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TEA domain transcription factor 1(TEAD1)induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

Signal Transduction and Targeted Therapy 2024年第3期9卷 1209-1220页

作者： Shuai Song Xiaokai Zhang Zihang Huang Yongchao Zhao Shuyang Lu linqi zeng Fengze Cai Tongyao Wang Zhiqiang Pei Xinyu Weng Wei Luo Hao Lu Zilun Wei Jian Wu Peng Yu Li Shen Xiaochun Zhang Aijun Sun Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiChina State Key Laboratory of Cardiology Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina National Clinical Research Center for Interventional Medicine ShanghaiChina Department of cardiac surgery Zhongshan HospitalFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Shanghai Institute of Hypertension Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Cardiac fibroblasts(CFs)are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure(HF).TEAD1 has been shown to be essential for heart development and ***,fibroblast endogenous TEAD1 in cardiac remodeling remains incompletely *** analyses revealed consistently upregulated cardiac TEAD1 expression in mice 4 weeks after transverse aortic constriction(TAC)and Ang-l *** investigation revealed that CFs were the primary cell type expressing elevated TEAD1 levels in response to pressure *** TEAD1 knockout was achieved by crossing TEAD1-floxed mice with CFs-and myofibroblasts-specific Cre *** and histological analyses demonstrated that CFs-and myofibroblasts-specific TEAD1 deficiency and treatment with TEAD1 inhibitor,VT103,ameliorated TAC-induced cardiac ***,RNA-seq and ChiP-seq analysis identified Wnt4 as a novel TEAD1 ***1 has been shown to promote the fibroblast-to-myofibroblast transition through the Wnt signalling pathway,and genetic Wnt4 knockdown inhibited the pro-transformation phenotype in CFs with TEAD1 ***,coimmunoprecipitation combined with mass spectrometry,chromatin immunoprecipitation,and luciferase assays demonstrated interaction between TEAD1 and BET protein BRD4,leading to the binding and activation of the Wnt4 *** conclusion,TEAD1 is an essential regulator of the pro-fibrotic CFs phenotype associated with pathological cardiac remodeling via the BRD4/Wnt4 signallingpathway.

关键词： TEAD1 expression Wnt4

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Expert recommendations on collection and annotation of otoscopy images for intelligent medicine

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Intelligent Medicine 2022年第4期2卷 230-234页

作者： Yuexin Cai Junbo zeng Liping Lan Suijun Chen Yongkang Ou linqi zeng Qintai Yang Peng Li Yubin Chen Qi Li Hongzheng Zhang Fan Shu Guoping Chen Wenben Chen Yahan Yang Ruiyang Li Anqi Yan Haotian Lin Yiqing Zheng Department of Otolaryngology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Shenshan Medical Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityShanweiGuangdong 516600Chin Zhongshan Ophthalmic Center Sun Yat-sen UniversityState Key Laboratory of OphthalmologyGuangzhouGuangdong 510623China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Otolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Otolaryngology-Head and Neck Surgery Nanfang HospitalSouth Medical UniversityGuangzhouGuangdong 510515China Department of Otolaryngology-Head&Neck Surgery Zhujiang HospitalSouth Medical UniversityGuangzhouGuangdong 510280China Department of Otolaryngology Zhongshan City People’s HospitalZhongshan Affiliated Hospital of Sun Yat-sen UniversityZhongshanGuangdong 528403China

Middle and outer ear diseases are common otological diseases *** and otoendoscopy exami-nations are essential first steps in the evaluation of patients with otological *** often occurs when the doctor lacks experience in interpreting the results of otoscopy or otoendoscopy,leading to delays in treatment or *** deep learning to process otoscopy images and developing otoscopic artificial-intelligence-based decision-making systems will become a significant trend in the ***,the uneven quality of otoscopy images is among the major obstacles to development of such artificial intelligence systems,and no standardized process for data acquisition,and annotation of otoscopy images in intelligent medicine has yet been fully *** standards for data storage and data management are unified with those of other specialties and are introduced in detail *** expert recommendation criterion improved and standardized the collection and annotation procedures for otoscopy images and fills the current gap in otologic intelligent medicine;it would thus lay a solid foundation for the standardized collection,storage,and annotation of oto-scopy images and the application of training algorithms,and promote the development of automatic diagnosis and treatment for otological *** full text introduced image collection(including patient preparation,equipment standards,and image storage),image annotation standards,and quality control.

