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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu chang Lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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袖带位置高低对血压值的影响分析

护理研究 2007年第24期21卷 2223-2224页

作者：常琳琳高玉霞李东宁于立娜成方元由瑶吉林大学护理学院

血压是机体的重要指标,尤其是在抢救生命的千金一刻.《护理学基础》中关于血压测量的标准操作是袖带下缘距肘窝2 cm～3 cm,听诊器置于肱动脉搏动最强处[1].临床操作中,医生和护士在测量血压时多将袖带下缘平行于肘窝,听诊器置于袖带内... 详细信息

血压是机体的重要指标,尤其是在抢救生命的千金一刻.《护理学基础》中关于血压测量的标准操作是袖带下缘距肘窝2 cm～3 cm,听诊器置于肱动脉搏动最强处[1].临床操作中,医生和护士在测量血压时多将袖带下缘平行于肘窝,听诊器置于袖带内肱动脉搏动最强处.但谭秀瑜等[2,3]研究认为,听诊器附件置于袖带内测得的血压值低于听诊器附件置于袖带下缘2 cm～3 cm测得的血压值,即两种方法测得的血压值有差异.两种测量法的血压值是否存在差异,通过实验我们得出不同结论.现介绍如下.

关键词：袖带附件机械元件血压值肘窝听诊器外周阻力高低

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四季草莓新品种艳红的选育

中国果树 2022年第2期 84-85页

作者：董静孙瑞隗永青王桂霞钟传飞常琳琳孙健张宏力高用顺陈杉艳孙吉茹陶磅张运涛北京市林业果树科学研究院北京市草莓工程技术研究中心农业农村部华北地区园艺作物生物学与种质创制重点实验室北京100093 昆明市农业科学研究院承德市农林科学院云南省农业科学院园艺作物研究所

艳红是以四季性优异草莓资源Z06-1为母本,以一季性草莓品种京桃香为父本杂交选育而成的四季草莓新品种。植株长势中,株态较直立,叶片深绿色,中心小叶椭圆形。夏季平均单果重14.0 g,果实长圆锥形,果面平整,红色,有光泽,外观好;果肉橙红,... 详细信息

艳红是以四季性优异草莓资源Z06-1为母本,以一季性草莓品种京桃香为父本杂交选育而成的四季草莓新品种。植株长势中,株态较直立,叶片深绿色,中心小叶椭圆形。夏季平均单果重14.0 g,果实长圆锥形,果面平整,红色,有光泽,外观好;果肉橙红,髓心空洞小,果个中等,硬度0.43 kg/cm^(2),可溶性固形物含量8.8%,酸甜适中,香味较浓,鲜食加工兼用,综合品质优良。艳红丰产性较好,夏季高温下开花结果能力较强,在保温条件下,采收期可从6月延续至12月。

关键词：四季草莓新品种艳红

基于差分雷达干涉测量的矿区地面沉降监测研究

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武汉大学学报（信息科学版） 2007年第10期32卷 888-891页

作者：董玉森 Ge linlin chang Hsingchun 张志中国地质大学地球科学学院 School of Surveying and Spatial Information Systems UNSWSydney 2052澳大利亚中国地质大学空间科学技术研究中心

收集了1992年12月至1998年6月JERS-1L波段雷达数据,利用差分雷达干涉测量技术进行地面沉降监测研究。通过"二轨法"进行差分处理,选择其中的6景差分雷达干涉图进行分析。在研究区内发现了4个沉降区域,并按照时间序列通过对地面形变图进... 详细信息

收集了1992年12月至1998年6月JERS-1L波段雷达数据,利用差分雷达干涉测量技术进行地面沉降监测研究。通过"二轨法"进行差分处理,选择其中的6景差分雷达干涉图进行分析。在研究区内发现了4个沉降区域,并按照时间序列通过对地面形变图进行分析,获取其中两个沉降区最大的垂直沉降量。

关键词：地面沉降雷达差分干涉测量 JERS-1卫星

Scapular metastasis from acinic cell carcinoma of parotid gland:A case report

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World Journal of Clinical Cases 2025年第9期13卷 41-46页

作者： Deng-Qun Sun chang-Chun Chen Duo-An Zheng Hai-Yan Xing Xue Peng Department of General Surgery The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Radiology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Pathology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Acinic cell carcinoma(ACC)is a malignant epithelial neoplasm that commonly occurs in the parotid *** is known to have a high recurrence rate and the potential to metastasize to the lung or cervical lymph ***,few cases of ACC with bone metastasis have been reported in the medical *** SUMMARY The clinical significance of this case report lies in the unique site of occurrence of the metastasis:To the best of our knowledge,this report is the only literature documenting ACC arising in a shoulder *** Unusual presentations of uncommon malignancies can present diagnostic challenges for both surgeons and *** is important to be aware of these rare occurrences in order to provide the best possible treatment for patients.

