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Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress

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Neural Regeneration Research 2014年第3期9卷 260-267页

作者： Tao Lei Haifeng Li Zhen Fang Junbin Lin Shanshan Wang lingyun xiao Fan Yang Xin Liu Junjian Zhang Zebo Huang Weijing Liao Department of Rehabilitation Medicine Zhongnan Hospital and Cerebral Vascular Diseases Research Center Zhongnan Hospital Wuhan University School of Pharmaceutical Sciences Wuhan University

Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a pre-liminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H202-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H202 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis poly-saccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.

关键词： nerve regeneration cerebral ischemia Angelica sinensis polysaccharides antioxidation reactive oxygen species rnitochondrial membrane potential apoptosis rnicrovessels NSFC grant neural regeneration

On String Stable Control of Platoon of Automated Vehicles with Predecessor-successor Information Framework

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Chinese Journal of Mechanical Engineering 2010年第5期23卷 627-634页

作者： xiao lingyun GAO Feng School of Transportation Science and Engineering Beihang University Beijing 100191 China Defective Product Administrative Center General Administration of Quality Supervision Inspection and Quarantine of China Beijing 100088 China

For the constant distance spacing policy,the existing researches of the string stability focus on the single-predecessor information framework（SPIF） and predecessor-successor information framework（PSIF）.The research results demonstrated that the string stability could not be guaranteed with the SPIF,and then the PSIF was proposed to resolve this string instability.But the issue,whether the string stability can be guaranteed when applying the PSIF,is still controversial.Meanwhile,most of the previous researches on the string stability were conducted without consideration of the parasitic time delays and lags.In this paper,the practical longitudinal vehicle dynamics model is built with consideration of the parasitic time delays and lags existing in the actuators,sensors or the communication systems.Secondly,the detailed theoretical analysis of string stability in frequency domain is conducted to demonstrate that the classical linear control laws can not ensure the string stability when applying both the symmetrical PSIF（SPSIF） and asymmetrical PSIF（APSIF）.Thirdly,a control law,which adds the position and velocity information of the leading vehicle,is proposed to guarantee string stability for small/medium platoon,and the other control law,which adds the acceleration information of the controlled vehicle,is proposed to guarantee string stability for large platoon as well as small/medium platoon.Finally,the comparative simulation is conducted to confirm the conducted analysis and the proposed control laws.The conducted research completes the means to analyze the string stability in frequency domain,provides the parameters＇ reference for the design and implementation of the practical automatic following controllers,and improves the reliability and stability of the platoon of automatic vehicles.

关键词： automatic vehicle following time delay control string stability information framework spacing policy automated vehicle intelligent transportation system

促甲状腺激素抗甲状腺过氧化物酶抗体抗甲状腺球蛋白抗体联合检测对自身免疫性甲状腺疾病的诊断价值

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实用医技杂志 2024年第5期31卷 351-354页

作者：李琰慕珂珂董炎红冯浩然郭佳佳杨景瑞肖凌云郑州四六○医院医学检验科郑州450007

目的探讨促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)联合检测对自身免疫性甲状腺疾病(AITD)的诊断价值。方法选取2022年8月至2023年7月郑州四六○医院收治的96例AITD患者作为AITD组,另选取同期接... 详细信息

目的探讨促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)联合检测对自身免疫性甲状腺疾病(AITD)的诊断价值。方法选取2022年8月至2023年7月郑州四六○医院收治的96例AITD患者作为AITD组,另选取同期接受体检的45名健康者作为对照组,均接受TSH、TPOAb、TGAb检测。比较2组、不同类型AITD患者上述指标水平,进行单因素与多因素logistic回归分析,采用受试者工作特征(ROC)曲线评估诊断价值。结果 AITD组TSH、TPOAb、TGAb水平较对照组更高(P0.05);多因素logistic分析结果显示,TSH[OR(95%CI)=2.369(1.295,3.417)]、TPOAb[OR(95%CI)=3.175(1.603,4.922)]、TGAb[OR(95%CI)=3.218(1.337,5.006)]是影响AITD发生的独立危险因素(P<0.05);绘制ROC曲线显示,TSH、TPOAb、TGAb、TSH+TPOAb、TSH+TGAb、TPOAb+TGAb、联合检测诊断AITD的曲线下面积(AUC)分别为0.819、0.832、0.862、0.908、0.909、0.886、0.950。结论 TSH、TPOAb、TGAb与AITD之间存在密切关系,且不同类型AITD患者有所差异,上述指标可作为诊断AITD的重要依据,联合检测时具有更高的诊断价值。

