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Journal of Materials Science & Technology 2021年第26期85卷 245-254页

作者： Wenlong Liu Lin Tao Wei Feng Jiaxuan Liao lingzhao zhang School of Food and Biological Engineering Chengdu UniversityChengdu610106China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhouZhejiang 324000China School of Mechanical Engineering Chengdu UniversityChengdu610106China

It is a challenge to reduce the dielectric loss and increase the tunability of pure barium strontium titanate(BST)films for microwave tunable application because these two properties change ***,a novel composite of strontium titanate(ST)and potassium-doped BST(KBST)has been designed as ST/KBST/ST sandwich-type film with various ST and KBST layers.X-ray diffraction patterns show that the film exhibits cubic perovskite polycrystalline structure composed of BST and ST phase,mainly grow along(110)crystal plane with average grain size of less than 20 nm and decreasing BST phase/ST phase ratio with increasing film *** electron microscope shows that no interfacial layer can be observed,indicating that ST and KBST are fully *** dielectric loss and high tunability at-10-10 V and stable and excellent dielectric properties at 1 GHz are achieved,meeting the needs of microwave tunable application at high *** surface structures are also studied by other analysis methods,and ST/MgBST/ST sandwich-type film is compared.

关键词： ST/KBST/ST Sandwich-type Multilayer film Controllable dielectric performance High frequency application

SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/b-catenin signaling

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Genes & Diseases 2021年第5期8卷 677-688页

作者： Daopei Zou Yangmei Chen lingzhao zhang Xiaohui Yuan Yujie zhang Adelina Inggawati Pham Thi Kieu Nguyet Tianwen Gao Jin Chen Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Key Laboratory of Clinical Laboratory Diagnostics Ministry of EducationChongqing Medical UniversityChongqing400016PR China Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi’anShanxi Province710032PR China

Secreted frizzled-related protein 5(SFRP5)plays a pivotal role in regulating the development of many tissues and organs,however,as an inhibitor of Wnt signaling,the role of SFRP5 in vitiligo remains ***,we speculated that SFRP5 might be associated with melanogenesis in melanocytes by regulating Wnt signaling in *** this study,we found that SFRP5 was overexpressed in the skin lesions of patients with *** with that in normal epidermal melanocytes(PIG1),the expression of SFRP5 was increased in vitiligo melanocytes(PIG3V).To investigate the effect of SFRP5 on melanin synthesis,PIG1 cells were infected with recombinant SFRP5 adenovirus(AdSFRP5),and PIG3V cells were infected with recombinant siSFRP5 adenovirus(AdsiSFRP5).The results showed that SFRP5 overexpression inhibited melanin synthesis in PIG1 cells through downregulation of microphthalmia-associated transcription factor(MITF)and its target proteins via suppression of the Wnt/b-catenin signaling ***,SFRP5 silencing increased melanin synthesis and activated the Wnt signaling pathway in PIG3V ***,SFRP5 overexpression also downregulated the transcriptional activity of T cell factor/lymphoid enhancer factor(TCF/LEF)in PIG1 ***,this inhibitory effect of SFRP5 on melanin synthesis was reversed by treatment with the b-catenin agonist,*** inhibitory action of SFRP5 in pigmentation was further confirmed in vivo using a nude mouse ***,our results indicate that SFRP5 can inhibit melanogenesis in ***,our findings showed that SFRP5 plays a vital role in the development of vitiligo,and thus may serve as a potential therapeutic target for vitiligo.

关键词： Melanin synthesis Melanocytes MITF SFRP5 Vitiligo Wnt signaling

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分布式电磁频谱监测定位系统设计

电讯技术 2023年第7期63卷 987-992页

作者：魏睿张令召南京电子技术研究所南京210039

现代战争中,有效的电磁频谱管理是打赢电磁频谱战的关键。为提升电磁频谱管理能力,提出了分布式电磁频谱监测定位系统,采用分段射频采样方法进行全频带监测,同时采用Chan算法进行定位方程计算。系统具备电磁环境全频段实时监测能力,同... 详细信息

现代战争中,有效的电磁频谱管理是打赢电磁频谱战的关键。为提升电磁频谱管理能力,提出了分布式电磁频谱监测定位系统,采用分段射频采样方法进行全频带监测,同时采用Chan算法进行定位方程计算。系统具备电磁环境全频段实时监测能力,同时可以对威胁辐射源进行到达时间差(Time Difference of Arrival,TDOA)高精度定位。开展了城市环境中的电台信号监测实验和海上作战场景中辐射源定位仿真验证,实验结果证明该系统能够实现对电磁信号的实时监测和精细化分析。系统整体定位误差小于100 m,重点区域定位误差小于35 m,能够实现辐射源的高精度定位。本系统能够满足电磁频谱管理的需求,对我国电磁频谱战系统的发展具有参考意义。

