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Aggregate 2024年第1期5卷 419-426页

作者： Xiaohui Wu Fei Deng Yujie Chen Mengchen Xu Feihe Ma linqi shi Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical BiologyInstitute of Polymer Chemistry and College of ChemistryNankai UniversityTianjinP.R.China School of Materials Science and Engineering and State Key Laboratory of Separation Membranes and Membrane Processes Tiangong UniversityTianjinP.R.China

Natural molecular chaperones utilize spatially ordered multiple molecular forces to effectively regulate protein ***,synthesis of such molecules is a big *** concept of“aggregate science”provides insights to construct chemical entities(aggregates)beyond molecular levels to mimic both the structure and function of natural *** by this concept,herein we fabricate a novel multi-interaction(i.e.,electrostatic and hydrophobic interaction)cooperative nanochaperone(multi-co-nChap)to regulating protein *** multi-co-nChap is fabricated by rationally introducing electrostatic interactions to the surface(corona)and confined hydrophobic microdomains(shell)of traditional single-hydrophobic interaction *** demonstrate that the corona electrostatic attraction facilitates the diffusion of clients into the hydrophobic microdomains,while the shell electrostatic interaction balances the capture and release of *** finely synergizing corona electrostatic attraction with shell electrostatic repulsion and hydrophobic interaction,the optimized multi-co-nChap effectively facilitated de novo folding of nascent ***,the synergy between corona electrostatic attraction,shell electrostatic attraction and shell hydrophobic interaction significantly enhanced the capability of multi-co-nChap to protect native proteins from denaturation at harsh *** work provides important insights for understanding and design of nanochaperone,which is a kind of ordered aggregate with chaperone-like activity that beyond the level of single molecule.

关键词： chaperone-like activity cooperative effect nanochaperones ordered aggregates protein folding

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Synthesis and ultraviolet/aggregation-induced emission investigation of novel tetraphenylvinyl hydrazone derivatives: efficient multimodal chemosensors for fluoride ion

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Frontiers of Chemical Science and Engineering 2023年第12期17卷 2061-2073页

作者： Wenting Yin linqi shi Mengjiao Liang Yaodong Huang Junjiao Yang Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Analysis and Test Center of Beijing University of Chemical Technology Beijing University of Chemical TechnologyBeijing 100029China

Herein,three novel tetraphenylethylene hydrazone chemosensors TC12,SC16,and TC16 are prepared for the selective detection of F−.Two NH and one C=N units are incorporated into the sensors for better colorimetric responses,whereas the tetraphenyl unit is in charge of the aggregation-induced emission *** them,compounds SC16 and TC16 form stable gels with some organic *** the tetrahydrofuran/H2O solutions of the three compounds exhibit aggregation-induced emission effect,whereby the fluorescence emission increases by varying degrees with the volume of poor solvent ***,good aggregation-induced emission effects are observed in the self-assembly of SC16 and *** a sample chemosensor,TC12 in tetrahydrofuran responds to F−selectively with high sensitivity,with the colorimetric and fluorometric detection limits of 8.25×10^(−7) mol·L^(-1) and 2.69×10^(−7) mol·L^(-1),*** reversible gel-sol-gel phase transition and color changes indicate that both SC16-dimethyl sulfoxide and TC16-ethyl acetate gels specifically respond to F-with good *** detection results are well supported by ultraviolet-visible spectroscopy,fluorescent spectroscopy,and 1H nuclear magnetic *** importantly,the driving forces of gelation are visually clarified through the single crystal X-ray analysis of compound TOMe.

关键词： organogelator tetraphenylvinyldrazone single crystal aggregation-induced emission effect ion sensing

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Self-assembled nanochaperones enable the disaggregation of amyloid insulin fibrils

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Science China Chemistry 2022年第2期65卷 353-362页

作者： Hui Wang Ang Li Menglin Yang Yu Zhao linqi shi Rujiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China

