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Influences of traditional Chinese medicine intervention on the bone growth and metabolism of rats with simulated weightlessness

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 224-227页

作者： Jun zhu Department of Orthopaedics People's Hospital of Zhengzhou

Objective:To prohe into the influences of Chinese herbal compound on the growth and metabolism of weight-bearing bones of tail-suspended ***:Twenty-four male St) rats were randomly divided into blank conlrol group ***-suspended conlrol group(eight) and Chinese medicine treatment group leighti according to their *** treatment was done for the blank conlrol *** distilled water lavage was performed daily for the tail-suspended control *** the basis of the tail-suspended rat model,the rats were given Chinese herbal compound lavage every day in Chinese medicine treatment *** compound includes mulberry,Poria cocas and barbary *** lest cycle was four *** rats were killed after the *** right femoral bone was taken out for the physical measurements, and the left femoral bone was for the three-point beading *** influences of Chinese herbal compound on femoral hone growth and biomechanicsl properties of simulated weightlessness rats were ***:(1) After simulated weightlessness(tail-suspension),compared with the blank control group,all the physiological indexes of rat femoral bone decreased in tailsuspended group and Chinese medicine treatment group(P<0.05).The strength and rigidity of rat femoral bone decreased in tail-suspended group(P<0.01).the maximum load and rigidity coefficient also decreased with the inereasing toughness coefficient in the control group(P<0.01). i2i After the countermeasure of Chinese herbal compound,each biomcchanical indexes showed the tendency of increasing in Chinese medicine treatment group,and theses indexes were close to those of the blank control group(P<0.05),which indicated that(he bone loss caused by simulated weightlessness was ***:Chinese herbal compound for tonifying kidney could effectively prevent the bone loss and have some enhancements on the bone hiomechanical properties.

关键词： Chinese herbal compound Simulated weightlessness Rat femoral bone Biomechanical properties

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基于曲线参数方程的植物果实造型

计算机应用研究 2008年第11期25卷 3474-3476页

作者：刘骥曾令秋朱庆生重庆大学计算机学院重庆400030

基于曲线参数方程的植物果实造型方法通过果实主轴线和截面曲线参数方程计算出果实表面的网格面以及各顶点的法线,从而实现了植物果实的造型;通过在曲线方程上叠加扰动函数解决了果实生长过程中的形变问题。实验证明该方法能够较逼真地... 详细信息

基于曲线参数方程的植物果实造型方法通过果实主轴线和截面曲线参数方程计算出果实表面的网格面以及各顶点的法线,从而实现了植物果实的造型;通过在曲线方程上叠加扰动函数解决了果实生长过程中的形变问题。实验证明该方法能够较逼真地模拟植物果实形态及其生长过程。

关键词：植物果实造型曲线参数方程虚拟植物果实生长

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糖尿病足相关蛋白质组学的研究进展

中国糖尿病杂志 2024年第2期32卷 137-140页

作者：周舒婕赵玲朱方灵柯亭羽昆明医科大学第二附属医院内分泌科 650106

糖尿病足(DF)是DM严重慢性并发症,是DM患者致残、致死的主要原因。生物体组织器官及循环中蛋白质的变化可作为疾病发生发展的微观反映,蛋白质组学是探讨疾病发生及治疗,寻找潜在治疗靶点及预后生物标志物的重要技术。本文综述DF相关蛋... 详细信息

糖尿病足(DF)是DM严重慢性并发症,是DM患者致残、致死的主要原因。生物体组织器官及循环中蛋白质的变化可作为疾病发生发展的微观反映,蛋白质组学是探讨疾病发生及治疗,寻找潜在治疗靶点及预后生物标志物的重要技术。本文综述DF相关蛋白质组学的研究进展。

关键词：糖尿病足蛋白质组学生物标志物

防治血管再狭窄的新靶点——缝隙连接蛋白43

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中国新药与临床杂志 2008年第6期27卷 446-449页

作者：朱玲玉蒋丽萍南昌大学医学院药理教研室江西南昌330006

缝隙连接是介导相邻细胞间离子和小分子信号物质直接交换的跨膜通道,血管平滑肌细胞中主要表达连接蛋白43(connexin43,CX43)。研究表明,CX43表达上调与平滑肌细胞的增殖、迁移及细胞外基质生成密切相关,促使血管损伤后新内膜生成,引起... 详细信息

缝隙连接是介导相邻细胞间离子和小分子信号物质直接交换的跨膜通道,血管平滑肌细胞中主要表达连接蛋白43(connexin43,CX43)。研究表明,CX43表达上调与平滑肌细胞的增殖、迁移及细胞外基质生成密切相关,促使血管损伤后新内膜生成,引起血管再狭窄,提示CX43可能成为血管性疾病治疗的新靶点。本文综述CX43与血管再狭窄之间关系及以CX43为靶点的药物和基因治疗的研究进展。

关键词：连接蛋白43 冠状动脉再狭窄基因疗法缝隙连接

A tripole winter precipitation change pattern around the Tibetan Plateau in the late 1990s

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Atmospheric and Oceanic Science Letters 2022年第6期15卷 15-21页

作者： Yali zhu Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Key Laboratory of Meteorological Disaster/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Classical monsoon dynamics considers the winter/spring snow amount on the Tibetan Plateau(TP)as a major factor driving the East Asian summer monsoon(EASM)for its direct influence on the land-sea thermal ***,the TP snow increased and decreased after the late 1970s and 1990s,respectively,accompanying the two major interdecadal changes in the *** studies have explored the possible mechanisms of the EASM interdecadal variations,and change in TP snow is considered as one of the major drivers,few studies have illustrated the underlying mechanisms of the interdecadal changes in the winter TP *** study reveals a tripole pattern of change,with decreased winter precipitation over the TP and an increase to its north and south after the late *** analyses through numerical experiments demonstrate that the tropical Pacific SST changes in the late 1990s can robustly affect the winter TP precipitation through regulating the Walker and regional Hadley *** cooling over the tropical central-eastern Pacific can enhance the Walker circulation cell over the Pacific and induce ascending motion anomalies over the Indo-Pacific *** anomalies further drive descending motion anomalies over the TP and ascending motion anomalies to the north through regulating the regional Hadley ***,the positive-negative-positive winter precipitation anomalies around the TP are *** study improves the previously poor understanding of TP climate variation at interdecadal timescales.

关键词： Winter precipitation Tibetan plateau Interdecadal change East asian westerly jet stream Westerly-monsoon interaction

Effect of variation in gas distribution on explosion propagation characteristics in coal mines

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Mining Science and Technology 2010年第4期20卷 516-519页

作者： zhu Chuanjie State Key Laboratory of Coal Resources and Safe Mining China University of Mining & Technology Xuzhou 221008 China School of Safety Engineering China University of Mining & Technology Xuzhou 221116 China

In order to investigate the effect of variation in the distribution of gas on explosion propagation characteristics in coal mines, experiments were carried out in two different channels with variation in gas concentration and geometry. Flame and pressure transducers were used to track the explosion front velocity. The flame speed (Sf) showed a slight downward trend while the methane concentration varied from 10% to 3% in the experimental channel. The peak overpressure (Pmax) dropped dramatically when compared with normal conditions. As well, the values of Pmax and Sf decreased when the methane concentration dropped from 8% to 6%. The flame speed in the channel, connected to a cylinder with a length varying from 0.5 to 2 m, was greater than that in the normal channel. The peak overpressure was also higher than that under normal conditions because of a higher flame speed and stronger pressure piling up. The values of Pmax and Sf increased with an increase in cylinder length. The research results indicate that damage caused by explosions can be reduced by decreasing the gas concentration, which should be immediately detected in roadways with large cross-sections because of the possibility of greater destruction caused by more serious explosions.

关键词： variation in gas concentration geometric variation flame speed peak overpressure explosion propagation

On Boolean elements and derivations in 2-dimension linguistic lattice implication algebras

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Applied Mathematics(A Journal of Chinese Universities) 2023年第2期38卷 274-292页

作者： zhu Hua ZHAO Jian-bin School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Henan Key Laboratory of Financial Engineering Zhengzhou 450001China Key Laboratory of Big Data Analysis and Application Zhengzhou 450001China

A 2-dimension linguistic lattice implication algebra(2DL-LIA)can build a bridge between logical algebra and 2-dimension fuzzy linguistic *** this paper,the notion of a Boolean element is proposed in a 2DL-LIA and some properties of Boolean elements are *** derivations on 2DL-LIAs are introduced and the related properties of derivations are ***,it proves that the derivations on 2DL-LIAs can be constructed by Boolean elements.

