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Optimization of Regulation Valve Location for Heating System

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湖南大学学报（自然科学版） 2009年第S1期36卷 88-90页

作者： LIU ling-ling,chen hong-bing,LI De-ying(School of Environment and Energy Engineering,Beijing University of Civil Engineering and Architecture,Beijing 100044,China) School of Environment and Energy Engineering Beijing University of Civil Engineering and Architecture Beijing 100044 China

This paper mainly studied how to determine the best location of the self-operated flow control valve at the heating system *** the location of regulating valve directly affects the pipe network performance,the simulation and analysis of pressure change in heating system was carried out with Computational Fluid Dynamics(CFD)*** study shows the best location of regulating valve varies with the change of the supply and return pipe length when the heating area of each user is small,and when the heating area of each user is large(2 000 000～3 000 000 m2),the best location is on the supply pipe.

关键词： regulating valve optimization CFD simulation

Fundamental research on the size and velocity measurements of coal powder by trajectory imaging

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第5期14卷 377-382页

作者： Xue-cheng WU Ying-chun WU Cong-chang ZHANG Guo-neng LI Qun-xing HUANG ling-hong chen Kun-zan QIU Hao ZHOU Ke-fa CEN State Key Laboratory of Clean Energy Utilization Zhejiang University Institute for New Energy and Energy Saving Technology Zhejiang University of Science and Technology

A trajectory imaging based method for measuring the velocity and diameter of coal particles was *** using an industrial charge-coupled device(CCD)camera and a low power semiconductor laser,the images of coal particles under relatively long exposure time were recorded and then processed to yield both the velocities and *** research on this method with special attention to recording parameters,e.g.,magnification factor and exposure time,was carried *** most of the test cases,the results agree with those obtained by particle image velocimetry(PIV)and shadow imaging *** with good accuracy can be obtained when the imaging magnification factor and exposure time are set appropriately,making N be larger than 3.5,and R between 5-7,where N and R are the number of pixels occupied by the average width and the ratio of length to width of particle trajectory on the image,*** work indicates the feasibility and potential application of the present measurement method for online measurement of coal powder in pipes in industrial power plants.

关键词： Trajectory imaging Velocity measurement Size measurement Coal powder

Rehabilitation Effect of Systematic Exercise on Breast Cancer Patients after Adjuvant Chemotherapy

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Clinical oncology and cancer researeh 2010年第4期7卷 259-264页

作者： Wan-min QIANG Feng-qi DONG ling YAN Yu-hong chen Lei TANG Yong-qin JIANG Nursing Department Cancer Institute and China. Tianjin Medical University Hospital Tianjin 300060

OBJECTIVE To investigate the rehabilitation e. ect of systematic exercise on breast cancer patients a er adjuvant *** One hundred and ten subjects were randomly divided into 2 groups. The patients in the control group received original exercise. The others in the intervention group received systematic exercise including aerobics and 24 postures of Taichi for 4 months besides the original *** After the systematic exercise, the limb muscle strength, maximal oxygen uptake and lung capacity of the patients in intervention group were increased compared with those before the systematic exercise （P 〈 0.05）. The lung capacity of patients in the intervention group was signifi cantly increased than the control group after the exercise （P 〈 0.05）. The body mass index （BMI）,the ratio of waist and hip （WHR） of the patients in intervention group were decreased compared with those before the systematic exercise （P 〈 0.05）. The bone mineral density of control group was decreased comparing with pre-exercise （P 〈 0.05）, but there was no signifi cant di. erence in the intervention group between pre-exercise and pro-exercise （P 〉 0.05）. There was no significant dierence in the quality of life between the 2 groups a er the systematic exercise （P 〉 0.05）.CONCLUSION Systematic exercise can not only promote the restoration of limb function in patients with breast cancer after treatments, but also improve pulmonary function of the patients and lower the BMI and WHR of the patients. Systematic exercisecan improve the outcomes of overall rehabilitation.

关键词： breast cancer aerobics Taichi nursing

彩虹折射法对喷雾气液沉淀反应的原位表征（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第1期19卷 86-94页

作者： Xue-cheng WU Can LI Jian-zheng CAO Yong-xin ZHANG ling-hong chen Gerard GRéHAN Ke-fa CEN State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China UMR 6614/CORIA Normandie University CNRS bp 12 76801 Saint Etienne du Rouvray France

目的:喷雾气液吸收化学反应广泛存在于能源、化学和环境工程中。比如在能源环境领域,湿法烟气脱硫(WFGD)中的碱性喷雾吸收脱除气体污染物,乙醇胺(MEA)吸收脱除CO_2酸性气体。对这类反应的表征,有利于控制和改善污染物脱除效率。本文尝... 详细信息

目的:喷雾气液吸收化学反应广泛存在于能源、化学和环境工程中。比如在能源环境领域,湿法烟气脱硫(WFGD)中的碱性喷雾吸收脱除气体污染物,乙醇胺(MEA)吸收脱除CO_2酸性气体。对这类反应的表征,有利于控制和改善污染物脱除效率。本文尝试利用气液吸收沉淀反应过程中液滴折射率的变化来原位表征反应进程。创新点:1.基于彩虹折射法,首次对气液吸收沉淀反应的原位表征进行探究;2.通过若干实验和详细的传热计算分析,成功验证了其可行性和有效性。方法:1.通过与Abbe折射仪对比,确定全场彩虹测量的准确性(图3和公式(5));2.搭建全局彩虹技术(GRT)测量系统进行喷雾测量实验(图2),并记录反应过程中的彩虹图像和离线采样液滴用于显微分析(图4和5);3.对涉及到的气液吸收沉淀反应进行传热计算和分析(公式(7)^(13))。结论:1.初步表明了利用溶液折射率表征Ca(OH)_2质量分数的可行性。2.实验结果表明GRT的测量结果精确;反应后液滴折射率减少并趋向于水,反应进程可体现在彩虹角(即折射率)的变化上。3.不同浓度Ba(OH)_2吸收CO_2的反应进一步证明了该方法原位表征气液吸收沉淀反应的可行性。4.反应的传热计算和分析表明反应热所造成的温度升高可以忽略,验证了该方法的有效性。

关键词：彩虹折射法原位表征折射率气液吸收沉淀反应

Iron Chloride as Cocatalyst to Prepare Nano Cellulose Whiskers

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华东理工大学学报（自然科学版） 2010年第2期36卷 202-202页

作者： YE Dai-yong LI Jin-ling chen hong School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： chen Xiong hong ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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超声造影联合血清学指标评估失代偿期肝硬化患者门静脉高压的临床价值

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复旦学报（医学版） 2017年第4期44卷 467-471页

作者：张庆李玲丁红陈世耀徐汇区中心医院消化科上海200031 复旦大学附属中山医院消化科上海200032 复旦大学附属中山医院超声诊断科上海200032

目的探讨超声造影联合常规血清学标志物评估失代偿期肝硬化患者门静脉高压的可行性。方法根据肝静脉压力梯度(hepatic venous pressure gradient,HVPG)将54例失代偿期肝硬化门静脉高压患者分为HVPG<12 mmHg(1 mmHg=0.133 kPa)和HVPG≥12... 详细信息

目的探讨超声造影联合常规血清学标志物评估失代偿期肝硬化患者门静脉高压的可行性。方法根据肝静脉压力梯度(hepatic venous pressure gradient,HVPG)将54例失代偿期肝硬化门静脉高压患者分为HVPG<12 mmHg(1 mmHg=0.133 kPa)和HVPG≥12 mmHg两组。对血常规、肝功能、出凝血功能、Childpugh评分(Child-pugh score,CPS)及肝脏超声造影定量参数,包括肝动脉到达时间(hepatic artery arrival time,HAAT)、肝静脉到达时间(hepatic vein arrival time,HVAT)、门静脉到达时间(portal vein arrival time,PVAT)、肝动脉-肝静脉渡越时间(hepatic artery to hepatic vein arrive transmit time,HA-HVTT)、门静脉-肝静脉渡越时间(portal vein to hepatic vein arrive transmit time,PV-HVTT),进行单因素分析和Logistic回归分析,筛选出可以诊断门静脉高压的无创指标,并在此基础上构建诊断模型。通过ROC曲线评价模型的诊断价值并确定界值。结果建立诊断模型Y=-0.217×PV-HVTT+1.526×CPS-7.097。当模型的预测概率值≥0.631时,其判断HVPG≥12 mmHg的敏感性为87.5%,特异性为78.6%,ROC曲线下面积为0.857。结论由PV-HVTT和CPS建立的无创诊断模型对评估门静脉高压有一定的临床价值。

关键词：肝硬化门静脉高压肝静脉压力梯度超声造影无创性

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Open-MP与并行程序设计

计算机科学 2003年第11期30卷 133-135页

作者：陈峻陈宏建秦玲扬州大学信息工程学院计算机系扬州225009

1引言随着并行处理技术的发展,并行计算已日益成为现代科学与工程计算必不可少的工具.工作站机群(COW)以及大规模并行处理机(MPP)的发展与应用使得并行计算向高性能、可扩放、通用性发展.

关键词： MPI 并行程序设计

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia