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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

A stretchable, ionic conductive, and adhesive patch electrode with ultra-low on-skin impedance for electrophysiological signal recording

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Science China(Information Sciences) 2025年

作者： Yang LI Yuzhe GU Sheng QIAN Yuncong PANG Aoxi YU Shuwen ZHENG Wenjie xia Yuan LIAO Baoguang LIU Shujuan LIU Qiang ZHAO College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications (NJUPT) State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications (NJUPT)

Flexible electrodes have significant potential in fields such as healthcare and neuroscience, as they enable comprehensive recording and analysis of human electrical signals, providing deeper insights into physiological conditions and the state of internal organs and tissues [1, 2]. However, commercial Ag/AgCl wet electrodes face issues such as dehydration,poor comfort, and insufficient mechanical strength, while other types of electrodes, like dry and semi-dry electrodes,also have their own limitations, including the higher contact impedance. In contrast, ionically conductive electrodes offer potential advantages such as transparency, stability, and low impedance, making them a promising alternative to existing electrically conductive electrodes [3]. Acrylic acid (AA)and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) are commonly used in the synthesis of ionic gels, as they ionize in water to produce a large number of ions, helping to maintain moisture balance and reduce impedance caused by dehydration [4]. However, the presence of freely moving ions in the gel network can interfere with conductivity, highlighting the need to introduce new conductive networks to enhance performance [5].

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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知识图谱技术在关联贷款审计中的应用研究

金融科技时代 2025年第1期33卷 55-60页

作者：夏敏广东省农村信用社联合社

文章从客户关联角度,将存在关联的贷款客户视为一个整体,研究关联贷款对银行整体风险的影响。知识图谱技术能够对海量的商业银行贷款客户数据进行分析,且将关联关系可视化,揭示商业银行关联贷款的形成、银行信用风险传导等规律。知识图... 详细信息

文章从客户关联角度,将存在关联的贷款客户视为一个整体,研究关联贷款对银行整体风险的影响。知识图谱技术能够对海量的商业银行贷款客户数据进行分析,且将关联关系可视化,揭示商业银行关联贷款的形成、银行信用风险传导等规律。知识图谱技术适用于开展大数据分析,找到关联贷款形成的数据特征及底层逻辑,对于商业银行防范化解关联贷款风险,具有重要的实践意义。

关键词：知识图谱关联贷款审计

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导学案在初中英语阅读教学中的应用研究

英语教师 2025年第1期 132-137页

作者：唐霞浙江省杭州市临安区锦城第六初级中学浙江杭州310000

介绍初中英语阅读教学中导学案的编写原则,即坚持“以生为本”、坚持明确任务、坚持激发学生思考、坚持阅读策略指导。结合教学案例,探索导学案在初中英语阅读教学中的应用途径,即准备定向,激活思维;合作讨论,深化思维;归纳总结,整合思... 详细信息

介绍初中英语阅读教学中导学案的编写原则,即坚持“以生为本”、坚持明确任务、坚持激发学生思考、坚持阅读策略指导。结合教学案例,探索导学案在初中英语阅读教学中的应用途径,即准备定向,激活思维;合作讨论,深化思维;归纳总结,整合思维;分层练习,拓展思维。实践证明,在初中英语阅读教学中应用导学案,能有效培养学生的独立阅读能力和综合语用能力。

关键词：初中英语阅读教学导学案

基于渐进决策理论的我国产业学院政策变迁分析

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宁波职业技术学院学报 2025年第1期29卷 33-38页

作者：夏晴河海大学公共管理学院江苏南京211100

产业学院是应用型人才培养的新型组织载体,是深化产教融合的主要抓手,也是赋能新质生产力的重要引擎。产业学院的高质量发展离不开产业学院政策保障。梳理相关政策文件并回顾其发展历程,可以发现,我国产业学院政策的演变表现出“渐进调... 详细信息

产业学院是应用型人才培养的新型组织载体,是深化产教融合的主要抓手,也是赋能新质生产力的重要引擎。产业学院的高质量发展离不开产业学院政策保障。梳理相关政策文件并回顾其发展历程,可以发现,我国产业学院政策的演变表现出“渐进调试”状态。基于渐进决策理论,我国产业学院政策在变迁基础、变迁目标、变迁主体、变迁效果四方面表现出演进特征。运用该理论来阐述我国产业学院政策的变迁历程及演进特征,对于推动我国产业学院的理性发展具有理论价值。

