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Global warming strengthens the association between ENSO and the Asian-Australian summer monsoon

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Science China Earth Sciences 2024年第1期67卷 309-312页

作者： bao YANG Minhui HE School of Geography and Ocean Science Nanjing UniversityNanjing 210093China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Previous studies have widely reported the linkages between Asian-Australian monsoon and the ENSO(Wu,2008;Azad and Rajeevan,2016;Chen et al.,2020;Shekhar et al.,2022;Zhang J et al.,2022;Chen et al.,2023;Hau et al.,2023;Heidemann et al.,2023).It is well accepted that the monsoon is weaker during the El Niño phase and stronger during the La Niña *** example,an anomalously strong western Pacific subtropical high in 2020,related to the La Niña event.

关键词： event monsoon Asian

Glutamine transporters as effective targets in digestive system malignant tumor treatment

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Oncology Research 2024年第10期32卷 1661-1671页

作者： FEI CHU KAI TONG XIANG GU MEI bao YANFEN CHEN BIN WANG YANHUA SHAO ling WEI School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou510006China Department of Pharmacy Tianjin Medical University General HospitalTianjin300070China

Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human *** cells take up a large amount of glutamine to meet their rapid proliferation requirements,which is supported by the upregulation of glutamine *** inhibition of glutamine transporters effectively inhibits cell growth and proliferation in *** all cancers,digestive system malignant tumors(DSMTs)have the highest incidence and mortality rates,and the current therapeutic strategies for DSMTs are mainly surgical resection and *** to the relatively low survival rate and severe side effects associated with DSMTs treatment,new treatment strategies are urgently *** article summarizes the glutamine transporters involved in DSMTs and describes their role in ***,glutamine transportertarget drugs are discussed,providing theoretical guidance for the further development of drugs DSMTs treatment.

关键词： Glutamine transporter Targeted therapy Inhibitors Cancer

A novel weld-pool-length monitoring method based on pixel analysis in plasma arc additive manufacturing

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Advances in Manufacturing 2024年第2期12卷 335-348页

作者： bao-Ri Zhang Yong-Hua Shi Bionic Robot Research Department Ji Hua LaboratoryFoshan528200GuangdongPeople’s Republic of China Guangdong Provincial Engineering Research Center for Special Welding Technology and Equipment School of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou510640People’s Republic of China

The real-time monitoring of the weld pool during deposition is important for automatic control in plasma arc additive *** obtain a high deposition accuracy,it is essential to maintain a stable weld pool *** this study,a novel passive visual method is proposed to measure the weld pool *** the proposed method,the image quality was improved by designing a special visual system that employed an endoscope and a *** also includes pixel brightness-based and gradient-based algorithms that can adaptively detect feature points at the boundary when the weld pool geometry *** algorithm can also be applied to materials with different solidification *** was performed to measure the real weld pool length in world coordinates,and outlier rejection was performed to increase the accuracy of the ***,tests were carried out on the intersection component,and the results showed that the proposed method performed well in tracking the changing weld pool length and was applicable to the real-time monitoring of different types of materials.

关键词： Plasma arc additive manufacturing(PAAM) Weld pool geometry Gradient analysis Real-time detection

Infection with SARS-CoV-2 can cause pancreatic impairment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2143-2160页

作者： Wei Deng Linlin bao Zhiqi Song ling Zhang Pin Yu Yanfeng Xu Jue Wang Wenjie Zhao Xiuqin Zhang Yunlin Han Yanhong Li Jiangning Liu Qi Lv Xujian Liang Fengdi Li Feifei Qi Ran Deng Siyuan Wang Yibai Xiong Ruiping Xiao Hongyang Wang Chuan Qin NHC Key Laboratory of Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking UniversityBeijing 100871China State Key Laboratory of Biomembrane and Membrane Biotechnology Peking-Tsinghua Center for Life SciencesBeijing 100871China Chinese Academy of Engineering Eastern Hepatobiliary Surgery Hospital225 Changhai RoadYangpu DistrictShanghai 200438China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438PR China National Laboratory for Oncogenes and Related Genes Cancer Institute of Shanghai Jiao Tong UniversityShanghai 200441PR China Changping National laboratory(CPNL) Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity National Health Commission of the People’s Republic of ChinaBeijingPR China