The deposition of highly ordered amyloid fibrils is recognized as a hallmark of amyloidosis diseases such as Alzheimer’s disease and Parkinson’s *** the amyloid fibrils is considered as one of the effective strategies for the control and treatment of amyloidosis *** this article,by simulating the function of natural molecular chaperones,co-assembled block copolymer micelles with coordination groups of nitrilotriacetic acid(NTA)and hydrophobic microdomains of poly(Nisopropylacrylamide)(PNIPAM)on the surface were used as nanochaperones(n Chaps)to disaggregate amyloid insulin *** ions chelated by NTA can bind the histidine imidazole residues while the PNIPAM microdomains can interact with the exposed hydrophobic sites on the amyloid insulin fibrils,which synergistically perturb the stability of amyloid insulin fibrils,loosen their structure,and finally promote their disaggregation.A combination of characterizations with fluorescence spectroscopy,transmission electron microscopy(TEM),dynamic hight scattering(DLS),and quartz crystal microbalance(QCM)demonstrated that mature amyloid insulin fibrils were completely disaggregated after incubating with n Chaps for 90 *** study may provide a promising strategy for the development of n Chaps for the treatment of amyloidosis diseases.

关键词： amyloid fibrils insulin nanochaperones disaggregation

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Protein@PP-Zn nanocomplex assembled by coordination of zinc ions used for intracellular protein delivery

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Science China Chemistry 2023年第8期66卷 2354-2362页

作者： Liyun Cui Sainan Liu Fan Wu Hua Chen Yuanfeng Li linqi shi Yong Liu Rujiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China Wenzhou Institute University of Chinese Academy of SciencesWenzhou Key Laboratory of Interdiscipline and Translational MedicineWenzhou325001China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China

In recent years,intracellular delivery of protein drugs has attracted great attention,and polymer-based systems have been extensively exploited to develop efficient and safe ***,efficient intracellular delivery of protein drugs remains a challenge because of the cell membrane barrier and endosome ***,we report a protein@PP-Zn nanocomplex,which consists of an imidazole-containing block polymer poly(ethylene glycol)-block-poly(β-amino ester)(PEG-b-PAE(Im),PP),zinc ions,and protein drugs,for efficient intracellular protein ***-b-PAE(Im)could conjugate proteins via the bridging effect of zinc ions which simultaneously coordinate with imidazole groups on polymer and electron donor groups,such as imidazole and primary amine groups,on protein to improve the loading stability of *** a slightly acidic environment near cancer cells,the protonation of PAE(Im)backbone increases the positive charge density of the nanocomplex and promotes *** under a more acidic environment in endosomes,further protonation of imidazole groups leads to the disintegration of the nanocomplex and the breakdown of endosomes because of the proton sponge ***,protein is released into the *** the assistance of the nanocomplex,proteins with different sizes and isoelectric points are effectively delivered into *** work provides a stable,efficient and universal strategy for intracellular protein delivery.

关键词： protein zinc ions intracellular delivery coordination polymer

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Calixarene-integrated nano-drug delivery system for tumortargeted delivery and tracking of anti-cancer drugsin vivo

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Nano Research 2022年第8期15卷 7295-7303页

作者： Lina Xu Jingshan Chai Ying Wang Xinzhi Zhao Dong-Sheng Guo linqi shi Zhanzhan Zhang Yang Liu Key Laboratory of Functional Polymer Materials of Ministry of Education College of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Nano-drug delivery systems(nanoDDS)have been extensively investigated clinically to improve the therapeutic effect of anticancer ***,the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general *** this work,a calixarene-integrated nanoDDS(CanD)that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is *** hypoxia-responsive calixarene(SAC4A)exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B(RhB)under normoxic condition while decreasing the binding affinity under hypoxic condition,which leads to the drug release and fluorescence recovery ***,the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability,resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in ***,CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.

关键词： drug delivery system calixarene host-guest interaction hypoxia-responsiveness drug tracking

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An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

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CCS Chemistry 2022年第1期4卷 272-285页

作者： Ke Xue Cuihong Yang Chun Wang Yang Liu Jianfeng Liu linqi shi Chunlei Zhu Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical BiologyInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071 Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192

