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汉黄芩素通过NRF2/HO-1信号途径诱导大鼠CIA-FLS细胞铁死亡

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中国病理生理杂志 2024年第7期40卷 1276-1282页

作者：何凌飞张超凡连杰申傲轩董倩男康晓吴昊湖北恩施学院湖北恩施455099

目的:探讨汉黄芩素(WOG)通过核因子E2相关因子2(NRF2)/血红素加氧酶1(HO-1)信号途径诱导胶原诱导性关节炎大鼠成纤维细胞样滑膜细胞(大鼠CIA-FLS细胞)铁死亡的机制。方法:将大鼠CIA-FLS细胞分为:对照组、低、中、高剂量(25、50和100μmo... 详细信息

目的:探讨汉黄芩素(WOG)通过核因子E2相关因子2(NRF2)/血红素加氧酶1(HO-1)信号途径诱导胶原诱导性关节炎大鼠成纤维细胞样滑膜细胞(大鼠CIA-FLS细胞)铁死亡的机制。方法:将大鼠CIA-FLS细胞分为:对照组、低、中、高剂量(25、50和100μmol/L)汉黄芩素组、铁死亡抑制剂(LIP-1)组、LIP-1+高剂量汉黄芩素组、HO-1激动剂钴原卟啉(COPP)组和COPP+高剂量汉黄芩素组,CCK-8法检测细胞活力;结晶紫染色法检测细胞形态;检测氧化应激标志物谷胱甘肽(GSH)、丙二醛(MDA)和超氧化物歧化酶(SOD)的水平;DCFH-DA荧光探针检测细胞内活性氧(ROS)的含量,Western blot检测Kelch样ECH关联蛋白1(KEAP-1)、NRF2和HO-1蛋白表达水平。结果:与正常对照组相比,给予WOG处理后,大鼠CIA-FLS细胞活力显著下降(P<0.01),氧化应激水平显著上升(P<0.01),ROS含量显著增加(P<0.01),NRF2和HO-1蛋白表达水平显著下降(P<0.01),KEAP-1水平显著增加(P<0.01);与WOG组相比,LIP-1处理组的细胞活力显著上升(P<0.01),氧化应激水平显著下降(P<0.01),ROS含量显著减少(P<0.01);与WOG组相比,加入COPP后,NRF2和HO-1蛋白表达水平显著上升(P<0.01),KEAP-1水平显著下降(P<0.01)。结论:WOG能通过NRF2/HO-1信号途径,促进氧化应激来诱导大鼠CIA-FLS细胞铁死亡。

关键词：汉黄芩素类风湿关节炎 CIA-FLS细胞 NRF2/HO-1信号通路铁死亡

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The Necessary and Sufficient Conditions of Exponential Stability for heat and Wave Equations with Memory

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Journal of Systems Science & Complexity 2024年第3期37卷 1037-1051页

作者： LI lingfei ZHANG Xiaoyi ZHOU Xiuxiang School of Science Northeast Electric Power UniversityJilin 132012China School of Mathematics and Statistics Lingnan Normal UniversityZhanjiang 524048China

This paper is addressed to a study of the stability of heat and wave equations with *** necessary and sufficient conditions of the exponential stability are investigated by the theory of Laplace transform. The results show that the stability depends on the decay rate and the coefficient of the kernel functions of the memory. Besides, the feedback stabilization of the heat equation is obtained by constructing finite dimensional controller according to unstable eigenvalues. This stabilizing procedure is easy to operate and can be applicable for other parabolic equations with memory.

关键词： Memory stability stabilization

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GraphFlow+:Exploiting Conversation Flow in Conversational Machine Comprehension with Graph Neural Networks

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Machine Intelligence Research 2024年第2期21卷 272-282页

作者： Jing Hu lingfei Wu Yu Chen Po Hu Mohammed J.Zaki School of Computer Science Central China Normal UniversityWuhan 430079China Pinterest San Francisco 94016USA Meta Mountain View 94039USA Rensselaer Polytechnic Institute Troy 12180USA

The conversation machine comprehension(MC)task aims to answer questions in the multi-turn conversation for a single ***,recent approaches don’t exploit information from historical conversations effectively,which results in some references and ellipsis in the current question cannot be *** addition,these methods do not consider the rich semantic relationships between words when reasoning about the passage *** this paper,we propose a novel model GraphFlow+,which constructs a context graph for each conversation turn and uses a unique recurrent graph neural network(GNN)to model the temporal dependencies between the context graphs of each ***,we exploit three different ways to construct text graphs,including the dynamic graph,static graph,and hybrid graph that combines the *** experiments on CoQA,QuAC and DoQA show that the GraphFlow+model can outperform the state-of-the-art approaches.

