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特低扬程大流量贯流泵站水泵选型

排灌机械工程学报 2022年第4期40卷 353-358页

作者：李玲玉上海友为工程设计有限公司上海200093

针对特低扬程大流量水泵的选型问题,以某设计净扬程仅0.32 m的贯流泵站为例,进行水泵性能预测.利用现有水力模型的泵段特性曲线及装置特性曲线进行相似换算,并对计算结果进行比较.通过进一步的数学推演,提出了采用水泵泵段特性参数推算... 详细信息

针对特低扬程大流量水泵的选型问题,以某设计净扬程仅0.32 m的贯流泵站为例,进行水泵性能预测.利用现有水力模型的泵段特性曲线及装置特性曲线进行相似换算,并对计算结果进行比较.通过进一步的数学推演,提出了采用水泵泵段特性参数推算泵装置效率指标的方法,并结合数值模拟及装置模型试验进行验证.结果表明,对于运行净扬程1 m以下竖井贯流泵装置,可利用现有南水北调的低扬程水力模型降低nD值进行选型计算.由于水泵流道水头损失占比较高,其最优工况效率与具有3 m左右扬程水泵相比低了约6%,故采用扬程差距较大的模型装置特性参数换算的偏差较大,采用模型泵泵段特性参数换算更准确.采用泵段效率和泵装置效率换算公式,对泵段曲线工况点及对应流道损失进行换算,可较为准确地预测装置效率曲线高效区扬程范围,可为特低扬程泵站设计提供参考.

关键词：特低扬程大流量选型相似换算效率

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Sintilimab combined with anlotinib and chemotherapy as second-line or later therapy in extensive-stage small cell lung cancer: a phase II clinical trial

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4590-4599页

作者： Xiao Han Jun Guo lingyu li Yong Huang Xue Meng linlin Wang Hui Zhu Xiangjiao Meng Qian Shao Xing li Yan Zhang Jin Wang Yanhua Chen Yingjie Zhang Yiru Chen Changbin Zhu Zhehai Wang Department of Medical Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandongChina Department of Medical Oncology Shanghe County People’s HospitalJinanShandongChina Department of Imageology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanChina Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical ScienceJinanShandongChina School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina Department of Translational Medicine Amoy DiagnosticsXiamenFujianChina

Treatment options for patients with relapsed extensive-stage small cell lung cancer(ES-SCLC)remain *** study aims to evaluate the efficacy and safety of combining anlotinib and sintilimab plus chemotherapy as a second line or later therapy for ES-SCLC *** is a phase II clinical trial(ChiCTR2100049390)conducting at Shandong Cancer *** with ES-SCLC and received at least one prior systemic treatment were *** trial design involved a combination therapy(sintilimab,anlotinib,and nab-paclitaxel)administered over six 21-day cycles,followed by maintenance sintilimab *** primary endpoint was objective response rate(ORR).Circulating tumor DNA sequencing was employed for exploratory *** July 2021 to April 2023,25 eligible patients were *** confirmed ORR was 60%(95%CI:38.7–78.9%)and the DCR was 76%(95%CI:54.9–90.6%).The mPFS was 6.0 months(95%CI:5.4–9.7),and the 6-month PFS rate was 49.2%.The mOS was 13.4 months(95%CI:11.8-NR),with a 12-month survival rate of 62.2%.Treatment-related adverse events(TRAEs)of any grade occurred in 80%of patients,with the most common being fatigue(40%)and nausea(32%).TRAEs of Grade 3 or higher were reported in 12%of *** analysis indicated that low on-treatment blood tumor mutation burden was associated with longer PFS and OS and a potential role of KMT2D mutation in treatment *** combination therapy shows promising efficacy and a manageable safety profile as a second-line or later treatment for ES-SCLC,with genomic insights providing potential biomarkers for treatment response.