This study reports the fabrication of a novel photothermal material formed via the physical blending of excess lauric acid(LA)and cupric acetate,followed by efficient ligand ***,the copper–LA complex exhibited a 12-fold enhancement of the molar extinction coefficient in the nearinfrared(NIR)region relative to aqueous cupric *** by this interesting finding,we formulated these photothermal materials into colloidally dispersed nanoparticles via a technique that combined nanoprecipitation and in situ surface polymerization for antibacterial *** resultant nanoparticles exhibited rapid and stable photothermal responses to NIR irradiation,with a 4-fold enhanced photothermal conversion efficiency relative to aqueous cupric *** a positively charged monomer was incorporated during in situ surface polymerization,these positively charged nanoparticles were ingested efficiently and subsequently digested by drug-resistant *** combining the LA-mediated membrane-damaging effect,copper-mediated Fenton-like reaction,as well as the photothermal effect of the copper–LA complex,a broad-spectrum,multimodal,and synergistic antibacterial effect was achieved both in vitro and in vivo,with the killing efficiency up to 99.99%for ampicillin-resistant Escherichia coli(Ampr ***)and 99.9999%for methicillinresistant Staphylococcus aureus(MRSA).Our newly developed nanobiocide represents a class of exceptional broad-spectrum antibacterial materials,holding great potential for treating drug-resistant infections in clinical settings.

关键词： nanobiocides photothermal materials in situ surface polymerization drug-resistant bacteria multimodal and synergistic therapy

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Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation

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Bioactive Materials 2023年第9期27卷 288-302页

作者： Yuanfeng Li Yin-Zi Piao Hua Chen Keqing shi Juqin Dai Siran Wang Tieli Zhou Anh-Tuan Le Yaran Wang Fan Wu Rujiang Ma linqi shi Yong Liu Translational Medicine Laboratory The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325035China Wenzhou Institute University of Chinese Academy of SciencesOujiang LaboratoryZhejiang Lab for Regenerative MedicineVision and Brain HealthWenzhouZhejiang325001China Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China Department of Clinical Laboratory The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325035China Nano Institute Phenikaa UniversityYen NghiaHa DongHa NoiViet Nam

New antimicrobial strategies are urgently needed to meet the challenges posed by the emergence of drug-resistant bacteria and bacterial *** work reports the facile synthesis of antimicrobial dynamic covalent nano-networks(aDCNs)composing antibiotics bearing multiple primary amines,polyphenols,and a cross-linker acylphenylboronic ***,the iminoboronate bond drives the formation of aDCNs,facilitates their stability,and renders them highly responsive to stimuli,such as low pH and high H2O2 ***,the representative A1B1C1 networks,composed of polymyxin B1(A1),2-formylphenylboronic acid(B1),and quercetin(C1),inhibit biofilm formation of drug-resistant Escherichia coli,eliminate the mature biofilms,alleviate macrophage inflammation,and minimize the side effects of free *** bacterial eradication and inflammation amelioration efficiency of A1B1C1 networks are also observed in a peritoneal infection *** facile synthesis,excellent antimicrobial performance,and biocompatibility of these aDCNs potentiate them as a much-needed alternative in current antimicrobial pipelines.

关键词： Biofilms Dynamic covalent bonds On-demand drug release Resistance reversal Biosafety

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Observation of transition from superfluorescence to polariton condensation in CsPbBr3 quantum dots film

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Light(Science & Applications) 2024年第2期13卷 316-324页

作者： Danqun Mao linqi Chen Zheng Sun Min Zhang Zhe-Yu shi Yongsheng Hu Long Zhang Jian Wu Hongxing Dong Wei Xie Hongxing Xu State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Key Laboratory of Materials for High-Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences201800 ShanghaiChina Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China CAS Center for Excellence in Ultraintense Laser Science Shanghai 201800China School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China

The superfluorescence effect has received extensive attention due to the many-body physics of quantum correlation in dipole gas and the optical applications of ultrafast bright radiation field based on the cooperative quantum ***,we demonstrate not only to observe the superfluorescence effect but also to control the cooperative state of the excitons ensemble by externally applying a regulatory dimension of coupling light fields.A new quasi-particle called cooperative exciton-polariton is revealed in a light-matter hybrid structure of a perovskite quantum dot thin film spin-coated on a Distributed Bragg *** the nonlinear threshold,polaritonic condensation occurs at a nonzero momentum state on the lower polariton branch owning to the vital role of the synchronized *** phase transition from superfluorescence to polariton condensation exhibits typical signatures of a decrease of the linewidth,an increase of the macroscopic coherence as well as an accelerated radiation decay *** findings are promising for opening new potential applications for super-brightness and unconventional coherent light sources and could enable the exploitation of cooperative effects for quantum optics.

