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The suppression of cervical cancer ferroptosis by macrophages:The attenuation of ALOX15 in cancer cells by macrophages-derived exosomes

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2645-2662页

作者： Yanlin Luo Yibing Chen Huan Jin Benxin Hou Hongsheng Li Xiang Li lingfeng liu Yuan Zhou Yonghua Li Yong Sang Song Quentin liu Zhengzhi Zou Department of Gynecologic Oncology the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450001China MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science Guangdong Provincial Key Laboratory of Laser Life ScienceCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Institute of Clinical Pharmacology School of Basic Medical ScienceAcademy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Genetic and Prenatal Diagnosis Center Department of Gynecology and ObstetricsFirst Affiliated HospitalZhengzhou UniversityZhengzhou 450001China Department of General Surgery the Third People's Hospital of Hainan ProvinceSanya 572000China Department of Breast Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China Department of Obstetrics and Gynecology Cancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 03080South Korea State Key Laboratory of Oncology in South China Cancer CenterSun Yat-sen UniversityGuangzhou 510631China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Induction of cancer cell ferroptosis has been proposed as a potential treatment in several cancer ***-associated macrophages(TAMs)play a key role in promoting tumor malignant progression and therapy ***,the roles and mechanisms of TAMs in regulating tumor ferroptosis is still unexplored and remains *** study shows ferroptosis inducers has shown therapeutic outcomes in cervical cancer in vitro and in *** have been found to suppress cervical cancer cells ***,macrophage-derived miRNA-660-5p packaged into exosomes are transported into cancer *** cancer cells,miRNA-660-5p attenuates ALOX15 expression to inhibit ***,the upregulation of miRNA-660-5p in macrophages depends on autocrine IL4/IL13-activated STAT6 ***,in clinical cervical cancer cases,ALOX15 is negatively associated with macrophages infiltration,which also raises the possibility that macrophages reduce ALOX15 levels in cervical ***,both univariate and multivariate Cox analyses show ALOX15 expression is independent prognostic factor and positively associated with good prognosis in cervical ***,this study reveals the potential utility of targeting TAMs in ferroptosis-based treatment and ALOX15 as prognosis indicators for cervical cancer.

关键词： Cervical cancer Tumor-associated macrophage ALOX15 Ferroptosis Exosome miRNA-660-5p Macrophages infiltration STAT6

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Single-shot non-line-of-sight imaging based on chromato-axial differential correlography

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Photonics Research 2024年第1期12卷 106-114页

作者： lingfeng liu SHUO ZHU WENJUN ZHANG LIANFA BAI ENLAI GUO JING HAN Jiangsu Key Laboratory of Spectral Imaging and Intelligent Sense Nanjing University of Science and TechnologyNanjing 210094China

Non-line-of-sight(NLOS)imaging is a challenging task aimed at reconstructing objects outside the direct view of the ***,traditional NLOS imaging methods typically rely on intricate and costly equipment to scan and sample the hidden *** methods often suffer from restricted imaging resolution and require high system ***,we propose a single-shot high-resolution NLOS imaging method via chromato-axial differential correlography,which adopts low-cost continuous-wave lasers and a conventional *** leveraging the uncorrelated laser speckle patterns along the chromato-axis,this method can reconstruct hidden objects of diverse complexity using only one exposure *** achieved background stability through singleshot acquisition,along with the inherent information redundancy in the chromato-axial differential speckles,enhances the robustness of the system against vibration and colored stain *** approach overcomes the limitations of conventional methods by simplifying the sampling process,improving system stability,and achieving enhanced imaging resolution using available *** work serves as a valuable reference for the real-time development and practical implementation of NLOS imaging.

关键词： axial speckle overcome

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Study on the Formalized Development of the Street Stall Economy-based on Domestic and International Experiences and Perspectives

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Journal of Economic Science Research 2021年第4期4卷 6-12页

作者： Yixuan Chen lingfeng liu Hao liu Yukun Sun Xi’an Jiaotong Liverpool University SuzhouJiangsu215123China Georgia Institute of Technology United States Beijing University of Posts and Telecommunications BeijingChina City University of Macao MacaoChina

The ground-floor economy has a long history as a significant part of the informal *** to the dependence on its own social status and relationship to the government’s political and economic objectives,it has developed precariously in recent *** the face of post-epidemic problems,a shortcut is to learn from international *** paper used the structural theory and drew from the secondary data,demonstrating the background of informal economy and exploring the rational ways to maintain and develop street ***,legalization and network digitization are proven international approaches,which display the empirical and theoretical implications to urban practice and studies.

