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基于积极心理学的动机性访谈对慢性阻塞性肺疾病患者自我效能感及生活质量的影响

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临床医学研究与实践 2024年第30期9卷 150-153页

作者：惠珂刘凌华刘晓梅王晓庆宋敏王君李文婷张秋丽陕西省人民医院呼吸与危重症科陕西西安710068

目的探讨基于积极心理学的动机性访谈对慢性阻塞性肺疾病(COPD)患者自我效能感及生活质量的影响。方法选取2021年8月至2022年8月我院收治的200例COPD患者为研究对象,按照随机数字表法将其分为对照组和观察组,各100例。对照组开展常规护... 详细信息

目的探讨基于积极心理学的动机性访谈对慢性阻塞性肺疾病(COPD)患者自我效能感及生活质量的影响。方法选取2021年8月至2022年8月我院收治的200例COPD患者为研究对象,按照随机数字表法将其分为对照组和观察组,各100例。对照组开展常规护理,观察组在常规护理的基础上开展基于积极心理学的动机性访谈。比较两组的护理效果。结果护理后,观察组的第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)及最大通气量(MVV)高于对照组(P<0.05)。护理后,观察组的焦虑自评量表(SAS)、抑郁自评量表(SDS)评分低于对照组(P<0.05)。护理后,观察组的一般自我效能感量表(GSES)评分高于对照组,慢性阻塞性肺病评估测试(CAT)评分低于对照组(P<0.05)。观察组的护理满意度高于对照组(P<0.05)。结论基于积极心理学的动机性访谈可改善COPD患者的心理状态,提高肺功能、自我效能感、生活质量及护理满意度。

关键词：积极心理学动机性访谈慢性阻塞性肺疾病自我效能感

Therapeutic Efficacy of Complex Decongestive Therapy in the Treatment of Elephantiasis of the Lower Extremities

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第1期2卷 40-43,62页

作者： Jiajia CHEN Li WANG linghua HAN Ningfei liu Ziyou YU Lymphology Centre of Department of Plastic&Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Objective To evaluate the therapeutic efficacy of complex decongestive therapy in the treatment of elephantiasis of the lower *** Seventeen patients with unilateral lower limb elephantiasis were included in the study(5 with primary lymphedema and 12 with secondary lymphedema).All patients were treated with one course(4 weeks)of complex decongestive *** inextracellular fluid(ECF),BMI,circumferences,and skin properties including skin stiffness(SF),percent water content(PWC),and trans-epidermal water loss(TEWL)were measured before and after *** The“elephantiasis-like”appearance of the affected limb was greatly improved after *** ECF,BMI,and circumferences were significantly decreased after treatment(P<0.001)with an average ECF of 2.97±1.82 L,BMI of 1.638±2.647 kg/m^2,and circumference of 6.58±2.79 *** values of PWC,TEWL,and SFwere 50.5%±10.6%,18.55±10.2 g/m^2 h,and 0.161±0.176 N,respectively,before treatment and 36.05%±7%,8.3±2.07 g/m^2h,and 0.086±0.038 N,respectively,after treatment,there by showing significant decreases(P<0.05).Conclusion Complex decongestive therapy is effective in the treatment of advanced stages of chronic lymphedema.

关键词： Lymphedema elephantiasis manual lymph drainage complex decongestive therapy skin

Differentiation of embryonic stem cells into corneal epithelium

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Science China(Life Sciences) 2005年第5期48卷 471-480页

作者： WANG Zhichong GE Jian HUANG Bing GAO Qianying liu Bingqian WANG linghua YU Ling FAN Zhigang LU Xiaoming liu Jingbo Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Our project was to determine whether embryonic stem (ES) cells could be induced to differentiate into corneal epithelia by superficial corneoscleral limbal stroma. To achieve this goal, ES-GFP cell line D3 was pre-induced by retinoic acid (RA). The pre-induced cells were seeded on deepithelialized superficial corneoscleral slices (SCSS) to form a monolayer, and di-vided into three groups. Group 1 was cultured and passaged in vitro for direct detection. Group 2 was exposed to air-liquid interfaces for 10 days and implanted into the subcutaneous layer of nude mice for 2 weeks for further induction in vivo. Group 3 was cultured in vitro without any in-ducing factors for control. There were no teratomas found in nude mice which were implanted with differentiated ES cells after two weeks. The differentiated cells showed an appearance of epithelia both in vitro and in vivo. Expression of CK3, P63 and PCNA was detected by immuno-histochemical staining in the differentiated cells in group 1 and 2. Microvillis and zonula oc-cludens were observed on the surface of the differentiated cells under an electron microscope. In the control group, ES cells differentiated freely without any inducing factors. Most cells were shed and formed a neuronal dendrite-like structure, and a minority of cells appeared polymorphic. These results demonstrate that ES cells can differentiate into corneal epithelia on the surface of SCSS under the controlled condition. Differentiated ES cells could be used as epithelial seeding cells for the reconstruction of ocular surface and corneal tissue engineering in the future.

关键词： embryonic stem cells, differentiation, corneal epithelium, microenvironment, superficial corneoscleral limbal stroma.

Radial propagation of magnetospheric substorm-injected energetic electrons observed using a BD-IES instrument and Van Allen Probes

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Science China Earth Sciences 2016年第7期59卷 1508-1516页

作者： ZONG QiuGang HAO YiXin ZOU Hong FU SuiYan ZHOU XuZhi REN Jie WANG linghua YUAN ChongJing liu ZhiYang JIA XiangHong QUAN Lin liu Ying WANG YongFu Institute of Space Physics and Applied Technology Peking UniversityBeijing 100871China Institute of Geology and Geophysics Chinese Atcademy of SciencesBeijing 100029China State Key Laboratory of Space Medicine Fundamentals and Application Chinese Astronaut Research and Training CenterBeijing 100094China Beijing Institute of Tracking and Telecommunications Technology Beijing 100094China

In cases where substorm injections can be observed simultaneously by multiple spacecraft,they can help elucidate the potential mechanisms of particle transport and energization,of great importance to understanding and modeling the *** this paper,using data returned from the BeiDa-IES（BD-IES） instrument onboard a satellite in an inclined（55°） geosynchronous orbit（IGSO）,in combination with two geo-transfer orbiting（GTO） satellite Van Allen Probes（A and B）,we analyze a substorm injection event that occurred on the 16 th of October *** this substorm injection,the IGSO onboard BD-IES was outbound,while both Van Allen Probe satellites（A and B） were inbound,a configuration of multiple trajectories that provides a unique opportunity to simultaneously investigate both the inward and outward radial propagation of substorm *** by AE/AL indices,this substorm was closely related to an IMF/solar wind discontinuity that showed a sharp change in IMF Bz direction to the *** innermost signature of this substorm injection was detected by Van Allen Probes A and B at L-3.7,while the outermost signature was observed by the onboard BD-IES instrument at *** data indicate that the substorm had a global,rather than just local,***,we suggest that electric fields carried by fast-mode compressional waves around the substorm injection are the most likely candidate mechanism for the electron injection signatures observed in the inner- and outermost inner magnetosphere.

关键词： Substonn injection Energetic electrons Energetic particle acceleration Drift Dispersionless injection

Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer

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Cancer Biology & Medicine 2019年第1期16卷 66-78页

作者： Yuxiang Wang Xian Li Xueling liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding linghua Meng Division of Anti-Tumor Pharmacology Shanghai Institute of Materia Medica Chinese Academy of Sciences University of Chinese Academy of Sciences Division of Anti-Tumor Pharmacology State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Department of Medicinal Chemistry Shanghai Institute of Materia Medica Chinese Academy of Sciences

Objective: Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer(NSCLC).However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important role in tumorigenesis and drug resistance in NSCLC. The activity of PI3Kα-selective inhibition against KRAS-mutated NSCLC remains largely ***: Cell proliferation was detected by sulforhodamine B assay. Cell cycle distribution and apoptosis were measured by flow cytometry. Cell signaling was assessed by Western blot and immunohistochemistry. RNA interference was used to down-regulate the expression of cyclin D1. Human NSCLC xenografts were employed to detect therapeutic efficacy in ***: CYH33 possessed variable activity against a panel of KRAS-mutated NSCLC cell lines. Although CYH33 blocked AKT phosphorylation in all tested cells, Rb phosphorylation decreased in CYH33-sensitive, but not in CYH33-resistant cells, which was consistent with G1 phase arrest in sensitive cells. Combined treatment with the CDK4/6 inhibitor, PD0332991, and CYH33 displayed synergistic activity against the proliferation of both CYH33-sensitive and CYH33-resistant cells, which was accompanied by enhanced G1-phase arrest. Moreover, down-regulation of cyclin D1 sensitized NSCLC cells to CYH33. Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells. Co-treatment with these two drugs demonstrated synergistic activity against A549 and H23 xenografts, with enhanced inhibition of Rb ***: Simultaneous inhibition of PI3Kα and CDK4/6 displayed synergistic activity against KRAS-mutated NSCLC. These data provide a mechanistic rationale for the combination of a PI3Kα inhibitor and a CDK4/6 inhibitor for the treatment of KRASmutated NSCLC.

关键词： PI3Kα CDK4/6 KRAS NSCLC CYH33

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生育对城镇体制内女性工资收入的影响

人口与经济 2018年第5期 10-19页

作者：刘娜卢玲花湘潭大学商学院湖南湘潭411105

聚焦受计划生育政策严格限制的我国城镇体制内女职工群体,探究生育行为对女职工工资收入的影响。利用中国家庭追踪调查(CFPS) 2010、2012及2014年三期混合截面数据展开的2SLS回归分析证实,生育子女对城镇体制内女职工工资收入存在显著... 详细信息

聚焦受计划生育政策严格限制的我国城镇体制内女职工群体,探究生育行为对女职工工资收入的影响。利用中国家庭追踪调查(CFPS) 2010、2012及2014年三期混合截面数据展开的2SLS回归分析证实,生育子女对城镇体制内女职工工资收入存在显著的负向影响。每多生育一个孩子,女职工工资率将显著下降18. 4%,月工资亦显著下降15. 9%。此"生育工资惩罚"效应在生育一孩时较生育二孩时边际影响更大,对受教育程度较低或没有管理职务的女职工影响更强。政策层面,应重点关注体制内家庭生育意愿的动态变化,推动和完善职业职务配套鼓励措施,为我国顺利推进"全面二孩"政策保驾护航。

关键词：生育工资惩罚体制内全面二孩工具变量法

“移动战伤单元”16排移动CT头部扫描试验报告

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中华神经创伤外科电子杂志 2020年第4期6卷 214-218页

作者：王松叶易蕊段利达张震侯国峰张志强王振方刘凌华于强栗志利荆亚新代秋声徐如祥 66242部队医院内蒙古苏尼特右旗011299 解放军总医院第七医学中心神经外科北京100700 66019部队卫生连内蒙古苏尼特右旗011299 江苏摩科特医疗科技有限公司苏州215123 北创动力(北京)科技发展有限公司北京100050

目的探讨国产16排移动CT在救护车运载条件下进行头部扫描成像的可行性。方法选取陆军某部训练基地的志愿者健康官兵95人,随机分为3组:Ⅰ组(77人),救护车在停止行驶状态下进行头部扫描;Ⅱ组(11人),救护车在行驶状态下进行头部扫描;Ⅲ组(7... 详细信息

目的探讨国产16排移动CT在救护车运载条件下进行头部扫描成像的可行性。方法选取陆军某部训练基地的志愿者健康官兵95人,随机分为3组:Ⅰ组(77人),救护车在停止行驶状态下进行头部扫描;Ⅱ组(11人),救护车在行驶状态下进行头部扫描;Ⅲ组(7人),设置电磁波干扰环境。分析对比3组受检者在不同状态下,移动CT扫描成像质量、运动伪影、数据采集及信息传输情况。结果骨窗成像:3组受检者颅骨、眼眶、鼻蝶窦等成像清晰。脑组织窗成像:3组受检者均可清晰显示眼球、视神经、脑干、脑皮质及脑白质等结构,但颅底部分层面均存在不同程度的运动伪影,其中Ⅰ组16.88%(13/77)受检者有较轻微的线状运动伪影,Ⅱ组81.82%(9/11)受检者有较明显的运动伪影;Ⅲ组14.29%(1/7)受检者有轻微线状运动伪影。经χ^2检验,Ⅰ组、Ⅲ组分别与Ⅱ组比较,差异均有统计学意义(χ^2=21.645、7.901,均P0.05)。在电磁干扰状态下,移动CT数据采集及信息传输正常,3组辐射剂量CTDIvol均为36.27 mGy。结论16排移动CT在救护车行驶及电磁干扰状态下扫描成像稳定安全,数据采集及信息传输正常。

