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Efficient removal and recovery of Cd^(2+)from aqueous solutions by capacitive deionization(CDI)method using biochars

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Journal of Materials Science & Technology 2023年第17期148卷 10-18页

作者： Zhao Song lingyu li Yidi Chen Xiaoguang Duan Nanqi Ren State Key Laboratory of Urban Water Resource and Environment Shenzhen Key Laboratory of Organic Pollution Prevention and ControlSchool of Civil and Environmental EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Biochars are low-cost and sustainable materials for environmental *** this work,we pre-pared three biochars using pomelo peel(P-BC),algae(A-BC),and corncob(C-BC)to recover Cd^(2+)from wastewater via capacitive deionisation(CDI).A-BC possesses the highest amount of mesopores and nitro-gen functionality and attains the highest removal of Cd^(2+)via physical *** the electro-sorption capacity,C-BC and A-BC perform better capacitive removal of Cd^(2+)than P-BC due to the smaller charge-transfer and mass-transfer ***,this work investigated the impacts of surface morphology,cell voltage,NaCl,initial pH,and Cd^(2+)concentrations on Cd^(2+)capacitive removal and electrode regen-eration *** results indicated that A-BC and C-BC may be prospective materials for Cd^(2+)removal from wastewater by ***,the presence of competing cations at high concentrations may influence the removal of Cd^(2+)at a low level,requiring the modification of A-BC and C-BC in future work.

关键词： Biochar Cd removal Capacitive deionisation Heavy metals Selectivity

A New Inter-Sequence Analysis Method Using Objective Scaling Measure

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Wuhan University Journal of Natural Sciences 2020年第1期25卷 27-32页

作者： li lingyu li Weiwei YI Pingtao GUO Yajun School of Economics&Management Nanchang UniversityNanchang 330031JiangxiChina School of Business Administration Northeastern UniversityShenyang 110167LiaoningChina

The inter-sequence analysis method is a popular decision making method considering subjective information of the decision *** validity of this method is sensitive to the subjective information provided by the decision maker ***,a new weighting method based on the inter-sequence analysis method is *** new method can appropriately reduce the participation of the subjective judgment of the decision maker,and then accordingly decrease the influence of the subjective judgment to the *** only needs the decision maker to give the inter sequence of the *** importance comparison of two criteria is objectively determined by considering the ratio of a criterion being superior to another *** numerical examples are given to illustrate the calculation process of the new method.

关键词： multi-criteria decision making inter-sequence analysis method weighting method superiority number transition function

Sliding modes of fault activation under constant normal stiffness conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第5期15卷 1213-1225页

作者： Chuanqing Zhang Jie Xu Shengji Jin Guojian Cui Yuhang Guo lingyu li State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Shenyang University of Technology Shenyang110870China

Fault activation has been the focus of research community for ***,the studies of fault activation remain immature,such as the fault activation mode and its major factors under constant normal stiffness(CNS)conditions associated with large thickness of fault surrounding rock *** this study,the rock friction experiments were conducted to understand the fault activation modes under the CNS *** major parameters,*** initial normal stress and loading rate,were considered and calibrated in the *** reveal the response mechanism of fault activation,the local strains near the fault plane were recorded,and the macroscopic stresses and displacements were *** testing results show that the effect of displacement-controlled loading rate is more pronounced under the CNS conditions than that under constant normal load(CNL)*** the normal and shear stresses drop suddenly when the stick-slip *** decrease and increase of the normal stress are synchronous with the shear stress in the regular stick-slip scenario,but mismatch with the shear stress during the chaotic stick-slip *** results are helpful for understanding the fault sliding mode and the prediction and prevention of fault slip.

关键词： Fault activation Rock friction mechanics Sliding modes Constant normal stiffness(CNS) Displacement-controlled loading rates Rockburst

Immune evasion and therapeutic opportunities based on natural killer cells

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Chinese Journal of Cancer Research 2023年第3期35卷 283-298页

作者： Jinjin Zhang Feifei Guo lingyu li Songling Zhang Yufeng Wang Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Department of Gynecology Obstetrics and Gynecology CenterThe First Hospital of Jilin UniversityChangchun 130021China Department of Gynecological Oncology Obstetrics and Gynecology CenterThe First Hospital of Jilin UniversityChangchun 130021China

Natural killer(NK)cells can elicit an immune response against malignantly transformed cells without recognizing antigens,and they also exhibit cytotoxic effects and immune surveillance functions in tumor *** several studies have shown the promising antitumor effects of NK cells in immunotherapy,their function is often limited in the tumor microenvironment because tumor cells can easily escape NK cell-induced ***,for efficient tumor immunotherapy,the mechanism by which tumor cells escape NK cell-induced cytotoxicity must be fully *** novel molecules and checkpoint receptors that mediate the disruption of NK cells in the tumor microenvironment have been *** this review,we analyze and detail the major activating and inhibitory receptors on the surface of NK cells to delineate the mechanism by which tumor cells suppress NKG2D ligand expression and increase tumor receptor and inhibitory receptor expression[NKG2A,programmed cell death1(PD-1),and T-cell immunoglobulin and immunoreceptor tyrosine inhibitory motif(TIGIT)]on the NK cell surface,and thus inhibit NK cell *** also reviewed the current status of treatments based on these surface *** comparing the therapeutic effects related to the treatment status and bypass mechanisms,we attempt to identify optimal single or combined treatments to suggest new treatment strategies for tumor immunotherapy.

