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Deformation of amorphous azobenzene-containing polymer films induced by polarized light

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Acta Mechanica Sinica 2012年第4期28卷 1203-1208页

作者： ling-hui he CAS Key Laboratory of Mechanical Behavior and Design of Materials University of Science and Technology of China 230026 HefeiChina

Photomechanical response of amorphous polymer films containing azobenzene chromophores in side chains is studied. By invoking the trans-cis isomerization mech- anism, the steady-state deformation of the film induced by uniform illumination of linearly polarized light is obtained analytically. The deformation turns out to be of entropic origin,produced to compensate the entropy decrease due to photo-induced redistribution of azobenzene chromophores normal to the polarization direction. The predicted elongation direction of the film is consistent with previous experimental observations.

关键词： Amorphous polymer. Azobenzene side-chain Photo-induced deformation

Automated removal of stripe interference in full-disk solar images

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Research in Astronomy and Astrophysics 2016年第6期16卷 13-20页

作者： Sheng Zheng Shuan he Yao Huang hui-ling he Gang-Hua Lin College of Science China Three Gorges University College of Computer and Information Technology China Three Gorges University National Astronomical Observatories Chinese Academy of Sciences Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of Sciences

The quality of full-disk solar Hα images is significantly degraded by stripe interference. In this paper, to improve the analysis of morphological evolution, a robust solution for stripe interference removal in a partial full-disk solar Hα image is proposed. The full-disk solar image is decomposed into a set of support value images on different scales by convolving the image with a sequence of multiscale support value filters, which are calculated from the mapped least-squares support vector machines （LS-SVMs）. To match the resolution of the support value images, a scale-adaptive LS-SVM regression model is used to remove stripe interference from the support value images. We have demonstrated the advantages of our method on solar Hα images taken in 2001-2002 at the Huairou Solar Observing Station. Our experimental results show that our method can remove the stripe interference well in solar Hα images and the restored image can be used in morphology researches.

关键词： methods: data analysis -- techniques: image processing -- Sun: general

Multi-Residue Determination of Eight Anabolic Steroids by GC-MS in Muscle Tissues from Pigs

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Agricultural Sciences in China 2010年第2期9卷 306-312页

作者： ZENG Dong-ping, LIN Cui-ping, ZENG Zhen-ling, HUANG Xian-hui and he Li-min Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, P.R. China [b] Laboratory of Veterinary Pharmacology College of Veterinary Medicine South China Agricultural University Guangzhou 510640 P.R. China

A gas chromatography-mass spectrometry （GC-MS） method to determine eight anabolic steroids （diethylstilbestrol, methyltestosterone, norethindrone, 17α-ethynylestradiol, estradiol, 6α-methyl-17α-hydroxy-progesterone, estradiol benzoate, and chlormadinone acetate） was developed. Muscle samples were extracted with liquid-liquid extraction and clean-up was performed in two steps, the extracts obtained were derivatized with heptafluorbutyric （HBF） anhydride and analyzed by GC-MS. In the above method, the linear scope was 2.5-50 μg kg^-1. The range of the recoveries was 78.5-148% for diethylstilbestrol, 70.8-109% for methyltestosterone, 69.8-87.2% for norethindrone, 67.7-120% for 17α-ethynylestradiol, 82.8-103% for estradiol, 70.3-99.2% for 6α-methyl-17α-hydroxy-progesterone, 73.0-104% for estradiol benzoate, and 72.9- 91.8% for chlormadinone acetate. The range of the coefficients of variation within batches was 0.4-12%; the range of the coefficients of variation between batches was 6.4-11%. The limit of detections and the detection capability were 0.99 and 3.30 μg kg^-1 for diethylstilbestrol, 1.05 and 3.50 μg kg^-1 for methyltestosterone, 1.19 and 3.97 μg kg^-1 for norethindrone, 0.94 and 3.13 μg kg^-1 for 17α-ethynylestradiol, 1.45 and 4.83 μg kg^-1 for estradiol, 1.56 and 5.20 μg kg^-1 for 6α-methyl-17α- hydroxy-progesterone, 1.92 and 6.40 μg kg^-1 for estradiol benzoate, and 2.41 and 8.03 μg kg^-1 for chlormadinone acetate, respectively. These results showed that the method was widely available, accurate, and sensitive.

关键词： anabolic steroids GC-MS multi-residue determination pigs

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多目的批处理过程的优化周期调度

上海交通大学学报 2002年第8期36卷 1127-1131页

作者：陈昌领邵惠鹤上海交通大学自动化研究所上海200030

基于状态任务网络 ( State Task Network,STN)描述批处理过程 ,提出了多目的批处理过程的混合整数规划 ( Mixed Integer Linear Programming,MILP)周期调度数学模型 .建模采用连续时间描述 ,并将任务和设备分配给事件点集总表达为一类 0... 详细信息

基于状态任务网络 ( State Task Network,STN)描述批处理过程 ,提出了多目的批处理过程的混合整数规划 ( Mixed Integer Linear Programming,MILP)周期调度数学模型 .建模采用连续时间描述 ,并将任务和设备分配给事件点集总表达为一类 0 - 1变量 .相对于已有的多目的批处理过程周期调度数学模型 ,该模型规模小。

关键词：周期调度多目的批处理过程混合整数线性规划状态任务网络数学模型化工过程

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

精神分裂症患者等级伦敦塔任务的近红外光谱成像研究

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中华精神科杂志 2012年第6期45卷 321-326页

作者：刘琳琳王惠玲王熇生苏德振陈诚吴士豪杨灿王高华牛海晶蒋田仔武汉大学人民医院精神卫生中心 430060 北京师范大学认知神经科学与学习国家重点实验室中国科学院自动化所模式识别实验室

目的比较精神分裂症患者与健康人在不同难度等级伦敦塔（the Tower of London，TOL）认知任务下的脑区激活程度和模式的差异。方法利用功能性近红外光谱成像技术（thnctional near infrared spectroscopy，fNRS），记录30例精神分裂症... 详细信息

目的比较精神分裂症患者与健康人在不同难度等级伦敦塔（the Tower of London，TOL）认知任务下的脑区激活程度和模式的差异。方法利用功能性近红外光谱成像技术（thnctional near infrared spectroscopy，fNRS），记录30例精神分裂症患者（患者组）和30名健康对照（对照组）在fNIRS仪不同难度等级的TOL任务下双侧前额叶皮质血红蛋白浓度的变化；以阳性与阴性症状量表评分评定患者组的精神症状。结果（1）患者组较对照组在各难度等级的TOL测验上的正确答题数少，反应时间长（P均〈0．05）。（2）激活程度比较：患者组在各难度等级TOL任务下前额叶皮质激活均弱于对照组（P〈0．05）。（3）激活模式比较：中间的前额叶皮质：对照组的激活程度为中等任务〉容易任务〉困难任务[容易、中等及刖难仟务期氧合血红蛋白的差值（Aoxy—Hb）分别为4．05±4．89、5．93±3．94、2．12±1．78，P〈0．05]，患者组不同难度TOL任务下激活程度差异无统计学意义（P〉0．05）；背外侧前额叶皮质：对照组不同难度TOL任务下激活程度差异无统计学意义（P〉0．05），患者组随着任务难度的增加其激活程度降低（容易、中等及困难任务期Aoxy—Hb分别为5．19±9．12、3．24±6．74、0．01±0．82，P〈0．05）。结论精神分裂症患者存在前额叶功能低下。

关键词：精神分裂症额叶前皮质谱学近红外线伦敦塔

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急性等容血液稀释在猪肝原位移植术中的应用

四川动物 2003年第1期22卷 53-55页

作者：屈强王晓斌唐显玲丁玉辉何春水何延政泸州医学院附属医院麻醉科四川泸州646000 泸州医学院附属医院血液外科

目的—观察应用贺斯 (羟乙基淀粉注射液 ,HAES steril6 % )实施急性等容血液稀释 (ANH)对猪肝原位移植术血液动力学及凝血功能的影响。方法— 16只健康家猪 ,体重 2 0～ 30kg ,随机分为Ⅰ组 (对照组n =9)和Ⅱ组 (实验组n =7) ,在气管插... 详细信息

目的—观察应用贺斯 (羟乙基淀粉注射液 ,HAES steril6 % )实施急性等容血液稀释 (ANH)对猪肝原位移植术血液动力学及凝血功能的影响。方法— 16只健康家猪 ,体重 2 0～ 30kg ,随机分为Ⅰ组 (对照组n =9)和Ⅱ组 (实验组n =7) ,在气管插管全麻下行猪肝原位移植术。无肝期采用体外静脉转流。除常规输液输血外 ,Ⅱ组于转流前应用贺斯行ANH。术中不同时期作血液动力学、血气及生化测定。结果—两组血液动力学均较稳定 ,两组在转流期前后凝血功能无差异。结论—在猪原位肝移植术中 ,应用贺斯实施ANH对血液动力学的稳定和凝血功能无明显影响。

