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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 1996-2005页

作者： Wenwen Han Hongying Yang linlin tong Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

The toxic cyanides in cyanide residues produced from cyanidation process for gold extraction are harmful to the *** is one of the main minerals existing in cyanide *** this work,the interaction of cyanide with pyrite and the decyanation of pyrite cyanide residue were *** revealed that high pH value,high cyanide concentration,and high pyrite dosage promoted the interaction of cyanide with *** cyanidation of pyrite was pseudo-second-order with respect to *** decyanation of pyrite cyanide residue by Na_(2)SO_(3)/air oxidation was *** cyanide removal efficiency was 83.9% after 1 h of reaction time under the optimal conditions of pH value of 11.2,SO_(3)^(2-) dosage of 22 mg·g^(-1),and air flow rate of 1.46 L·min^(-1).X-ray photoelectron spectroscopy analysis of the pyrite samples showed the formation of Fe(Ⅲ)and FeSO_(4) during the cyanidation *** cyanide that adsorbed on the pyrite surface after cyanidation mainly existed in the forms of free cyanide(CN^(-))and ferrocyanide(Fe(CN)_(6)^(4-)),which were effectively removed by Na_(2)SO_(3)/air *** the decyanation process,air intake promoted pyrite oxidation and weakened cyanide adsorption on the pyrite *** study has practical significance for gold enterprises aiming to mitigate the environmental impact related to cyanide residues.

关键词： pyrite cyanide decyanation sodium sulfite/air oxidation cyanide residue

Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin linlin tong Jia Zhao Lan Zhang Na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

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砷在富氧底吹炼铜过程中的走向及物相结构

中国有色金属学报 2024年第3期34卷 908-922页

作者：王保仁杨洪英金哲男佟琳琳马志远东北大学多金属矿生态冶金教育部重点实验室沈阳110819 东北大学冶金学院沈阳110819

采用Factsage热力学分析、元素分析、XRD、SEM−EDS及金相显微镜等手段研究了富氧底吹炼铜工艺中砷的走向和物相结构。结果表明:通过适当降低富氧浓度,可以提高熔炼温度增加烟气和烟尘中砷的分配。混合炉料中砷主要存在于毒砂和砷黝铜矿... 详细信息

采用Factsage热力学分析、元素分析、XRD、SEM−EDS及金相显微镜等手段研究了富氧底吹炼铜工艺中砷的走向和物相结构。结果表明:通过适当降低富氧浓度,可以提高熔炼温度增加烟气和烟尘中砷的分配。混合炉料中砷主要存在于毒砂和砷黝铜矿中,少部分存在于返渣的冰铜相和细烟尘中;冰铜中砷主要以含砷锑冰铜形式存在,平均砷含量为4.75%(质量分数);粗铜中砷主要与铜、锑、铅等形成固溶体,平均砷含量为7.78%;底吹炉渣中砷主要分布于渣相所含的含砷锑冰铜(26.38%)中,少部分存在于玻璃相基底(1.73%)和铁橄榄石相(2.08%)中;磁选前渣中砷主要存在于渣中的复杂含砷冰铜相中,大部分被渣包裹,平均砷含量为37.26%。

关键词：砷富氧底吹炼铜工艺矿物学赋存状态

Interface behavior of chalcopyrite during flotation from cyanide tailings

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International Journal of Minerals,Metallurgy and Materials 2022年第3期29卷 439-445页

作者： Xuemin Qiu Hongying Yang Guobao Chen linlin tong Zhenan Jin Qin Zhang Key Laboratory for Ecological Utilization of Multi-metallic Mineral Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

The interface characteristics of cyanide tailings are different from those of the raw ore. In this study, valuable elements could not be thoroughly recovered via the flotation of cyanide tailings from Shandong, China. The interface and floatability of these tailings were investig- ated by phase analysis and flotation tests. The chalcopyrite in the cyanide tailings was fine and had a porous surface. The floatability of 68% chalcopyrite was similar to that of galena in the presence of a collector. A layer of fine galena particles compactly wrapped the chalcopyrite. The chalcopyrite recovery sharply decreased as the nonpolar oil residue in cyanide tailings was extracted using alcohol;however, this removal had no effect on the galena. The remaining chalcopyrite in the flotation tailings was covered with an oxidation layer consisting of O, Fe, S, Pb, Cu, Zn, and Si.

