检索结果-南通市图书馆

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

干细胞的趋电性迁移及机制

中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

在线全文

学校读者我要写书评

暂无评论

L形冷弯薄壁型钢组合钢管混凝土柱轴压性能

哈尔滨工业大学学报 2025年第1期57卷 77-91页

作者：吴丽丽刘艳霞武海鹏韩港豪中国矿业大学(北京)力学与土木工程学院北京100083

为解决异形钢管混凝土柱阴角对其承载力的影响,提出了用1个冷弯薄壁方钢管和2个U形钢管焊接成L形钢管,内填充混凝土形成L形冷弯薄壁型钢组合钢管混凝土柱形式。设计了5组共10根试件的轴压试验,并开展了有限元参数分析,研究了钢管厚度、... 详细信息

为解决异形钢管混凝土柱阴角对其承载力的影响,提出了用1个冷弯薄壁方钢管和2个U形钢管焊接成L形钢管,内填充混凝土形成L形冷弯薄壁型钢组合钢管混凝土柱形式。设计了5组共10根试件的轴压试验,并开展了有限元参数分析,研究了钢管厚度、U形管外伸长度和钢材强度等参数对构件承载力和延性等力学性能的影响。结果表明:该类试件的主要破坏形态为中上部局部鼓曲破坏,适量增大U形管外伸长度可以提高承载力,但增大到一定程度之后易发生弯扭破坏;承载力和延性随着钢管厚度和钢材强度增大而增加;混凝土强度对构件的初始刚度和峰值荷载的影响都很小,但对曲线下降段的影响较大;试件端部和中部截面阴角处的混凝土应力值比各边中部更大,说明采用U形钢管与方钢管组合的方式改善了阴角处钢管对混凝土约束普遍较弱的问题。基于“统一理论”,给出了两种承载力建议计算公式,与试验结果吻合较好,两种计算方法在0.44~1.94的约束效应系数范围内具有良好的适用性。

关键词： L形 U形管钢管混凝土柱轴心受压承载力

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

A novel high-order scheme for numerical simulation of wake flow over helicopter rotors in hover

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2022年第5期35卷 260-274页

作者： Shaoqiang han Wenping SONG Zhonghua han Institute of Aerodynamic and Multidisciplinary Design Optimization National Key Laboratory of Science and Technology on Aerodynamic Design and ResearchSchool of AeronauticsNorthwestern Polytechnical UniversityXi’an 710072China

Accurate prediction of tip vortices is crucial for predicting the hovering performance of a helicopter rotor.A new high-order scheme(we call it WENO-K)proposed by our research group is employed to minimize numerical dissipation and extended to numerical simulation of unsteady compressible viscous flows dominated by tip vortices over hovering ***-K is referred to as an adaptively optimized WENO scheme with Gauss-Kriging reconstruction,and its advantage is to reduce dissipation in smooth regions of flow while preserving high-resolution around *** WENO-K scheme is adopted to reconstruct left and right state values within the Roe Riemann solver updating the inviscid fluxes on a structured dynamic overset *** minimize the accuracy loss for high-order reconstruction on artificial boundaries of overset grid,a method of multilayer fringes is proposed to carry out interpolation between background grid and blade *** parallel computing considering automatic load balance on averagely partitioned overset grid is developed to reduce the wall-clock time of an unsteady *** results for Caradonna-Tung(C-T)rotor in hover at the conditions of subsonic and transonic tip Mach numbers show that the thrust coefficient error for the result of WENO-K scheme is no more than 3%.Compared with WENO-JS scheme,WENO-K scheme achieves about 40%improvement on accuracy of predicting rotor thrust with only 4.1%extra computational *** importantly,WENO-K scheme can capture more sophisticated unsteady flow structures and resolve tip vortices to a larger wake age with an increment of about 270°compared to WENO-JS scheme.

关键词： Dynamic overset grid Helicopter rotors High-order scheme Unsteady flow Vortex flow WENO scheme

Differences in clinical and genetic characteristics between early-and late-onset narcolepsy in a han Chinese cohort

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1887-1893页

作者： Hui Ouyang Fang han Ze-Chen Zhou Jun Zhang Department of Clinical Neurology Peking University People’s HospitalBeijingChina Department of Clinical Pulmonology Peking University People’s HospitalBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina

Early-and late-onset narcolepsy constitutes two distinct diagnostic ***,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset *** study compared clinical data and single-nucleotide polymorphisms(SNPs)between early-and late-onset patients in a large cohort of 899 han Chinese narcolepsy ***,cerebrospinal fluid,and clinical data were prospectively collected from patients,and patients were genotyped for 40 previously reported narcolepsy risk-conferring *** risk scores(GRSs),associations of five different sets of SNPs(GRS1–GRS5)with early-and late-onset narcolepsy,were evaluated using logistic regression and receiver operating characteristic *** sleep latency was significantly shorter in early-onset cases than in late-onset *** severity was greater among late-onset patients,with higher rates of sleep paralysis,hypnagogic hallucinations,health-related quality of life impairment,and concurrent presentation with four or more *** levels did not differ significantly between early-and late-onset *** rs3181077(CCR1/CCR3)and rs9274477(HLA-DQB1)were more prevalent among early-onset *** GRS1(26 SNPs;OR=1.513,95%CI:0.893–2.585;P<0.05)and GRS5(6 SNPs;OR=1.893,95%CI:1.204–2.993;P<0.05)were associated with early-onset narcolepsy,with areas under the receiver operating characteristic curves of 0.731 and 0.732,*** GRS1 nor GRS5 included SNPs in HLA *** results indicate that symptomology and genetic risk factors differ between early-and late-onset *** protocol was approved by the Institutional Review Board(IRB)Panels on Medical Human Subjects at Peking University People’s Hospital,China(approval *** 86)in October 2011.