关键词： Acinic cell carcinoma Shoulder mass Scapular Metastasis Case report

Semi-analytical Modeling of the Influence of Macro Bending Effects on Micro Contact-Inhomogeneity Problems

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Acta Mechanica Solida Sinica 2023年第6期36卷 860-874页

作者： Jinran Li linlin Sun Ning Zhao Pu Li School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Road Construction Technology and Equipment of the Ministry of Education Chang’an UniversityXi’an 710064China Shaanxi Key Laboratory of Gear Transmissions Xi’an 710072China School of Science Harbin Institute of TechnologyShenzhen 518055China

This study examines the effects of macroscopic bending and microscopic contact loading in inhomogeneous materials using a semi-analytical model based on Eshelby’s equivalent inclusion *** model accounts for bending effects through the beam theory,with bending stress included in the Eshelby’s equivalent inclusion *** macroscopic displacement resulting from bending effects is incorporated into the microscopic contact solver,and the final displacement is determined using the conjugate gradient method in an iterative *** efficiency can be improved by incorporating the discrete convolution and fast Fourier *** core scheme is validated using the finite element method,yielding accurate and efficient results for bending-contact problems in inhomogeneous *** reveal the interplay between bending,contact loading,and inhomogeneity,as stress around the inhomogeneity alters and the stress concentration area expands under increasing bending ***,low-magnitude negative bending moments reduce both contact pressure and stress around the *** position where inhomogeneities are least affected shifts from the neutral surface depending on the coupling *** model provides a valuable bridge for connecting the macroscopic bending effect and microscale contact-inhomogeneity problems by visualizing stress fields and assessing pressure distributions.

关键词： Contact analysis Bending effects Inhomogeneity Equivalent inclusion method Semi-analytical model

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草莓优系及其亲本果实挥发性物质成分分析

北京农学院学报 2020年第1期35卷 36-41页

作者：吕浩孙瑞王桂霞董静常琳琳孙健钟传飞李睿张宏力张运涛北京农学院植物科学技术学院北京102206 北京市林业果树科学研究院北京100093 北京市草莓工程技术研究中心北京100093

【目的】以草莓优系‘玉泉公主’和‘香山公主’及其亲本‘燕香’、‘红颜’品种为材料,研究其成熟期果实挥发性物质成分及香气特性,为香气育种提供参考依据。【方法】采用顶空固相微萃取-气质联用技术测定草莓优系及其亲本的成熟期果... 详细信息

【目的】以草莓优系‘玉泉公主’和‘香山公主’及其亲本‘燕香’、‘红颜’品种为材料,研究其成熟期果实挥发性物质成分及香气特性,为香气育种提供参考依据。【方法】采用顶空固相微萃取-气质联用技术测定草莓优系及其亲本的成熟期果实挥发性物质相对含量,分析比较优系和亲本之间的香气物质差异。【结果】4个品种(系)草莓成熟期果实中共发现酯类、醇类、酮类、醛类、呋喃类、酸类和烯烃类7大类79种挥发性物质,其中酯类是最主要的挥发性物质,主要酯类成分为丁酸乙酯、己酸乙酯、己酸甲酯、乙酸己酯等。醇类物质在‘玉泉公主’和父母本中相对含量较高,‘香山公主’中较低,但均以橙花叔醇和沉香醇为主。呋喃类物质只在‘玉泉公主’中含量较高,以2,5-二甲基-4-甲氧基-3(2H)-呋喃酮为主。【结论】‘玉泉公主’的特征香气物质为异戊酸乙酯、己酸乙酯、橙花叔醇和2,5-二甲基-4-甲氧基-3(2H)-呋喃酮,这种香气组合使其呈强烈菠萝果香。‘香山公主’中,相对含量较高的丁酸甲酯、丁酸乙酯和己酸乙酯的香气组合是其呈浓果香的主要原因。

关键词：草莓(Fragaria ananassa Duch.) 品种(系) 亲本挥发性物质

Few-layered hexagonal boron nitride nanosheets stabilized Pt NPs for oxidation promoted adsorptive desulfurization of fuel oil

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Green Energy & Environment 2024年第3期9卷 495-506页

作者： Peiwen Wu Xin Song linlin Chen Lianwen He Yingcheng Wu Duanjian Tao Jing He chang Deng Linjie Lu Yanhong Chao Mingqing Hua Wenshuai Zhu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang212013China College of Chemical Engineering and Environment State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum-BeijingBeijing102249China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang330022China College of Science State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum-BeijingBeijing102249China

A few-layered hexagonal boron nitride nanosheets stabilized platinum nanoparticles(Pt/h-BNNS)is engineered for oxidation-promoted adsorptive desulfurization(OPADS)of fuel *** was found that the few-layered structure and the defective sites of h-BNNS not only are beneficial to the stabilization of Pt NPs but also favor the adsorption of aromatic *** employing Pt/h-BNNS with a Pt loading amount of 1.19 wt%as the active adsorbent and air as an oxidant,a 98.0%sulfur removal over dibenzothiophene(DBT)is achieved along with a total conversion of the DBT to the corresponding sulfones(DBTO_(2)).Detailed experiments show that the excellent desulfurization activity originates from the few-layered structure of h-BNNS and the high catalytic activity of Pt *** addition,the OPADS system with Pt/h-BNNS as the active adsorbent shows remarkable stability in desulfurization performance with the existence of different interferents such as olefin,and aromatic ***,the Pt/h-BNNS can be recycled 12 times without a significant decrease in desulfurization ***,a process flow diagram is proposed for deep desulfurization of fuel oil and recovery of high value-added products,which would promote the industrial application of such OPADS strategy.

关键词： Desulfurization Adsorption Catalytic oxidation Active adsorbent Dibenzothiophene

Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-Hua Chen Ming-Yuan Kang Yi-Ting chang Sheng-Yang Huang Yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report