检索结果-南通市图书馆

Targeting carnitine palmitoyl transferase 1A(CPT1A)induces ferroptosis and synergizes with immunotherapy in lung cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1675-1689页

作者： Lei ma Chong Chen Chunxing Zhao Tong Li lingyu ma Jiayu Jiang Zhaojun Duan Qin Si Tsung-Hsien Chuang Rong Xiang Yunping Luo Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Collaborative Innovation Center for Biotherapy Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Department of Lung Cancer Surgery Tianjin Medical University General HospitalTianjin 300052China Immunology Research Center National Health Research InstitutesZhunanMiaoliTaiwanROC Department of Immunology Nankai UniversityTianjin 300071China

Despite the successful application of immune checkpoint therapy,no response or recurrence is typical in lung cancer.Cancer stem cells(CSCs)have been identified as a crucial player in immunotherapy-related resistance.Ferroptosis,a form of cell death driven by iron-dependent lipid peroxidation,is highly regulated by cellular metabolism remolding and has been shown to have synergistic effects when combined with immunotherapy.Metabolic adaption of CsCs drives tumor resistance,yet the mechanisms of their ferroptosis defense in tumor immune evasion remain elusive.Here,through metabolomics,transcriptomics,a lung epithelialspecific Cptla-knockout mouse model,and clinical analysis,we demonstrate that CPT1A,a key rate-limiting enzyme of fatty acid oxidation,acts with L-carnitine,derived from tumor-associated macrophages to drive ferroptosis-resistance and CD8^(+)T cells inactivation in lung cancer.Mechanistically,CPT1A restrains ubiquitination and degradation of c-Myc,while c-Myc transcriptionally activates CPT1A expression.The CPT1A/c-Myc positive feedback loop further enhances the cellular antioxidant capacity by activating the NRF2/GPX4 system and reduces the amount of phospholipid polyunsaturated fatty acids through ACSL4 downregulating,thereby suppressing ferroptosis in CSCs.Significantly,targeting CPT1A enhances immune checkpoint blockadeinduced anti-tumor immunity and tumoral ferroptosis in tumor-bearing mice.The results illustrate the potential of a mechanismguided therapeutic strategy by targeting a metabolic vulnerability in the ferroptosis of CsCs to improve the efficacy of lung cancer immunotherapy.

关键词： immunotherapy metabolism peroxidation

Sodium intake:a double-edged sword wielded by the brain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第7期67卷 1545-1547页

作者： lingyu Xu Xiaolong ma Yi Wang Zhong Chen Key Laboratory of Neuropharmacology and Pharmaceutical Sciences Zheiiang Chinese Medical UniversityHangzhou 310053China Institute of Pharmacology&Toxicology College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China

Taste receptors on the tongue discriminate between five fundamental tastes:sour,sweet,bitter,salty,and umami(Chandrashekar et al.,2006).Typically,stimuli that evoke bitterness and acidity prompt aversive responses by animals,whereas sweet and umami flavors are appetitive and enjoyable.Saltiness is unique in that it transitions from an appetitive to an aversive stimulus with increasing concentrations.

关键词： prompt sweet sword

A Finite-time Distributed Cooperative Control Approach for Microgrids

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2022年第4期8卷 1194-1206页

作者： Jiancheng Zhang Xinsheng Wang lingyu ma Department of Control Science and Engineering Harbin Institute of TechnologyHarbin 150006China Department of Information Engineering Shandong Management UniversityJinan 250100China

Reactive power sharing cannot be achieved using many existing microgrid(MG)control methods,but the convergence speed of these methods is slow.To solve these problems,a finite-time distributed control approach is proposed in this paper,which is based on the hierarchical control structure.The hierarchical control structure consists of a dual loop control,a droop control used as a primary control and a secondary control.First,the secondary controller is modeled,and the MG system composed of distributed generators(DGs)is considered as a multi-agent system.The secondary controller consists of a frequency regulator,voltage regulator and power regulator.Secondly,the adaptive virtual impedance module is established,using the output of the reactive power regulator as its input.Thirdly,a dual loop controller is combined with a primary controller and secondary controller to generate a pulse width modulation(PWM)signal to control the power and voltage of the MG.In order to reduce the fluctuation of the MG,a damping module is introduced when the structure of the system changes.Finally,the stability of the proposed control strategy is proved by the related theorems.A simulation system is established in the matlab environment,and the simulation results show that the proposed method is effective.

