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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Ming-Ming LI~(a,b,#),Li-Ying WU~(b,#),Tong ZHAO~b,Xin HUANG~b,Zhao-Hui LIU~b,Lei XIONG~b,Kuan ZHANG~b,Jia SUN~b,ling-ling zhu~(b*),Ming FAN~(a,b,*) a Beijing Institute for Neuro-Science,Capital Medical University School of Basic Medical Sciences,Beijng 100069,China b Institute of Basic Medical Sciences,Beijng 100850,China

Objectives:To investigate the effects of 5-HMF on HIF-1α.HIF-1 transcription factor is a master regulator of genes that promote adaptation to hypoxia or ischemia,which makes it a very attractive candidate for pharmacological research.5- hydroxymethyl-2-furfural(5-HMF),the product of carbohydrate metabolism,has favorable biological effects such as anti-oxidant activity and anti-sickle cell *** previous study found that 5-HMF played an obvious role in ***,whether the protective role of 5-HMF is mediated by HIF- 1,is not yet *** we know,HIF-1αis the active subunit of ***-Luc mouse is a transgenic mouse that ubiquitously expresses a bioluminescent reporter consisting of firefly luciferase fused to a region of HIF-1α.It is a valuable tool,noninvasive and rapid,which can be used to monitor HIF-1 *** this study,we investigated the effects of 5-HMF on HIF-1αusing ODD-Luc ***:ODD-Luc mice were randomly divided into vehicle (0.9%N.S.),positive(CoCl) and 5-HMF *** were screened for bioluminescence by IVIS imaging system after 5-HMF or CoCl *** 1 h,and then the kidney and cortex of mice were taken out for the following ***-1αproteins of the kidney and cortex from ODD-Luc mice were determined by western blots. Furthermore the mRNA level of HIF-1 targeting gene VEGF was determined by ***:5-HMF increased light emission in ODD-Luc mice,especially in the regions of the kidney and brain(P<0.01),while CoCl only caused an increase in the regions of the *** levels of HIF-1αprotein in kidney and cortex were both higher in 5-HMF and CoCl groups than in vehicle group(P<0.05).The level of VEGF mRNA was increased by 5- HMF in ***:Our results indicate that 5-HMF possesses the ability to induce functional HIF-1αexpression,and thus may have the therapeutic potential in the treatment of hypoxic and ischemic diseases. Furthermore,ODD-Luc mice will be useful for evaluating therapeutic agen

关键词： 5-HMF HIF-1α ODD-Luc mice

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Satellite remote sensing reveals overwhelming recovery of forest from disturbances in Asia

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 46-51页

作者： Yiying zhu Hesong Wang Anzhi Zhang School of Ecology and Nature Conservation Beijing Forestry UniversityBeijingChina Key Laboratory of Regional Climate and Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Forestry and Landscape Architecture Xinjiang Agricultural UniversityUrumqiChina

Forest ecosystems play key roles in mitigating human-induced climate change through enhanced carbon uptake;however,frequently occurring climate extremes and human activities have considerably threatened the stability of *** the same time,detailed accounts of disturbances and forest responses are not yet well quantified in *** study employed the Breaks For Additive Seasonal and Trend method-an abrupt-change detection method-to analyze the Enhanced Vegetation Index time series in East Asia,South Asia,and Southeast *** approach allowed us to detect forest disturbance and quantify the resilience after *** showed that 20%of forests experienced disturbance with an increasing trend from 2000 to 2022,and Southeast Asian countries were more severely affected by ***,95%of forests had robust resilience and could recover from disturbance within a few *** resilience of forests suffering from greater magnitude of disturbance tended to be stronger than forests with lower disturbance *** summary,this study investigated the resilience of forests across the low and middle latitudes of Asia over the past two *** authors found that most forests exhibited good resilience after disturbance and about two-thirds had recovered to a better state in *** findings of this study underscore the complex relationship between disturbance and resilience,contributing to comprehension of forest resilience through satellite remote sensing.