关键词： quantum condensation polar

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LED灯模拟不同光强对3种荒漠植物幼苗生长和形态的影响

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林业科技通讯 2024年第5期 109-114页

作者：郝国琦上官瑶瑶石林奇赵维军马琛琛贾亚军丁国辉马利国曹毅博甘肃农业大学林学院兰州730070

研究LED灯模拟不同光强对3种荒漠植物幼苗——红砂(Reamuria songarica)、碱蓬(Suaeda glauca)和木地肤(Kochia prostrata)生长和形态的影响,探究荒漠植物幼苗对光强的响应。通过采用白色LED灯模拟不同光强(光强分别为1 053、2 140、3 ... 详细信息

研究LED灯模拟不同光强对3种荒漠植物幼苗——红砂(Reamuria songarica)、碱蓬(Suaeda glauca)和木地肤(Kochia prostrata)生长和形态的影响,探究荒漠植物幼苗对光强的响应。通过采用白色LED灯模拟不同光强(光强分别为1 053、2 140、3 306、4 450和5 503 lx)。每组灯光下种植5株3种荒漠植物幼苗,每组试验重复5次,40 d后测量每组幼苗株高、茎长、主根长、干质量和鲜质量。试验表明:对比发现LED灯光下的幼苗,40 d内3种荒漠植物碱蓬生长最快;随着光强的增加3种荒漠植物株高、茎长、主根长、干质量和鲜质量都呈现出上升趋势;光强达到4 450 lx时3种幼苗的生长和形态都达到顶峰;光强达到5 503 lx时出现光抑制现象。试验结果显示,适宜的光强处理能促进红砂、碱蓬、木地肤幼苗的株高、茎长、主根长、干质量和鲜质量指标增强,光强过强不利于幼苗的生长,试验对今后荒漠植物幼苗培育具有参考意义。

关键词：荒漠植物幼苗 LED灯形态指标光照强度

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In-biofilm generation of nitric oxide using a magnetically-targetable cascade-reaction container for eradication of infectious biofilms

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Bioactive Materials 2022年第8期7卷 321-334页

作者： Guang Yang Da-Yuan Wang Yong Liu Fan Huang Shuang Tian Yijin Ren Jianfeng Liu Yingli An Henny C.van der Mei Henk J.Busscher linqi shi State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer MaterialsMinistry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071PR China University of Groningen and University Medical Center Groningen Department of Biomedical EngineeringAntonius Deusinglaan 19713AVGroningenthe Netherlands University of Groningen and University Medical Center Groningen Department of OrthodonticsHanzeplein 19700RBGroningenthe Netherlands Key Laboratory of Radiopharmacokinetics for Innovative Drugs Chinese Academy of Medical Sciencesand Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300192PR China

Cascade-reaction chemistry can generate reactive-oxygen-species that can be used for the eradication of infectious ***,suitable and sufficient oxygen sources are not always available near an infection site,while the reactive-oxygen-species generated are ***,we developed a magnetic cascade-reaction container composed of mesoporous Fe_(3)O_(4)@SiO_(2) nanoparticles containing glucose-oxidase and L-arginine for generation of ***-oxidase was conjugated with APTES facilitating coupling to Fe_(3)O_(4)@SiO_(2) nanoparticles and generation of H_(2)O_(2) from glucose.L-arginine was loaded into the nanoparticles to generate NO from the H_(2)O_(2) *** an externally-applied magnetic field,cascade-reaction containers could be homogeneously distributed across the depth of an infectious ***-reaction containers with coupled glucose-oxidase were effective in killing planktonic,Gram-positive and Gram-negative *** efficacy of the L-arginine based second cascade-reaction was only observed when H_(2)O_(2) as well as NO were generated *** vivo accumulation of cascade-reaction containers inside abdominal Staphylococcus aureus biofilms upon magnetic targeting was observed real-time in living mice through an implanted,intra-vital ***,vancomycin-resistant,abdominal *** biofilms could be eradicated consuming solely endogenous glucose,without any glucose ***,a new,non-antibiotic-based infection-control strategy has been provided,constituting a welcome addendum to the shrinking clinical armamentarium to control antibiotic-resistant bacterial infections.

关键词： Magnetic nanoparticles Bacterial infection Glucose Reactive-oxygen-species Intra-vital window

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