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Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 652-659页

作者： Lin LU Wen-hui PENG Wei wang ling-jie wang Qiu-jing CHEN Wei-feng SHEN Department of Cardiology Ruoin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Institute of Cardiovascular Diseases School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

Objective:Advanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE).This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat ***:Thirty-two male Sprague-Dawley rats were divided into four groups based on the presence or absence of streptozotocin-induced diabetes with or without atorvastatin treatment (10 mg/kg for 24 weeks).Serum sRAGE and glycated albumin (GA) levels were measured with enzyme-linked immunosorbent assay (ELISA) and improved bromocresol purple *** AGEs,RAGE,endogenous secretory RAGE (esRAGE),and sRAGE were determined with reverse transcription-polymerase chain reaction (RT-PCR) and Western ***:Mesangial expansion and microalbuminuria were aggravated in diabetic rats,and improved with atorvastatin *** sRAGE levels were lower in diabetic than in normal *** atorvastatin treatment,serum and renal sRAGE levels were up-regulated,while renal RAGE expression was decreased in diabetic rats,associated with a reduction in accumulation of AGEs,though renal esRAGE mRNA expression was not significantly ***:Atorvastatin exerted a beneficial effect on diabetic nephropathy with reduced AGE accumulation,down-regulating RAGE expression and up-regulating sRAGE in the kidney.

关键词： Receptor for advanced glycation end-product (RAGE) Endogenous secretory RAGE (esRAGE) Soluble RAGE (sRAGE) Diabetic nephropathy Atorvastatin

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Obstructive sleep apnea increases heart rhythm disorders and worsens subsequent outcomes in elderly patients with subacute myocardial infarction

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Journal of Geriatric Cardiology 2021年第1期18卷 30-38页

作者： ling-jie wang Li-Na PAN Ren-Yu YAN Wei-Wei QUAN Zhi-Hong XU Department of Cardiology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Geriatrics Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

OBJECTIVE Obstructive sleep apnea(OSA)is a potential cardiovascular *** aimed to investigate the association of OSA with heart rhythm disorders and prognosis in elderly patients with new-onset acute myocardial infarction(AMI).METHODS We prospectively enrolled 252 AMI elderly patients(mean age,68.5±6.9 years)who were undergoing revascularization and completed a sleep study during their *** subjects were categorized into non-OSA(apnea–hypopnea index(AHI)<15,n=130)and OSA(AHI≥15,n=122)groups based on the *** changes in the autonomic nervous system,incidence of arrhythmia during nocturnal sleep,and major adverse cardiovascular and cerebrovascular events(MACCEs)were compared between the *** The mean AHI value in all AMI patients was 22.8±*** patients showed higher levels of body mass index and peak high-sensitivity C-reactive protein and lower levels of minimum nocturnal oxygen saturation(Min Sa O2),as well as greater proportion of multivessel coronary artery disease(all P<0.05).The OSA group also showed significant increases in heart rate variability and heart rate turbulence onset(both P<0.05)and higher incidence of arrhythmia(including sinus,atrial,and ventricular in origin).At a median follow-up of 6 months(mean 0.8–1.6 years),OSA(AHI≥15)combined with hypoxia(Min Sa O2≤80%)was independently associated with the incidence of MACCEs(hazard ratio[HR]:4.536;95%confidence interval[CI]:1.461-14.084,P=0.009)after adjusting for traditional risk *** OSA and OSA-induced hypoxia may correlate with the severity of myocardial infarction,increase the occurrence of heart rhythm disorders in elderly subacute MI patients,and worsen their short-term poor outcomes.