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of ***,we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates(NHPs)models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVID-19 ***-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and *** and limited phenotypic and histopathological changes were observed in adult *** proteomics and metabolomics results indicated metabolic disorders,mainly enriched in insulin resistance pathways,in infected adult NHPs,along with elevated fasting C-peptide and C-peptide/glucose ratio ***,in elder COVID-19 NHPs,SARS-CoV-2 infection causes loss of beta(β)cells and lower expressed-insulin in situ characterized by islet amyloidosis and necrosis,activation ofα-SMA and aggravated fibrosis consisting of lower collagen in serum,an increase of pancreatic inflammation and stress markers,ICAM-1 and G3BP1,along with more severe glycometabolic *** contrast,vaccination maintained glucose homeostasis by activating insulin receptorαand insulin receptorβ.Overall,the cumulative risk of diabetes post-COVID-19 is closely tied to age,suggesting more attention should be paid to blood sugar management in elderly COVID-19 patients.

关键词： infected elevated homeostasis

Investigating impacts of different building contents on the post-earthquake evacuation time using an agent-based model with considering turning behavior

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 939-955页

作者： bao Yu School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572025China

Accurate assessment of crowd evacuation inside the post-earthquake environment is critical from many perspectives,but this issue receives much less attention compared to the seismic losses of structural and non-structural *** could be attributed to the fact that post-earthquake evacuation analysis is complex due to the interaction between human behavior and the actual built environment induced by different building *** study attempts to tackle this problem by investigating the impacts of different building contents on post-earthquake evacuation time by using an agent-based model that considers turning *** this end,the agent-based model is first described,including:properties of the agent-based model with turning behavior,key aspects in its formulation considering different evacuation stages,and influence of different building contents(namely,debris from partition walls and ceiling systems,and various types of equipment)on the agent’s ***,a school building is used as a benchmark problem to validate the model without earthquake,and the findings indicate that the agent-based model can match the real safety drill results reasonably *** the validation,the school building is subsequently designed in accordance with modern seismic design codes,and the influence of debris and equipment on post-earthquake evacuation time is quantitatively studied using a suite of pulse-type ground motions as *** on this case study,recommendations are made for structural and architectural designers in an effort to reduce the potential evacuation ***,debris induced by partition walls or ceiling systems should be controlled as it has the greatest impact on the total evacuation time.

关键词： seismic fragility evacuation agent-based model route choice built environment

Establishment and performance analysis of a new multiplex detection method for influenza an and B virus antigen

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World Journal of Clinical Cases 2024年第23期12卷 5338-5345页

作者： Cheng-Jing Xia bao-Hua Li Yan-Ni Guo Xiao-He Zhou Run-ling Zhang Ying-No Niu Department of Clinical Laboratory West WingShenzhen Hospital(Guangming)of University of Chinese Academy of SciencesShenzhen 518106Guangdong ProvinceChina Laboratory Nanjing Vazyme Biotech Co.LtdNanjing 210033Jiangsu ProvinceChina

BACKGROUND Influenza A and B virus detection is pivotal in epidemiological surveillance and disease *** and accurate diagnostic techniques are crucial for timely clinical intervention and outbreak *** dot-encoded microspheres have been widely used in *** integration of quantum dot-encoded microspheres with flow cytometry is a well-established technique that enables rapid ***,establishing a multiplex detection method for influenza A and B virus antigens based on flow cytometry quantum dot microspheres will help in disease *** To establish a codetection method of influenza A and B virus antigens based on flow cytometry quantum dot-encoded microsphere technology,which forms the foundation for the assays of multiple respiratory virus *** Different quantum dot-encoded microspheres were used to couple the monoclonal antibodies against influenza A and *** known influenza A and B antigens were detected both separately and simultaneously on a flow cytometer,and the detection conditions were optimized to establish the influenza A and B antigen codetection method,which was utilized for their detection in clinical *** results were compared with the fluorescence quantitative polymerase chain reaction(PCR)method to validate the clinical performance of this *** The limits of detection of this method were 26.1 and 10.7 pg/mL for influenza A and B antigens,respectively,which both ranged from 15.6 to 250000 pg/*** the clinical sample evaluation,the proposed method well correlated with the fluorescent quantitative PCR method,with positive,negative,and overall compliance rates of 57.4%,100%,and 71.6%,*** A multiplex assay for quantitative detection of influenza A and B virus antigens has been established,which is characterized by high sensitivity,good specificity,and a wide detection range and is promising for clinical applications.