关键词： Otoscopy image Intelligent medicine Annotation Collection

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热处理对金鲳鱼挥发性成分的影响

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食品科技 2020年第9期45卷 122-127页

作者：杨昭梁瑞进何春兰曾琳琦莫观连李晓娜广东食品药品职业学院食品学院广东广州510520 广东食品药品职业学院医疗器械学院广东广州510520

采用顶空固相微萃取-气相色谱-质谱联用法对热处理前后金鲳鱼鱼肉、鱼皮和体表黏液的挥发性成分进行分析鉴定。结果表明:从生鲜金鲳鱼鱼肉、鱼皮和体表黏液中共鉴定出57种挥发性成分,包括8种醇类、13种醛类、2种酮类、2种酯类、30种烃类... 详细信息

采用顶空固相微萃取-气相色谱-质谱联用法对热处理前后金鲳鱼鱼肉、鱼皮和体表黏液的挥发性成分进行分析鉴定。结果表明:从生鲜金鲳鱼鱼肉、鱼皮和体表黏液中共鉴定出57种挥发性成分,包括8种醇类、13种醛类、2种酮类、2种酯类、30种烃类和2种其他类物质。经过100℃加热处理后,从热处理金鲳鱼鱼肉、鱼皮和体表黏液中共鉴定出挥发性成分60种,包括8种醇类、14种醛类、5种酮类、3种酯类、25种烃类和5种其他类物质。

关键词：金鲳鱼顶空固相微萃取气相色谱-质谱联用挥发性成分

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顶空固相微萃取-气相色谱-质谱联用分析银鲳不同部位挥发性成分

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食品科技 2020年第3期45卷 307-314页

作者：梁志理杨昭黄佳佳梁瑞进曾琳琦莫观连广东食品药品职业学院食品学院广东广州510520

采用顶空固相微萃取-气相色谱-质谱联用法对银鲳不同部位中的挥发性成分进行分析鉴定。结果表明:银鲳背、肚、头、尾4个部位共鉴定出挥发性成分108种,包括醇类12种、醛类12种、酮类6种、酯类5种、烃类67种、其他类6种。银鲳背、肚、头、... 详细信息

采用顶空固相微萃取-气相色谱-质谱联用法对银鲳不同部位中的挥发性成分进行分析鉴定。结果表明:银鲳背、肚、头、尾4个部位共鉴定出挥发性成分108种,包括醇类12种、醛类12种、酮类6种、酯类5种、烃类67种、其他类6种。银鲳背、肚、头、尾4个部位分别鉴定出53、42、56和48种挥发性成分。银鲳背、肚、头、尾4个部位含有16种相同的挥发性成分,包括5种醛类、1种酯类、9种烃类和1种其他类。

关键词：银鲳顶空固相微萃取气相色谱-质谱联用挥发性成分

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水解度对牡蛎酶解产物功能特性和抗氧化活性的影响

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食品工业 2021年第5期42卷 134-138页

作者：杨昭黄佳佳姚玉静曾琳琦凌叶婷广东食品药品职业学院食品学院广州510520

采用胰蛋白酶和风味蛋白酶组成复合酶对牡蛎进行限制性水解,获得OH0、OH_(1)、OH2、OH3和OH4这5种酶解产物,考察水解度对牡蛎酶解产物功能特性(乳化性、起泡性和泡沫稳定性)和抗氧化活性(DPPH清除率和总还原力)的影响。结果表明,水解度... 详细信息

采用胰蛋白酶和风味蛋白酶组成复合酶对牡蛎进行限制性水解,获得OH0、OH_(1)、OH2、OH3和OH4这5种酶解产物,考察水解度对牡蛎酶解产物功能特性(乳化性、起泡性和泡沫稳定性)和抗氧化活性(DPPH清除率和总还原力)的影响。结果表明,水解度对牡蛎酶解产物乳化性影响较小,对起泡性、泡沫稳定性、DPPH清除率和总还原力影响较大。OH_(1)在pH 4,6,8和10环境中均有较强的起泡性,在pH 6环境中起泡性最大为70.07%。在pH 4和6环境中,牡蛎酶解产物的起泡性随着水解度的增加呈现先升高后降低趋势。在pH 8环境中,随着水解度增加,牡蛎酶解产物起泡性呈现逐渐降低趋势。OH4在pH 4,6,8和10环境中均有较强泡沫稳定性。随着水解度增加,牡蛎酶解产物DPPH清除率呈现先升高后降低趋势,总还原力则呈现逐渐升高趋势。

关键词：牡蛎水解度酶解产物功能特性抗氧化活性

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蛋白酶种类对龟肉酶解液品质的影响

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食品工业 2021年第3期42卷 188-191页

作者：杨昭曾琳琦凌叶婷莫芷晴何春兰广东食品药品职业学院广州510520

利用碱性蛋白酶和复合蛋白酶对中华草龟、中华花龟和鳄龟肉进行水解,对所得的6种酶解液(分别标记为ACRH、CCRH、AOSH、COSH、ACSH和CCSH)的品质特性进行比较分析。结果表明:ACRH的感官分值最高,为92.0。AOSH的蛋白质含量和蛋白质回收率... 详细信息

利用碱性蛋白酶和复合蛋白酶对中华草龟、中华花龟和鳄龟肉进行水解,对所得的6种酶解液(分别标记为ACRH、CCRH、AOSH、COSH、ACSH和CCSH)的品质特性进行比较分析。结果表明:ACRH的感官分值最高,为92.0。AOSH的蛋白质含量和蛋白质回收率均最高,分别为0.718 g/100 g和38.54%。COSH的小于1 000 Da和小于2 000 Da肽面积百分比均最高,分别为97.10%和98.64%。COSH的羟自由基清除率为6种酶解液中最大的,59.70%。综合考虑,中华花龟肉复合蛋白酶酶解液可能具有较大的研究价值和开发前景。

关键词：中华草龟中华花龟鳄龟酶解液

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

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Frontiers of Medicine 2020年第1期14卷 30-42页

作者： Qian Wang linqi Zhang Comprehensive AIDS Research Center Beijing Advanced Innovation Center for Structural BiologyCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesDepartment of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China

Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I(HIV-1)through antiretroviral ***,vaccine development has remained *** discoveries in broadly neutralizing monoclonal antibodies(bNAbs)has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody *** and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein(Env)during *** review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.

关键词： HIV-1 broadly neutralizing antibodies Env conformational states vaccine design SOSIP

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MSM and HIV-1 infection in China

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National Science Review 2015年第4期2卷 388-391页

作者： Hong Shang linqi Zhang Key Laboratory of AIDS Immunology of Ministry of Health Department of Laboratory MedicineNo. 1 Hospital of China Medical University Comprehensive AIDS Research Center and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases School of Medicine Tsinghua University

Addressing HIV-1/AIDS problem in China’s complex socioeconomic environment has never been straightforward Dynamic economic changes over the past few decades continue to create new challenges to intervention eforts particularly among one of the worst hit and hardest to reach populations,men who have sex with men(MSM).MSM represents a diverse population coming

关键词： MSM and HIV-1 infection in China AIDS HIV

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ORC-GAC-Fe^0 system for the remediation of trichloroethylene and monochlorobenzene contaminated aquifer:1. Adsorption and degradation