关键词：肝移植术血液动力学急性等容血液稀释猪羟乙基淀粉

2012年-2016年金华市无偿献血人群HIV感染情况分析

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中国卫生检验杂志 2017年第18期27卷 2711-2712,2715页

作者：吴斌唐慧玲何星徐倩倩徐婷金华市疾病预防控制中心浙江金华321002 金华市中心血站浙江金华321000

目的分析金华地区无偿献血人群艾滋病病毒(HIV)感染状况及流行特征,探究血液安全隐患,探寻新形势下保证血液安全的策略。方法对2012年-2016年金华市无偿献血人群中HIV感染者的检出情况进行分析。结果金华市无偿献血人群2012年-2016年检... 详细信息

目的分析金华地区无偿献血人群艾滋病病毒(HIV)感染状况及流行特征,探究血液安全隐患,探寻新形势下保证血液安全的策略。方法对2012年-2016年金华市无偿献血人群中HIV感染者的检出情况进行分析。结果金华市无偿献血人群2012年-2016年检测229 055人份,共检测出HIV阳性32例,不确定36例。32例HIV阳性献血者中,男性占93.75%,女性占6.25%;年龄为19岁~52岁,平均年龄为(32.34±8.99)岁;初中文化占37.5%(12/32),高中或中专占34.4%(11/32),大专及以上占18.8%(6/32)。未婚占43.8%(14/32),已婚占43.8%(14/32),离异或丧偶占12.5%(4/32);经流行病学调查,异性性传播占81.2%,同性性传播占18.8%。结论金华市无偿献血者HIV抗体阳性率逐年增高,血液安全存在隐患,应加大艾滋病知识的宣传力度,发展低危无偿献血队伍,从源头保证血液安全。

关键词：无偿献血艾滋病病毒传播途径

Discovery of a novel small inhibitor R J19 targeting to human Hsp90

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Nuclear Science and Techniques 2017年第10期28卷 71-78页

作者： hui-ling Cao Kai-Kai Lyu Bin Liu Jian Li Jian-Hua he Shaanxi Key Laboratory of Ischemic Cardiovascular Disease Institute of Basic and Translational MedicineXi'an MedicalUniversityXi'an 710021China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Protein Modification and Tumor HubeiPolytechnic University School of MedicineHuangshi 435003China Shanghai Institute of Applied Physics Chinese Academy ofSciencesShanghai 201204China Biotech and Biomedicine Science Co.Ltd. Shenyang 110000China Department of Molecular and Cellular Biochemistry Collegeof MedicineUniversity of KentuckyLexingtonKY 40508USA

heat shock protein 90(Hsp90) can promote growth and proliferation of cancer cells by helping in folding, conformational maturation, and activation of various client proteins. Therefore, Hsp90 has been paid more attention to as an anticancer drug target. Reported Hsp90 inhibitors have several limitations such as poor solubility, limited bioavailability, and hepatotoxicity. here, a novel small inhibitor RJ19 has been designed using fragment-based drug discovery and synthesized. Additionally, a crystal structure of Hsp90 N-RJ19 was determined by X-ray diffraction(resolution limit, 2.0 A, PDB code 4 L90). The crystal structure of Hsp90 N-RJ19 was analyzed in detail and compared with that of native Hsp90 N, Hsp90 N-ATP, and Hsp90 N-GDM,respectively. It was indicated that RJ19 interacted with Hsp90~N at the ATP-binding pocket, which suggests that RJ19 may replace nucleotides to bind with Hsp90~N to result in chaperone function failure of Hsp90. RJ19, therefore, has emerged as a promising anticancer lead compound. Rearrangement and displacement of L2 Loop in Hsp90~N-RJ 19 play a key role in the function failure, which also makes the pocket wider and longer facilitating structure modification of RJ19 later. The complex crystal structure and interaction between RJ19 and Hsp90~N provide a rational basis for the design and optimization of novel anticancer drugs.

关键词：热休克蛋白90 HSP90 抑制剂晶体结构 X射线衍射法抗癌药物 Hsp90 生物利用度