关键词： Conversational machine comprehension(MC) reading comprehension question answering graph neural networks(GNNs) natural language processing(NLP)

PbGIF1 promoting cell-proliferation in pear fruit is transcriptionally activated by Pb RR1

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Horticultural Plant Journal 2024年第3期10卷 689-697页

作者： Huibin Wang Guangya Sha Rui Gao Jianwen Pang Rui Zhai Chengquan Yang Zhigang Wang lingfei Xu College of Horticulture Northwest A&F UniversityYanglingShaanxi 712100China College of Life Science Hebei Agricultural UniversityBaodingHebei 071000China

As a cell proliferation regulator involved in wide biological processes in plants,GRF-INTERACTING FACTOR(GIF)controls different tissues ***,whether GIF participates in fruit development remains *** to transcriptome data,we identified PbGIF1was highly expressed during fruit development in cytokinins induced parthenocarpy *** the present study,the biofunction of PbGIF1 was initially *** of PbGIF1 promoted fruit size of transgenic *** size of flesh fruit was not affected by cell expansion but the cell proliferation was promoted by overexpressing Pb *** accelerated cell proliferation process was also observed in PbGIF1-overexpressed transgenic pear fruit *** transcriptional regulation of cytokinins on PbGIF1 was further confirmed by exogenous CPPU treatments in pear *** investigate the underlying mechanism,the cytokinins-responded factor,PbRR1,was further focused *** results of Yeast-one-hybrid assay suggested that PbRR1 can bind to the promoter sequence of *** transcriptional activation of PbRR1 on PbGIF1 was also confirmed by Dual-Luciferase *** together,the results showed that cytokinins control pear fruit development via the transcriptional activation of PbGIF1 by PbRR1.

关键词： PbGIF1 Cell proliferation Pear Fruit development Cytokinins PbRR1

heavy metal pollution and health risk in China

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Global health Journal 2017年第1期1卷 47-55页

作者： Rian Yu lingfei he Ridong Cai Biyun Li Zhipeng Li Kedi Yang Department of Occupational and Environmental health School of Public HealthGuangdong Pharmaceutical UniversityGuangzhouGuangdong 510310China The First Affiliated Hospital of Guangdong Pharmaceutical University GuangzhouGuangdong 510080China Fuyong Institute for Prevention and health Care Bao'an DistrictShenzhenGuangdong 518103China Department of Occupational and Environmental health MOE Key Lab of Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Following rapid social and economic development over the past several decades,pollution by heavy metals has been both serious and widespread in many areas of the world,including *** situations of heavy metal pollution in China were reviewed,and the health risk and control policy of such pollution were also analyzed and discussed in present paper.

关键词： heavy metal metal pollution health risk

Insights on advanced g‐C_(3)N_(4)in energy storage:Applications,challenges,and future

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Carbon Energy 2024年第4期6卷 22-78页

作者： Xiaojie Yang Jian Peng lingfei Zhao Hang Zhang Jiayang Li Peng Yu Yameng Fan Jiazhao Wang Huakun Liu Shixue Dou School of Nuclear Technology and Chemistry&Biology Hubei Key Laboratory of Radiation Chemistry and Functional MaterialsHubei University of Science and TechnologyXianningChina Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South WalesAustralia State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanChina Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghaiChina

Graphitic carbon nitride(g‐C_(3)N_(4))is a highly recognized two‐dimensional semiconductor material known for its exceptional chemical and physical stability,environmental friendliness,and pollution‐free *** remarkable properties have sparked extensive research in the field of energy *** review paper presents the latest advances in the utilization of g‐C_(3)N_(4)in various energy storage technologies,including lithium‐ion batteries,lithium‐sulfur batteries,sodium‐ion batteries,potassium‐ion batteries,and *** of the key strengths of g‐C_(3)N_(4)lies in its simple preparation process along with the ease of optimizing its material *** possesses abundant amino and Lewis basic groups,as well as a high density of nitrogen,enabling efficient charge transfer and electrolyte solution ***,the graphite‐like layered structure and the presence of largeπbonds in g‐C_(3)N_(4)contribute to its versatility in preparing multifunctional materials with different dimensions,element and group doping,and conjugated *** characteristics open up possibilities for expanding its application in energy storage *** article comprehensively reviews the research progress on g‐C_(3)N_(4)in energy storage and highlights its potential for future applications in this *** exploring the advantages and unique features of g‐C_(3)N_(4),this paper provides valuable insights into harnessing the full potential of this material for energy storage applications.