关键词： Consensus droop control finite-time microgrid power sharing virtual impedance

Neutral color and self-healable electrochromic system based on CuI/Cu and I_(3)^(-)/I^(-)conversions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 4437-4443页

作者： Junsen Zhong Bingkun Huang Kunjie Yang Zuju ma lingyu Du Ning Luo Fengjiao Tang Chuanxin Hou Fuyi Jiang Litao Kang College of Environment and materials Engineering Yantai UniversityYantai 264005China School of Energy and Power Engineering Shandong UniversityJinan 250061China Shandong Laboratory of Advanced materials and Green manufacturing(Yantai) Yantai 264001China

The electrochromic(EC)mechanisms of inorganic materials are usually based on reversible cation insertion/extraction or metal deposition/dissolution,which are plagued by ion trapping and dendrite growth,respectively.In this paper,a novel conversion-type electrochromic mechanism is proposed,by making good use of the CuI/Cu redox couple.This CuI-based electrochromic system shows a neutral color switching from transparent and dim grey.By simply increasing the bleaching voltage,I_(3)^(-)/I^(-)redox couple can be further activated.The generated I_(3)^(-)will readily react with Cu,effectively improving the conversion reversibility and thereby rejuvenating the degraded electrochromic performance.Thanks to the well-designed electrode and the self-healing ability,this conversion electrochromic system achieves rapid response times(tcoloring:23 s,tbleaching:6 s),decant optical modulation amplitude(26.4%),high coloration efficiency(86.15 cm^(2)·C^(-1)),admirable cyclic durability(without performance degradation after 480 cycles)and excellent optical memory ability(transmittance variationmay inspire the exploration of novel electrochromic materials and devices.

关键词： electrochromic CuI conversion reaction self-healing neutral color

Quantitative analysis of microplastics in coastal tidal-flat reclamation in Dongtai,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2022年第8期16卷 235-245页

作者： Xue Bai Chang Li lingyu ma Pei Xin Fengjie Li Zhenjia Xu Key Laboratory of Integrated Regulation and Resource Development on Shallow Lake of Ministry of Education College of EnvironmentHohai UniversityNanjing 210098China Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210098China

Coastal tidal flats have received considerable attention in recent years,as they provide a direct channel for the discharge of terrestrial microplastics into the ocean.Land reclamation is occurring increasingly frequently in coastal tidal-flats;however,the environmental impacts of these activities remain unclear.Therefore,this pioneering study assessed the microplastic emission characteristics of reclamation geotextiles and performed a risk assessment accordingly.Morphological characterization of geotextile samples collected from five sites in Dongtai,China,provided evidence of sedimentary weathering.Based on several assumptions,the average abundance of microplastics in soil covered by geotextiles was estimated to reach 349137 particles/kg dry weight,with the total microplastic load in the reclaimed area estimated to be 20.678.06 t.Compared with previous studies,this research demonstrates that coastal reclamation areas store a high concentration of microplastics,aggravating marine microplastic pollution.Moreover,conditional fragmentation model results revealed that the weathering and distribution characteristics of soil microplastics in coastal tidal-flat areas exhibit spatial heterogeneity,being more easily affected by natural factors(such as tides)than those in inland areas.As a result of tides,the annual discharge of geotextile-originating microplastics from the studied areas into the ocean was approximately 2465.52960.77 t.These findings prove that the risks posed by engineering-microplastics are significant,indicating that further investigations are required on the precise laws of transfer and migration,as well as the toxicity mechanisms,in order to improve analytical techniques and policies in this field.

