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推进新时代政府机关党建工作高质量发展的若干思考——以湖北黄石为例

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湖北理工学院学报（人文社会科学版） 2022年第6期39卷 30-35页

作者：柯凌云中共黄石市委党校湖北黄石435002

政府机关党的建设工作是党和国家工作中的重要组成部分。从理论、历史、现实三重维度而言,政府机关党建都具有重要地位。黄石党建工作的百年发展历程和实践表明,要把握政府机关党建工作的特点规律,以突出“五性”为重要抓手,全面提升机... 详细信息

政府机关党的建设工作是党和国家工作中的重要组成部分。从理论、历史、现实三重维度而言,政府机关党建都具有重要地位。黄石党建工作的百年发展历程和实践表明,要把握政府机关党建工作的特点规律,以突出“五性”为重要抓手,全面提升机关党建工作水平,为推进黄石高质量发展提供坚强的思想、政治和组织保障。

关键词：新时代政府机关党建黄石

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渝浅8井干法脱硫影响因素分析及对策

石油工业技术监督 2020年第7期36卷 43-46页

作者：肖仁维熊兰琼柯凌云中国石油西南油气田分公司重庆气矿重庆400021 中国石油西南油气田分公司通信与信息技术中心重庆400021

通过分析渝浅8井站脱硫塔出口天然气硫化氢浓度与脱硫剂消耗量变化,评价了脱硫效果,探讨了影响脱硫效果的因素,并进行了工艺改进。脱硫塔装料不规范、加湿器装置未综合利用、脱硫塔未串联重复使用是影响脱硫效果的主要因素,提出相应的对... 详细信息

通过分析渝浅8井站脱硫塔出口天然气硫化氢浓度与脱硫剂消耗量变化,评价了脱硫效果,探讨了影响脱硫效果的因素,并进行了工艺改进。脱硫塔装料不规范、加湿器装置未综合利用、脱硫塔未串联重复使用是影响脱硫效果的主要因素,提出相应的对策:①加装旁通装置,解决了启用加湿器需关井的问题;②串联、并联结合工艺充分消耗前塔硫容;③规范支撑垫的安装。改造工艺实施后日天然气处理量增加0.3×10^4 m^3,脱硫剂更换周期延长95%,节能技术措施效果明显。

关键词：干法脱硫加湿器硫容脱硫塔支撑垫

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γ-γ符合测量系统的新型前端读出电路研制

原子能科学技术 2020年第8期54卷 1500-1507页

作者：颜俊伟牛晓阳柯凌云杨海波陈金达杜成名张秀玲孙志朋苏弘孔洁中国科学院近代物理研究所甘肃兰州730000 中国科学院大学核科学与技术学院北京100049

研制了一种新型前端读出电路,用于重离子治癌装置中符合测量原型系统的研究和测试。电路主要包括能量链、时间链和数据处理单元。能量链由截止频率7 MHz的抗混叠滤波器和模数转换器(ADC)组成,形成波形采样电路;时间链由高速比较器构成... 详细信息

研制了一种新型前端读出电路,用于重离子治癌装置中符合测量原型系统的研究和测试。电路主要包括能量链、时间链和数据处理单元。能量链由截止频率7 MHz的抗混叠滤波器和模数转换器(ADC)组成,形成波形采样电路;时间链由高速比较器构成的定时甄别电路和时间数字转换器(TDC)组成;数据处理单元基于现场可编程门阵列(FPGA)设计实现。电路的线性度优于0.8%,噪声小于0.8 mV(RMS)。配合LaBr 3单晶体条测试,能量分辨为4.5%(FWHM),在与LYSO晶体阵列配合测试时,位置映射散点图清晰。该前端读出电路性能优于CAMAC系统,具有较好的实际应用前景。

关键词：符合测量系统前端读出电路现场可编程门阵列能量分辨位置分辨

基于BIM模型的装配式建筑混凝土梁柱墙连接节点稳定性分析

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粉煤灰综合利用 2024年第5期38卷 87-91页

作者：陈军房朝君柯凌云李松波浙江大学建筑设计研究院有限公司浙江杭州310063 中国建筑第七工程局有限公司河南郑州450000

装配式混凝土建筑结构复杂,在设计梁柱墙连接节点稳定性模型时,若未考虑钢骨和混凝土之间的粘结滑移情况,会导致模型模拟效果不佳。为此,基于BIM进行装配式建筑混凝土梁柱墙连接节点稳定性分析。拆分装配式建筑构件,建立BIM模型构件库,... 详细信息

