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Tsunami hazard assessment in the South China Sea:A review of recent progress and research gaps

Science China Earth Sciences 2022年第5期65卷 783-809页

作者： Linlin Li Qiang QIU Zhigang li Peizhen ZHANG Guangdong Provincial Key Laboratory of Geodynamics and Geohazards School of Earth Sciences and EngineeringSun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China China-Pakistan Joint Research Center on Earth Sciences CAS-HECIslamabad 45320Pakistan

The South China Sea region is potentially threatened by tsunami hazards originated from multiple sources:the Manila subduction zone in the east,the littoral Fault Zone(LFZ)in the north,numerous submarine landslides on the continental slopes and the volcanic islands in the Luzon Strait.Infrequent but potentially devastating tsunami hazard poses a great threat to the populous coastal region,fishery,oil and gas exploitation in the deep sea,etc.Here we review the recent progress in tsunami hazard assessment in the South China Sea region,focusing on two primary sources:submarine earthquakes and landslides.We sort and review the literature by the two commonly used approaches:deterministic and probabilistic tsunami hazard assessment for both source types.By simulating tsunamis generated by typical earthquakes originated from the Manila Trench,the LFZ and landslides in the continental slopes,we investigate their tsunamigenic mechanism and key tsunami characteristics in the South China Sea region.We point out the research gaps and highlight the key issues to be addressed in the future.

关键词： Tsunami Submarine earthquake Submarine landslide the littoral Fault Zone

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Recent Progress in Nanoscale Covalent Organic Frameworks for Cancer Diagnosis and Therapy

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Nano-Micro Letters 2021年第11期13卷 246-265页

作者： Shuncheng Yao Zhirong liu Linlin Li Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

Covalent organic frameworks(COFs)as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic molecules.Their precise assembly,welldefined coordination network,and tunable porosity endow COFs with diverse characteristics such as low density,high crystallinity,porous structure,and large specific-surface area,as well as versatile functions and active sites that can be tuned at molecular and atomic level.These unique properties make them excellent candidate materials for biomedical applications,such as drug delivery,diagnostic imaging,and disease therapy.To realize these functions,the components,dimensions,and guest molecule loading into COFs have a great influence on their performance in various applications.In this review,we first introduce the influence of dimensions,building blocks,and synthetic conditions on the chemical stability,pore structure,and chemical interaction with guest molecules of COFs.Next,the applications of COFs in cancer diagnosis and therapy are summarized.Finally,some challenges for COFs in cancer therapy are noted and the problems to be solved in the future are proposed.

关键词： Covalent organic frameworks Nanomedicine Drug delivery Cancer diagnosis and therapy

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Recent advances of implantable systems and devices in cancer therapy and sensing

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Nano Research 2023年第9期16卷 11653-11666页

作者： Zhuoheng Jiang Zhaoyang Yue Zhirong liu Linlin Li Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China School of Chemistry and Chemical Engineering Center on Nanoenergy ResearchSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China

Malignant tumors have the capability to metastasize and colonize,meaning that they can spread to other organs and tissues,distributing metastatic focus and are hard to target.Although significant advances have been made in cancer treatment,it remains one of the leading causes of death around the globe.In recent years,new-emerging implantable systems and devices have been developed to tackle the challenge of metastatic tumors.In this review,implantable systems for suppressing tumors and preventing tumor recurrence are reported.In particular,we emphasize the responsive drug delivery systems and the external field assisted catalytic therapy for tumor treatment,as well as implantable biosensors for tumor microenvironment monitoring.We also conclude the open challenges and future perspectives of implantable systems and devices for cancer therapy and sensing.

关键词： implantable devices cancer therapy drug delivery biosensor nanogenerator

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Data-Driven Fault Compensation Tracking Control for Coupled Wastewater Treatment Process

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 294-297页

作者： Peihao Du Weimin Zhong Xin Peng Linlin Li Zhi li the Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China IEEE the Key Laboratory of Knowledge Automation for Industrial Processes of Ministry of Education the School of Automation and Electrical EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Dear Editor, This letter is concerned with the data-driven fault compensation tracking control for a coupled wastewater treatment process(WWTP)subject to sensor faults. Invariant set theory is introduced to eliminate the completely bounded and differentiable conditions of coupled non-affine dynamics and to explicitly express the control inputs.An adaptive fault compensation mechanism is constructed to accommodate the effects of sensor faults. By employing a cubic absolutevalue Lyapunov criteria。