关键词：促甲状腺激素抗甲状腺过氧化物酶抗体抗甲状腺球蛋白抗体联合检测自身免疫性甲状腺疾病

Highly-chlorinated inert and robust interphase without mineralization of oxide enhancing high-rate Li metal batteries

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Chinese Chemical Letters 2024年第6期35卷 239-243页

作者： Long Li Kang Yang Chenpeng Xi Mengchao Li Borong Li Gui Xu Yuanbin xiao Xiancai Cui Zhiliang Liu lingyun Li Yan Yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesSchool of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Material Sciences and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Side reactions and dendrite growth triggered by the unstable interface and inhomogeneous deposition have become the biggest obstacle to the commercialization for lithium metal batteries.In this study,a highly-chlorinated organic-inorganic hybrid interfacial protective layer is developed by rationally tuning the interfacial passivation and robustness to achieve the convenient and efficient Li metal anode.The polyvinyl chloride(PVC)can effectively resist water and oxygen,which is confirmed by density functional theory.The organic-dominant solid electrolyte interphases(SEI)with lithium chloride are investigated by the X-ray photoelectron spectroscopy(XPS)with little mineralization of oxide,such as Li_(2)O and Li_(2)CO_(3).With such artificial SEI,a uniform and dense lithium deposition morphology are formed and an ultra-long stable cycle of over 500 h are achieved even at an ultra-high current density of 10 m A/cm^(2).Moreover,the simple and convenient protected anode also exhibits excellent battery stability when paired with the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)and LiFePO_(4)(LFP)cathode,showing great potential for the commercial application of lithium metal batteries.

关键词： Highly-chlorinated Water/oxygen resistance Stable interphase Dendrite-free lithium metal batteries High-rate

基于DOE的智能手机塑料后盖加热参数优化问题

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机械设计与研究 2022年第3期38卷 175-179页

作者：肖凌云于随然上海交通大学机械与动力工程学院上海200240

随着经济的发展和技术的进步,日益增加的废旧手机带来严重的环境和资源压力。为了解决智能手机塑料后盖的高效拆除问题,提出了热风加热法这一新型拆除方法。为了验证该方法的可行性,同时得到该方法中兼具有效性、安全性和快速性的可靠方... 详细信息

随着经济的发展和技术的进步,日益增加的废旧手机带来严重的环境和资源压力。为了解决智能手机塑料后盖的高效拆除问题,提出了热风加热法这一新型拆除方法。为了验证该方法的可行性,同时得到该方法中兼具有效性、安全性和快速性的可靠方案,使用正交试验设计法设计仿真实验,对加热参数中风温T、风速v和距离H的参数优化问题进行了深入研究。研究结果表明,热风加热法在理论上是可行的,并得到了一组适用于塑料后盖拆解工艺的可靠方案:(T,v,H)=(240℃,36 m/s,8 mm),该方案加热时间为20 s。

关键词：手机拆解塑料后盖热风加热正交试验设计

Ursolic acid inhibiting excessive reticulophagic flux contributes to alleviate ochratoxin A-induced endoplasmic reticulum stress- and mitochondrial-mediated apoptosis

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Food Science and Human Wellness 2024年

作者： Huiqiong Deng Wenying Chen lingyun Han Boyang Zhang Xun Luo Song Yao Hongwei Wang Yao Zhou Shuangchao Liu xiao Li Shen School of Public Health Zunyi Medical University Chongqing Fuling District Center for Disease Control and Prevention Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes Research and Development Department Allife Medicine Inc.

Foods and animal feeds frequently become contaminated with the nephrotoxic ochratoxin A (OTA). Our prior research has indicated that ursolic acid (UA)， which is widely present in fruits and medicinal plants， has the potential to alleviate nephrotoxicity triggered by OTA. Additionally， excessive induction of endoplasmic reticulum (ER)-phagy exacerbates OTA-induced apoptosis. Therefore， further investigation is essential to comprehend whether UA can mitigate OTA-induced apoptosis by influencing ER-phagy. This objective is accomplished through a series of experiments involving assessments of cell viability， apoptosis， fluorescence microscopy， and western blot analysis. The outcomes of these experiments reveal that pre-treatment with 4 μmol/L UA for 2 h can markedly reverse the elevated apoptotic rate， the co-localization of ER and lysosomes， and the protein expressions of GRP78， p-eIF2α， Chop， Bax， and Bak， as well as the reduced cell viability and the protein expressions of Lonp1， Trap1， p62， Tex264， FAM134B， Bcl-2， and Bcl-xl， all caused by exposure to 1 μmol/L OTA for 24 h in human proximal tubule epithelial-originated kidney-2 (HK-2) cells (P < 0.05). Interestingly， the increased expression of LC3B-II induced by OTA is further amplified by UA pre-treatment (P < 0.05). In conclusion， OTA triggers a harmful feedback loop between ER stress (ERS) and excessive ER-phagy， thereby further promoting ERS- and mitochondrial-mediated apoptosis in vitro. However， this effect is significantly mitigated by UA through the inhibition of autophagosome-lysosome fusion， consequently blocking the excessive ER-phagic flux.