关键词：移动CT CT扫描头部成像救护车

泰安城区地下水中挥发性和半挥发性有机物特征与健康风险评价

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环境污染与防治 2024年第2期46卷 208-215页

作者：刘乾孟令华中化地质矿山总局山东地质勘查院山东泰安271000

为查清泰安城区地下水有机污染现状,对《地下水质量标准》(GB/T 14848—2017)中规定的26项挥发性和半挥发性有机物组分进行检测,并利用健康风险评价模型对饮水摄入、皮肤接触、洗浴呼吸吸入3种暴露途径产生的非致癌风险和致癌风险进行... 详细信息

为查清泰安城区地下水有机污染现状,对《地下水质量标准》(GB/T 14848—2017)中规定的26项挥发性和半挥发性有机物组分进行检测,并利用健康风险评价模型对饮水摄入、皮肤接触、洗浴呼吸吸入3种暴露途径产生的非致癌风险和致癌风险进行评价。研究结果表明:地下水样品中挥发性和半挥发性有机物检出率为35.34%,15项被检出的组分中,1,1,2-三氯乙烷检出率最高,为16.38%,其次为四氯乙烯(12.07%)和三氯乙烯(6.90%)。与GB/T 14848—2017的Ⅲ类水标准限值相比,挥发性和半挥发性有机物总超标率为5.17%,出现超标的组分为1,1,2-三氯乙烷、三氯乙烯、苯并(a)芘,最大检出质量浓度分别为26.90、149.00、0.024μg/L,为标准值的5.38、2.13、2.40倍,表明研究区地下水已受到一定程度的有机污染。挥发性和半挥发性有机物非致癌风险指数介于1.52×10^(-6)~1.48,均值为4.33×10^(-2),超限率仅为0.86%,非致癌风险较低,对人体的健康危害程度小;致癌风险值介于2.04×10^(-9)~3.37×10^(-5),均值为1.77×10^(-6),超限率为6.90%,风险点呈点状分布,引起致癌风险的组分为1,1,2-三氯乙烷、三氯甲烷、三氯乙烯,需重点关注和控制。非致癌风险和致癌风险的主要暴露途径均为饮水摄入,皮肤接触和洗浴呼吸吸入产生的风险可以忽略。研究成果对泰安城区地下水供水安全和有机污染防治具有指导意义。

关键词：地下水挥发性和半挥发性有机物健康风险评价泰安

基于DV-Hop算法的无线传感器网络定位精度优化

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激光与光电子学进展 2021年第22期58卷 490-496页

作者：刘川洲张玲华南京邮电大学通信与信息工程学院江苏南京210003 南京邮电大学江苏省通信与网络技术工程研究中心江苏南京210023

在无线传感器网络定位领域,DV-Hop算法因其实现简单得以广泛使用。针对DV-Hop算法定位误差较大的问题,提出一种基于DV-Hop多通信半径的加权定位算法。该算法利用多通信半径并通过引入修正因子细化和优化跳数,利用最小均方误差准则和加... 详细信息

在无线传感器网络定位领域,DV-Hop算法因其实现简单得以广泛使用。针对DV-Hop算法定位误差较大的问题,提出一种基于DV-Hop多通信半径的加权定位算法。该算法利用多通信半径并通过引入修正因子细化和优化跳数,利用最小均方误差准则和加权方式修正平均跳距,并利用加权最小二乘法估算未知节点坐标。通过仿真得出所提算法在相同实验条件下的定位精度较DV-Hop算法提升约60.5%,相较于双通信半径优化算法和3-DV-Hop算法分别提升约36.4%和13.8%。

关键词：传感器无线传感器网络 DV-Hop 节点定位最小均方误差加权最小二乘法