关键词： differentiable eliminate absolute

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Nanozymes for regulation of reactive oxygen species and disease therapy

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Chinese Chemical Letters 2021年第9期32卷 2715-2728页

作者： Yujie Dai Yiming Ding Linlin Li Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Center on Nanoenergy Research School of Chemistry and Chemical EngineeringSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China

With high catalytic activity and stability,nanozymes have huge advantage in generating or eliminating the reactive oxygen species(ROS)due to their intrinsic enzyme-mimicking abilities,therefore attracting wide attention in ROS-related disease therapy.To better design nanozyme-based platforms for ROSrelated biological application,we firstly illustrate the catalytic mechanism of different activities,and then introduce different strategies for using nanozymes to augment or reduce ROS level for the applications in cancer therapy,pathogen infection,neurodegeneration,etc.Finally,the challenges and future opportunities are proposed for the development and application of nanozymes.

关键词： Nanozyme Reactive oxygen species(ROS) Cancer therapy Peroxidase Oxidases Photodynamic therapy

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In vivo tunable CRISPR mediates efficient somatic mutagenesis to generate tumor models

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Protein & Cell 2019年第6期10卷 450-454页

作者： Xiaomeng An Linlin Li Sen Wu State Key Laboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing 100193 China State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Diseases Reference Laboratory Key Laboratoryof Animal Virology of Ministry of Agriculture Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730000 China

Dear Editor, CRISPR/Cas9 has revolutionized genome editing technology due to its simplicity and robustness (Mali et al., 2013). Several inducible CRISPR/Cas9 systems recently developed make spatiotemporal genome editing possible (Kon ermann et al., 2013;Balboa et al., 2015;Dow et al., 2015;Zetsche et al., 2015;liu et al., 2016;Kleinjan et al., 2017;Maji et al.. 2017;Senturk et al., 2017;Lu et al., 2018).

关键词： Dear Editor genome editing technol Balboa

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Nanomaterials for lubricating oil application:A review

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Friction 2023年第5期11卷 647-684页

作者： linlin DUAN Jian li Haitao DUAN State Key Laboratory of Special Surface Protection Materials and Application Technology Wuhan Research Institute of Materials ProtectionWuhan 430030China

Friction and wear are ubiquitous,from nano-electro-mechanical systems in biomedicine to large-scale integrated electric propulsion in aircraft carriers.Applications of nanomaterials as lubricating oil additives have achieved great advances,which are of great significance to control friction and wear.This review focuses on the applications of nanomaterials in lubricating oil and comprehensively compares their tribological characteristics as lubricating oil additives.Statistical analysis of tribology data is provided and discussed accordingly;moreover,the interaction between nanomaterials and sliding surface,lubricating oil,other additives,and synergistic lubrication in nanocomposites are systematically elaborated.Finally,suggestions for future research on nanomaterials as lubricating oil additives are proposed.Hence,this review will promote a better fundamental understanding of nanomaterials for lubricating oil application and help to achieve the superior design of nanoadditives with outstanding tribological performances.

关键词： nanomaterial additive friction modifier lubrication wear

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Micro/nano needles for advanced drug delivery

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Progress in Natural Science:Materials International 2020年第5期30卷 589-596页

作者： Xiangchun Meng Zeyu Zhang Linlin Li Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences School of Chemistry and Chemical Engineering Guangxi University School of Nanoscience and Technology University of Chinese Academy of Sciences

Along with the boost of drugs’ exploitation, drug delivery has been a common concern among researchers and patients. As an emerging strategy, the micro-and nano-needle(MNN) is a single or an array of micro/nanoneedles,and promises to be a robust technology for efficient, noninvasive and convenient drug delivery. Compared with the conventional injection, MNN can pierce the bio-membranes to transfer cargos without any damage of tissue or nerves. And regarding the topical drug release, MNN is more efficient than oral administration and topical cream.More specifically, microneedle, a powerful technique, has been widely applied in different diseases such as diabetes, anti-obesity and contraception through skin and ocular surface. Correspondingly, many novel microneedles and optimization methods have been developed recently to improve the drug delivery efficacy. Nanoneedle, much smaller than microneedle, can minimize the skin damages caused by the repeated use of microneedles.Nanoneedles with nanoscaled size are usually used to penetrate the cell membrane. And recently many stimulusaided methods like electrical and magnetic force have been invented to deepen penetration and improve transfer effects. The aim of this review is to introduce the recent advances of MNN-based drug delivery, including their types, application locations and diseases, optimization of delivery strategies and future development prospects.

