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Tuina alleviates neuropathic pain through regulate the activation of microglia and the secretion of inflammatory cytokine in spinal cord

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Journal of Traditional Chinese Medicine 2024年第4期 762-769页

作者： WU Zhiwei ZHU Qingguang kong lingjun SONG Pengfei ZHOU Xin GUO Guangxin ZHANG Shuaipan HE Tianxiang CHENG Yanbin FANG Min Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Institute of Tuina Shanghai Institute of Traditional Chinese Medicine Shuguang Hospital Shanghai University of Traditional Chinese Medicine Department of Acupuncture and Tuina Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To observe the analgesic effects of Tuina on neuropathic pain(NPP) and the underlying mechanisms. METHODS: Forty-eight Sprague-Dawley(SD) rats were assigned by random into three treatment groups: sham, chronic constriction injury(CCI), and Tuina. Each group contained sixteen rats. CCI model was generated by ligating the right sciatic nerve. Behavioral changes of CCI were assessed by the paw withdrawal threshold(PWT) and paw withdrawal latency(PWL). In addition, biochemical techniques such as immunofluorescence staining, enzyme-linked immunosorbent assay(ELISA) and Western blotting were used to profile levels of microglia activation and inflammatory factors in the spinal dorsal horn(SDH) of rats. Tuina(clockwise pressing and rubbing) was performed at Chengshan(BL57) to observe the analgesic effects on CCI rats and the underlying mechanisms. RESULTS: Rats with CCI experienced significant reduction in the PWT and PWL of the right hind paw relative to CCI group at day 3. Tuina treatment rescued this situation significantly on days 10 and 14. Besides, Iba-1, microglia M1 receptor CD68, tumor necrosis factor-α(TNF-α), and interleukin-1β(IL-1β) were higher in the right SDH for CCI group compared to the sham group on day 14. As expected, Tuina partially downregulated the CCI-induced overexpressed Iba-1, CD68, TNF-α, and IL-1β in the SDH of CCI model. CONCLUSION: Tuina induces a time-dependent cumulative analgesic effect in CCI rats by inhibiting the activation of microglia and the secretion of IL-1β and TNF-α in SDH.

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Design of good QC-LDPC codes without small girth in the p-plane

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Journal of Systems Engineering and Electronics 2011年第2期22卷 183-187页

作者： lingjun kong Yang Xiao Institute of Information Science Beijing Jiaotong University Beijing 100044 E R. China Faculty of Information Engineering and Automation Kunming University of Science and Technology Kunming 650500 P. R. China

A construction method based on the p-plane to design high-girth quasi-cyclic low-density parity-check （QC-LDPC） codes is proposed. Firstly the good points in every line of the p-plane can be ascertained through filtering the bad points, because the designed parity-check matrixes using these points have the short cycles in Tanner graph of codes. Then one of the best points from the residual good points of every line in the p-plane will be found, respectively. The optimal point is also singled out according to the bit error rate （BER） performance of the QC-LDPC codes at last. Explicit necessary and sufficient conditions for the QC-LDPC codes to have no short cycles are presented which are in favor of removing the bad points in the p-plane. Since preventing the short cycles also prevents the small stopping sets, the proposed construction method also leads to QC-LDPC codes with a higher stopping distance.

关键词： quasi-cyclic low-density parity-check （QC-LDPC）codes circulant matrices girth stopping set stopping distance.

LLR calculation for LDPC coded SCBT in 60 GHz WPAN

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Journal of Systems Engineering and Electronics 2010年第5期21卷 734-739页

作者： lingjun kong Yang Xiao Ming Lei Ye Huang Institute of Information Science Beijing Jiaotong University Beijing 100044 E R. China NEC Laboratories NEC Corporation Beijing 100084 P. R. China Communications Technology Laboratories Intel China Research Center Beijing 100080 E R. China

The single-carrier block transmission（SCBT）,a.k.a.,single-carrier frequency-domain equalization（SC-FDE）,is being considered as an option technique for the wireless personal area network（WPAN） operating at 60 GHz.It is found that for residential environment,in non-line-of-sight（NLOS） multi-path channels,the SCBT is much more effective to combat the inter-symbol interference（ISI） compared with orthogonal frequency division multiplexing（OFDM）.Low-density parity-check（LDPC） codes are a class of linear block codes which provide near capacity performance on a large collection of data transmission and storage channels while simultaneously admitting implementable decoders.To facilitate using LDPC codes for SCBT system,a new log-likelihood ratio（LLR） calculation method is proposed based on pilot symbols（PS）.Golay Sequences whose sum autocorrelation has a unique peak and zero sidelobe are used for creating the PS.The position and length of the PS are not fixed in the data blocks.The simulation results show that the proposed method can significantly improve the LDPC decoding performance in SCBT system.This is very promising to support ultra high-data-rate wireless transmission.

关键词： single-carrier block transmission single-carrier frequency-domain equalization low-density parity-check code log-likelihood ratio wireless personal area network.

