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mLife 2024年第1期3卷 87-100页

作者： Yakun Li Yuyun Wei Xiao Guo Xiaohui Li lining lu Lihua Hu Zheng-Guo He State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Scienceand TechnologyGuangxi UniversityNanningChina

Insertion sequences(ISs)exist widely in bacterial genomes,but their roles in the evolution of bacterial antiphage defense remain to be ***,we report that,under the pressure of phage infection,the IS1o96 transposition of Mycobacterium smegmatis into the Isr2 gene can occur at high frequencies,which endows the mutant mycobacterium with a broad-spectrum antiphage ***2 functions as a negative regulator and directly silences expression of a gene island composed of 11 lipid metabolism-related *** complete or partial loss of the gene island leads to a significant decrease of bacteriophage adsorption to the mycobacterium,thus defending against phage ***,a phage that has evolved mutations in two tail-filament genes can re-escape from the Isr2 inactivation-triggered host *** study uncovered a new signaling pathway for activating antimycobacteriophage immunity by Is transposition and provided insight into the natural evolution of bacterial antiphage defense.

关键词： antiphage defense bacteriophage gene island insertion sequence mycobacteria

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基于A*算法的汽车总线拓扑图自动绘制设计

汽车实用技术 2024年第6期49卷 124-130页

作者：郑生文卢利宁李志文湖南湖大艾盛汽车技术开发有限公司湖南长沙410000

为了适应现代汽车通信系统日益复杂化的需求,消除汽车总线拓扑图因人工绘制带来的出错隐患,提升研发效率,文章提出了一种基于A*算法的汽车总线拓扑图的自动绘制设计方案。首先,文章提炼出实际工程项目中拓扑图绘制所需要素,随后梳理拓... 详细信息

为了适应现代汽车通信系统日益复杂化的需求,消除汽车总线拓扑图因人工绘制带来的出错隐患,提升研发效率,文章提出了一种基于A*算法的汽车总线拓扑图的自动绘制设计方案。首先,文章提炼出实际工程项目中拓扑图绘制所需要素,随后梳理拓扑图自动绘制流程,最后使用A*算法优化节点与网段间连线过程。基于某车实际通信系统,同传统人工绘制比较,验证了本设计可在保证清晰、美观、准确的同时,显著提高汽车总线拓扑图的绘制效率。

关键词：汽车总线拓扑图绘制 A*算法软件设计

Anticorrosion performance of the coating/metal system by electrochemical impedance spectra

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Journal of University of Science and Technology Beijing 2008年第4期15卷 457-460页

作者： Yinghuai Zhang lining Xu Minxu lu Pu Zhang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

In order to investigate the anticorrosion performance of the organic coating/metal system, electrochemical impedance spectra （EIS） were measured in the 3.5wt% NaCl solution, the chemical component and the formation of corrosion products scale were analyzed by laser Raman microspectroscopy, and the pattern of the organic coating/metal system was observed by scanning electron microscopy （SEM）. The characteristics and the delamination process of the organic coating/metal system were investigated systematically, and the emphases were on the transportation of the corrosive medium and the changes of the coating/metal interface. The results show that the impedance decreases at the initial immersion, then increases at the middle-immersion, and again decreases at last, which is related to the corrosion products scale. The concentration of Cl in the coating, which destroys the corrosion products scale, increases with the immersion time.

关键词： organic coating electrochemical impedance spectra corrosion product scale anticorrosion

Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop

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Science China Chemistry 2020年第2期63卷 237-243页

作者： lining lu Yu Guo Tian Wang lujun Liang Suwen Zhao Feng Wang Lei Liu Tsinghua-Peking Center for Life Sciences Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Center for Synthetic and Systems BiologyState Key Laboratory of Chemical Oncogenomics(Shenzhen)Department of ChemistryTsinghua UniversityBeijing 100084China School of Life Science Beijing Institute of TechnologyBeijing 100081China iHuman Institute School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China

MINDY-1 is a recently discovered new family of deubiquitinating enzymes(DUB),but one of its yeast homologs,YGL082 W,does not show any DUB activity in *** alignment shows that YGL082 W possesses the correct catalytic triad,and yet did not catalyze either the hydrolysis of di-ubiquitin,crosslinking with C-terminally propargylated ubiquitin,or hydrolysis of *** obtaining a crystal structure of the catalytic domain of YGL082 W,we identified an interesting difference between the catalytic center loop of YGL082 W and that of its human homolog *** the conformation of the catalytic center loop was previously reported to be important for the deubiquitination activity of MINDY-1,we hypothesized that Glu27(instead of the corresponding Pro136 in MINDY-1) of the catalytic center loop of YGL082 W may impair the conformational change and account for the lack of *** hypothesis was supported by homology modeling and molecular dynamics simulations,which showed that the Pro-to-Glu mutation(P136 E mutation for MINDY-1) creates a hydrogen bond that inhibits the conformation change of the catalytic center loop of *** experiments through site-directed mutation validated this hypothesis,showing that the P27 E mutation caused MIY1(a homologous active DUB from yeast) to lose activity.