关键词： Influenza A Influenza B Quantum dot microspheres Antigen detection Multiplex detection

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细菌群体感应信号分子及其检测方法

中国感染控制杂志 2024年第7期23卷 901-909页

作者：李俊伟凌保东成都医学院药学院四川成都610500 成都医学院结构特异性小分子药物研究四川省高校重点实验室四川成都610500

群体感应(quorum sensing,QS)是细菌种内与种间传递信息的重要通讯机制,是细菌感染防治的重要靶点。然而,QS网络复杂多样,信号分子种类繁多,含量低,其检测是QS系统研究中的热点和难点。本文对QS信号分子结构和相应检测方法进行综述,并... 详细信息

群体感应(quorum sensing,QS)是细菌种内与种间传递信息的重要通讯机制,是细菌感染防治的重要靶点。然而,QS网络复杂多样,信号分子种类繁多,含量低,其检测是QS系统研究中的热点和难点。本文对QS信号分子结构和相应检测方法进行综述,并对未来研究方向与存在的问题进行展望,以期为QS系统通路与机制,药学、食品、临床、环境等多个领域的研究提供参考。

关键词：群体感应信号分子生物传感器仪器检测

Spatiotemporal changes of gross primary productivity and its response to drought in the Mongolian Plateau under climate change

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Journal of Arid Land 2024年第1期16卷 46-70页

作者： ZHAO Xuqin LUO Min MENG Fanhao SA Chula bao Shanhu bao Yuhai College of Geographical Science Inner Mongolia Normal UniversityHohhot 010022China Inner Mongolia Key Laboratory of Remote Sensing and Geographic Information Systems Hohhot 010022China

Gross primary productivity(GPP)of vegetation is an important constituent of the terrestrial carbon sinks and is significantly influenced by *** the impact of droughts on different types of vegetation GPP provides insight into the spatiotemporal variation of terrestrial carbon sinks,aiding efforts to mitigate the detrimental effects of climate *** this study,we utilized the precipitation and temperature data from the Climatic Research Unit,the standardized precipitation evapotranspiration index(SPEI),the standardized precipitation index(SPI),and the simulated vegetation GPP using the eddy covariance-light use efficiency(EC-LUE)model to analyze the spatiotemporal change of GPP and its response to different drought indices in the Mongolian Plateau during *** main findings indicated that vegetation GPP decreased in 50.53% of the plateau,mainly in its northern and northeastern parts,while it increased in the remaining 49.47%***,meadow steppe(78.92%)and deciduous forest(79.46%)witnessed a significant decrease in vegetation GPP,while alpine steppe(75.08%),cropland(76.27%),and sandy vegetation(87.88%)recovered *** aridification areas accounted for 71.39% of the affected areas,while 28.53% of the areas underwent severe aridification,mainly located in the south and central ***,the warming aridification areas of desert steppe(92.68%)and sandy vegetation(90.24%)were *** warming was found to amplify the sensitivity of coniferous forest,deciduous forest,meadow steppe,and alpine steppe GPP to ***,the drought sensitivity of vegetation GPP in the Mongolian Plateau gradually decreased as altitude *** cumulative effect of drought on vegetation GPP persisted for 3.00-8.00 *** findings of this study will improve the understanding of how drought influences vegetation in arid and semi-arid areas.

关键词： gross primary productivity(GPP) climate change warming aridification areas drought sensitivity cumulative effect duration(CED) Mongolian Plateau

Optimization Method for Electrical Water Heaters Considering Shifting Potentials of Electricity Consumption and Water-use Activities

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1250-1259页

作者： Yuqing bao Zhonghui Zuo Xuehua Wu School of Electrical and Automation Engineering Nanjing Normal UniversityNanjing 210046China School of Electrical Engineering Nanjing Vocational University of Industry TechnologyNanjing 210023China

Electrical water heaters(EWHs)are important can-didates to provide demand-response *** traditional op-timization method for EWHs focuses on the optimization of the electricity consumption,without considering the shifting poten-tial of the water-use *** paper proposes an optimiza-tion method for EWHs considering the shifting potentials of both the electricity consumption and water-use ***-sidering that the water-use activities could be monolithically shifted,the shifting model of the water-use activities was *** addition to the thermodynamic model of the EWH,the optimal scheduling model of the EWH was developed and solved using mixed-integer linear *** studies were performed on a single EWH and aggregate EWHs,demon-strating that the proposed method can shift the water-use activi-ties and therefore increase the load-shifting potential of the EWHs.

关键词： Electrical water heater(EWH) demand response load-shifting water-use activity