关键词： Immune evasion natural killer cell NKG2D PD-1 combination therapy

Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition

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Food Science and Human Wellness 2023年第1期12卷 312-323页

作者： lingyu li Ning Qiu Yaqi Meng Chenyan Wang Yoshinori Mine Russell Keast Vincent Guyonnet Key Laboratory of Environment Correlative Dietology Ministry of EducationCollege of Food Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Food Science University of GuelphGuelphOntario N1G 2W1Canada CASS Food Research Centre School of Exercise and Nutrition SciencesDeakin UniversityBurwoodVictoria 3125Australia FFI Consulting Ltd 2488 Lyn RoadBrockville ON K6V 5T3Canada

Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects,but their mechanisms of action remain *** study aimed to investigate the anti-inflammatory effects of preserved egg white(PEW)treatment on dextran sulfate sodium(DSS)-induced colitis in mice and the underlying *** results showed that treatment with PEW in mice with DSS-induced colitis for 14 days effectively improved the clinical signs,inhibited the secretion and gene expression of pro-inflammatory cytokines,and reduced myeloperoxidase(MPO)activity and oxidative stress *** addition,western blotting results showed that PEW significantly suppressed DSS-induced phosphorylation levels of nuclear factor-kappa B(NF-κB)p65 and p38 mitogen-activated protein kinase(MAPK)in colon tissues of mice with *** also enhanced the production of short-chain fatty acids(SCFAs)and modulated gut microbiota composition in mice with DSS-induced colitis,including increasing the relative abundance of beneficial bacteria Lachnospiraceae,Ruminococcaceae and Muribaculaceae,and reducing the relative abundance of harmful bacteria *** together,our study demonstrated that preserved egg white could alleviate DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition.

关键词： Preserved egg white Colitis Oxidative stress NF-κB MAPK Gut microbiota

人脐带间充质干细胞来源外泌体抗小鼠肾缺血再灌注损伤的机制

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中国组织工程研究 2025年第13期29卷 2706-2712页

作者：李灵玉魏华锋罗豪王浩贺佳辉姚雅韡吕兴华兰州大学第一临床医学院甘肃省兰州市730000 兰州大学第一医院日间手术中心甘肃省兰州市730000

背景:人脐带间充质干细胞来源外泌体参与多种损伤修复过程,其对肾缺血再灌注损伤的影响以及具体机制还没有完全阐明。目的:探讨人脐带间充质干细胞来源外泌体治疗肾缺血再灌注损伤的分子机制。方法:①培养人脐带间充质干细胞,使用外泌... 详细信息

背景:人脐带间充质干细胞来源外泌体参与多种损伤修复过程,其对肾缺血再灌注损伤的影响以及具体机制还没有完全阐明。目的:探讨人脐带间充质干细胞来源外泌体治疗肾缺血再灌注损伤的分子机制。方法:①培养人脐带间充质干细胞,使用外泌体提取试剂盒获取外泌体并鉴定;②采用活体荧光成像技术检测外泌体在肾缺血再灌注损伤小鼠肾脏中的分布;③C57/BL6雄性小鼠30只,按随机数字表法分为5组:假手术组、肾缺血再灌注组、假手术组+Compound C组、肾缺血再灌注+外泌体组、肾缺血再灌注+外泌体+Compound C组,每组6只。除假手术组外,其余组均夹闭双侧肾蒂45 min,再灌注24 h建立肾缺血再灌注小鼠模型;假手术组+Compound C组和外泌体+Compound C组于造模前30 min腹腔注射AMPK抑制剂Compound C;外泌体组和外泌体+Compound C组在肾蒂夹闭前15 min经尾静脉注射外泌体。再灌注24 h检测各组小鼠血清肌酐和尿素氮水平、肾组织白细胞介素6和肿瘤坏死因子α水平、肾组织凋亡相关因子的表达。结果与结论:①人脐带间充质干细胞外泌体具有典型的茶托形态,直径分布在40-160 nm范围内,表达外泌体表面特异性标志膜蛋白;②与假手术组相比,肾缺血再灌注损伤小鼠肾脏更易聚集人脐带间充质干细胞外泌体;③外泌体预处理可减轻肾缺血再灌注小鼠肾损伤,降低肾小管上皮细胞凋亡水平,并且这种保护作用可被AMPK抑制剂所逆转。结果表明,人脐带间充质干细胞来源外泌体发挥肾缺血再灌注损伤的保护作用可能与激活AMPK/YAP1通路抗细胞凋亡有关。

