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结核性胸腔积液胸腔置管存在的护理问题及风险管理

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中国现代医生 2013年第21期51卷 122-124页

作者：孟令香深圳市第三人民医院肺结核一病区广东深圳518122

目的探讨胸腔内留置中心静脉导管治疗结核性胸腔积液患者在置管过程中存在的护理问题,进一步完善相关护理干预流程,降低护理风险。方法回顾性分析64例采用单腔中心静脉导管留置胸腔进行引流治疗结核性胸腔积液患者的临床资料,并总结护... 详细信息

目的探讨胸腔内留置中心静脉导管治疗结核性胸腔积液患者在置管过程中存在的护理问题,进一步完善相关护理干预流程,降低护理风险。方法回顾性分析64例采用单腔中心静脉导管留置胸腔进行引流治疗结核性胸腔积液患者的临床资料,并总结护理要点。结果 62例患者均一次置管成功,1例患者术前准备不到位致置管失败,发生导管相关性感染5例,导管脱出5例,胸水标本留取不符合消毒隔离要求4例。结论置管前的充分准备及心理护理、置管中严格无菌操作、密切观察病情、置管后引流管期间加强管道的维护,是确保胸腔内置管引流术治疗成功以及提高护理质量的关键。

关键词：结核性胸腔积液中心静脉导管胸腔置管护理风险管理

Optically driven intelligent computing with ZnO memristor

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Fundamental Research 2024年第1期4卷 158-166页

作者： Jing Yang lingxiang Hu Liufeng Shen Jingrui Wang Peihong Cheng Huanming Lu Fei Zhuge Zhizhen Ye Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100029China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200072China Institute of Wenzhou Zhejiang UniversityWenzhou 325006China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Artificial vision is crucial for most artificial intelligence *** artificial visual systems have been facing challenges in terms of real-time information processing due to the physical separation of sensors,memories,and processors,which results in the production of a large amount of redundant data as well as the data conversion and transfer between these three components consuming most of the time and *** optoelectronic memristors with the ability to realize integrated sensing-computing-memory(ISCM)are key candidates for solving such challenges and therefore attract increasing *** present,the memristive ISCM devices can only perform primary-level computing with external light signals due to the fact that only monotonic increase of memconductance upon light irradiation is achieved in most of these ***,we propose an all-optically controlled memristive ISCM device based on a simple structure of Au/ZnO/Pt with the ZnO thin film sputtered at pure Ar *** device can perform advanced computing tasks such as nonvolatile neuromorphic computing and complete Boolean logic functions only by light irradiation,owing to its ability to reversibly tune the memconductance with ***,the device shows excellent operation stability ascribed to a purely electronic memconductance tuning ***,this study is an important step towards the next generation of artificial visual systems.

关键词： Memristor All-optically controlling ZnO thin filmArtificial vision Nonvolatile neuromorphic computing Logic-in-memory

Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS

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The Journal of Biomedical Research 2024年第1期38卷 37-50页

作者： Sumeng Wang Silu Chen Huiqin Li Shuai Ben Tingyu Zhao Rui Zheng Meilin Wang Dongying Gu lingxiang Liu Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China.

The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is *** address this gap,we conducted a study aiming to investigate this association and identify relevant *** analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune ***,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)*** employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune *** findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal ***,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA *** conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets.

关键词： trans-omics DNA replication tumor immune microenvironment causal mediation colorectal tumorigenesis

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二氧化硅溶胶在棉织物上吸附的动力学研究

纺织学报 2010年第12期31卷 73-77页

作者：宋林艳马晓光孟令翔张莹天津工业大学改性与功能纤维天津市重点实验室天津300160

为确定二氧化硅溶胶在棉织物上的吸附动力学,采用硅钼蓝法对其进行了研究。通过对Langmuir吸附模型和Freundlich吸附模型的比较,确定二氧化硅溶胶在织物上的吸附符合Langmuir吸附模型;通过对不同初始浓度溶胶液性能的测试,确定了其反应... 详细信息

为确定二氧化硅溶胶在棉织物上的吸附动力学,采用硅钼蓝法对其进行了研究。通过对Langmuir吸附模型和Freundlich吸附模型的比较,确定二氧化硅溶胶在织物上的吸附符合Langmuir吸附模型;通过对不同初始浓度溶胶液性能的测试,确定了其反应级数为一级;通过测定不同吸附温度下残液中硅浓度的方法得到了不同温度下的吸附速率常数,其活化能为13.56 kJ/mol,指前因子A0为1.287 s-1。

关键词：硅溶胶棉织物吸附动力学

Tensor Decomposition-Based Channel Estimation and Sensing for Millimeter Wave MIMO-OFDM V2I Systems

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ZTE Communications 2024年

作者： WANG Jilin ZENG Xianlong YANG Yonghui PENG Lin LI lingxiang National Key Laboratory of Wireless Communications， University of Electronic Science and Technology of China ZTE Corporation State Key Laboratory of Mobile Network and Mobile Multimedia Technology

An integrated sensing and communication (ISAC) scheme for a millimeter wave (mmWave) multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) Vehicle-to-Infrastructure (V2I) system is presented， in which both the access point (AP) and the vehicle equip large antenna arrays and employ hybrid analog and digital beamforming structures to compensate the path loss meanwhile compromise between hardware complexity and system performance. Based on the sparse scattering nature of the mmWave channel， the received signal at the AP is organized to a four-order tensor by the introduced novel frame structure. A CANDECOMP/PARAFAC (CP) decomposition-based method is proposed for time-varying channel parameter extraction， including angles of departure/arrival (AODs/AOAs)， Doppler shift， time delay and path gain. Then leveraging the estimates of channel parameters， a nonlinear weighted least-square problem is proposed to accurately recover the location， heading and velocity of vehicles. Simulation results show that the proposed methods are effective and efficient in time-varying channel estimation as well as vehicle sensing in mmWave MIMO-OFDM V2I systems.

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Predicting Illness Severity and Short-Term Outcomes of COVID-19:A Retrospective Cohort Study in China

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The Innovation 2020年第1期1卷 116-124,115页

作者： Chuming Chen Haihui Wang Zhichao Liang Ling Peng Fang Zhao Liuqing Yang mengli Cao Weibo Wu Xiao Jiang Peiyan Zhang Yinfeng Li Li Chen Shiyan Feng Jianming Li lingxiang meng Huishan Wu Fuxiang Wang Quanying Liu Yingxia Liu Department of Infectious Diseases Shenzhen Key Laboratory of Pathogen and ImmunityState Key Discipline of Infectious DiseaseThe Third People’s Hospital of ShenzhenSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenGuangdong 518000China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong 518000China These authors contributed equally

Introduction COVID-19,caused by SARS-CoV-2,is a highly contagious disease.1 By April 8,2020,more than 1,350,000 patients were diagnosed with COVID-19 globally,with more than 79,000 deaths worldwide attributable to the disease.2 Recent clinical data reported that mild and critical patients manifested different *** of the mild patients with COVID-19 had symptoms such as fever,cough,and mild pneumonia,whereas the critical cases presented dyspnea,respiratory failure,sepsis,organ dysfunction,and even eventual death.

关键词： patients clinical respiratory

利用生物信息学发现SPINK1为结直肠癌MTX耐药潜在治疗靶点

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南开大学学报（自然科学版） 2020年第3期53卷 58-61页

作者：李鹏杨景文孙轶孟令祥秦海张锡鹏天津市人民医院肛肠科天津300121

为筛选结直肠癌MTX耐药的潜在靶点,运用生物信息学手段从GEO(Gene expression omnibus)收集并整理有关结直肠癌甲氨蝶呤(MTX)耐药相关数据,利用GEO2R筛选对照细胞和耐药细胞表达差异的基因,并用细胞生物学手段验证该基因是否参与MTX耐药... 详细信息

为筛选结直肠癌MTX耐药的潜在靶点,运用生物信息学手段从GEO(Gene expression omnibus)收集并整理有关结直肠癌甲氨蝶呤(MTX)耐药相关数据,利用GEO2R筛选对照细胞和耐药细胞表达差异的基因,并用细胞生物学手段验证该基因是否参与MTX耐药.结果显示15个基因在MTX耐药结直肠癌细胞中差异表达,其中13个上调,2个下调;其中表达差异最显著的是SPINK1.通过细胞增殖实验、细胞毒性实验证实敲低SPINK1抑制细胞增殖,解除结直肠癌甲氨蝶呤耐药性.该研究表明SPINK1可能是结直肠癌耐药潜在的治疗靶点.利用细胞生物学方法进一步确认其功能,可为进一步实验验证提供依据.

关键词：结直肠癌生物信息学甲氨蝶呤耐药 SPINK1

品管圈对提高小儿磁共振检查镇静成功率的效果观察

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中国实用护理杂志 2015年第8期31卷 592-594页

作者：孟令香刘晓宁唐芳广东省深圳市第三人民医院感染科 518020

目的分析应用品管圈对提高小儿磁共振检查镇静成功率的效果。方法将通过首次镇静顺利完成磁共振检查定义为镇静成功，反之则为镇静失败。选取感染科行磁共振检查的住院患儿（≤3岁）做为研究对象。将2013年3～12月收治的89例患儿作为... 详细信息

目的分析应用品管圈对提高小儿磁共振检查镇静成功率的效果。方法将通过首次镇静顺利完成磁共振检查定义为镇静成功，反之则为镇静失败。选取感染科行磁共振检查的住院患儿（≤3岁）做为研究对象。将2013年3～12月收治的89例患儿作为对照组，将2014年3~8月收治的145例患儿作为观察组，运用品管圈分析导致小儿镇静失败的原因，并制订相关对策。比较开展品管圈活动前后的镇静成功率及护理质量满意度。结果观察组镇静成功率为84．83％（123／145），对照组为68．54％（61／89），2组比较，差异有统计学意义x^2=6．28；观察组患者对护理质量的满意度为93．79％（136／145），显著高于对照组的80．90％（72／89），二者比较，x^2=6．04，差异有统计学意义。结论应用品管圈管理患儿磁共振检查前镇静工作，可有效提高镇静成功率，从而提高护理质量满意度。

关键词：儿童磁共振成像品管圈

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实体膨胀管开发及修井应用技术研究

石油钻采工艺 2009年第A1期31卷 139-142页

作者：王木乐孟令祥石俊生李媛王春喜中原油田公司采油工程技术研究院河南濮阳457001 华北油田公司质量安全环保处计量中心站河北任丘062552 华北油田公司采油四厂质量监督中心河北廊坊102800

中原油田是复杂断块油田,套管损坏对油田开发后期带来了严重影响,2005年以来研究开发了实体膨胀管补贴套管技术,在膨胀管材料、连接技术、密封技术、膨胀工艺等方面的研究取得了突破,具有修复后内通径大、密封可靠、强度高、耐腐蚀等优... 详细信息

中原油田是复杂断块油田,套管损坏对油田开发后期带来了严重影响,2005年以来研究开发了实体膨胀管补贴套管技术,在膨胀管材料、连接技术、密封技术、膨胀工艺等方面的研究取得了突破,具有修复后内通径大、密封可靠、强度高、耐腐蚀等优点,整体技术达到了国际先进水平,并在套管堵漏、封堵出水层及套管加固等方面进行了应用。截至2008年底,已经成功应用21口井,下井最大深度3450 m,补贴最长井段53 m,形成了适应深井、高温高压、高矿化度井的膨胀管补贴技术,可进一步推广应用。

关键词：实体膨胀管连接密封膨胀胀头膨胀工艺