装配式混凝土建筑结构复杂,在设计梁柱墙连接节点稳定性模型时,若未考虑钢骨和混凝土之间的粘结滑移情况,会导致模型模拟效果不佳。为此,基于BIM进行装配式建筑混凝土梁柱墙连接节点稳定性分析。拆分装配式建筑构件,建立BIM模型构件库,计算出各类构件的抗弯承载力和剪力参数;依据梁柱墙连接节点上螺栓的使用情况,计算出连接节点承载力等相关参数;将BIM技术与Revit软件结合,输入构件库内的构件参数以及连接节点参数,获得各构件模型并组成为整体BIM模型,分析装配式建筑混凝土梁柱墙连接节点稳定性。结果表明:建立的模型效果好,混凝土梁柱墙连接节点稳定性模拟误差低于1%,考虑到了钢骨和混凝土之间的粘结滑移情况,极限荷载下模拟节点稳定的性能得到了提高,增加了稳定性。

关键词：装配式建筑混凝土连接节点稳定性 BIM模型

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应用于在束PET的光纤链路设计

原子核物理评论 2022年第1期39卷 88-94页

作者：胡岷池柯凌云颜俊伟王长鑫千奕佘乾顺赵红赟孔洁中国科学院近代物理研究所兰州730000 中国科学院大学核科学与技术学院北京100049 中国科学院大学计算机科学与技术学院北京100049

医用重离子加速器(Heavy-Ion Medical Machine,HIMM)中安装在束正电子发射断层扫描装置(In-beam Positron Emission Tomography,In-beam PET)可实现治疗时对肿瘤靶区的照射剂量和位置分布的实时监测功能。在束PET工作时,事件经探测器阵... 详细信息

医用重离子加速器(Heavy-Ion Medical Machine,HIMM)中安装在束正电子发射断层扫描装置(In-beam Positron Emission Tomography,In-beam PET)可实现治疗时对肿瘤靶区的照射剂量和位置分布的实时监测功能。在束PET工作时,事件经探测器阵列采集,由前端数据获取单元(Data Acquisition Unit, DAQU)进行数字化后,通过光纤链路传输集中至中央处理模块(Central processor module, CPM),然后通过PCIe接口传输至上位机。单个前端数据获取单元获取的数据率最大可达2.2 Gbit/s,因此对数据传输链路的带宽提出了较高要求。由于前端数据获取单元的核心控件是Cyclone V系列FPGA,中央处理模块的核心控件是Kintex-7系列FPGA,不同公司的FPGA间实现可靠的实时通信也带来了挑战。基于以上问题,进行了应用于在束PET的光纤链路设计,实现了Cyclone V系列FPGA与Kintex-7系列FPGA间的稳定通信。经过测试,该设计达到了高稳定、无误码的实时性能指标。

关键词：医用重离子加速器(HIMM) 光纤通讯在束PET 现场可编程门阵列

Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model

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Regenerative Biomaterials 2021年第2期8卷 74-84页

作者： Bei Qian Jialun Li ke Guo Nengqiang Guo Aimei Zhong Jie Yang Jiecong Wang Peng Xiao Jiaming Sun lingyun Xiong Department of Plastic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China Wuhan Clinical Research Center for Superficial Organ Reconstruction Wuhan 430022China

Associated with persistent oxidative stress,altered inflammatory responses,poor angiogenesis and epithelization,wound healing in diabetic patients is impaired.N-acetylcysteine(NAC)is reported to resist excess reactive oxygen species(ROS)production,prompt angiogenesis and maturation of the *** have revealed that graphene oxide(GO)can regulate cellular behavior and form cross-links with naturally biodegradable polymers such as collagen(COL)to construct composite ***,we reported a COL-based implantable scaffold containing a mixture of GO capable of the sustained delivery of NAC to evaluate the wound healing in diabetic *** morphological,physical characteristics,biocompatibility and NAC release profile of the GO-COL-NAC(GCN)scaffold were evaluated in *** healing studies were performed on a 20mm dorsal full-skin defect of streptozotocin(STZ)-induced diabetic *** injured skin tissue was removed at the 18th day post-surgery for histological analysis and determination of glutathione peroxidase(GPx),catalase(CAT)and superoxide dismutase(SOD)*** diabetic rats,we confirmed that the GCN scaffold presented a beneficial effect in enhancing the wound healing ***,due to the sustained release of NAC,the scaffold may potentially induce the antioxidant defense system,upregulating the expression levels of the antioxidant enzymes in the wound *** findings revealed that the antioxidant biocompatible composite collagen dressing could not only deliver NAC in situ for ROS inhibition but also promote the wound healing *** scaffold with valuable therapy potential might enrich the approaches for surgeon in diabetic wound treatment in the future.