关键词：电磁频谱战电磁频谱管理频谱监测辐射源定位

暗筒式日照计安装误差导致的记录迹线偏离分析

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气象与减灾研究 2014年第2期37卷 61-68页

作者：张令钊福建省气象科学研究所福建福州350001

由日照记录迹线描述方程,给出标准日照记录迹线,并对日照计安装偏差对日照记录正确性和日照迹线状态改变的影响进行了分析,发现日照计安装偏差造成的记录误差,水平最甚,方位次之,纬度最轻。用日照记录迹线形状来判断日照计安装偏差,纬... 详细信息

由日照记录迹线描述方程,给出标准日照记录迹线,并对日照计安装偏差对日照记录正确性和日照迹线状态改变的影响进行了分析,发现日照计安装偏差造成的记录误差,水平最甚,方位次之,纬度最轻。用日照记录迹线形状来判断日照计安装偏差,纬度不准最易,方位不准次之,水平不准最难。并提出了暗筒式日照计的正确安装方法,确保其水平、方位、纬度误差最小。

关键词：日照计原理误差分析安装方法

Modeling of University R&D Team Cohesiveness

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Modeling of University R&D Team Cohesiveness

超声引导下持续髂筋膜阻滞在股骨颈骨折手术中的应用效果分析

第六届（2011）中国管理学年会——组织行为与人力资源管理分会场

作者： zhang lingzhao Jing Runtian (School of Eeonomies&Management,University of Eleetronic Seience andTechnology of China, Chengdu 610054,China)

The increased complexity and sociality of R&D activities makes university R&D team cohesiveness a hot topic of discussion. University R&D team is the primary organization undertaking R&D activities, its members are teachers who have professional background, certain direction, and have self-realization objectives, they are typical knowledge workers. Coupling between needs of team teachers and organizational support is the key point of team cohesiveness. Based on needs of R&D team and organizational support theory, this article creates a theoretical model of university R&D team cohesiveness, and analyzes its structure, function, and operating mechanism.

关键词： university R&D team theory of needs organizational support cohesiveness model

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中国烧伤创疡杂志 2023年第1期35卷 58-61,70页

作者：张灵召王二丽长葛市人民医院麻醉科河南许昌461500

目的探讨超声引导下持续髂筋膜阻滞在股骨颈骨折手术中的应用效果。方法选取2019年4月至2021年3月长葛市人民医院收治的80例股骨颈骨折患者作为研究对象,并按照随机数表法将其随机分为观察组(40例)与对照组(40例)。观察组患者行超声引... 详细信息

目的探讨超声引导下持续髂筋膜阻滞在股骨颈骨折手术中的应用效果。方法选取2019年4月至2021年3月长葛市人民医院收治的80例股骨颈骨折患者作为研究对象,并按照随机数表法将其随机分为观察组(40例)与对照组(40例)。观察组患者行超声引导下持续髂筋膜阻滞联合喉罩全身麻醉,对照组患者单纯行喉罩全身麻醉,对比观察两组患者心率、平均动脉压、视觉模拟评分法(VAS)评分变化情况及不良反应发生情况。结果麻醉诱导30 min与术毕时,两组患者心率及平均动脉压均呈先下降后升高趋势,但观察组患者变化程度无统计学差异(F=2.010、0.863,P=0.139、0.425),而对照组患者变化程度较为显著(F=22.271、18.364,P均<0.001),且麻醉诱导30 min时观察组患者心率及平均动脉压均明显高于对照组(t=2.666、3.033,P=0.009、0.003),而术毕时观察组患者心率及平均动脉压均明显低于对照组(t=2.588、2.242,P=0.012、0.028);术后6、12、48 h,两组患者VAS评分均逐渐降低(F=407.181、388.974,P均<0.001),但观察组患者各时间点VAS评分均明显低于对照组(t=5.355、5.589、7.140,P均<0.001);观察组患者术后不良反应发生率为5.0%,与对照组患者的术后不良反应发生率10.0%无明显差异(χ^(2)=0.721,P=0.396)。结论超声引导下持续髂筋膜阻滞联合喉罩全身麻醉有利于维持股骨颈骨折患者术中血流动力学稳定性,降低术后疼痛程度。

关键词：股骨颈骨折髂筋膜阻滞喉罩全身麻醉镇痛不良反应

基于高通量测序对白癜风黑素细胞的综合生物信息学分析

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第三军医大学学报 2021年第16期43卷 1566-1574页

作者：蒲以欢陈阳美陈雪诺张灵瞾陈佳怡高天文陈瑾重庆医科大学附属第一医院皮肤科重庆400016 重庆医科大学附属第一医院消化内科重庆400016 空军军医大学西京医院皮肤科西安710032

目的筛选人类白癜风黑素细胞中差异表达的编码和非编码RNAs,分析它们之间相互作用并对鉴定出的重要RNAs进行表达量验证,以探讨其在白癜风发病过程中可能扮演的角色。方法对人类白癜风黑素细胞株和正常黑素细胞株进行高通量测序,用R软件... 详细信息

