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A Preliminary Study on the Rural Land System Reform in the Context of Rural Revitalization

Asian Agricultural Research 2024年第6期16卷 5-10页

作者： Jinrong yang Yimei HE Zisheng yang linlin CAO Institute of Land Resources and Sustainable Development Yunnan University of Finance and EconomicsKunming 650221China School of Tourism and Hotel Management Yunnan University of Finance and EconomicsKunming 650221China

With the deepening of reform and opening up,the rural land system has experienced the evolution from contracting to transfer to the current rural revitalization strategy,and has always been closely linked to the well-being of farmers and the vigorous development of the rural *** reform of this system is not only a key driving force for rural economic development,but also an important cornerstone for realizing the rural revitalization *** in-depth analysis of the connotation of rural revitalization and rural land system reform,this study discusses in detail the internal dynamic mechanism of rural land system reform driving rural revitalization,and comprehensively analyzes the current implementation of rural land system *** this basis,this study puts forward the strategic concept of promoting the rural land system reform in the context of rural *** have shown that the rural land system reform has mainly played a positive role in the following four aspects in promoting rural revitalization:providing a solid material foundation for rural revitalization,optimizing the allocation of rural resources,promoting the transformation and upgrading of rural industrial structure,and promoting rural social harmony and *** the context of the current rural revitalization,the rural land system reform is undoubtedly one of the core issues of China s rural *** order to further improve this system,we need to continue to optimize and innovate the rural land transfer system,the homestead reform system,and the rural collective construction land market entry system.

关键词： Rural revitalization Land system Reform Rural economy

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Micelle-directed self-assembly of single-crystal-like mesoporous stoichiometric oxides for high-performance lithium storage

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National Science Review 2024年第4期11卷 195-205页

作者： Yanhua Wan Changyao Wang Xingmiao Zhang yang Yin Mengmeng Liu Bing Ma linlin Duan Yuzhu Ma Wei Zhang Changlin Zheng Dongliang Chao Fei Wang Yongyao Xia Wei Li Department of Chemistry Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers College of Chemistry and Materials ScienceFudan University State Key Laboratory of Surface Physics and Department of Physics Fudan University

Due to their uncontrollable assembly and crystallization process,the synthesis of mesoporous metal oxide single crystals remains a formidable ***,we report the synthesis of single-crystal-like mesoporous Li2TiSiO5by using soft micelles as *** key lies in the atomic-scale self-assembly and step-crystallization processes,which ensure the formation of single-crystal-like mesoporous Li2TiSiO5microparticles via an oriented attachment growth mechanism under the confinement of an in-situ formed carbon *** mesoporous Li2TiSiO5anode achieves a superior rate capability(148 mAh g-1at5.0 A g-1) and outstanding long-term cycling stability(138 mAh g-1after 3000 cycles at 2.0 A g-1) for lithium storage as a result of the ultrafast Li+diffusion caused by penetrating mesochannels and nanosized crystal frameworks（5-10 nm）.In comparison,bulk Li2TiSiO5exhibits poor rate capability and cycle performance due to micron-scale diffusion *** method is very simple and reproducible,heralding a new way of designing and synthesizing mesoporous single crystals with controllable frameworks and chemical functionalities.

关键词： mesoporous materials micelles single-crystal-like Li2TiSiO5 lithium-ion batteries

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Analysis of The Effect of General Medicine-Based Education in Type 2 Diabetes Mellitus Patients in Neijiang City, China

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Journal of Clinical and Nursing Research 2024年第5期8卷 129-134页

作者： Xiaoxia yang linlin Yi Xun Wu The First People’s Hospital of Neijiang City Neijiang CitySichuan Province 641000China

Objective:To investigate and analyze the current situation of cognition,attitude,behavior,and influencing factors of Type 2 Diabetes Mellitus(T2DM)patients in Neijiang City,and to explore the effectiveness of the application of the education program based on the popularization of science in general ***:Seventy cases of T2DM patients in Neijiang City were selected and randomly divided into 35 cases each in the observation group and the control *** observation group received general medicine science education intervention and the control group received traditional health *** such as cognitive level,attitude,and behavioral change between the two groups were compared to assess the effect of general medical science ***:Before the intervention,there was no difference between the two groups in terms of knowledge,beliefs,and behaviors in general medicine,glycemic control,body mass index(BMI),and satisfaction with health education(P>0.05).After 3 months of the intervention,there was a highly significant difference in the aforementioned levels between the two groups(P<0.05).Conclusion:The approach of general medicine popularization had a significant effect on the treatment and management of T2DM patients in Neijiang *** improved the patient’s cognitive level and self-management ability of the disease,increased their treatment adherence,and improved the therapeutic effect.