关键词： collagen graphene oxide N-acetylcysteine sustained release diabetic wound healing

Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy

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Cellular & Molecular Immunology 2018年第1期15卷 82-84页

作者： ke Rui Xiang Lin Jie Tian Xiaohui Wang lingyun Sun Xiaoping Hong Dongzhou Liu Shengjun Wang Liwei Lu Department of Laboratory Medicine Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Department of Laboratory Medicine and Jiangsu Key Laboratory of Laboratory MedicineJiangsu University Medical SchoolZhenjiangChina Department of Rheumatology and Immunology Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingChina Department of Rheumatology and Immunology 2nd Clinical Medical College of Jinan UniversityShenzhen People's HospitalShenzhenChina

Extensive studies have demonstrated that mesenchymal stem cells(MSCs)are multipotent mesoderm-derived stromal cells that can differentiate into a variety of cell types,including adipocytes,osteoblasts,chondrocytes,myocytes and neuronal cells.1 MSCs are found in numerous organs and tissues,including bone marrow,heart,lung,muscle,peripheral blood,adipose tissue,cartilage,synovium,dental pulp,tonsil,umbilical cord,placenta,thymus and olfactory mucosa.1 MSCs have been shown to possess potent immunosuppressive functions and tissue repair capacities,which have facilitated the clinical applications of MSCs in treating a diverse range of disorders involving angiogenesis and fibrosis,including rheumatic diseases and graft-versus-host diseases.2,3 Here,we provide a brief commentary on newly emerging evidence of the immunoregulatory function and potential application of ecto-mesenchymal stem cells.

关键词： organs lung graft

A General Electrochemical Synthesis of Sulfonimidoyl Fluorides,Azides,and Acetates

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CCS Chemistry 2024年第8期6卷 2021-2030页

作者： Yi-Min Jiang Yong-Ying Lin lingyun Zhu Yi Yu Yuanming Li Yuqi Lin ke-Yin Ye key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou 350108

Sulfonimidoyl fluorides,the aza-bioisostere of sulfonyl fluorides,are emerging as a promising linkage agent in the sulfur(VI)fluoride exchange reaction(SuFEx).However,conventional synthetic approaches typically require the use of either unstable sulfonimidoyl chlorides,toxic and corrosive sulfur fluorides,or expensive electrophilic fluorinating ***,we report an electrochemistry-enabled oxidative nucleophilic fluorination of readily available and bench-stable sulfinamides using a commercially available and easy-to-handle triethylamine *** other nucleophilic agents,this electrochemical approach also serves as a general approach to diverse sulfonimidoyl derivatives,including sulfonimidoyl azides and acetates.

关键词： electrochemistry click chemistry sulfur(VI)fluoride exchange reaction sulfonimidoyl fluoride sulfinamide

Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants

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Asian Journal of Andrology 2011年第1期13卷 166-171页

作者： Shilin Zhang Yanping Tang Tao Wang Jun Yang ke Rao lingyun Zhao Wenzhen Zhu Xianghu Meng Shaogang Wang Jihong Liu Weimin Yang Zhangqun Ye Department of Urology Tongii Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Genetics School of Basic Medical Sciences Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Although some genes that cause Kallmann syndrome （KS） have been identified by traditional linkage analysis and candidate gene techniques, the syndrome＇s molecular etiology in the majority of patients remains poorly understood. In this paper, we present the clinical assessments of a consanguineous Hart Chinese family with three KS descendants. To understand the molecular etiology of KS from a genome-wide perspective, we investigated the genome-wide profile of structural variation in this family using the Affymetrix Genome-Wide Human SNP Array 6.0 platform. The results revealed that the three affected individuals had common copy number variants （microdeletions） on chromosomes lp21.1, 2q32.2, 8q21.13, 14q21.2 and Xp22.31. Moreover, the copy number variants on Xp22.31 were located in the intron of KAL 1, which causes X-linked KS. Two PCR assays were performed on these regions to validate the results obtained using the chips. In addition, genomic microdeletions in this region were verified in one of 29 Han Chinese sporadic KS cases and one of four other family cases, but not in 26 Han Chinese sporadic normosmic idiopathic hypogonadotropic hypogonadism cases and 100 unrelated Han Chinese normal controls. Our results provide a novel insight into the relative contributions of certain copy number variants to KS＇s molecular etiology and generate a list of interesting candidate regions for further studies.

关键词： DNA copy number variations hypogonadism Kallmann syndrome male infertility