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Journal of Environmental Sciences 2004年第1期16卷 108-112页

作者： linqi CHENYing-xu PlagentzV SchaferD DahmdkA DepartmentofEnvironmentalEngineering ZhejiangUniversityHangzhou310029China InstitutefurGeowissensehaften UniversitatKielOlshausenstrasse40D-24098KielGermany

Activities at a former Chemistry Triangle in Bitterfeld, Germany, resulted in contamination of groundwater with a mixture of trichloroethylene(TCE) and monochlorobenzene(MCB). The objective of this study was to develop a barrier system, which includes an ORC(oxygen release compounds) and GAC(granular activated carbon) layer for adsorption of MCB and bioregeneration of GAC, a Fe 0 layer for chemical reductive dechlorination of TCE and other chlorinated hydrocarbon in situ . A laboratory-scale column experiment was conducted to evaluate the feasibility of this proposed system. This experiment was performed using a series of continuous flow Teflon columns including an ORC column, a GAC column, and a Fe 0 column. Simulated MCB and TCE contaminated groundwater was pumped upflow into this system at a flow rate of 1.1 ml/min. Results showed that 17%—50% of TCE and 28%—50% of MCB were dissipated in ORC column. Chloride ion, however, was not released, which suggest the dechlorination do not happen in ORC column. In GAC column, the adsorption of contaminants on activated carbon and their induced degradation by adapted microorganisms attached to the carbon surface were observed. Due to competitive exchange processes, TCE can be desorbed by MCB in GAC column and further degraded in iron column. The completely dechlorination rate of TCE was 0.16—0.18 cm -1 , 1—4 magnitudes more than the formation rate of three dichloroethene isomers. Cis-DCE is the main chlorinated product, which can be cumulated in the system, not only depending on the formation rate and its decaying rate, but also the initial concentration of TCE.

关键词： groundwater remediation permeable reactive barriers trichloroethylene monochlorobenzene

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Effect of height-diameter ratio on the mechanical characteristics of shale with different bedding orientations

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2482-2502页

作者： Yide Guo Xibing Li linqi Huang School of Resources and Safety Engineering Central South UniversityChangsha410083China

Geological exploration cores obtained from shale gas wells several kilometers deep often show different height-diameter ratios(H/D)because of complex geological conditions(core disking or developed fractures),which makes further standard specimen preparation for mechanical evaluation of reservoirs *** multi-cluster hydraulic fracturing,shale reservoirs between planes of hydraulic fractures with different lengths could be simplified to have different H/D *** the effect of H/D on the mechanical characteristics of shale specimens with different bedding orientations will support mechanical evaluation tests of reservoirs based on disked geological cores and help to optimize multicluster fracturing *** this study,we performed uniaxial compression tests and acoustic emission(AE)monitoring on cylindrical Longmaxi shale specimens under five bedding orientations and four H/D *** experimental results showed that both the H/D-dependent mechanical properties and AE parameters demonstrated significant *** H/D did not change the uniaxial compressive strength(UCS)evolution versus bedding orientation,demonstrating a V-shaped relationship,but enhanced the curve *** stress level of crack damage for the specimens significantly increased with increasing H/D,excluding the specimens with a bedding orientation of 0°.With increasing H/D,the cumulative AE counts of the specimens with each bedding orientation tended to exhibit a stepped jump against the loading *** proportion of low-average-frequency AE signals(below 100 kHz)in specimens with bedding orientations of 45°and 60°increased to over 70%by increasing H/D,but it only increased to 40%in specimens with bedding orientations of 0°,30°,and 90°.Finally,an empirical model that can reveal the effect of H/D on anisotropic UCS of shale reservoir was proposed,the anisotropic proportion of tensile and shear failure cracks in specimens under four H/D ratios was classified based o

关键词： Geological cores Multi-cluster hydraulic fracturing Height-diameter ratio Longmaxi shale Uniaxial compression test

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