关键词： treatment phase fatigue

Research on visual differences of exits of different grades of tunnels based on machine learning

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Digital Transportation and Safety

Digital Transportation and Safety 2024年第3期3卷 75-81页

作者： Fangtong Jiao Zhenwei Shi lingyu li Wenpin Xu Qing Lan School of Transportation and Vehicle Engineering Shandong University of TechnologyZibo 255000ShandongChina Department of Transportation Engineering Hebei University of Water Resources and Electric EngineeringCangzhou 061001HebeiChina Hebei Higher Institute of Transportation Infrastructure Research and Development Center for Digital and Intelligent Technology Application Cangzhou 061001HebeiChina

Tunnels are vital in connecting crucial transportation hubs as transportation infrastructure *** in tunnel design standards and driving conditions across different levels directly impact driver visual perception and traffic *** study employs a Gaussian hybrid clustering machine learning model to explore driver gaze patterns in highway tunnels and *** utilizing contour coefficients,the optimal number of classification clusters is *** of driver visual behavior across tunnel levels,focusing on gaze point distribution,gaze duration,and sweep speed,was *** indicate freeway tunnel exits exhibit three distinct fixation point categories aligning with Gaussian distribution,while highway tunnels display four such ***,in both tunnel types,65%of driver gaze is concentrated on the near area ahead of their *** emerge in highway tunnels due to oncoming traffic,leading to 13.47%more fixation points and 0.9%increased fixation time in the right lane compared to regular highway tunnel ***,scanning speeds predominantly fall within the 0.25-0.3 range,accounting for 75.47%and 31.14%of the total sweep speed.

关键词： Traffic safety Tunnel exit Machine learning model Fixation characteristics Scanning characteristics

一般框架下ℓ_(1)-αℓ_(2)最小化的压缩数据分离

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中国科学：数学 2023年第9期53卷 1269-1286页

作者：黄尉李玲玉合肥工业大学数学学院合肥230009

本文考虑一般框架下压缩数据分离问题,即重构多模态数据中的不同子成分.基于已有的ABP(the analysis basis pursuit)算法和ADS(the analysis Dantzig selector)算法,结合ℓ_(1)-αℓ_(2)(0<α≤1)最小化,本文提出对偶ℓ_(1)-αℓ_(2)分解ABP算法及对偶ℓ_(1)-αℓ_(2)分解ADS算法.若多模态数据的两个不同子成分f_(1)和f_(2)分别在不同的一般框架D_(1)∈R^(n×d1)和D_(2)∈Rℓ_(1)-αℓ_(2)下(近似)稀疏,则当测量矩阵满足一定的约束等距性条件且框架间满足某个相互相干性条件时,本文提出的两种算法均可保证多模态数据不同子成分的稳定恢复.数值实验表明,本文的算法相对ℓ1最小化具有较高的重构成功率.

关键词：压缩数据分离 ℓ_(1)-αℓ_(2)最小化限制等距性条件对偶框架 ℓ_(1)分析法

Analyzing the cellular and molecular atlas of ovarian mesenchymal cells provides a strategy against female reproductive aging

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Science China(life Sciences) 2023年第12期66卷 2818-2836页

作者： Longzhong Jia Wenji Wang Jing liang Shudong Niu Yibo Wang Jian Yang lingyu li Ge Wang Xueqiang Xu Lu Mu Kaixin Cheng Xuebing Yang Yijing Wang Haoshu Luo Guoliang Xia Yuwen Ke Yan Zhang Hua Zhang State Key Laboratory of Animal Biotech Breeding College of Biological SciencesChina Agricultural UniversityBeijing 100193China School of life Sciences Taizhou UniversityTaizhou 318000China National Institute of Biological Sciences Beijing 102206China Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China College of Life ScienceNingxia UniversityYinchuan 750021China