目的筛选人类白癜风黑素细胞中差异表达的编码和非编码RNAs,分析它们之间相互作用并对鉴定出的重要RNAs进行表达量验证,以探讨其在白癜风发病过程中可能扮演的角色。方法对人类白癜风黑素细胞株和正常黑素细胞株进行高通量测序,用R软件进行差异表达(differentially expressed,DE)分析,利用互作基因的检索工具STRING构建蛋白相互作用网络(protein-protein interaction,PPI),用生物信息学算法miRanda鉴定miRNA-mRNA和miRNA-lncRNA的相互作用环。并用Cytoscape软件构建CeRNA网络,运用DAVID数据库对筛选获得的DE mRNAs进行功能富集和通路分析,最后对鉴定的关键RNAs进行RT-qPCR验证。结果差异表达分析共筛选出5958个DE mRNAs,1650个DE LncRNAs和450个DE miRNAs。PPI网络中top10枢纽基因(JUN,HIST2H3PS2,SOX2,EGR1,MMP9,NGF,BMP2,HSPA5,EDN1,SERPINE1)显示与白癜风发病密切相关。本研究还挖掘了与top20枢纽基因有相互作用的LncRNAs,通过取它们的交集鉴定出7个关键LncRNAs,其中分子功能和信号通路富集最丰富的3个LncRNAs(ENST0000623111、NONHSAT245258.1和NONHSAT 189782.1)被分别构建了竞争性内源性RNA(CeRNA)子网络,CeRNA子网络中预测的hsa-miR-92b-5p在白癜风黑素细胞中的表达有显著差异。另外,RT-qPCR结果与我们分析结果基本一致。结论本研究经过层层鉴定及筛选出的枢纽基因以及关键的ncRNAs可能在白癜风发病中发挥重要作用,这些发现可能为白癜风的研究提供了新的见解和策略。

关键词：白癜风黑素细胞高通量测序 ncRNA PPI CeRNA

双波长脉冲染料激光联合30%超分子水杨酸治疗中重度痤疮的效果

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中华医学美学美容杂志 2022年第1期28卷 5-8页

作者：黄晴胡丽刘林蒲以欢张玉洁李倩邵馨怡张灵曌陈瑾陈阳美重庆医科大学附属第一医院皮肤科重庆400016

目的:探讨双波长脉冲染料激光联合30%超分子水杨酸治疗面部中重度痤疮的疗效及安全性。方法:2020年5月至2021年1月,重庆医科大学附属第一医院皮肤科就诊的中重度痤疮患者60例,男24例、女36例;年龄18~40(26±4)岁,分为观察组和对照组,每... 详细信息

目的:探讨双波长脉冲染料激光联合30%超分子水杨酸治疗面部中重度痤疮的疗效及安全性。方法:2020年5月至2021年1月,重庆医科大学附属第一医院皮肤科就诊的中重度痤疮患者60例,男24例、女36例;年龄18~40(26±4)岁,分为观察组和对照组,每组30例。观察组予以水杨酸两周治疗1次共6次;另外加双波长脉冲染料激光每月治疗1次共3次。对照组仅予以双波长脉冲染料激光治疗,每月治疗1次共3次。结果:观察组有效22例,占73.3%,对照组有效14例,占46.7%,观察组疗效优于对照组,差异有统计学意义(χ2=4.44,P<0.05)。两组患者均未出现明显不良反应。结论:双波长脉冲染料激光联合30%超分子水杨酸治疗面部中重度痤疮疗效较好、安全性高,值得临床应用。

关键词：寻常痤疮治疗结果超分子水杨酸脉冲染料激光疗效

CO_(2)点阵激光及其联合疗法治疗凹陷型痤疮瘢痕进展

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中国皮肤性病学杂志 2022年第1期36卷 104-107页

作者：张玉洁陈阳美邵馨怡刘林蒲以欢张灵曌陈佳怡陈瑾重庆医科大学附属第一医院皮肤科重庆400042

痤疮瘢痕是常见的痤疮后遗症之一,严重影响患者的身心健康,常见的治疗方法有:药物治疗、激光治疗、射频治疗、填充治疗、化学剥脱、微针疗法、富血小板血浆治疗、外科治疗等。目前剥脱性CO_(2)激光仍然是主流的治疗方式,本文综述CO_(2)... 详细信息

痤疮瘢痕是常见的痤疮后遗症之一,严重影响患者的身心健康,常见的治疗方法有:药物治疗、激光治疗、射频治疗、填充治疗、化学剥脱、微针疗法、富血小板血浆治疗、外科治疗等。目前剥脱性CO_(2)激光仍然是主流的治疗方式,本文综述CO_(2)点阵激光及其联合疗法治疗凹陷型痤疮瘢痕的疗效及其安全性,为临床提供参考。

关键词：痤疮瘢痕点阵激光 CO_(2)激光

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress