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思维导图联合细节管理在消毒供应中心的应用效果

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中国卫生标准管理 2024年第15期15卷 157-160页

作者：王凌娜合肥市第二人民医院消毒供应中心安徽合肥230000

目的探讨思维导图联合细节管理在消毒供应中心的应用效果。方法选择2022年1月—2023年1月在合肥市第二人民医院消毒供应中心从业的工作人员100名为研究对象,根据管理方法不同将工作人员分为参照组与观察组,各50名。参照组实施常规管理,... 详细信息

目的探讨思维导图联合细节管理在消毒供应中心的应用效果。方法选择2022年1月—2023年1月在合肥市第二人民医院消毒供应中心从业的工作人员100名为研究对象,根据管理方法不同将工作人员分为参照组与观察组,各50名。参照组实施常规管理,观察组实施思维导图+细节管理。比较2组专业水平、手术器械消毒灭菌质量、手术器械交接缺陷率、管理满意度。结果观察组理论知识、实践操作评分均高于参照组(P<0.05)。观察组手术器械洗涤、消毒、灭菌、回收合格率均高于参照组,差异有统计学意义(P<0.05)。观察组手术器械交接缺陷率为1.33%,参照组为3.17%,观察组明显低于参照组(P<0.05)。观察组管理满意度(98.00%)高于参照组(84.00%),差异有统计学意义(P<0.05)。结论思维导图联合细节管理能够明显降低消毒供应中心手术器械交接缺陷率,同时还可以提高工作人员的专业水平、手术器械消毒灭菌质量、管理满意度。

关键词：消毒供应中心手术器械思维导图细节管理消毒灭菌质量交接缺陷率

鱼骨图分析模式改进措施对消毒供应中心院感预防的价值

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中国卫生标准管理 2024年第3期15卷 156-159页

作者：王凌娜合肥市第二人民医院消毒供应中心安徽合肥230000

目的探讨在消毒供应中心院感预防的过程中实施鱼骨图分析模式的效果。方法选择2022年1月—2023年1月在合肥市第二人民医院消毒供应中心工作人员40名为研究对象,按照随机数表法将工作人员分为对照组(n=20)与观察组(n=20)。对照组实施常... 详细信息

目的探讨在消毒供应中心院感预防的过程中实施鱼骨图分析模式的效果。方法选择2022年1月—2023年1月在合肥市第二人民医院消毒供应中心工作人员40名为研究对象,按照随机数表法将工作人员分为对照组(n=20)与观察组(n=20)。对照组实施常规管理措施,观察组实施基于鱼骨图分析模式的改进措施。对2组医院感染发生率、医疗器械消毒合格率、工作人员专业能力进行统计比较。结果观察组医院感染发生率为0,对照组医院感染发生率为30.00%,观察组明显低于对照组(P<0.05)。观察组在实施鱼骨图分析模式的改进措施后,其医疗器械消毒合格率为99.33%(298/300),高于对照组的96.67%(290/300),差异有统计学意义(P<0.05)。观察组工作人员实施鱼骨图分析模式的改进措施后其各项指标得分均较对照组显著要高(P<0.05)。结论消毒供应中心质量控制及院感预防中实施基于鱼骨图分析模式的改进措施,价值较高,同时有助于提高工作人员专业能力。

关键词：消毒供应中心鱼骨图分析模式质量控制院感预防改进措施专业能力

Epigenetic regulation of aging:implications for interventions of aging and diseases

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4283-4304页

作者： Kang wang Huicong Liu Qinchao Hu lingna wang Jiaqing Liu Zikai Zheng Weiqi Zhang Jie Ren Fangfang Zhu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences100101 BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences100101 BeijingChina University of Chinese Academy of Sciences 100049 BeijingChina School of Biomedical Engineering Shanghai Jiao Tong University200030 ShanghaiChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for Bioinformation100101 BeijingChina Hospital of Stomatology Sun Yat-sen University510060 GuangzhouChina Guangdong Provincial Key Laboratory of Stomatology Guanghua School of StomatologySun Yat-sen University510060 GuangzhouChina Institute for Stem Cell and Regeneration Chinese Academy of Sciences100101 BeijingChina Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu HospitalCapital Medical University100053 BeijingChina Beijing Institute for Stem Cell and Regenerative Medicine 100101 BeijingChina

Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks,including genetic and epigenetic *** aging-associated epigenetic changes include DNA methylation,histone modification,chromatin remodeling,non-coding RNA(ncRNA)regulation,and RNA modification,all of which participate in the regulation of the aging process,and hence contribute to aging-related ***,understanding the epigenetic mechanisms in aging will provide new avenues to develop strategies to delay ***,aging interventions based on manipulating epigenetic mechanisms have led to the alleviation of aging or the extension of the lifespan in animal *** molecule-based therapies and reprogramming strategies that enable epigenetic rejuvenation have been developed for ameliorating or reversing aging-related *** addition,adopting health-promoting activities,such as caloric restriction,exercise,and calibrating circadian rhythm,has been demonstrated to delay ***,various clinical trials for aging intervention are ongoing,providing more evidence of the safety and efficacy of these ***,we review recent work on the epigenetic regulation of aging and outline the advances in intervention strategies for aging and age-associated diseases.A better understanding of the critical roles of epigenetics in the aging process will lead to more clinical advances in the prevention of human aging and therapy of aging-related diseases.

关键词： aging prevention hence

Exercise-with-melatonin therapy improves sleep disorder and motor dysfunction in a rat model of ischemic stroke

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Neural Regeneration Research 2024年第6期19卷 1336-1343页

作者： Haitao Zhao Tong Zhang Haojie Zhang Yunlei wang lingna Cheng School of Rehabilitation Medicine Capital Medical UniversityBeijingChina Department of Neurological Rehabilitation Beijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina School of Rehabilitation Medicine University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina Laboratory of Brain Injury Repair and Rehabilitation China Rehabilitation Science InstituteBeijingChina

Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly *** this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 *** treated the rats with exercise and melatonin therapy for 7 consecutive *** showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power ***,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory *** the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy *** findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.

关键词： exercise glutamate receptor 2 hippocampus ischemic stroke learning melatonin memory sleep disorder synaptic plasticity

Quality Analysis and High-Performance Liquid Chromatographic Fingerprint Analysis of New Cultivated Kind of <i>Lonicerae japonicae</i>Flos “Hua Jin 6” from Different Harvest Times

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Chinese Medicine 2017年第1期8卷 18-32页

作者： lingna wang Yongqing Zhang School of Pharmacy Shandong University of Traditional Chinese Medicine Jinan China

Lonicerae japonicaeFlos (LJF) is widely used in traditional Chinese medicines for the treatment of various diseases, which is now in great demand every year and has a broad development prospect. However, the flowering phase of common LJF varieties is so short, which seriously restricts the development of LJF industry. As a new cultivated kind of Lonicerae japonicae Flos, “Hua Jin 6” has characteristics in long flowering phase and conveniently picking, which makes it have a broad development prospect. The aim of this study is to provide scientific guidance for its suitable harvest period by measuring yield and quality of “Hua Jin 6” from different harvest time. Studies show that flower size had a slowly rising trend from the first day to the seventh day, and then slowly declined or kept stable. There were no significant differences of total phenolic acid contents in different samples from different days, but contents of total flavonoids were on the rise and up to maximum in the ninth day. The contents of total iridoids had an increasing tendency from the first day to the fifth day and then kept relatively stable in other days. We demonstrated that the quality of “Hua Jin 6” is relatively stable and suitable for harvesting in all flower buds white stage in term of HPLC fingerprints. Our findings can make it possible to select the suitable time for different harvest purpose.

关键词： Lonicerae japonicae Flos New Cultivate Kind “Hua Jin 6” Quality Analysis HPLC Fingerprint Harvest Time

金银花多酚和多糖同步提取工艺优化及其抗氧化活性研究

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中国食品添加剂 2024年第3期35卷 1-10页

作者：梁金月周洪鑫张雨晴王玲娜李佳赵东升山东中医药大学药学院济南250355 新疆医科大学药学院乌鲁木齐830011 新疆埃乐欣药业有限公司乌鲁木齐830011

以金银花为原料,以硫酸铵浓度、乙醇含量、料液比、超声时间、提取温度、超声功率六个因素进行同步提取单因素实验。在单因素实验基础上,以多酚和多糖提取量为双指标,利用响应面法优化超声辅助乙醇-硫酸铵双水相萃取法同步提取金银花中... 详细信息

以金银花为原料,以硫酸铵浓度、乙醇含量、料液比、超声时间、提取温度、超声功率六个因素进行同步提取单因素实验。在单因素实验基础上,以多酚和多糖提取量为双指标,利用响应面法优化超声辅助乙醇-硫酸铵双水相萃取法同步提取金银花中多酚和多糖的工艺。并对提取的金银花多酚和多糖进行体外抗氧化研究。提取最优工艺条件为硫酸铵浓度0.2 mg/mL,超声时间30 min,超声温度59℃,料液比1∶70(g/mL),以此条件下测得多酚提取量为25.6 mg/g,多糖提取量为152.11 mg/g。体外抗氧化结果表明,金银花多酚和多糖对DPPH·、ABTS^(+)·具有显著清除能力,对Fe^(3+)有较强还原能力。利用超声辅助双水相萃取法实现了金银花多糖和多酚同步提取。多糖和多酚抗氧化活性均显著,其中金银花多酚抗氧化能力在一定范围内强于VC。

关键词：金银花双水相提取同步提取响应面抗氧化活性

蒙脱石散对甲磺酸阿帕替尼在大鼠体内的吸收影响

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药学与临床研究 2024年第3期32卷 218-222页

作者：祖元元周晓鹰薛宏波吴静王玲娜何光照常州市肿瘤医院药事科常州213032 常州大学药学院常州213164 常州市食品药品纤维质量监督检验中心常州213022

目的:建立大鼠血浆中测定甲磺酸阿帕替尼的超高效液相色谱串联质谱方法,并考察蒙脱石散对甲磺酸阿帕替尼在大鼠体内吸收的影响。方法:采用含内标的乙腈作为蛋白沉淀剂处理血浆样本,经含0.1%甲酸水溶液和乙腈进行梯度洗脱,在正离子多反... 详细信息

目的:建立大鼠血浆中测定甲磺酸阿帕替尼的超高效液相色谱串联质谱方法,并考察蒙脱石散对甲磺酸阿帕替尼在大鼠体内吸收的影响。方法:采用含内标的乙腈作为蛋白沉淀剂处理血浆样本,经含0.1%甲酸水溶液和乙腈进行梯度洗脱,在正离子多反应监测模式下对甲磺酸阿帕替尼进行定量分析,并进行方法学验证。将大鼠随机分成3组,先分别灌胃给予等体积的水(对照组)、含蒙脱石散240 mg·kg^(-1)的混悬液(常规剂量组)和含蒙脱石散2400 mg·kg^(-1)的混悬液(高剂量组),再全部灌胃给予甲磺酸阿帕替尼40 mg·kg^(-1)。各组大鼠于给药后不同时间点经颈静脉处采集全血。血浆样品预处理后测定甲磺酸阿帕替尼的浓度,绘制血药浓度-时间曲线,另采用WinNonlin(v 8.2)软件计算其药代动力学参数。结果:该检测方法在1~2000 ng·mL^(-1)范围内线性关系良好。精密度、准确度、提取回收率、基质效应和稳定性均满足相关要求。对照组、常规剂量组和高剂量组,甲磺酸阿帕替尼药峰浓度分别为(571±261)、(650±215)和(961±390)ng·mL^(-1),曲线下面积分别为(3104±2463)、(3624±1469)和(4578±2738)h·ng·mL^(-1)。结论:蒙脱石散可能影响甲磺酸阿帕替尼在大鼠体内的吸收。建议临床关注基于蒙脱石散与甲磺酸阿帕替尼的相互作用。

关键词：蒙脱石散甲磺酸阿帕替尼吸收药物相互作用液相色谱串联质谱大鼠

Graphene as adsorbent for highly efficient extraction of modified nucleosides in urine prior to liquid chromatography-tandem mass spectrometry analysis

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Chinese Chemical Letters 2024年第4期35卷 490-495页

作者： Cheng Guo Xiaoxiao Zhang Xiujuan Hong Yiqiu Hu lingna Mao Kezhi Jiang Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory of Organosilicon Chemistry and Material Technology College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Department of General Practice The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 17 modified nucleosides in human urine. We found graphene could effectively adsorb various modified nucleosides in human urine samples. With this method, we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy *** revealed that the levels of 12 modified nucleosides were all diminished in urine from lung cancer patients, compared with healthy controls. It is worth noting that we demonstrated, for the first time, the presence of 5,2-O-dimethyluridine(m~5U_m) in human urine. Together, we established a robust analytical method for simultaneous determinations of 17 modified nucleosides in human urine, and our results revealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer, implying the potential applications of these modified nucleosides as noninvasive biomarkers for the early detection of lung cancer. Moreover, this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.

关键词： Mass spectrometry RNA modification Modified nucleosides Graphene Biomarker Urine

Accelerating lithium-sulfur battery reaction kinetics and inducing 3D deposition of Li_(2)S using interactions between Fe_(3)Se_(4)and lithium polysulfides

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Journal of Energy Chemistry 2024年第8期95卷 540-553,I0012页

作者： Yihan Lin Liheng Li Longjie Tan Yongliang Li Xiangzhong Ren Peixin Zhang Chuanxin He lingna Sun College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongChina

Although lithium-sulfur batteries(LSBs)exhibit high theoretical energy density,their practical application is hindered by poor conductivity of the sulfur cathode,the shuttle effect,and the irreversible deposition of Li_(2)*** address these issues,a novel composite,using electrospinning technology,consisting of Fe_(3)Se_(4)and porous nitrogen-doped carbon nanofibers was designed for the interlayer of *** porous carbon nanofiber structure facilitates the transport of ions and electrons,while the Fe_(3)Se_(4)material adsorbs lithium polysulfides(LiPSs)and accelerates its catalytic conversion ***,the Fe_(3)Se_(4)material interacts with soluble LiPSs to generate a new polysulfide intermediate,Li_(x)FeS_(y)complex,which changes the electrochemical reaction pathway and facilitates the three-dimensional deposition of Li_(2)S,enhancing the reversibility of *** designed LSB demonstrates a high specific capacity of1529.6 mA h g^(-1)in the first cycle at 0.2 *** rate performance is also excellent,maintaining an ultra-high specific capacity of 779.7 mA h g^(-1)at a high rate of 8 *** investigation explores the mechanism of the interaction between the interlayer and LiPSs,and provides a new strategy to regulate the reaction kinetics and Li_(2)S deposition in LSBs.

关键词： Lithium-sulfur batteries Polysulfide intermediates Li_(2)S electrodeposition Interlayers Electrostatic spinning Adsorption Catalysis