关键词： case-control studies clinical features genetic association studies genetic load genetic loci genetic phenomena hypothalamic diseases precision medicine risk assessment single nucleotide polymorphism

Data-Driven Based Fault Prognosis for Industrial Systems:A Concise Overview

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 330-345页

作者： Kai Zhong Min han Bing han Faculty of Electronic Information and Electrical Engineering Dalian University of TechnologyDalian 116024China Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of Education Dalian University of TechnologyDalian 116024China State Key Laboratory of Navigation and Safety Technology Shanghai Ship and Shipping Research InstituteShanghai 200135China

Fault prognosis is mainly referred to the estimation of the operating time before a failure occurs,which is vital for ensuring the stability,safety and long lifetime of degrading industrial *** to the results of fault prognosis,the maintenance strategy for underlying industrial systems can realize the conversion from passive maintenance to active *** the increased complexity and the improved automation level of industrial systems,fault prognosis techniques have become more and more ***,the datadriven based prognosis approaches,which tend to find the hidden fault factors and determine the specific fault occurrence time of the system by analysing historical or real-time measurement data,gain great attention from different industrial *** this context,the major task of this paper is to present a systematic overview of data-driven fault prognosis for industrial ***,the characteristics of different prognosis methods are revealed with the data-based ones being ***,based on the different data characteristics that exist in industrial systems,the corresponding fault prognosis methodologies are illustrated,with emphasis on analyses and comparisons of different prognosis ***,we reveal the current research trends and look forward to the future challenges in this *** review is expected to serve as a tutorial and source of references for fault prognosis researchers.

关键词： Data-driven fault prognosis feature extraction industrial systems

Identification of LRRC46 as a novel candidate gene for high myopia

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第9期67卷 1941-1956页

作者： lingxi Jiang Chao Dai Yao Wei Bo Zhao Qi Li Zhengzheng Wu Liang Zou Zimeng Ye Zhenglin Yang Lulin Huang Yi Shi Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics Department of Laboratory MedicineSichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Ophthalmology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China School of Food and Bioengineering Chengdu UniversityChengdu 610106China School of Medicine University of SydneySydney 2050Australia Jinfeng Laboratory Chongging 400000China

High myopia(HM)is the primary cause of blindness,with the microstructural organization and composition of collagenous fibers in the cornea and sclera playing a crucial role in the biomechanical behavior of these *** a previously reported myopic linkage region,MYP5(17q21-22),a potential candidate gene,LRRC46(c.C235T,p.Q79X),was identified in a large han Chinese ***46 is expressed in various eye tissues in humans and mice,including the retina,cornea,and *** subsequent cell experiments,the mutation(c.C235T)decreased the expression of LRRC46 protein in human corneal epithelial cells(HCE-T).Further investigation revealed that Lrrc46^(-/-)mice(KO)exhibited a classical myopia *** thickness of the cornea and sclera in KO mice became thinner and more pronounced with age,the activity of limbal stem cells decreased,and microstructural changes were observed in the fibroblasts of the sclera and *** performed RNA-seq on scleral and corneal tissues of KO and normal control wild-type(WT)mice,which indicated a significant downregulation of the collagen synthesis-related pathway(extracellular matrix,ECM)in KO *** in vitro studies further indicated that LRRC46,a member of the important LRR protein family,primarily affected the formation of *** study suggested that LRRC46 is a novel candidate gene for HM,influencing collagen protein VⅢ(Col8a1)formation in the eye and gradually altering the biomechanical structure of the cornea and sclera,thereby promoting the occurrence and development of HM.

关键词： high myopia LRRC46 biomechanics collagen protein VⅢ

Elastic, Piezoelectric and Acoustic Properties of Wurtzite MnO from Density Functional Calculation

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2013年第6期59卷 751-755页

作者： han han Surface Physics Laboratory (National Key Laboratory) Key Laboratory of Computational Physical Sciencesand Department of Physics ~dan University Shanghai 200433 China

The wurtzite MnO has been obtained lately and is expected to have large potentiai in varies applications. Since elastic properties are the bases of various applications, we calculate these properties of wurtzite MnO based on the density-functionai theory and compare it with other two phases of MnO （rocksalt and zinc-blende MnO）. The Young＇s modulus of wurtzite and zinc-blende MnO are 65.6 GPa and 73.4 GPa, respectively, which are much lower than those of rocksaJt MnO （177.6 GPa）. More importantly, both the Poisson ratio and the bulk modulus to shear modulus ratio indicate that wurtzite MnO should have much better ductile properties than rocksalt MnO. The calculated piezoelectric constants of wurtzite MnO are comparable to those of ZnO, This suggests wurtzite MnO is a good piezoelectric material. Furthermore, the slowness surfaces of acoustic waves of them are given from Christoffel equation.

关键词： wurtzite MnO density functional calculation elastic properties piezoelectric properties acousticproperties