关键词： Coastal reclamation Engineering geotextiles Soil microplastics Weathering simulation marine emission

Molecule-based vertical transistor via intermolecular charge transport throughπ-πstacking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 4573-4581页

作者： Cheng Liu Cheng Fu lingyu Tang Jianghua Wu Zhangyan Mu Yamei Sun Yanghang Pan Bailin Tian Kai Bao Jing ma Qiyuan He Mengning Ding Key Laboratory of Mesoscopic Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Jiangsu Key Laboratory of Advanced Organic materials School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Department of materials Science and Engineering City University of Hong KongHong Kong 999077China

Theπ-πstacking is a well-recognized intermolecular interaction that is responsible for the construction of electron hopping channels in numerous conducting frameworks/aggregates.However,the exact role ofπ-to-πchannels within typical single crystalline organic semiconductors remains unclear as the orientations of these molecules are diverse,and their control usually requires additional side chain groups that misrepresent the intrinsic properties of the original semiconducting molecules.Therefore,the construction of conduction channels with intrinsicπ-πstacking in the molecule-based device is crucial for the utilization of their unique transport characteristics and understanding of the transport mechanism.To this end,we present a molecular intercalation strategy that integrates two-dimensional layered materials with functional organic semiconductor molecules for functional molecule-based electronics.Various organic semiconductor molecules can be effectively intercalated into the van der Waals gaps of semi-metallic TaS_(2) withπ-πstacking configuration and controlled intercalant content.Our results show that the vertical charge transport in the stacking direction shows a tunneling-dominated mechanism that strongly depends on the molecular structures.Furthermore,we demonstrated a new type of molecule-based vertical transistor in which TaS_(2) andπ-πstacked organic molecules function as the electrical contact and the active channel,respectively.On/off ratios as high as 447 are achieved under electrostatic modulation in ionic liquid,comparable to the current state-of-the-art molecular transistors.Our study provides an ideal platform for probing intrinsic charge transport acrossπ-πstacked conjugated molecules and also a feasible approach for the construction of high-performance molecule-based electronic devices.

关键词： π-πstacking electrochemical intercalation organic semiconductor electrical transport tunneling field effect transistor

IGF2BP3 Enhances the Growth of Hepatocellular Carcinoma Tumors by Regulating the Properties of macrophages and CD8^(+)T Cells in the Tumor Microenvironment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第6期11卷 1308-1320页

作者： lingyu ma Jiayu Jiang Qin Si Chong Chen Zhaojun Duan Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijingChina

Background and Aims:Overexpression of IGF2BP3 is associated with the prognosis of hepatocellular carcinoma(HCC).However,its role in regulating tumor immune microenvironment(TME)is not well characterized.Here,we investigated the effects of IGF2BP3 on macrophages and CD8^(+)T cells within the TME of HCC.Methods:The relationship between IGF2BP3 and immune cell infiltration was analyzed using online bioinformatics tools.Knockout of IGF2BP3 in mouse hepatoma cell line Hepa1-6 was established using CRISPR/Cas9 technology.In vitro cell coculture and subcutaneously implanted hepatoma mice model were used to explore the effects of IGF2BP3 on immune cells.Expression of CCL50l transforming growth factor beta 1(TGF-β1)was detected with quantitative real-time polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay.The binding of IGF2BP3 and its target RNA was verified by trimolecular fluorescence complementation system and RNA immunoprecipitation followed by quantitative or semiquantitative polymerase chain reaction.Results:IGF2BP3 expression was elevated in HCC and was positively correlated with macrophage infiltration.Patients with higher IGF2BP3 expression and lower macrophage infiltration had a better survival rate.We found that IGF2BP3 could bind to the mRNA of CCL5 or TGF-β1,increasing their expression,and inducing macrophage infiltration and M2 polarization while inhibiting the activation of CD8^(+)T cells.Furthermore,inhibition of IGF2BP3 combined with anti-CD47 antibody treatment significantly suppressed the growth of hepatoma in Hepa1-6 xenograft tu-mor mice.Conclusions:IGF2BP3 promoted the infiltration and M2-polarization of macrophages and suppressed CD8^(+)T activation by enhancing CCL5 and TGF-β1 expression,which facilitated the progression of Hepa1-6 xenograft tumor.

