In this paper, we show the existence and uniqueness of solutions to a large class of SFDEs with the generalized local Lipschitzian coefficients. Some moment estima- tes of the solutions are given by establishing new I...
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In this paper, we show the existence and uniqueness of solutions to a large class of SFDEs with the generalized local Lipschitzian coefficients. Some moment estima- tes of the solutions are given by establishing new Ito operator inequalities based on the Razumikhin technique. These estimates improve, extend and unify some related results including exponential stability of Mao (1997) [20], decay stability of Wu et al. (2010,2011) [32,33], Pavlovic et al. (2012) [24], asymptotic behavior of Luo et al. (2011) [18] and Song et al. (2013) [26]. Moreover, stochastic version of Wintner theorem in continuous space is established by the comparison principle, which improve and extend the main results of Xu et al. (2008 [39], 2013 [36]). When the methods presented are applied to the SFDEs with impulses and SFDEs in Hilbert spaces, we extend the related results of Govindana et al. (2013) [7], Liu et al. (2007) [15], Vinod- kumar (2010) [29] and Xu et al. (2012) [35]. Two examples are provided to illustrate the effectiveness of our results.
Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)***,many patients without apparent HR defects also respond well t...
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Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)***,many patients without apparent HR defects also respond well to PARP inhibitors/*** biomarker responsible for this mechanism remains ***,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient *** inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA ***,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/*** gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we *** importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS ***,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell *** drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired ***,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy.
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