关键词： Street stall economy Post-epidemic International experience Spatialization Legalization Pluralistic autonomy Network digitization

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Real time monitoring of nucleic acids ligation based on molecular beacon

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Chinese Science Bulletin 2003年第12期48卷 1215-1218页

作者： Zhiwen Tang Kemin Wang Weihong Tan Jun Li lingfeng liu Qiuping Guo Xiangxian Meng Shasheng Huang Du Li Weifang Luo Hunan Univ Coll Chem & Chem Engn Inst Biol Technol State Key Lab Chemobiosensing & Chemometr Changsha 410082 Peoples R China

A novel method has been developed to monitor the nucleic acids ligation process. Molecular beacon was employed here to convert the ligation information into fluo-rescence signal quickly and quantitatively. This method pro-vides effective and original approach to researching the dy-namic ligation process and the interactions between nucleic acids and ligase. An analytical method for T4 DNA ligase based on this way has been built up with a linear detection range from 2.3×10-4 U/mL to 0.23 U/mL. It is rapid and sensitive to detect 2.8×10-5 U T4 DNA ligase in 10 min.

关键词： nucleic acids ligation T4 DNA ligase real time assay molecular beacon.

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Experimental research on knuckle pattern recognition algorithm based on transfer learning

Experimental research on knuckle pattern recognition algorit...

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第40届中国控制会议

作者： CHEN Hongli liu lingfeng XIA Xiaojing College of Intelligent Systems Science and Engineering Harbin Engineering University Shanghai Electro-Mechanical Engineering Institute

Aiming at the cumbersome feature extraction of traditional machine learning algorithms and the common problems of single feature and low recognition accuracy,a convolutional neural network model that can extract image features by itself is used to conduct experimental research on the task of knuckle pattern recognition and *** pre-processing the knuckle pattern image,design a pre-training network model of the Vgg-16 architecture to perform migration learning on the knuckle pattern data *** order to improve the portability and overfitting of the pre-training network,the pre-training network Part of the layer thawing and the classifier are jointly trained,the pre-training network model is fine-tuned and optimized,and the parameter abandonment method is *** analysis of the experimental results shows that the pre-training network model is more suitable for the recognition and classification tasks of this experiment after fine-tuning and *** recognition accuracy of the network model on the test set is further increased,which enhances the generalization ability of the pre-training network in this experiment The analysis of the experimental results shows that the pre-training network model is more suitable for the recognition and classification tasks of this experiment after fine-tuning and *** recognition accuracy of the network model on the test set is further increased,which enhances the generalization ability of the pre-training network in this experiment.

关键词： Deep learning Knuckle pattern recognition Convolutional neural network Transfer learning

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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli Li Lemei Zhu lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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C/C热防护结构弹性波仿真分析方法及损伤对弹性波的影响

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复合材料学报 2019年第10期36卷 2448-2457页

作者：袁慎芳刘凌峰邱雷陈健刘安琪南京航空航天大学机械结构力学及控制国家重点实验室结构健康监测与预测研究中心

热防护结构(Thermal protection structures,TPS)作为可重复使用航天飞行器的关键结构,其安全性和可维护性至关重要。已有的针对可重复使用航天飞行器TPS的结构健康监测的研究不多,特别是C/C、C/SiC等复合材料制造的TPS。针对可重复使... 详细信息

热防护结构(Thermal protection structures,TPS)作为可重复使用航天飞行器的关键结构,其安全性和可维护性至关重要。已有的针对可重复使用航天飞行器TPS的结构健康监测的研究不多,特别是C/C、C/SiC等复合材料制造的TPS。针对可重复使用航天飞行器C/C TPS,研究其基于主动弹性波的结构健康监测方法。提出了一种TPS弹性波数值仿真方法,在验证方法有效性的基础上,开展了面向C/C TPS损伤监测的弹性波传播特性研究,从信号时域特征、弹性波传播波场、损伤散射信号、损伤散射信号波场及损伤因子5个方面全面分析了弹性波在C/C TPS中的传播特性及损伤带来的影响。结果表明,当分层损伤边长大于25mm后,损伤因子剧烈变化,因此采用基于弹性波的结构健康监测方法可以很好地监测C/C TPS内部分层损伤及损伤的扩展情况。