关键词： OSA Obstructive sleep apnea increases heart rhythm disorders and worsens subsequent outcomes in elderly patients with subacute myocardial infarction

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Association between Serum Homocysteine and Oxidative Stress in Elderly Patients with Obstructive Sleep Apnea/hypopnea Syndrome

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Biomedical and Environmental Sciences 2010年第1期23卷 42-47页

作者： ling wang,jie LI 2,YAN XIE,AND XUE-GUANG ZHANG Laboratory of Clinical Immunology,the First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu,China Laboratory of Clinical Immunology the First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu China

Objective Elderly patients with obstructive sleep apnea/hypopnea syndrome （OSAHS） has a higher risk of cardiovascular and cerebrovascular disease. However, changes of homocysteine （Hey） as markers of cardiovascular and eerebrovascular disease associated with OSAHS and their mechanism have not been elucidated so far. This study aims to investigate the changes of both serum Hcy and oxidative stress and their possible links with OSAHS in elderly patients. Methods Based on polysomnogram （PSG） and age, 83 patients with OSAHS were recruited and divided into elderly-OSAHS （n=32） and non-elderly OSAHS groups （n=51）. Fifty two subjects without OSAHS were divided into elderly control （n=29） and non-elderly control groups （n-23）. A total of 135 subjects were included in the present study. All subjects were recorded for PSG variables and the contents of homocysteine （Hcy）, malonaldehyde （MDA）, and glutathione （GSH） which were detected after sleep. Serum homocysteine was measured by cyclophorase. MDA and GSH were measured by speetrophotometer. Results （1） The serum levels of Hcy showed significant difference among the four groups （P〈0.05）. The concentrations of Hcy in elderly OSAHS patients were higher than in other groups, while those in the elderly control group were higher than in the non-elderly control; the concentrations in the non-elderly OSAHS group were higher than in the non-elderly control. （2） The concentrations of MDA and GSH changed at an equal pace with Hcy in the four groups. （3） Multielement linearity regression analysis indicated a statistically significant relationship between Hcy concentration and age, MDA, GSH, and apnea hypopnea index （AHI）. Conclusions （1） The concentrations of Hcy and oxidative stress have increased with advancing age. （2） The concentrations of Hcy and oxidative stress have further increased in the elderly patients with OSAHS. （3） Oxidative stress might cause high-level serum Hcy in the elderly patients with OSAHS.

关键词： Elderly Obstructive sleep apnea/hypopnea syndrome Homocysteine Oxidative stress Malonaldehyde Glutathione

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Orthodontic retreatment of an adult woman with mandibular backward positioning and temporomandibular joint disorder:A case report

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World Journal of Clinical Cases 2022年第2期10卷 691-702页

作者： Li-Yuan Yu Kai Xia Wen-Tian Sun Xin-Qi Huang Jing-Yu Chi ling-jie wang Zhi-He Zhao Jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Stomatology Strategic Support Force Medical Center of PLABeijing 10010China Department of Stomatology Qingyang People's HospitalQingyang 745000Gansu ProvinceChina

BACKGROUND The role of occlusal factors on the occurrence of temporomandibular joint disorders(TMDs)is still unclear and it is tricky for orthodontists to treat malocclusions in patients with *** report the case of the second orthodontic treatment of an adult female with Class II division 2 malocclusion associated with *** the removal of anterior occlusal interference,TMD symptoms were alleviated and cone beam computed tomography(CBCT)images showed the bilateral condyles shifted *** SUMMARY This case report presented an orthodontic retreatment of an adult female with TMD and mandibular backward positioning based on CBCT examination and Joint Space Index(JSI)*** left and right JSI values of-38.5 and-52.6 indicated that the position of bilateral condyles had posterior *** years prior to this evaluation,she underwent orthodontic treatment resulting in the extraction of two upper premolars and one lower central *** joint symptoms,including pain and sounds,were alleviated along with verified mandibular forward repositioning by extraction of another lower central *** Mandibular backward positioning could be associated with *** analysis based on CBCT is a convenient way to examine condylar positions quantitatively.

关键词： Cone beam computerized tomography Joint Space Index Temporomandibular joint disorder Case report

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Syntheses and Olfactory Characters of Some Endo-α-Substituted-Bicyclo[2. 2. 2]-Octenyl (or Octanyl) Methanols

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Chemical Research in Chinese Universities 1992年第3期8卷 219-223页

作者： TANG Shi-xiong , CAO Yu-rong, wang Xiu-ling, XUE jie-you, wang Xiao-lan (Department of Chemistry, Nankai University, Tianjin, 300071)

Sixteen title compounds were synthesized, twelve of which are new ones. Their structures were determined by 1H NMR, IR and MS, the refractive indices or melting points were measured. Odors of all the title compounds w... 详细信息

关键词： Endo-α-substituted-bicyclo[2. 2. 2] octenyl methanol Synthesis Odor

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四川盆地海相、湖相页岩气形成条件对比及开发策略

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天然气地球科学 2017年第4期28卷 633-641页

作者：朱彤俞凌杰王烽中国石化石油勘探开发研究院北京100083

四川盆地页岩气勘探已在川东南—川南海相下志留统、川东—川东北湖相下侏罗统泥页岩层系获得了商业发现和工业气流,展示了四川盆地页岩气具有多领域、多层系、多类型的特点。采用氩离子抛光—扫描电镜、压汞—吸附联合测定、脉冲渗透率... 详细信息

四川盆地页岩气勘探已在川东南—川南海相下志留统、川东—川东北湖相下侏罗统泥页岩层系获得了商业发现和工业气流,展示了四川盆地页岩气具有多领域、多层系、多类型的特点。采用氩离子抛光—扫描电镜、压汞—吸附联合测定、脉冲渗透率和X-射线衍射等实验测试方法,通过对海相、湖相泥页岩沉积相、生烃条件、储集特征、可压裂性和富集类型多方面对比表明,海相龙马溪组优质页岩主要发育于克拉通台内凹陷深水陆棚沉积,具有分布广,厚度稳定,有机碳含量高,有机质孔、页理、有机硅均发育的良好的生、储、可压裂一体的页岩气物质基础,3类页岩气富集类型(盆内超高压页岩气型、盆内缘超压页岩气型和盆外常压页岩气型),其中盆内超高压页岩气型和盆内缘超压页岩气型为最有利的页岩气勘探类型;湖相大安寨段有利的页岩与灰岩薄互层岩性组合,主要发育于最大湖进期碳酸盐岩湖泊的湖坡风暴滩与湖坡泥交替沉积环境,具累计厚度大,有机碳含量较高,粒缘孔缝发育,渗透性较好,钙质脆性矿物含量高的较好的生、储、可压裂近配的页岩气物质基础,是湖相有利的页岩气勘探类型。针对海、湖相不同类型页岩气的形成特点,开展适应性勘探开发技术的攻关,是实现多领域页岩气经济有效开发的关键。

关键词：页岩气海相页岩湖相泥页岩生烃条件储集特征富集类型四川盆地

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Valsartan Decreases Platelet Activity and Arterial Thrombotic Events in Elderly Patients with Hypertension

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Chinese Medical Journal 2015年第2期128卷 153-158页

作者： Fang Wu Hong-Yan wang Fan Cai ling-jie wang Feng-Ru Zhang Xiao-Nan Chen Qian Yang Meng-Hui Jiang Xue-Feng wang Wei-Feng Shen Department of Geriatrics Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China Department of Cardiology Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China Institute of Health Sciences Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200025 China Department of Laboratory Medicine Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China