关键词： deubiquitinating enzymes(DUB) enzymology X-ray crystal structure molecular dynamics

A　Research　of　China　Stock　Market　by　Capital-Asset　Pricing　Model

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Systems Science and Systems Engineering 1997年第3期7卷 51-55页

作者： ZHAN Yuanrui lu lining Management Institute Tianjin University, Tianjin 300400

Capital Asset Pricing Model (CAPM) is an important investment portfolio model,which is developmented from Markowitz’s investment portfolio theory. This paper initially verifies CAPM by means of the statistical regression analysis on the data in Shanghai stock exchange, including 164 kinds of going public stocks, from September 1992 to October 1994. The paper analyzes the current situation of China stock exchange and suggests how to develop its trade.

关键词： Capital Asset Pricing Model(CAPM) stock market the statistical regression analysis.

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古尔班通古特沙漠灌木冠幅预测模型

中国沙漠 2022年第4期42卷 139-150页

作者：王明娜张定海张志山路丽宁甘肃农业大学财经学院甘肃兰州730070 甘肃农业大学理学院甘肃兰州730070 中国科学院西北生态环境资源研究院沙坡头沙漠研究试验站甘肃兰州730000

古尔班通古特沙漠是中国第二大沙漠,也是中国固定和半固定沙丘主要分布区,固沙灌木种较多。冠幅不仅是反映固沙灌木可视化的重要参数,也是反映沙漠植被生长情况的重要变量。以3种沙丘(固定沙丘、半固定沙丘和流动沙丘)上主要固沙灌木为... 详细信息

古尔班通古特沙漠是中国第二大沙漠,也是中国固定和半固定沙丘主要分布区,固沙灌木种较多。冠幅不仅是反映固沙灌木可视化的重要参数,也是反映沙漠植被生长情况的重要变量。以3种沙丘(固定沙丘、半固定沙丘和流动沙丘)上主要固沙灌木为研究对象,利用12种基础模型、BP(Backpropagation Neural Network)神经网络和支持向量机(Support Vector Machine,SVM)机器学习算法建立了基于固沙灌木株高和冠长率的冠幅预测模型,同时将两种机器学习算法拟合结果与基础模型进行比较,最终选出了适合研究区的冠幅预测模型。结果表明:(1)不同沙丘类型和不同灌木种类的最优冠幅预测模型不同,且固定沙丘和半固定沙丘模型优于流动沙丘。3种沙丘类型最优拟合为M2(Quadratic Model)模型;(2)白梭梭(Haloxylon persicum)在半固定沙丘和流动沙丘上拟合的最优模型分别为M2、M7(Gompertz),沙拐枣(Calligonum mongolicum)最优模型为M2,蛇麻黄(Ephedra distachya)和油蒿(Artemisia ordosica)在半固定沙丘和流动沙丘上拟合较优模型分别为M2、M7。总体来说,基础模型M2和M7可以较好地预测不同类型的灌木冠幅值;(3)基于径向基(Radial Basis Function)核函数的支持向量回归机的冠幅预测模型明显优于BP神经网络模型。

关键词：株高冠幅冠长率基础模型 BP神经网络 SVM支持向量机

美国国立卫生研究院(NIH)是如何开展基金资助的——访NIH国家研究资源中心

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中国科学基金 1999年第4期13卷 232-235页

作者：吕立宁中国医学科学院基础医学研究所北京100005

NIH国家研究资源中心(National Center for Re-search Resources简称NCRR)是NIH下属中心之一,它通过资助各类研究资源项目,鼓励生物医学研究人员发展并应用先进的高新技术、仪器设备、动物模型及各类生物材料,向接受NIH资助的研究人员... 详细信息

NIH国家研究资源中心(National Center for Re-search Resources简称NCRR)是NIH下属中心之一,它通过资助各类研究资源项目,鼓励生物医学研究人员发展并应用先进的高新技术、仪器设备、动物模型及各类生物材料,向接受NIH资助的研究人员提供最有效的利用多类资源的条件。1 国家资源中心(NCRR)概况 NCRR没有自己的研究实体,所设的4个资助领域(生物医学技术、临床研究、比较医学。