关键词：热防护结构(TPS) C/C 弹性波损伤监测数值仿真

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港珠澳大桥岛隧工程建造技术

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东南大学学报（自然科学版） 2023年第6期53卷 955-964页

作者：林鸣裴岷山刘晓东林巍刘凌锋中国交通建设集团有限公司北京100088 ²中交公路规划设计院有限公司北京100088

港珠澳大桥是世界最长的跨海大桥,主通航孔临近中国香港机场,为了不影响中国香港机场,采用了6.7km沉管隧道方案,在隧道两端各修建了一个人工岛实现桥隧转换,港珠澳大桥沉管隧道是我国第一次建设的大型跨海沉管隧道.岛隧工程是港珠澳大... 详细信息

港珠澳大桥是世界最长的跨海大桥,主通航孔临近中国香港机场,为了不影响中国香港机场,采用了6.7km沉管隧道方案,在隧道两端各修建了一个人工岛实现桥隧转换,港珠澳大桥沉管隧道是我国第一次建设的大型跨海沉管隧道.岛隧工程是港珠澳大桥的控制性工程,工程位于开散海域,水文气象地质条件复杂;珠江口是世界最繁忙的通航海域之一,安全风险很大.同时,工程需要穿越中华白海豚核心保护区,在生态环境保护方面具有很大挑战性,对港珠澳大桥采用设计施工总承包模式进行建设,并研发了快速筑岛和跨海沉管隧道成套技术.结果表明,在岛隧工程7a的大规模海上工程建设中,实现了安全零伤亡,珠江口白海豚保护区的生物种群和生态环境得到了良好的保护.

关键词：港珠澳大桥岛隧工程人工岛沉管隧道钢圆筒筑岛

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FRP管混凝土桩与钢管混凝土桩黏结性能对比分析

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东南大学学报（自然科学版） 2019年第5期49卷 933-939页

作者：王正振龚维明戴国亮刘凌锋东南大学混凝土及预应力混凝土结构教育部重点实验室南京210096 东南大学土木工程学院南京210096

为对比研究FRP管混凝土桩和钢管混凝土桩的黏结性能,进行了4组推出试验,分析了黏结方式、混凝土种类、试件长细比、外管壁厚等对黏结性能的影响.结果表明:相同试验条件下,钢管混凝土试件的黏结强度明显大于FRP管混凝土试件;使用膨胀混... 详细信息

为对比研究FRP管混凝土桩和钢管混凝土桩的黏结性能,进行了4组推出试验,分析了黏结方式、混凝土种类、试件长细比、外管壁厚等对黏结性能的影响.结果表明:相同试验条件下,钢管混凝土试件的黏结强度明显大于FRP管混凝土试件;使用膨胀混凝土、增大试件长径比及增大外管壁厚均可提高试件的黏结强度,但使用膨胀混凝土的提高效果最明显,可使其增大近10倍;不同的黏结方式下,应变随滑移量及截面高度的变化关系不同,对于直接黏结型试件,靠近荷载施加部位的应力首先发挥,而螺纹型试件的应变沿整个试件高度同时发挥.

关键词： FRP管混凝土桩钢管混凝土桩推出试验黏结强度对比分析

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新时期大学教师职业角色研究综述及其研究框架构建

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广东交通职业技术学院学报 2024年第3期23卷 102-107页

作者：刘灵凤广东交通职业技术学院广东广州510650

教师是促成国家职业教育变革的关键因素,不仅要具备知识传递、科学研究的能力,更要具备服务社会发展的职能。随着人工智能、大数据等技术的发展,大学教师的职业角色面临着被工具化、边缘化和模糊化的危机,如何明晰角色使命并通过实践提... 详细信息

教师是促成国家职业教育变革的关键因素,不仅要具备知识传递、科学研究的能力,更要具备服务社会发展的职能。随着人工智能、大数据等技术的发展,大学教师的职业角色面临着被工具化、边缘化和模糊化的危机,如何明晰角色使命并通过实践提升认知成为教师发展的一个重要命题。本文在梳理近年国内外针对大学教师角色认知及其影响因素的文献基础上,构建了大学教师职业角色“影响因素-认知评价-应对策略”的研究框架,可以为后续的教师角色认知提升研究提供支撑。

关键词：大学教师教师角色角色认知影响因素职业角色

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