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胎体结构对轮胎耐撞击性能的影响研究

橡胶工业 2022年第9期69卷 709-713页

作者：金汉杰肖凌云王琰周晓琴国家市场监督管理总局缺陷产品管理中心北京100101 国家市场监管重点实验室(产品缺陷与安全) 北京100101

针对同品牌同规格不同胎体结构的两种轿车子午线轮胎开展耐撞击性能对比研究,分别选取5条轮胎进行室内摆锤冲击试验,对轮胎撞击动能和撞击后状态进行分析。结果表明:单层帘布高反包胎体结构轮胎撞击动能明显小于双层帘布低反包胎体结构... 详细信息

针对同品牌同规格不同胎体结构的两种轿车子午线轮胎开展耐撞击性能对比研究,分别选取5条轮胎进行室内摆锤冲击试验,对轮胎撞击动能和撞击后状态进行分析。结果表明:单层帘布高反包胎体结构轮胎撞击动能明显小于双层帘布低反包胎体结构轮胎,鼓包发生率更高,耐撞击性能明显较差;胎体结构对轮胎耐撞击性能具有重要影响。

关键词：轮胎胎体结构单层帘布高反包双层帘布低反包耐撞击性能

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基于运行参数的电动汽车火灾原因判别模型

消防科学与技术 2023年第3期42卷 422-428页

作者：林烨董红磊肖凌云曲现国国家市场监督管理总局缺陷产品管理中心北京100101 上海机动车检测认证技术研究中心有限公司上海201805 国家市场监管重点实验室(产品缺陷与安全) 北京102200

分析2018-2021年的电动汽车火灾事故信息,归纳起火电动汽车典型特点。利用Origin分析电动汽车火灾BMS运行参数数据,发现由电池包进水、动力电池故障(电芯热失控、电池包内线路故障)引发事故的运行参数典型特征(SOC、电压、温度、绝缘电... 详细信息

分析2018-2021年的电动汽车火灾事故信息,归纳起火电动汽车典型特点。利用Origin分析电动汽车火灾BMS运行参数数据,发现由电池包进水、动力电池故障(电芯热失控、电池包内线路故障)引发事故的运行参数典型特征(SOC、电压、温度、绝缘电阻等)。基于此利用神经网络方法构建了基于运行参数的电动汽车火灾原因判别模型,12项运行参数为输入信息,3类起火原因为输出信息。模型通过训练达到期望误差水平0.05,检验样本正确率达到了100%,证明了模型可靠性。结果表明,不同原因电动汽车火灾事故,其运行参数具有不同特征及规律,运用原因判别模型能够有效地辅助判别电动汽车起火原因。

关键词：电动汽车火灾火灾原因 BMS参数神经网络

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数据挖掘与现场调查结合的电动汽车事故分析

中国安全科学学报 2022年第1期32卷 180-187页

作者：梁新苗肖凌云王澎董红磊曲现国刘川中国汽车工程研究院股份有限公司数据中心重庆401122 国家市场监管技术创新中心(新能源汽车数字监管技术及应用) 重庆401122 国家市场监督管理总局缺陷产品管理中心北京100088 中国标准化研究院长三角分院浙江嘉兴314006

为了解电池热失控引起的电动汽车自燃事故起因,降低事故发生率,统计梳理2020年新能源汽车起火事故概况,并基于动力电池失效机制和车辆运行数据,提出一种融合事故阶段安全参数关联分析、事故现场调查和全生命周期数据一致性分析的事故多... 详细信息

为了解电池热失控引起的电动汽车自燃事故起因,降低事故发生率,统计梳理2020年新能源汽车起火事故概况,并基于动力电池失效机制和车辆运行数据,提出一种融合事故阶段安全参数关联分析、事故现场调查和全生命周期数据一致性分析的事故多维分析方法,采用该方法深入剖析一起电动汽车起火事故。研究结果表明:事故多维分析方法可通过探究事故车辆的损毁情况和运行数据的变化特征,分析从故障到事故的演变过程,溯源事故原因。

关键词：电动汽车事故分析自燃动力电池运行数据现场调查