关键词： Micro- and nano needle Drug delivery Noninvasiveness Stimuli-responsive

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Influence of traditional Chinese medicines on the in vivo metabolism of lopinavir/ritonavir based on UHPLC-MS/MS analysis

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Journal of Pharmaceutical Analysis 2022年第2期12卷 270-277页

作者： Linlin Li Xinxiang Yu Dongmin Xie Ningning Peng Weilin Wang Decai Wang Binglong li Department of Clinical Pharmacy School of PharmacyShandong First Medical University&Shandong Academy of Medical SciencesTai'anShandong271016China

A fast,reliable,and cost-effective liquid chromatography-tandem mass spectrometry method was established to determine the effects of the traditional Chinese medicine employed to treat coronavirus disease 2019,namely,lianhua Qingwen granules,Huoxiang Zhengqi capsules,Jinhua Qinggan granules,Shufeng Jiedu capsules,and Angong Niuhuang pills,on the pharmacokinetics of lopinavir/ritonavir in rats.Blood samples were prepared using the protein precipitation method and atazanavir was selected as the internal standard(IS).Separation was performed on an Agilent ZORBAX eclipse plus C18(2.1 mm×50 mm,1.8 μm)column using acetonitrile and water containing 0.1%formic acid as the mobile phase for gradient elution.The flow rate was 0.4 mL/min and the injection volume was 2 μL.Agilent Jet Stream electrospray ionization was used for mass spectrometry detection under positive ion multiple reaction monitoring mode at a transition of m/z 629.3→447.3 for lopinavir,m/z 721.3→296.1 for ritonavir,and m/z 705.4→168.1 for the IS.The method showed good linearity in the concentration range of 25→2500 ng/mL(r=0.9981)for lopinavir and 5e500 ng/mL(r=0.9984)for ritonavir.The intra-day and inter-day precision and accuracy were both within±15%.Items,such as dilution reliability and residual effect,were also within the acceptable limits.The method was used to determine the effects of five types of traditional Chinese medicines on the pharmacokinetics of lopinavir/ritonavir in rats.The pharmacokinetic results showed that the half-life of ritonavir in the groups administered lianhua Qingwen granules and Huoxiang Zhengqi capsules combined with lopinavir/ritonavir was prolonged by approximately 1.5-to 2-fold relative to that in the control group.Similarly,the pharmacokinetic parameters of lopinavir were altered.Overall,the results of this study offer important theoretical parameters for the effective clinical use of five types of traditional Chinese medicines combined with lopinavir/ritonavir to reduce the occurrence of clinical adverse reactions.

关键词： Lopinavir/ritonavir Combination of Chinese and western medicine Drug-drug interaction Ultra high-performance liquid chromatography-tandem mass spectrometry Pharmacokinetics COVID-19

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Efficient Identification of water conveyance tunnels siltation based on ensemble deep learning

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Frontiers of Structural and Civil Engineering 2022年第5期16卷 564-575页

作者： Xinbin WU Junjie li linlin WANG Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116024China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China

The inspection of water conveyance tunnels plays an important role in water diversion projects.Siltation is an essential factor threatening the safety of water conveyance tunnels.Accurate and efficient identification of such siltation can reduce risks and enhance safety and reliability of these projects.The remotely operated vehicle(ROV)can detect such siltation.However,it needs to improve its intelligent recognition of image data it obtains.This paper introduces the idea of ensemble deep learning.Based on the VGG16 network,a compact convolutional neural network(CNN)is designed as a primary learner,called Silt-net,which is used to identify the siltation images.At the same time,the fully-connected network is applied as the meta-learner,and stacking ensemble learning is combined with the outputs of the primary classifiers to obtain satisfactory classification results.Finally,several evaluation metrics are used to measure the performance of the proposed method.The experimental results on the siltation dataset show that the classification accuracy of the proposed method reaches 97.2%,which is far better than the accuracy of other classifiers.Furthermore,the proposed method can weigh the accuracy and model complexity on a platform with limited computing resources.

关键词： water conveyance tunnels siltation images remotely operated vehicles deep learning ensemble learning computer vision

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