关键词： Forest ecosystem Enhanced vegetation index Breaks for additive seasonal and trend method Disturbance Resilience

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Copper modified platinum electrode for amperometric detection of spectinomycin sulfate by anion-exchange chromatography

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Chinese Chemical Letters 2009年第10期20卷 1245-1247页

作者： ling ling Xi Pei Min Zhang Yan zhu Department of Chemistry Xixi Campus Zhejiang University Hangzhou 310028 China

A La^3＋-Cu/Pt modified electrode was fabricated by electrodepositing process in CuS04 solution by adding a small amount of lanthium compound, and it was employed for direct current （DC） amperometric detection of spectinomycin by anion-exchange chromatography. Without derivatization, this method can simultaneously determine the main component and impurities in spectinomycin pharmaceutical raw material. Ease of preparation, being applied in DC detection mode and good catalytic stability confirmed the interests of this modified electrode as amperometric sensor for the determination of spectinomycin.

关键词： Copper/platinum chemically modified electrode High performance anion-exchange chromatography Direct current amperometricdetection Spectinomycin

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Viscoelastic Property Evolution of Thermoplastic Polyurethane during Annealing Treatment and Its Correlation with Segmental Crystallization

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Chinese Journal of Polymer Science 2024年第12期42卷 1976-1985,I0010页

作者： Jian-Wen Shan Yan-Bo zhu ling-ling Ni Peng-Ju Pan State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou310058China

Viscoelastic properties of thermoplastic polyurethane(TPU)is of fundamental importance for its *** this work,we prepared different TPUs from polycaprolactone(PCL)diol,diphenylmethane-4,4′-diisocyanate(MDI),and 1,4-butanediol(BDO),and investigated the viscoelastic behavior of three TPUs with different hard segment content during thermal annealing *** storage modulus(G′)of TPU increases over time in a medium annealing temperature(T_(a))region,but remains unchanged at both high and low temperature *** growth of loss modulus(G″)over time is slower than that of G′.At medium T_(a),both G′and G″increase during the repeating frequency(ω)sweep,due to the gradual crystallization of hard *** indicates that the crystallites primarily restrain the relaxation of unit with large *** increments of G′and G″are weakened when the content of hard segment in TPU is *** TPU with high content of hard segments,a complete high elastic platform with a width of 3 orders of magnitude was observed only through one frequency scan test at medium T_(a).In addition,the crystallites of hard segments grow up continuously during frequency scan test(isothermal annealing treatment)and cause the extreme increase in G′and G″withωin lowωregion.

关键词： Thermoplastic polyurethane Viscoelastic properties Annealing Crystalization

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The relaxation of galaxy clusters at redshift z=0 in IllustrisTNG simulation

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Research in Astronomy and Astrophysics 2020年第12期20卷 261-269页

作者： Chao Li ling zhu Rui Guo National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We study the dynamical states of the 30 most massive galaxy clusters in the TNG100 simulation at redshift z = 0 using three types of tracers: stars, dark matter particles and satellite galaxies. If the massive galaxy cluster is spherically symmetric and relaxed, we can obtain the underlying total mass distribution accurately from its dynamical tracers using the spherical Jeans equations. Although the three tracers of clusters have very different number densities, velocity dispersions and anisotropies, they still trace the same total mass profile. We obtain the total mass profiles of clusters using these tracers separately and compare them with the true mass distributions. We find that:(1) the kinematics of dark matter trace the total mass of all clusters well and the mass inferred from dark matter are generally consistent with the true mass profiles with relative deviations smaller than ~ 25% at all radii;(2) stars in ~ 60% massive clusters are approaching equilibrium and the total mass of these clusters inferred from stars have relative deviations smaller than ~50% at all radii. Stellar substructures are rich and the mass inferred from stars tend to be over-estimated in the inner region;and(3) satellite galaxies are unrelaxed in the inner region and become more relaxed as the radius increases. The total mass inferred from satellites are under-estimated in all regions.

关键词： galaxies:clusters:general galaxies:clusters:dynamical tracers methods:numerical

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Optimal AP Deployment in Cell-Free Massive MIMO Systems with LoS/NLoS Transmissions:A Stochastic Geometry Approach

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China Communications 2024年第9期21卷 146-158页

作者： Jiang ling Zhang Qi zhu Hongbo Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China

Cell-free massive multiple-input multipleoutput(MIMO)is a promising technology for future wireless communications,where a large number of distributed access points(APs)simultaneously serve all users over the same time-frequency *** users and APs may locate close to each other,the line-of-sight(Lo S)transmission occurs more frequently in cell-free massive MIMO ***,in this paper,we investigate the cell-free massive MIMO system with Lo S and non-line-of-sight(NLo S)transmissions,where APs and users are both distributed according to Poisson point *** tools from stochastic geometry,we derive a tight lower bound for the user downlink achievable rate and we further obtain the energy efficiency(EE)by considering the power consumption on downlink payload transmissions and circuitry *** on the analysis,the optimal AP density and AP antenna number that maximize the EE are *** is found that compared with the previous work that only considers NLo S transmissions,the actual optimal AP density should be much smaller,and the maximized EE is actually much higher.

关键词： cell-free massive MIMO energy efficiency LoS/NLoS transmissions stochastic geometry

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang zhu Chenxi Ding Zhe Sui Hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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Novel Polyamides Containing Biphenyl-phthalazinone Moieties

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Chinese Chemical Letters 2001年第6期12卷 517-518页

作者： Xiu ling zhu Xi Gao JIAN Rui ling WANG Department of Polymer Science&Materials Dalian University of TechnologyDalian 116012

A novel diamine monomer 2H-(4-aminophenyl)-4-[4-(4-aminophenoxy) biphenyl]phthalazinone 1 containing aza hetero cycle was synthesized and utilized for preparation of new high molecular weight aromatic polyamides with various aromatic dicarboxylic acids with the inherent viscosity of 0.50 similar to 1.62 g/dL. These polyamides had rather high glass transition temperatures of 327 similar to 356 degreesC and their structure was confirmed by IR, H-1 NMR and MS. They are readily soluble in polar solvents such as NMP, DMF etc, and easily cast into tough, flexible films.

关键词： Polyarylamide biphenyl-phthalazinone solubility thermostability

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zhu Chen: health care reform in China

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National Science Review 2015年第4期2卷 520-527页

作者： Mu-ming Poo ling Wang CAS Center for Excellence in Brain Science and Intelligence Technology

As China’s economy continues to prosper,adequate health care for all people has become an uppermost issue for the *** 2007,as China began its reform of the health care system on a scale unprecedented in recent history,zhu Chen was appointed to head the Ministry of Health and took charge of this formidable *** leaving his Ministry post in 2013,Chen remains actively involved in the formulation of China’s health care-related policies in his capacity as a Vice Chairman of the Standing Commitee of the National People’s Congress of China,the Chairman of the Chinese Peasants and Workers Democratic Party,and most recently the President of the Red Cross Society of China.

关键词： zhu Chen health care reform in China

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Low complexity power control approach based on MMSE detection for V-BLAST

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Journal of Systems Engineering and Electronics 2006年第4期17卷 743-749页

作者： Zhao Kun Qiu ling zhu Jinkang PCN & SS Lab Univ. of Science and Technology of China Hefei 230027 P. R. China

A low complexity Per-Antenna Power Control （PAPC） approach based on Minimum Mean Squared Error （MMSE） detection for V-BLAST is proposed in this paper. The PAPC approach is developed for minimizing the Bit Error Rate （BER） averaged over all substreams when the data throughput and the total transmit power keep constant over time. Simulation results show that the Power-controlled V-BLAST （P-BLAST） outperforms the conventional V-BLAST in terms of BER performance with MMSE detector, especially in presence of high spatial correlation between antennas. However, the additional complexity for P-BLAST is not high. When MMSE detector is adopted, the P-BLAST can achieve a comparable BER performance to that of conventional V-BLAST with Maximum Likelihood （ML） detector but with low complexity.

关键词： Vertical Bell Lab Layered Space-Time power control MINMAX minimum mean squared error aximum likelihood.

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