关键词： General medicine Type 2 diabetes Effect evaluation

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从家庭照顾迈向社会照顾:德国和日本儿童照顾政策及其启示

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理论月刊 2022年第3期 86-96页

作者：杨琳琳南京理工大学马克思主义学院江苏南京210094

儿童照顾体现了照顾责任在国家与家庭及两性之间的分工,目前投资取向的社会照顾政策成为近些年来福利国家社会政策的一个新转向。中国与德国、日本在儿童照顾方面具有相似的政策安排,均推崇以家庭为核心的照顾主体,但是在政策实施上却... 详细信息

儿童照顾体现了照顾责任在国家与家庭及两性之间的分工,目前投资取向的社会照顾政策成为近些年来福利国家社会政策的一个新转向。中国与德国、日本在儿童照顾方面具有相似的政策安排,均推崇以家庭为核心的照顾主体,但是在政策实施上却呈现出不同的路径。德国通过慷慨的照顾津贴、完善的照顾时间政策和公共照顾服务体系成为自主家庭主义国家的新进代表;日本在少子化危机促使下进行幼托政策的整合与改革,成为东亚国家中整合型社会照顾政策的发展雏形。有鉴于此,在幼有所育的民生目标指导下,中国应及时更新政策价值理念、精准照顾对象、完善照顾政策内容、建立多元照顾协同机制,促进家庭照顾转向社会照顾。

关键词：家庭照顾社会照顾德国日本儿童照顾政策

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二维快速子空间DOA估计算法

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华中科技大学学报（自然科学版） 2008年第4期36卷 20-23页

作者：马洪杨琳琳黎英云华中科技大学电子与信息工程系武汉光电国家实验室(筹) 湖北武汉430074

提出一种二维快速子空间DOA估计算法,该算法利用阵列协方差矩阵的一个子矩阵得到降维的信号子空间,不需估计整个阵列的协方差矩阵,也不需进行特征值分解,从而使得该方法具有运算量小、复杂度低和易于实时处理的特点,因而可以应用在小数... 详细信息

提出一种二维快速子空间DOA估计算法,该算法利用阵列协方差矩阵的一个子矩阵得到降维的信号子空间,不需估计整个阵列的协方差矩阵,也不需进行特征值分解,从而使得该方法具有运算量小、复杂度低和易于实时处理的特点,因而可以应用在小数据样本和快速时变的信号环境中.理论分析和计算机仿真结果表明:与MUSIC算法相比,该算法运算量最多为MUSIC算法的1/4,低信噪比条件下DOA估计性能损失并不大,当信噪比大于5dB时,性能与MUSIC算法相当.

关键词：阵列信号处理 DOA(波达方向)估计快速子空间算法谱峰搜索计算复杂度

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An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer

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Science Bulletin 2024年第13期69卷 2122-2135页

作者： Lingping Kong Fanlu Meng Ping Zhou Ruixin Ge Xiaoshan Geng Zhihao yang Guo Li linlin Zhang Jing Wang Jinfeng Ma Cheng Dong Jun Zhou Sijin Wu Diansheng Zhong Songbo Xie Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215028China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Key Laboratory of Ocular TraumaTianjin Medical UniversityTianjin 300052China

Targeting oncogenic mutant p53 represents an attractive strategy for cancer treatment due to the high frequency of gain-of-function mutations and ectopic expression in various cancer *** extensive efforts,the absence of a druggable active site for small molecules has rendered these mutants therapeutically *** we develop a selective and effective proteolysis-targeting chimera(PROTAC)for p53-R175H,a common hotspot mutant with dominant-negative and oncogenic *** a novel iterative molecular docking-guided post-SELEX(systematic evolution of ligands by exponential enrichment)approach,we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for *** this resulting aptamer as a binder for PROTACs,we successfully developed a selective p53-R175H degrader,named ***53m induces the ubiquitin–protea some-dependent degradation of p53-R175H while sparing wildtype ***,dp53m demonstrates significant antitumor efficacy in p53-R175H-driven cancer cells both in vitro and in vivo,without ***,dp53m significantly and synergistically improves the sensitivity of these cells to cisplatin,a commonly used chemotherapy *** findings provide evidence of the potential therapeutic value of dp53m in p53-R175H-driven cancers.

关键词： P53 Aptamer PROTAC Cancer Drug resistance

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Unraveling adaptive changes in electric vehicle charging behavior toward the postpandemic era by federated meta-learning

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The Innovation 2024年第2期5卷 21-23页

作者： linlin You Rui Zhu Mei-Po Kwan Min Chen Fan Zhang Bisheng yang Man Sing Wong Zheng Qin School of Intelligent Systems Engineering Sun Yat-Sen UniversityShenzhen 518107China Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A*STAR)1 Fusionopolis WaySingapore 138632Republic of Singapore Institute of Space and Earth Information Science Chinese University of Hong KongHong KongChina Key Laboratory of Virtual Geographic Environment(Ministry of Education) Nanjing Normal UniversityNanjing 210023China Institute of Remote Sensing and Geographical Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China State Key Laboratory of Information Engineering in Surveying Mappingand Remote SensingWuhan UniversityWuhan 430079China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina

Dear Editor,Electric vehicle(EV)sales have significantly grown over the years to fulfill growing demands for economic travel and greenhouse gas mitigation.1 However,the surge in the number of EVs has led to charging anxiety as users struggle to find an available charging station before running out of electricity,resulting in longer reserve and waiting times.2 Moreover,severe mobility restrictions caused by infectious diseases,such as coronavirus disease 2019(COVID-19),have greatly affected people’s travel behavior3,4 and hindered their willingness to use EVs,given that charging in public spaces consumes time and increases the risk of contracting the virus.5 This implies that in the postpandemic era,in which individuals coexist with the virus,the interplay between the two important trends,namely vehicle electrification and mobility restrictions,can extensively affect people’s daily commuting by using EVs.

关键词： travel behavior charging

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Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin linlin Tong Jia Zhao Lan Zhang Na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

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双层探测器光谱CT冠状动脉支架成像的最适虚拟单能量及对比剂浓度的模体研究

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中华放射学杂志 2020年第6期54卷 521-526页

作者：杨林林侯阳马跃贾政中国医科大学附属盛京医院放射科沈阳110004 飞利浦(中国)投资有限公司健康科技CT市场部沈阳110000

目的探讨双层探测器光谱CT虚拟单能量成像对离体冠状动脉支架显示的最适能级及对比剂浓度。方法选取不同材质18枚支架,植入人造模拟冠状动脉血管内,配置常规浓度、低浓度(常规剂量的1/2)对比剂分别填充。行光谱CT扫描,常规浓度及低浓度... 详细信息

目的探讨双层探测器光谱CT虚拟单能量成像对离体冠状动脉支架显示的最适能级及对比剂浓度。方法选取不同材质18枚支架,植入人造模拟冠状动脉血管内,配置常规浓度、低浓度(常规剂量的1/2)对比剂分别填充。行光谱CT扫描,常规浓度及低浓度进行50~100 keV(间隔10 keV)、120 keV单能级重建,分别记为A50~100、120 keV组和B50~100、120 keV组;另一组常规浓度数据进行常规iDose4重建,记为conv组。对图像进行主观评价,包括支架结构评分(Likert 5分法)及支架内管腔评分(Likert 4分法);客观评价包括背景噪声、对比噪声比(CNR)及支架内径差(ALN)。采用Kruskal-Wallis H检验和析因设计方差分析统计分析各组之间主观和客观评价指标差异。结果A80、90 keV组[(3.56±0.64)、(4.11±0.58)分]和B90 keV组[(3.61±0.50)分]支架结构评分显著优于其他组(P均0.05),且A70 keV组的噪声最小。A50、60、70 keV组(26.85±5.19、26.03±4.29、24.46±5.40)及B50、60、70 keV组(25.88±5.67、24.18±5.46、24.91±7.67)支架管腔内CNR值显著高于其他组,差异均有统计学意义(P均0.05)。且A50 keV组支架管腔内CNR值最高。A90、100、120 keV组[(32.22±6.16)%、(30.79±5.55)%、(27.05±4.47)%]ALN值高于conv组[(41.76±6.00)%],差异均具有统计学意义(P均0.05),且A120 keV组ALN值最低。结论关于支架模体成像,DLCT单能量较混合能量成像质量更佳。行DLCT扫描时,90 keV(支架结构显示)与70 keV(支架管腔显示)结合重建可在浓度减半时不降低成像质量。

关键词：支架体层摄影术,X线计算机造影剂

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The Influence of Internet Use on Women’s Depression and Its Countermeasures—Empirical Analysis Based on Data from CFPS

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International Journal of Mental Health Promotion 2024年第3期26卷 229-238页

作者： Dengke Xu linlin Shen Fangzhong Xu School of Economics Hangzhou Dianzi UniversityHangzhou310018China School of Mathematics and Computer Science Zhejiang A&F UniversityHangzhou311300China

Based on China Family Panel Studies(CFPS)2018 data,the multiple linear regression model is used to analyze the effects of Internet use on women’s depression,and to test the robustness of the regression *** the same time,the effects of Internet use on mental health of women with different residence,age,marital status and physical health status are ***,we can obtain that Internet use has a significant promoting effect on women’s mental health,while the degree of Internet use has a significant inhibitory effect on women’s mental *** addition,the study found that women’s age,education,place of residence,marital status,length of sleep,working status and physical health status are the main factors affecting the mental health of Chinese *** the heterogeneity investigation of residence,age,marital status and physical health status,Internet use has a greater negative impact on the Center for Epidemiological Studies Depression Scale(CES-D8)scores of women in rural areas,has a significant positive impact on the mental health of middle-aged and elderly women or women with spouses,and has a positive impact on the mental health of physically unhealthy ***,in view of women’s mental health needs and the problems existing in the use of the Internet,this paper puts forward some suggestions to further improve the overall mental health level of women.

关键词： Internet use depression multiple linear regression heterogeneity

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