关键词： Hepatocellular carcinoma IGF2BP3 TGF-β1 CCL5 M2 macrophage CD8^(+)T cell

A Distributed Reactive Power Sharing Approach in Microgrids with Improved Droop Control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2021年第6期7卷 1238-1246页

作者： Xinsheng Wang Jiancheng Zhang Mingli Zheng lingyu ma the Department of Control Science and Engineering Harbin Institute of TechnologyNo.2 Culture West RoadWeihaiChina the Department of Information Engineering Shandong Management UniversityNo.3500 Dingxiang RoadJinanChina

Conventional droop control causes frequency and voltage deviations(from rated value)in a inverter-intensive microgrid(MG),and the reactive power sharing cannot be obtained when the communication structure of the MG or load suddenly changes.Compared with a centralized control and droop control scheme,a distributed hierarchical control structure of the MG can overcome the limitation of communication and realize reactive power sharing.In this paper,an improved droop control is adopted,which is based on the hierarchical control structure.The hierarchical control structure consists of zerolevel control,primary control and a proposed secondary control.First,the secondary controller is modeled,and the MG system composed of distributed generators(DGs)is considered as a multi-agent system.The secondary controller can make up for the shortcomings of the droop controller and adjust the frequency and voltage to their rated values.Secondly,the reference voltage and frequency of the zero-level control are calculated,and combined with the primary control.The zero-level control and primary control can make the voltage and frequency of the MG run stably and provide reference voltage for the inverter.Finally,the stability of the system is proved by the theory of multi-agent consistency.A simulation system is established in the matlab/Simulink environment,and the results show the effectiveness of the proposed controller.

关键词： Consensus distributed generator hierarchical control microgrid reactive power sharing

Three-dimensional reconstruction of Picea wilsonii mast. pollen grains using automated electron microscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第2期63卷 171-179页

作者： Weiwei Shen lingyu ma Xi Zhang Xixia Li Yuanyuan Zhao Yanping Jing Yun Feng Xueke Tan Fei Sun Jinxing Lin Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083China College of Biological Sciences&Biotechnology Beijing Forestry UniversityBeijing 100083China Center for Biological Imaging Institute of BiophysicsChinese Academy of SciencesBeijing 100083China

Three-dimensional electron microscopy(3 D-EM) has attracted considerable attention because of its ability to provide detailed information with respect to developmental analysis. However, large-scale high-resolution 3 D reconstruction of biological samples remains challenging. Herein, we present a 3 D view of a Picea wilsonii mast. pollen grain with 100 nm axial and38.57 nm lateral resolution using AutoCUTS-SEM(automatic collector of ultrathin sections-scanning electron microscopy). We established a library of 3,127 100 nm thick serial sections of pollen grains for preservation and observation, demonstrating that the protocol can be used to analyze large-volume samples. After obtaining the SEM images, we reconstructed an entire pollen grain comprising 734 serial sections. The images produced by 3D reconstruction clearly revealed the main components of the P.wilsonii pollen grain, i.e., two sacci and pollen corpus, tube cell, generative cell, and two degenerated prothallial cells, and their internal organization. In addition, we performed a quantitative analysis of the different pollen grain cells, including sacci, and found that there were 202 connections within a saccus SEM image. Thus, for the first time, this study provided a global 3D view of the entire pollen grain, which will be useful for analyzing pollen development and growth.

关键词： 3D reconstruction AutoCUTS-SEM electron microscopy pollen