关键词：渐进决策理论产业学院政策变迁

马克思的“机器体系”:基于资本逻辑的技术批判路径

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河北大学学报（哲学社会科学版） 2025年第1期50卷 63-73页

作者：夏莹四川美术学院重庆400053 清华大学哲学系北京100084

马克思在《资本论》及其手稿的准备阶段以劳动为诠释资本逻辑的核心要素,提出“机器体系”的概念,作为资本生产三要素之一的劳动工具。该概念彰显出被资本主义生产关系所左右的机器,在其自动化的迭代中转变为可以左右人的活劳动形式的... 详细信息

马克思在《资本论》及其手稿的准备阶段以劳动为诠释资本逻辑的核心要素,提出“机器体系”的概念,作为资本生产三要素之一的劳动工具。该概念彰显出被资本主义生产关系所左右的机器,在其自动化的迭代中转变为可以左右人的活劳动形式的“体系”。劳动者,一方面沦为站在机器体系旁边的智能器官,另一方面却也作为推进资本增殖的酵母而左右着机器体系可能迭代的速度与方向,机器体系本质上仍然是人的产物。由此决定了机器体系的诞生固然依赖于资本主义生产方式,但却因作为人的产物,具有了逃离资本的可能性方式。马克思在《1857—1858年经济手稿》中,借助于机器体系的生产对人类社会财富之本质规定的变革,提出机器体系为人的解放所提供的自由时间的增加,以及对劳动价值论的瓦解,从而瓦解资本逻辑的全部可能性,为今天处于激进迭代的技术批判提供了一种基于资本逻辑所特有的批判视角。

关键词：机器体系资本逻辑劳动财富

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简牍所见秦及西汉初期的未成年“户人”研究

南都学坛 2025年第1期45卷 13-20页

作者：文霞广东第二师范学院历史与社会发展学院广东广州510303

秦及西汉初期的简牍中出现了一些未成年“户人”,他们均为男性。未成年人成为“户人”的主要影响因素包括性别、尊卑及家庭规模等,年龄不是重要考量因素。未成年男性或担任“户人”,或提前服役,过于繁重的赋役迫使未成年男性作为劳动力... 详细信息

秦及西汉初期的简牍中出现了一些未成年“户人”,他们均为男性。未成年人成为“户人”的主要影响因素包括性别、尊卑及家庭规模等,年龄不是重要考量因素。未成年男性或担任“户人”,或提前服役,过于繁重的赋役迫使未成年男性作为劳动力的价值得到提升。未成年人“户人”被提前成人化,既体现了国家在行政管理上对个人身份信息的漠视,也说明了皇帝和官僚集团极尽可能压榨人民的剩余劳动。

关键词：简牍未成年人户人女户

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中小学学科德育实施的内在逻辑与有效路径

北京教育学院学报 2025年第1期39卷 41-46页

作者：刘霞江苏省教育科学研究院德育与心理健康教育研究所江苏南京210013

落实立德树人根本任务、建立高质量的学校德育工作体系、培育学生核心素养要求必须深入实施学科德育。学科德育是学科知识和德育要素的内在耦合,是学科学习与道德养成的同向同构。实施中小学学科德育要遵循学科逻辑和德育逻辑,通过课堂... 详细信息

落实立德树人根本任务、建立高质量的学校德育工作体系、培育学生核心素养要求必须深入实施学科德育。学科德育是学科知识和德育要素的内在耦合,是学科学习与道德养成的同向同构。实施中小学学科德育要遵循学科逻辑和德育逻辑,通过课堂教学主渠道,完成公共知识向个人能力和素养的转译,达成学科德育目标。因此,要坚持从道德价值的角度深度解读教材的育人价值,从道德养成的角度选择适合的教学方式,从道德评价的角度引领课程作业和评价改革,优化学科德育实施路径,提升育人效果。

关键词：立德树人学科德育核心素养学科实践

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