关键词：美国卫生学研究机构 NIH 基金资助科研基金

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古尔班通古特沙漠固沙灌木的冠幅预测模型

生态科学 2022年第5期41卷 81-89页

作者：路丽宁张定海李功麟甘肃农业大学理学院数量生物研究所兰州730070

以古尔班通古特沙漠中三种类型沙丘(固定沙丘、半固定沙丘和流动沙丘)上主要固沙灌木梭梭(Haloxylon ammodendron)、白梭梭(Haloxylon persicum)、沙拐枣(Calligonum mongolicum)、蛇麻黄(Ephedra distachya)和油蒿(Artemisia ordosica)为研究对象,利用12个基础模型建立了不同沙丘类型上所有灌木和不同类型灌木的冠幅模型。模型拟合结果表明:不论是不同沙丘类型上所有灌木的拟合效果还是不同类型灌木的拟合效果,固定沙丘和半固定沙丘均优于流动沙丘。同时,两个近“S”形模型M7(Gompertz Model)和M12(HossfeldⅠModel)对三种类型沙丘上的固沙灌木均有较好拟合效果;M1(Linear Model)、M2(Quadratic Model)、M3(Power Model)、M6(Logistic Model)、M7、M9(Gauss Model)、M10(Mitscherlinch Model)和M12八个模型适用于研究区绝大部分固沙灌木冠幅模型的模拟。但不同沙丘类型上所有灌木和不同类型的灌木都有不同的最优冠幅模型。研究可为今后该地区相关生态模型建立和防风固沙效益的评价提供科学依据。

关键词：古尔班通古特固沙灌木沙丘类型冠幅预测模型

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Impact of surface-reflected seismic waves on the seismic isolation performance of circular tunnel isolation layers

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Journal of Mountain Science 2024年第3期21卷 901-917页

作者： lu Jiahui luO Junjie HUANG Xiangyun HONG Junliang HE YanXin ZHOU Fulin Department of Civil Engineering Xi’an University of Architecture and Technology(XAUAT)Xi’an 710055China Earthquake Engineering Research and Test Centre Guangzhou UniversityGuangzhou 510623China Guangdong Provincial Key Laboratory of Earthquake Engineering and Applied Technology Guangzhou UniversityGuangzhou 510623China Key Laboratory of Earthquake Resistance Earthquake Mitigation and Structural SafetyMinistry of EducationGuangzhou UniversityGuangzhou 510623China

Seismic isolation is an effective strategy to mitigate the risk of seismic damage in ***,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under *** this study,we employ the wave function expansion method to provide analytical solutions for the dynamic responses of linings in an elastic half-space and an infinite elastic *** comparing the results of the two models,we investigate the seismic isolation effect of tunnel isolation layers induced by reflected seismic *** findings reveal significant differences in the dynamic responses of the lining in the elastic half-space and the infinitely elastic ***,the dynamic stress concentration factor(DSCF)of the lining in the elastic half-space exhibits periodic fluctuations,influenced by the incident wave frequency and tunnel depth,while the DSCF in the infinitely elastic space remain ***,the seismic isolation application of the tunnel isolation layer is found to be less affected by surface-reflected seismic *** results provide valuable insights for the design and assessment of the seismic isolation effect of tunnel isolation layers.

关键词： Circular tunnel seismic isolation Surface reflection Response of liners Wave-function expansion method

Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit

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CCS Chemistry 2019年第5期1卷 476-489页

作者： Man Pan Qingyun Zheng Shuai Gao Qian Qu Yuanyuan Yu Ming Wu Huan Lan Yulei Li Sanling Liu Jiabin Li Demeng Sun lining lu Tian Wang Wenhao Zhang Jiawei Wang Yiming Li Hong-Gang Hu Changlin Tian Lei Liu Tsinghua-Peking Center for Life Sciences Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyCenter for Synthetic and Systems BiologyState Key Laboratory of Chemical OncogenomicsDepartment of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical BiologyGraduate School at ShenzhenTsinghua UniversityShenzhenGuangdong 518055China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China School of Biological and Medical Engineering Hefei University of TechnologyHefeiAnhui 230009China

Mutations in genes encoding PINK1(PTEN-induced kinase 1)and Parkin(E3 ubiquitin ligase)are identified in familial Parkinson’s ***,it remains unclear whether the phosphorylated Ub chains activate wild-type Parkin(w-Pa... 详细信息

关键词： chemical protein synthesis ubiquitin phosphorylation Parkin mitochondrial autophagy