Ovarian mesenchymal cells(oMCs)constitute a distinct microenvironment that supports folliculogenesis under physiological *** of exogenous non-ovarian mesenchymal-related cells has been reported to be an efficient approach to improve ovarian ***,the development and cellular and molecular characteristics of endogenous oMCs remain largely *** this study,we surveyed the single-cell transcriptomic landscape to dissect the cellular and molecular changes associated with the aging of oMCs in *** results showed that the oMCs were composed of five ovarian differentiatedMC(odMC)populations and one ovarian mesenchymal progenitor(oMP)cell *** cells could differentiate into various odMCs via an oMP-derived route to construct the ovarian stroma *** analysis revealed that ovarian aging was associated with decreased quantity of oMP cells and reduced quality of *** on the findings of bioinformatics analysis,we designed different strategies involving supplementation with young oMCs to examine their effects on female fertility and *** functional investigations revealed that oMCs supplementation prior to ovarian senescence was the optimal method to improve female fertility and extend the reproductive lifespan of aged females in the longterm.

关键词： single-cell analysis ovary mesenchyma mesenchymal progenitor cells aging infertility

The quantitative proteome atlas of a model cyanobacterium

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Journal of Genetics and Genomics 2022年第2期49卷 96-108页

作者： Jinlong Wang Xiahe Huang Haitao Ge Yan Wang Weiyang Chen limin Zheng Chengcheng Huang Haomeng Yang lingyu li Na Sui Yu Wang Yuanya Zhang Dandan Lu Longfa Fang Wu Xu Yuqiang Jiang Fang Huang Yingchun Wang State Key Laboratory of Molecular Developmental Biology The Innovative Academy of Seed DesignInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Photobiology Institute of BotanyChinese Academy of SciencesBejing 100093China Shandong Provincial Key Laboratory of Plant Stress College of Life ScienceShandong Normal UniversityJinanShandong 250014China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifengHenan 475004China Department of Chemistry University of Louisiana at LafayetteLafayetteLA 70504USA

Cyanobacteria are a group of oxygenic photosynthetic bacteria with great potentials in biotechnological applications and advantages as models for photosynthesis research. The subcellular localizations of the majority of proteins in any cyanobacteria remain undetermined, representing a major challenge in using cyanobacteria for both basic and industrial researches. Here, using label-free quantitative proteomics, we map 2027 proteins of Synechocystis sp. PCC6803, a model cyanobacterium, to different subcellular compartments and generate a proteome atlas with such information. The atlas leads to numerous unexpected but important findings, including the predominant localization of the histidine kinases Hik33 and Hik27 on the thylakoid but not the plasma membrane. Such information completely changes the concept regarding how the two kinases are activated. Together, the atlas provides subcellular localization information for nearly 60% proteome of a model cyanobacterium, and will serve as an important resource for the cyanobacterial research community.

关键词： Proteome atlas Cyanobacteria Proteomics Membranes Synechocystis

中国八大综合经济区环境治理绩效测度与时空演变

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中国人口·资源与环境 2023年第9期33卷 86-97页

作者：颉茂华李玲玉内蒙古大学经济管理学院内蒙古呼和浩特010021

环境治理绩效对推动绿色发展,实现“双碳”目标具有重要作用。基于非期望产出的SBM模型测算近十年中国八大综合经济区的环境治理绩效;同时,采用核密度估计和Dagum基尼系数测度环境治理绩效的时空差异,探讨环境治理绩效的时空分布情况;... 详细信息