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采动诱发断层活化响应机制特征研究

煤田地质与勘探 2024年第4期52卷 12-20页

作者：孙文斌郝建邦戴宪政孔令君山东科技大学能源与矿业工程学院山东青岛266590 煤炭资源高效开采与洁净利用国家重点实验室北京100013 陕西省煤矿水害防治技术重点实验室陕西西安710077

在煤矿开采过程中,采动引起的应力扰动是导致断层活化的关键因素,这种断层活化是煤矿安全开采面临的主要挑战之一。断层活化不仅易于诱发煤矿冲击地压、底板突水等地质灾害,而且对开采安全构成重大威胁。为分析采动效应下断层构造带的... 详细信息

在煤矿开采过程中,采动引起的应力扰动是导致断层活化的关键因素,这种断层活化是煤矿安全开采面临的主要挑战之一。断层活化不仅易于诱发煤矿冲击地压、底板突水等地质灾害,而且对开采安全构成重大威胁。为分析采动效应下断层构造带的演化机制,通过Flac^(3D)数值模拟软件及相似材料模拟试验,建立采动条件下断层的应力-位移响应模型,进行相关研究。结果表明:开采过程中,扰动对于应力的影响作用要先比位移产生,且应力会出现峰值;当应力出现峰值,达到屈服极限后,扰动对于位移的影响作用逐渐显现;随着工作面不断推进,采动导致上覆岩层大面积垮落,致使上覆岩层与断层带贯通,并逐渐诱发断层带的活化现象;采动影响下,断层活化并不是一次性全阶段活化,而是由上部到下部的逐渐活化,其具有明显的空间性、阶段性特征。明确了断层活化的发生特征,能够有效提高对于断层活化间接引起的冲击地压、底板突水等一系列地质灾害事故的预警预防,对于煤矿安全高效开采生产具有重要意义。

关键词：断层活化采动影响数值模拟相似试验应力分析

Fabricating high-performance sodium ion capacitors with P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2 and MOF-derived carbon

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Journal of Energy Chemistry 2019年第1期28卷 79-84页

作者： Haichen Gu lingjun kong Huijuan Cui Xianlong Zhou Zhaojun Xie Zhen Zhou School of Materials Science and Engineering National Institute for Advanced Materials Institute of New Energy Material Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University

Sodium ion capacitors(SICs) have been considered as a kind of promising devices to achieve both high power and energy density. However, it is still a challenge to achieve high energy output at elevated power delivery due to the poor rate capability of battery-type electrode materials and the kinetic mismatch with capacitor-type electrode materials. In this work, to fabricate SICs, P2-Na_(0.67)Co_(0.5)Mn_(0.5)O_2(P2-NCM)was chosen as the battery-type cathode material, and a typical metal-organic framework(MOF) material,zeolitic imidazolate framework-8(ZIF-8) derived carbon(ZDC) was utilized as the capacitor-type anode material. Due to the kinetic match and high-rate performance of both electrodes, the ZDC//P2-NCM SICs exhibited an energy output of 18.8 Wh kg^(-1) at a high power delivery of 12.75 kW kg^(-1).

关键词： Energy density Power density P2-phase material Zeolitic imidazolate framework-8 Sodium ion capacitors

Constructing bifunctional Co/MoC@N-C catalyst via an in-situ encapsulation strategy for efficient oxygen electrocatalysis

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Journal of Energy Chemistry 2021年第8期30卷 538-546,I0011页

作者： Hui Huang lingjun kong Ming Liu Jie He Wei Shuang Yunhua Xu Xian-He Bu School of Materials Science and Engineering National Institute for Advanced MaterialsTKL of Metal and Molecule Based Material ChemistryNankai University300071 TianjinChina School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology(Ministry of Education)and Tianjin Key Laboratory of Composite and Functional MaterialsTianjin University300072 TianjinChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai University300071 TianjinChina

The large-scale application of Zn-air battery requires the development of efficient,low-cost,and stable bifunctional electrocatalysts for the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR).Herein,an electrocatalyst of a Co/Mo C-nanoparticles embedded N-doped carbon(Co/Mo C@N-C)was prepared via the in-situ encapsulation of Co_(2)(CO)_(8)and Mo(CO)6 in ZIF-8 using ball-milling,followed by pyrolysis under an Ar atmosphere.When used as a bifunctional electrocatalyst,the as-prepared Co/Mo C@N-C showed an ORR half-wave potential of 0.824 V in an alkaline medium and an overpotential of only 290 m V for the OER at 10 m A cm^(-2),which was 70 m V lower than Ru O_(2).The Co/Mo C@N-C was also evaluated as a cathode in a solid-state Zn-air battery and delivered a higher peak discharge power density and better cycling stability(over 1600 min)than Pt/C-Ru O_(2).Most importantly,our work provides a new strategy to prepare bifunctional catalysts and promotes their applications in the energy conversion field.