Background：Angiotensin type 1 receptor （AT1R） antagonists are extensively used for blood pressure control in elderly patients with *** study aimed to investigate the inhibitory effects of AT1R antagonist valsartan on platelet aggregation and the occurrence of cardio-cerebral thrombotic events in elderly patients with ***：Two-hundred and ten patients with hypertension and aged 〉 60 years were randomized to valsartan （n =140） or amlodipine （n =70） on *** primary endpoint was platelet aggregation rate （PAR） induced by arachidonic acid at discharge,and the secondary endpoint was the rate of thrombotic events including brain infarction and myocardial infarction during *** aortic endothelial cells （HAECs） were stimulated by angiotensin Ⅱ （Ang Ⅱ,100 nmol/L） with or without pretreatment of valsartan （100 nmol/L）,and relative expression of cyclooxygenase-2 （COX-2） and thromboxane B2 （TXB2） and both p38 mitogen-activated protein kinase （p38MAPK） and nuclear factor-kB （NF-kB） activities were *** analyses were performed by GraphPad Prism 5.0 software （GraphPad Software,Inc.,California,USA）.Results：PAR was lower after treatment with valsartan （1 1.49 ± 0.69% vs.18.71 ± 2.47%,P 〈 0.001）,associated with more reduced plasmalevels of COX-2 （76.94 ± 7.07 U/L vs.116.4 ± 15.89 U/L,P 〈 0.001） and TXB2 （1667 ± 56.50 pg/ml vs.2207 ± 180.20 pg/ml）（all P 〈 0.001）.Plasma COX-2 and TXB2 levels correlated significantly with PAR in overall patients （r =0.109,P 〈 0.001）.During follow-up （median,18 months）,there was a significantly lower thrombotic event rate in patients treated with valsartan （14.3% vs.32.8%,P =0.002）.Relative expression of COX-2 and secretion of TXB2 with concordant phosphorylation ofp38MAPK and NF-kB were increased in HAECs when stimulated by Ang Ⅱ （100 nmol/L） but were significantly decreased by valsartan pretreatment （100 nmol/L）.Conclusions：AT1R antagonist valsartan decreases platelet activity by attenua

关键词： Angiotensin Type 1 Receptor Antagonist Elderly Hypertension Platelet Activity Thrombosis

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双金属催化剂Bi-Mo/TiO_2气相催化氧化2-甲基吡啶合成2-吡啶甲醛

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高校化学工程学报 2016年第5期30卷 1082-1087页

作者：张玲玲俞杰王晓钟张世界戴立言浙江大学化学工程与生物工程学院浙江杭州310027 浙江新三和医药化工股份有限公司浙江上虞312369

制备了气相催化氧化2-甲基吡啶合成2-吡啶甲醛的双金属Bi-Mo/TiO_2催化剂,采用XRD、H_2-TPR、SEM和XPS对催化剂进行了表征,并考察了催化剂组成、反应温度、原料流率等因素的影响。实验研究结果表明,Bi-Mo/TiO_2对2-甲基吡啶有比较高的... 详细信息

制备了气相催化氧化2-甲基吡啶合成2-吡啶甲醛的双金属Bi-Mo/TiO_2催化剂,采用XRD、H_2-TPR、SEM和XPS对催化剂进行了表征,并考察了催化剂组成、反应温度、原料流率等因素的影响。实验研究结果表明,Bi-Mo/TiO_2对2-甲基吡啶有比较高的催化活性是基于Bi_2Mo_3O_(12)和MoO_3的协同催化作用,Bi2Mo_3O_(12)和MoO_3的较佳摩尔比率为1:1,催化剂的较佳负载量为15%(wt),低反应温度和高原料流率可以提高对2-吡啶甲醛的选择性。较佳反应条件下(反应温度290℃,10%(wt)2-甲基吡啶水溶液的流率为0.5 m L×min-1,氧气的流率为0.1 L×min^(-1),空速12600 h^(-1)),2-甲基吡啶的转化率为70.9%,2-吡啶甲醛的选择性为83.1%。

关键词：双金属催化剂 2-甲基吡啶 2-吡啶甲醛选择性协同催化

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Increased serum high-mobility group box-1 and cleaved receptor for advanced glycation endproducts levels and decreased endogenous secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure

Increased serum high-mobility group box-1 and cleaved recept...

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中华医学会第十五次全国心血管病学大会

作者： ling jie wang Lin Lu Qiu Jing Chen Wei Feng Shen Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Aims High-mobility group box-1 (HMGB1) is a ligand for the receptor for advanced glycation endproducts (RAGE). An HMGB1-RAGE interaction has been implicated in cardiac dysfunction. We assessed the association of HMGB1...

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： jie wang Wei wang Xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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