关键词：人脐带间充质干细胞外泌体 AMPK-YAP1通路凋亡肾缺血再灌注损伤

(+)/(-)-Gerbeloid A,a pair of unprecedented coumarin-based polycyclic meroterpenoid enantiomers from Gerbera piloselloides:Structural elucidation,semi-synthesis,and lipid-lowering activity

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2657-2668页

作者： Chenxu Zhao Jingrong li Yue Hu lingyu li Meng Yu Yunfeng Huang Tao Zhang Hai Shang Zhongmei Zou State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Institute of Chinese Medicine Resources Guangxi Institute of Chinese Medicine&Pharmaceutical ScienceNanning 530000China

A pair of coumarin-based polycyclic meroterpenoid enantiomers(+)/(-)-gerbeloid A[(+)-1a and(-)-1b]were isolated from the medicinal plant Gerbera piloselloides,which have a unique caged oxatricyclo[4.***.2.0^(3,8)]decene *** planar and three-dimensional structures were exhaustively characterized by comprehensive spectroscopic data and X-ray diffraction *** by the hypothetical biosynthetic pathway,the biomimetic synthesis of racemic 1 was achieved using 4-hydroxy-5-methylcoumarin and citral as the starting material via oxa-6πelectrocyclization and intramolecular[2+2]***,the results of the biological activity assay demonstrated that both(+)-1a and(-)-1b exhibited potent lipid-lowering effects in 3T3-L1 adipocytes and the high-fat diet zebrafish ***,the lipid-lowering activity of(+)-1a is better than that of(-)-1b at the same concentration,and molecular mechanism study has shown that(+)-1a and(-)-1b impairs adipocyte differentiation and stimulate lipolysis by regulating C/EBPα/PPARγsignaling and Perilipin signaling in vitro and in *** findings provide a promising drug model molecule for the treatment of obesity.

关键词： Gerbera piloselloides Natural products Coumarin meroterpenoid Structural elucidation Biomimetic synthesis lipid-lowering activity 3T3-L1 adipocytes High-fat diet zebrafish model

Optimization of the Algorithm for Increasing Injection Rate in Water Injection Wells for Pressure Optimization in P Oilfield

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World Journal of Engineering and Technology 2023年第2期11卷 246-251页

作者： lingyu li Tianjin Branch of CNOOC Ltd. Tianjin China

In today’s society, with the continuous growth of energy demand, Bohai Oilfield, as an important offshore oil resource base in China, is facing increasingly severe challenges while contributing to national energy security. In order to improve the quality of water injection in the oilfield and gradually achieve efficient and stable production, Bohai Oilfield has launched a water injection well pressure optimization project, focusing on improving the efficiency and quality of water injection in the water injection wells, in order to achieve the optimal water injection plan. In practical work, P Oilfield continues to promote the development of water injection well pressure optimization projects, emphasizing practical exploration and continuous optimization of work plans. However, during the project implementation process, there were some problems, one of which was that the statistics of cumulative injection volume were not scientific enough, resulting in a more comprehensive and accurate presentation of the actual results of pressure optimization work. In the context of continuous improvement work, after careful analysis and research, P Oilfield has decided to optimize the cumulative injection rate algorithm to guide the oilfield’s water injection work in a more refined way, ensuring sufficient and good water injection, and enhancing the oilfield’s production efficiency and comprehensive competitiveness.

关键词： Offshore Oil Fields Water Injection Wells Pressure Optimization Water Injection Volume Calculation Method

Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069

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Chinese Chemical Letters 2019年第1期30卷 44-46页

作者： Chengli liu Chenglong Yang Yingjie Zeng Jing Shi lingyu li Wei li Ruihua Jiao Renxiang Tan Huiming Ge State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional Biomolecues School of Life Sciences Nanjing University

A novel alkaloid, chartrenoline(1), featuring an unusual 6/6/5/5-tetracyclic nucleus, was isolated from a marine Streptomyces chartreusis NA02069. The structure of 1 including its absolute configurations was established by extensive analyses of its high resolution mass, NMR and single-crystal X-ray diffraction data. A plausible biosynthetic pathway for chartrenoline(1) is proposed.

关键词： Alkaloid Chartrenoline Streptomyces chartreusis 6/6/5/5-Tetracyclic nucleus Marine-derived microorganism