关键词： g‐C_(3)N_(4) lithium‐ion batteries lithium‐sulfur batteries potassium‐ion batteries sodium‐ion batteries supercapacitors

Advances in research and utilization of botanical pesticides for agricultural pest management in Inner Mongolia, China

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Chinese herbal Medicines 2024年第2期16卷 248-262页

作者： Chunyan Guo lingfei Wang Namuhan Chen Mingxu Zhang Junying Jia Lijuan Lv Minhui Li College of Pharmacy Qiqihar Medical UniversityQiqihar 161000China Department of Basic Science Tianjin Agricultural UniversityTianjin 300384China Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Hohhot 010110China Inner Mongolia Academy of Chinese and Mongolian Medicine Hohhot 010010China University Engineering Research Center of Chinese(Mongolia)Ecological Planting Medicinal Materials(Nurture)in Inner Mongolia Autonomous Region Inner Mongolia Minzu UniversityTongliao 028000China Baotou Medical College Baotou 014060China Naiman Banner Medicinal Materials Research and Development Center Tongliao 028300China

Traditional Chinese herbal medicines not only cure human diseases,but also play an important role as *** with conventional chemical agents,traditional Chinese herbal medicines are characterized by low toxicity,low residues,and being eco-friendly,and they have become a research *** Chinese herbal medicines have tremendous flexibility and indefinite ***,this paper reviewed the types of insecticides belonging to traditional Chinese herbal medicines in Inner Mongolia,China,including their traditional uses,secondary metabolites,biological activities,action mechanisms,application methods,and development *** addition,the most relevant issues involved in the development of traditional Chinese herbal medicines was *** believe that traditional Chinese herbal medicines can be better implemented and developed;such that its other advantages,such as an insect repellent,can be ***,this study lays a solid foundation for further research on traditional Chinese herbal medicines in Inner Mongolia,China.

关键词： botanical pesticides organic agriculture pest management plant-derived biological products secondary metabolites

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工业互联网安全知识图谱构建研究综述

计算机科学与探索 2024年第2期18卷 279-300页

作者：常钰王钢朱鹏孔令飞何京恒内蒙古工业大学数据科学与应用学院呼和浩特010000

工业互联网安全知识图谱能够在丰富安全概念语义关系、提高安全知识库质量和增强安全态势可视化分析能力等方面发挥重要作用,已经成为认知、溯源和防护针对新能源工业控制系统攻击的关键。但是,与通用领域知识图谱构建相比,工业互联网... 详细信息

工业互联网安全知识图谱能够在丰富安全概念语义关系、提高安全知识库质量和增强安全态势可视化分析能力等方面发挥重要作用,已经成为认知、溯源和防护针对新能源工业控制系统攻击的关键。但是,与通用领域知识图谱构建相比,工业互联网安全知识图谱构建的各个环节仍然存在许多问题,影响了其实际应用效果。介绍了工业互联网安全知识图谱的概念、意义和其与通用知识图谱的区别;概括了工业互联网安全知识图谱本体构建的相关工作及其作用;重点研究了在工业互联网安全背景下,构建知识图谱的三个关键环节,即命名实体识别、关系抽取和共指消解的相关工作。对于每个环节,详细报告了该环节在领域背景下的发展历史和研究现状,深入分析了该环节面临的领域特有挑战,如非连续实体识别问题、候选词提取问题和缺乏领域高质量数据集等,并针对特有挑战展望了该环节未来的研究方向,为进一步提升工业互联网安全知识图谱的质量和实用性,从而更有效地应对新兴威胁和攻击提供借鉴和启示。

关键词：工业互联网安全知识图谱命名实体识别关系抽取共指消解

从ISSVA分类浅谈脉管源性疾病的病理诊断问题

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中华病理学杂志 2024年第3期53卷 217-223页

作者：刘秋雨孔令非河南省人民医院、郑州大学人民医院病理科郑州450003

脉管源性疾病的诊断不只是肿瘤与非肿瘤性病变的区分,更多的是以强调其疾病的本质为出发点,即有无内皮细胞增殖,进一步区分为真性肿瘤和畸形。本文以临床广泛推崇的国际脉管异常研究学会(The International Society for the Study of Va... 详细信息

脉管源性疾病的诊断不只是肿瘤与非肿瘤性病变的区分,更多的是以强调其疾病的本质为出发点,即有无内皮细胞增殖,进一步区分为真性肿瘤和畸形。本文以临床广泛推崇的国际脉管异常研究学会(The International Society for the Study of Vascular Anomalies,ISSVA)分类为基础,针对脉管源性疾病的相关病理诊断问题展开论述。

关键词：软组织肿瘤国际疾病分类法脉管畸形