关键词： cyanide tailings interface behavior chalcopyrite flotation surface wrapped layer

尼尔森选矿机富集机制对金矿分选效果的影响研究

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黄金科学技术 2024年第4期32卷 685-693页

作者：陈桥姬龙雪董欣倪蓉李岩松佟琳琳杨洪英兰州理工大学甘肃兰州730000 沈阳有色金属研究院辽宁沈阳110000 东北大学辽宁沈阳110000

尼尔森选矿机广泛应用于金矿选矿领域,查清重矿物富集机制对提高选矿效率具有重要意义。以甘肃某石英脉型金矿石(金品位为6.5×10^(-6))为原料,探究了MD3型尼尔森选矿机富集准数(X)与富集机制之间的关系,并考察了不同富集机制下的分选... 详细信息

尼尔森选矿机广泛应用于金矿选矿领域,查清重矿物富集机制对提高选矿效率具有重要意义。以甘肃某石英脉型金矿石(金品位为6.5×10^(-6))为原料,探究了MD3型尼尔森选矿机富集准数(X)与富集机制之间的关系,并考察了不同富集机制下的分选效果。结果表明:当X>9、5

关键词：金矿石尼尔森选矿机富集准数(X) 富集机制选矿效果

Plasmon coupling-driven enhanced high-order multiphoton excited fluorescent performance of metal-organic frameworks

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Nano Research 2024年第7期17卷 6502-6508页

作者： tong Meng Bo Li linlin Zeng Xianshun Sun Yupeng Tian Hongping Zhou Meng Zhou Dandan Li Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsMinistry of EducationAnhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Accessing high-order multiphoton excited fluorescence(H-MPEF)materials is challenging yet and needs complicated synthesis *** this study,we successfully assembled plasmonic Au nanorods(Au NRs)with multiphoton responsive metalorganic frameworks(MOFs),resulting in a significant several-fold enhancement of *** extent of multiphoton enhancement was found to be strongly dependent on the degree of overlap between the multiphoton excitation wavelength of MOFs and the localized surface plasmon resonance absorbance of Au NRs,indicating the importance of plasmon-induced resonance energy ***,plasmon-induced hot electron transfer played a vital role in enhanced multiphoton activity as ***,the optimum H-MPEF enhancement occurs at the second near-infrared(NIR-II)region,which provides a promising platform for fluorescent *** findings provide a feasible and practical method to fabricate optimized H-MPEF materials for biological imaging using tissue-penetrating NIR-II light.

关键词： metal-organic framework(MOF) plasmon resonance multiphoton activity fluorescence imaging

Laser-assisted synthesis of PtPd alloy for efficient ethanol oxidation

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Nano Research 2024年第7期17卷 6032-6037页

作者： Zihang Chen tong Liu Huijuan Zhang Beibei Pang Yuanhua Sun Longfei Hu Qiquan Luo Xiaokang Liu linlin Cao Tao Yao School of Nuclear Science and Technology National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230029China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China

The inefficiency of ethanol oxidation reaction(EOR)presents a significant obstacle in harnessing renewable biofuels with high energy density into *** efforts,most Pt-based catalysts still suffer from drawbacks such as poor activity and susceptibility to CO poisoning,particularly in acidic ***,we employed a physical laser-assisted approach to synthetize a PtPd alloy with a 1:1 atomic *** alloy demonstrates remarkable performance in acidic EOR,boasting a high mass activity of 1.86 A·mgPt^(−1)and competitive resistance to *** in situ synchrotron radiation infrared spectroscopy with theoretical calculations,we reveal that the synergic interaction between Pt and Pd enhances both the adsorption of OH*intermediate and the dehydrogenation ability of *** work will prove the feasibility of synthesizing bimetallic alloys by a physical laser-assisted strategy and promote the development of advanced alloy electrocatalysts.