环境治理绩效对推动绿色发展,实现“双碳”目标具有重要作用。基于非期望产出的SBM模型测算近十年中国八大综合经济区的环境治理绩效;同时,采用核密度估计和Dagum基尼系数测度环境治理绩效的时空差异,探讨环境治理绩效的时空分布情况;在此基础上,运用Malmquist指数模型研究技术进步、规模效率及纯技术效率对环境治理绩效的影响作用。研究发现:①中国八大综合经济区环境治理绩效整体呈现波动上升态势,但不同区域间或内部的环境治理绩效水平存在较大差别。②中国八大综合经济区环境治理绩效具有明显梯度效应,且环境治理绩效“两极化”程度缩小,存在动态收敛性特征。③中国八大综合经济区环境治理绩效总体差异呈现出波动下降趋势,主要差异贡献率源自区域间差异和交叉重叠,区域内差异贡献率相对较低。④技术进步是各地区环境治理绩效提升的主要影响因素,规模效率对环境治理绩效提升产生一定程度的抑制作用,纯技术效率对环境治理绩效提升具有一定程度的促进作用。基于以上研究结论,提出适度调整环境治理投资规模、加强环境治理技术创新能力、因地制宜考虑区域治理规模效率的政策建议。

关键词：环境治理绩效八大综合经济区 SBM模型 Dagum基尼系数 Malmquist指数

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In-situ route for the graphitized carbon/TiO composite photocatalysts with enhanced removal efficiency to emerging phenolic pollutants

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Chinese Journal of Catalysis 2020年第9期41卷 1378-1392页

作者： Yunqing liu Peiyu Xia lingyu li Xinyue Wang Jiaqi Meng Yuxin Yang Yihang Guo School of Environment Northeast Normal UniversityChangchun 130117JilinChina

TiO2 is the most photoactive material because of its superstrong photooxidizing ability,and TiO2 photocatalysis has been widely applied in sustainable water treatment and environmental ***,poor sunlight or visible-light harvesting efficiency and fast recombination rate of the photogenerated charge carriers severely limit the practical applications of *** overcome these problems,the present work demonstrates a facile in-situ co-condensation method combined with hydrothermal treatment to prepare a series of graphitized carbon/TiO2 composite photocatalysts,and anatase TiO2 phase andp-p-conjugated polycyclic aromatic carbon structure are created ***-prepared TiO2/C composites exhibit remarkably high visible-light photocatalytic activity in the degradation of aqueous emerging phenolic pollutants,acetaminophen(APAP)and methylparaben(MPB),and apparent rate constant of the TiO2/C composite with carbon doping level of 10.3%for APAP and MPB removal is 7.6 and 2.8 times higher than that of bare TiO2,and 6.2 and 2.6 times higher than that of Degussa P25 *** on the results of photoelectrochemical experiments,indirect chemical probe measurements,and ESR spectroscopy,it is verified that doping TiO2 with graphitized carbon is responsible for this enhanced photocatalytic activity,which renders the improved visible-light harvesting ability,the accelerated separation of the photogenerated charge carriers,and enlarged BET surface *** analyzing the intermediates yielded in the photodegradation process,the pathway of visible-light photocatalytic degradation of APAP and MPB over the TiO2/C composite is proposed.

关键词： Titanium dioxide Carbon Visible-light photocatalysis Composite Phenolic compound Water treatment

“双循环”新格局下饲料企业对外贸人才的实际需求及培养策略

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中国饲料 2024年第12期 101-104页

作者：李凌宇开封文化艺术职业学院河南开封475000

随着“双循环”新格局的加速形成,饲料企业在国际贸易中的表现逐渐增强,并对种植业、畜牧养殖业的发展起到了积极的推动作用。与国内市场相比,全球饲料市场的竞争越发激烈。而企业之间的竞争归根到底是人才间的竞争,只有立足饲料企业对... 详细信息

随着“双循环”新格局的加速形成,饲料企业在国际贸易中的表现逐渐增强,并对种植业、畜牧养殖业的发展起到了积极的推动作用。与国内市场相比,全球饲料市场的竞争越发激烈。而企业之间的竞争归根到底是人才间的竞争,只有立足饲料企业对外贸人才的实际需求,持续打造高质量的饲料外贸人才队伍,才能提高饲料企业在国际市场中的竞争力,进而构建出饲料行业的“双循环”新发展格局。

关键词： “双循环”新格局饲料企业外贸人才实际需求培养策略