关键词： In-situ ZIF-8 Bifunctional electrocatalyst New strategy

Deciphering of advantageous electrocatalytic water oxidation behavior of metal-organic framework in alkaline media

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Nano Research 2021年第12期14卷 4680-4688页

作者： Ming Liu lingjun kong Xuemin Wang Jie He Jijie Zhang Jian Zhu Xian-He Bu School of Materials Science and Engineering National Institute for Advanced MaterialsTKL of Metal and Molecule Based Material ChemistryNankai UniversityTianjin300350China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin300071China

Carboxylic acid-based metal-organic frameworks(MOFs)are normally passed for the“pre-catalysts”for oxygen evolution reaction(OER)due to the hydroxides constructed in-situ during its alkaline hydrolysis process(AHP)in lye.Whereas,it remains a mystery that they show advantageous activity over prototypical hydroxides when they are directly acted as OER catalysts.Herein,we propose for the first time that the steric hindrance effect of Nafion can induce enhanced catalytic activity of such MOFs.Different from conventional catalysts without AHP,the Nafion with 3D structure weakens the AHP of Co-MOF nanoribbons,thus forming small size and low crystallinity species(cobalt hydroxide)with more active sites.And the existence of Nafion also optimizes its electronic structure,which is confirmed by transmission electron microscopy(TEM),in-situ UV absorption spectra,in-situ Raman spectroscopy and so on.Compared with Co-MOF-K obtained by directly immersing the Co-MOF nanoribbons in 1.0 M KOH,the Co-MOF-NK obtained by AHP of Co-MOF mixed with Nafion shows better catalytic activity.Based on the above inspiration,we realized the low overpotential of 268 mV at 10 mA·cm^(−2) by preparing CoFe-MOF-NK.This work provides a new understanding of the structural reconstruction of MOFs in the field of electrocatalysis.

关键词： metal-organic frameworks structural reconstruction Nafion stereo hindrance water oxidation

Interconnected 1D Co3O4 nanowires on reduced graphene oxide for enzymeless H2O2 detection

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Nano Research 2015年第2期8卷 469-480页

作者： lingjun kong Zhiyu Ren Nannan Zheng Shichao Du Jun Wu Jingling Tang Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China School of Chemistry and Materials Science Heilongjiang University Harbin 150080 China Department of Pharmaceutics School of Pharmacy Harbin Medical University Harbin 150086 China

无酶的氢过氧化物(H 2 O 有高敏感和优秀选择的 2 ) 察觉为临床的诊断是合乎需要的。此处，一个维的公司 3 O 4 nanowires 成功地经由一个简单热水的过程和随后的热处理在减少的 graphene 氧化物(rGO ) 上被构造了。这些公司 3 ... 详细信息

无酶的氢过氧化物(H 2 O 有高敏感和优秀选择的 2 ) 察觉为临床的诊断是合乎需要的。此处，一个维的公司 3 O 4 nanowires 成功地经由一个简单热水的过程和随后的热处理在减少的 graphene 氧化物(rGO ) 上被构造了。这些公司 3 O 4 nanowires，由小 nanoparticles 集合了，与对方一起被交叉并且在 rGO 上使一只蜘蛛成为像网的结构。公司的形成 3 O 4 个 -rGO 混血儿被归因于 DDA 的指导结构、抛锚的角色并且分别地去。产生结构为事散开拥有丰富的活跃地点，电子的面向的传播，和未受阻碍的小径，它资助公司 3 O 有优秀 electrocatalytic 性能的 4 个 -rGO 混血儿。作为结果，获得的公司 3 O 4 个 -rGO 混血儿能为 H 用作有效电气化学的催化剂 2 O 2 氧化和高度敏感察觉。在生理的条件下面， H 的氧化电流 2 O 2 与 1.14 妈的敏感从 0.015～0.675 公里关于它的集中线性地变化??????????????

关键词：纳米四氧化三钴过氧化氢纳米石墨氢检测氧化物混合动力车 HepG2细胞连接

A highly active oxygen evolution electrocatalyst： Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly

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Nano Research 2016年第3期9卷 713-725页

作者： Jun Wu Zhiyu Ren Shichao Du lingjun kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China School of Chemistryand Materials Science Heilongjiang University Harbin 150080 China

A cost-efficient and stable oxygen evolution electrocatalyst is essential for improving energy storage and conversion efficiencies. Herein, 2D nanosheets with randomly cross-linked CoNi layered double hydroxide （LDH） and small CoO nanocrystals were designed and synthesized via in situ reduction and interface- directed assembly in air. The formation of CoNi LDH/CoO nanosheets was attributed to the strong extrusion of hydrated metal-oxide clusters driven by the interfacial tension. The obtained loose and porous nanosheets exhibited low crystallinity due to the presence of numerous defects. Owing to the orbital hybridization between metal 3d and O 2p orbitals, and electron transfer between metal atoms through Ni-O-Co, a number of Co and Ni atoms in the CoNi LDH present a high ＋3 valency. These unique characteristics result in a high density of oxygen evolution reaction （OER） active sites, improving the affinity between OH- and catalyst, and resulting in a large accessible surface area and permeable channels for ion adsorption and transport. Therefore, the resulting nanosheets exhibited high catalytic activity towards the OER. The CoNi LDH/CoO featured a low onset potential of 1.48 V in alkaline medium, and required an overpotential of only 300 mV at a current density of 10 mA.cm-2, while displaying good stability in accelerated durability tests.

关键词： CoNi double hydroxide,interface-directedassembly,oxygen evolution reaction,electrocatalysis,nanosheet