关键词： laser-assisted strategy Pt-based alloy in situ synchrotron radiation infrared spectroscopy ethanol oxidation reaction synergic interaction

Altered synaptic currents,mitophagy,mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention

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Journal of Pharmaceutical Analysis 2024年第3期14卷 348-370页

作者： Binbin Zhao Dongfeng Wei Qinghua Long Qingjie Chen Fushun Wang linlin Chen Zefei Li tong Li Tao Ma Wei Liu Linshuang Wang Caishui Yang Xiaxia Zhang Ping Wang Zhanjun Zhang State Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing100875China Institute of Gerontology Hubei University of Chinese MedicineWuhan430065China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Medical School Hubei Minzu UniversityEnshiHubei445000China HuBei University of Science and Technology XianningHubei437100China Institute of Brain and Psychological Science Sichuan Normal UniversityChengdu610066China Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription Ministry of EducationHubei University of Chinese MedicineWuhan430065China Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing100700China School of Systems Science Beijing Normal UniversityBeijing100875China BABRI Centre Beijing Normal UniversityBeijing100875China

Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial ***,the specific associations between these pathological changes remain *** this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro *** investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis,Nissl staining,thioflavin-S staining,enzyme-linked immunosorbent assay,Golgi-Cox staining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROS)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular *** results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD ***,intervention with Dengzhan Shengmai(DZSM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZSM intervention,which notably amplified the frequency and amplitude of synaptic *** cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular *** intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and ***,DZSM intervention led to favourable changes in mitochondrial parameters,including ROS expression,MMP and ATP contents,and mitochondrial *** conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZSM intervention.

关键词： Alzheimer's disease Synaptic currents Mitophagy Mitochondrial fusion and fission Dengzhan Shengmai capsules

Freezing-directed construction of enzyme/nano interfaces:Reagentless conjugation,superior activity,and better stability

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Chinese Chemical Letters 2024年第1期35卷 471-474页

作者： Ke Quan Jiajie tong Lifang Chen Shuyao Fang Mengjiao Li linlin Wu Zhihe Qing Hunan Provincial Key Laboratory of Cytochemistry School of Food and BioengineeringSchool of Chemistry and Chemical EngineeringChangsha University of Science and TechnologyChangsha 410114China Department of Oncology Tengzhou Central People’s Hospital Affiliated Xuzhou Medical UniversityTengzhou 277500China

Immobilizing enzyme to nano interfaces has demonstrated to be a favorable strategy for prompting the industrialized application of *** tremendous endeavor has been devoted to using gold nanoparticles(AuNPs)as conjugation matrix due to its fascinating physico-chemical properties,maintaining enzymatic activity while circumventing cumbersome modification remains a formidable ***,the freezing-directed conjugation of enzyme/nano interfaces was constructed without extra *** the proof of concept,glucose oxidase(GOx)was chosen as model *** one-pot conjugation process can be facilely completed at−20°C under aqueous ***,with the loading of GOx on AuNP at freezing,the enzyme exhibited superior catalytic activity and stability upon thermal and pH *** mechanism of boosted activity was then discussed in *** was found that higher loading density under freezing condition and more enzyme tending to bind AuNPs via Au-S bond were the main factors for the superior *** importantly,this methodology was universal and can also be applied to other enzyme which contains natural cysteine,such as horseradish peroxidase(HRP)and *** facile conjugation strategy accompanied by remarkable bioactivity expand the possibilities for enzymatic biosensing,microdevice and even drug delivery.

关键词： Enzyme conjugation Freezing AuNPs Catalytic activity

NiPt/Ti_(2)O_(3)纳米催化剂的制备及其催化水合肼制氢性能研究

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燃料化学学报（中英文） 2024年第3期52卷 421-428页

作者：赵荣琦徐林林刘通青岛科技大学材料科学与工程学院山东青岛266000 青岛恒星科技学院山东青岛266000

本研究利用H_(2)还原制备Ti_(2)O_(3)载体后,通过湿化学浸渍-还原法制备NiPt/Ti_(2)O_(3)纳米催化剂进行催化水合肼研究。研究表明,在催化剂的制备过程中,Ni和Pt之间形成了一种合金,该合金的形成使催化剂的催化活性升高,Ti_(2)O_(3)与N... 详细信息

本研究利用H_(2)还原制备Ti_(2)O_(3)载体后,通过湿化学浸渍-还原法制备NiPt/Ti_(2)O_(3)纳米催化剂进行催化水合肼研究。研究表明,在催化剂的制备过程中,Ni和Pt之间形成了一种合金,该合金的形成使催化剂的催化活性升高,Ti_(2)O_(3)与NiPt合金的相互作用提升了催化剂催化性能和循环稳定性。Ni_(5)Pt_(5)/Ti_(2)O_(3)催化剂催化水合肼产氢的反应的TOF值为1076.1 h^(−1)。

关键词：水合肼分解制氢 NiPt Ti_(2)O_(3)

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