboratory of Cancer Nanotechnology Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China

Porous silicon microcavities (PSM) optical crystals consisting of a Fabry-Perot microcavity embedded between two distributed Bragg reflectors have been fabricated by electrochemical etching. Scanning electron microscopy (SEM) clearly depicted their physical sandwich construction. The optical feature of the PSM structure was tuned by varying the anodization parameters. Through proper thermal oxidation and surface chemical modifications, the resulting structures were employed as optical sensors for the detection of environmental pollutants including volatile organic vapors (i.e. acetonitrile, toluene, cyclohexane, chloroform, acetone and ethanol) and interior decoration gases (i.e. toluene, ammonia and formaldehyde). Fourier transform infrared spectroscopy (FTIR) spectra confirmed the effective thermal annealing and surface modification chemistry, and the sensing process was accompanied by recording the modified structures' optical responses when exposed to target analytes. The PSM optical sensors showed good stability, sensitivity and selectivity, implying promising applications in gas sensing and en- vironmental monitoring.

关键词： porous silicon microcavity optical sensor thermal oxidation surface modification environmental pollutants detection

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Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor

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Bioactive Materials 2021年第4期6卷 951-962页

作者： Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He Mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin Jiang Ting Yin Ruijing Liang Yifan Ma lintao cai Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Lab for Health InformaticsShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsShenzhen Institutes of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen518055PR China HRYZ Biotech Co. Shenzhen518057PR China

The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic ***,unsatisfactory curative results and side effects for tumor treatment are still unsolved *** we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in ***,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial *** groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T *** vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood ***,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid *** CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients.

关键词： CAR-T cell Bioorthogonal click chemistry Glycometabolic labeling Off-target effects Cell immunotherapy

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Aptamer-Anchored Rubrene-Loaded Organic Nanoprobes for Cancer Cell Targeting and Imaging

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CCS Chemistry 2019年第3期1卷 251-260页

作者： Yuanyuan Li Chuansheng Li Tao Jiang Lihua Zhou Pengfei Zhang Ryan T.K.Kwok Jacky Wing Yip Lam Ping Gong lintao cai Ben Zhong Tang Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonChina HKUST Shenzhen Research Institute Shenzhen 518057China Guangdong Key Laboratory of Nanomedicine CAS Key Laboratory of Health InformaticsShenzhen Bioactive Materials Engineering Lab for MedicineInstitute of Biomedicine and Biotechnology.Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Pharmaceutical Sciences Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Dongguan Key Laboratory of Drug Design and Formulation Technology Key Laboratory for NanomedicineGuangdong Medical UniversityDongguan 523808China Center for Aggregation-Induced Emission NSFC Center for Luminescence from Molecular AggregatesSCUT-HKUST Joint Research LaboratoryState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Fluorescence imaging has become an indispensable technique in cancer research because it can reveal informative molecular,cellular,anatomical,and func-tional *** of advanced fluores-cent probes with superior sensitivity and biological selectivity for fluorescence imaging is thus *** move forward in this direction,we developed an easy self-assembly method for fabricating apta-mer-anchored rubrene-loaded organic fluorescent *** aptamer-modified organic nanop-robes integrated the best features of the organic light-emitting materials and the aptamers,thus endowing them with excellent cell-targeting capabil-ity,high stability,and good *** using this general method,a variety of biocompatible and highly bright organic fluorescent nanoprobes based on novel organic light-emitting materials with specific recognition could be easily constructed for real-time biosensing and long-term biomedical imaging.

关键词： aptamer organic nanoprobes fluores-cence cancer imaging biomedicine

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Targeting chemotherapy of choriocarcinoma by using CSA-binding nanoparticles loaded with doxorubicin

Targeting chemotherapy of choriocarcinoma by using CSA-bindi...

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中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Baozhen Zhang Jian Zhang Guogang Cheng Pengfei Zhao Mingbin Zheng Dan Li lintao cai Xiujun Fan Shoujun Li Laboratory for Reqroductive Health Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases

Choriocarcinoma was the first treated cancer by chemotherapy with high success rate about 70%in severe condition,which is relative high rate compare to other type of ***,it still requires high dose systemic chemo-drug delivery,which is harmful to other healthy tissue and *** sulfate A(CSA)is exclusively expressed in the *** this study,in order to target the choriocarcinoma cells only,

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阳极氧化法制备多孔氧化铝膜的研究

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东南大学学报（自然科学版） 1999年第6期29卷 45-47页

作者：赵冰蔡林涛顾宁东南大学生物科学与医学工程系南京210096

阳极化多孔氧化铝是典型的自组织的纳米结构材料．我们用酸溶液阳极氧化法制备了多孔氧化铝膜．从得到的ＡＦＭ图象及ＦＦＴ变换，证明了在适当的电解条件下。

关键词：多孔氧化铝纳米材料薄膜阳极氧化法制备

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Prevention and Treatment of Autoimmune Psoriasis by Directly Targeting c-Rel

Prevention and Treatment of Autoimmune Psoriasis by Directly...

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第十届全国免疫学学术大会

作者： Tingting Fan Shaowen Wang Linjian Yu Ruilin Liu Wenwen Geng Xiaochun Wan Huqiang Yi Yifan Ma lintao cai Youhai H.Chen Aishun Jin Qingguo Ruan Shenzhen Laboratory of Fully Human Antibody Engineering Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Key Laboratory of Cancer Nanotechnology Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Department of Pathology and Laboratory of Medicine University of Pennsylvania School of Medicine Department of Immunology Harbin Medical University

Objective:Psoriasis is a chronic inflammatory disorder of the *** evidence suggests that IL-17A may play an important role in the pathology of *** other members of the NF-κB family that are ubiquitously expressed,c-Rel is preferentially expressed by inflammatory cells and is used to directly control the expression of multiple inflammatory genes including *** therefore reasoned that targeting c-Rel may be a better strategy for the prevention and treatment of autoimmune ***:BMDCs were cultured with micelles-formulated si Rel/PEG-PLL-PLLeu or si NC/PEG-PLL-PLLeu complex and then stimulated or unstimulated with ***/C mice received a daily topical of imiquimod cream on the shaved back for 7 consecutive *** were then systemically administrated with si NC or si ***,scaling and thickening of the back skin were measured *** back skin were obtained for H&E *** expression level of c-Rel and its target gene m RNA were measured by q RT-PCR;The nuclear expression level of c-Rel was determined by western *** level of IL23p19 or IL-17A was determined using ***:si Rel treatment in vitro can effectively silencing the expression of c-Rel m RNA and protein in *** expression of both IL-23p19 m RNA and protein were also *** Rel treatment in vivo resulted in substantially lower scores for erythema,scaling,and thickening.H&E-stained sections of skin demonstrated decreased epidermal thickening in si Rel treated ***,splenocyte from si Rel treated mice produced significantly less ***,the expression of IL-23p19、IL-17A、IL-1βand IL-6 m RNA were significantly decreased in the skin of the si Rel treated ***:Treatment with si Rel can significantly decrease the severity of imiquimod induced autoimmune psoriasis,which appears to be related to decreased expression of multiple inflammatory cytokines including ***,c-Rel may be a potential therapeutic

关键词： c-Rel psorasis IL-17A siRNA nanoparticle

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