关键词： derivation Boolean element Lattice implication algebra(LIA) 2-dimension linguistic lattice implication algebra(2DL-LIA) 2-dimension fuzzy linguistic information

镉胁迫对转基因棉花SGK3和ZD-90种子品质性状的影响

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作物学报 2011年第5期37卷 929-933页

作者：李玲陈进红祝水金浙江大学农业与生物技术学院浙江杭州310029

以陆地棉标准系TM-1为对照,通过盆栽模拟试验,采用ICP-MS技术和NIRS技术测定不同水平镉胁迫下2个棉花品种(系)种子种仁的镉含量和营养成分。结果表明,3个参试的棉花品种(系)种仁中的镉含量随镉处理浓度的增加而显著增加,其中转基因抗虫... 详细信息

以陆地棉标准系TM-1为对照,通过盆栽模拟试验,采用ICP-MS技术和NIRS技术测定不同水平镉胁迫下2个棉花品种(系)种子种仁的镉含量和营养成分。结果表明,3个参试的棉花品种(系)种仁中的镉含量随镉处理浓度的增加而显著增加,其中转基因抗虫棉品种SGK3种子种仁的镉含量最高,低、中、高镉浓度处理后的种仁镉含量均显著高于其他品种(系),说明该品种具有较强的镉累积能力。转基因抗草甘膦棉花种质系ZD-90种仁中的镉含量虽显著低于SGK3,但高于甚至显著高于陆地棉标准系TM-1。镉处理可降低棉花种子的物理品质性状,且品种(系)间的差异达到显著水平。3个陆地棉品种中,镉处理对于TM-1的蛋白质、油分和棉酚含量有较大的影响,差异达到了显著水平。而SGK3和ZD-90的种子种仁营养成分受镉处理影响相对较小,不同处理间种仁的营养成分差异未达显著水平。耐镉害能力为SGK3>ZD-90>TM-1。相关性分析结果表明,棉花种子种仁的镉含量与棉酚含量呈显著负相关,但与其他种子物理品质性状和种仁营养品质性状的相关性未达显著水平。

关键词：棉花镉胁迫物理品质性状营养品质性状

快速免疫荧光法检测血浆NT-proBNP的分析性能评价

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中华检验医学杂志 2010年第12期33卷 1208-1212页

作者：唐筑灵徐国宾贵阳医学院附属医院生化科 550004 北京大学第一医院检验科

目的评价快速免疫荧光（RAMP）法检测血浆NT-proBNP的分析性能.方法 RAMP法测定264名健康体检者及78例心衰患者血浆NT-proBNP,参照CLSI方法学评价方案,评价RAMP法的精密度、线性、稳定性及干扰因素等,并与瑞士罗氏公司Elecsys法检测方... 详细信息

目的评价快速免疫荧光（RAMP）法检测血浆NT-proBNP的分析性能.方法 RAMP法测定264名健康体检者及78例心衰患者血浆NT-proBNP,参照CLSI方法学评价方案,评价RAMP法的精密度、线性、稳定性及干扰因素等,并与瑞士罗氏公司Elecsys法检测方法进行比对.结果 CV=20%时RAMP法功能灵敏度为48 ng/L,CV=10%时灵敏度为57 ng/L,线性范围18～8 000 ng/***法NT-proBNP室温下稳定24 h,4℃稳定3 d,-20 ℃稳定20 d,反复冻融3次对检测结果无影响.EDTA-K2和肝素抗凝血浆RAMP法测定结果比对,YEDTA-K2=0.953 9X肝素＋0.365 2,R2=0.982,P〈0.01,n=40.两种类型的抗凝标本在两种方法间的测量结果差异无统计学意义（P＞0.05）.轻度溶血（Hb=2 g/L）对RAMP法和Elecsys法测定结果影响较小,偏差〈5%,中、重度溶血（Hb=3～4 g/L）对结果影响大,偏差＞15%.加入3种浓度三酰甘油时RMAP法测定值从390 ng/L降为82 ng/L,Elecsys法测定值从390 ng/L降为178 ng/L;当标本中胆红素含量为16～330 μmol/L,两种方法测定值从7 777 ng/L降为7 741 ng/L,RAMP法抗乳糜和黄疸的干扰能力与Elecsys法相近.45份EDTA-K2抗凝血浆标本用2种方法检测比对,Passing和Bablok回归方程显示：YRAMP=0.972 8XElecsys-0.035 2,R2=0.994,P＞0.05,n=45.78份肝素抗凝血浆标本用2种方法检测比对,Passing和Bablok回归方程显示：YRAMP=0.983 2XElecsys-0.037 6,R2=0.991,P＞0.05,n=78.健康人血浆NT-proBNP水平随年龄递增,与性别相关,女性为105（60～120）ng/L,男性为59（44～91）ng/L,女性高于男性（Z=3.264,P〈0.01）.结论 RAMP快速免疫荧光法重复性,稳定性较好、线性范围宽,检测结果与罗氏电化学发光法一致性较好.

关键词：肽碎片利钠肽,脑荧光免疫测定肝素评价研究