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Predicting colorectal cancer prognosis based on long noncoding RNAs of disulfidptosis genes

World Journal of Clinical Oncology 2024年第1期15卷 89-114页

作者： Kui-ling Wang Kai-di Chen Wen-Wen Tang Ze-Peng Chen Yu-Ji Wang Guo-ping Shi Yu-Gen Chen Department of Colorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND A recently hypothesized cause of cell death called disulfidptosis has been linked to the expansion,emigration,and vascular rebuilding of cancer *** can be treated by targeting the pathways that trigger cell *** To discover the long non-coding RNA of the disulfidaptosis-related lncRNAs(DRLs),prognosis clinical survival,and treat patients with colorectal cancer with *** Initially,we queried the Cancer Genome Atlas database to collect transcriptome,clinical,and genetic mutation data for colorectal cancer(CRC).Training and testing sets for CRC patient transcriptome data were generated *** long non-coding RNAs(lncRNAs)related to DRLs were then identified and evaluated using a least absolute shrinkage and selection operator procedure,as well as univariate and multivariate Cox regression models.A prognostic model was then created after risk ***,Immune infiltration analysis,immune checkpoint analysis,and medication susceptibility analysis were used to investigate the causes of the different prognoses between high and low risk ***,we validated the differential expression and biomarker potential of riskpredictive lncRNAs through induction using both NCM460 and HT-29 cell lines,as well as a disulfidptosis *** In this work,eight significant lncRNAs linked to disulfidptosis were *** ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of differentially expressed genes between high-and low-risk groups from the prognostic model showed a close relationship with the immune response as well as significant enrichment in neutrophil extracellular trap formation and the IL-17 signaling ***,significant immune cell variations between the high-risk and low-risk groups were seen,as well as a higher incidence of immunological escape risk in the high-risk ***,Epirubicin,bortezomib,teniposide,and BMS-754807 were shown to have the lowest sensitivity among

关键词： Colorectal cancer Clinical outcomes disulfidptosis Drug sensitivity Immunotherapy

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MOF-derived Cu embedded into N-doped mesoporous carbon as a robust support of PdAu nanocatalysts for ethanol electrooxidation

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Rare Metals 2024年第3期43卷 1083-1094页

作者： Yu-Fu Huang Peng Wu Jun-ping Tang Jian Yang Jing Li Shuai Chen Xue-ling Zhao ChengChen Bin-Wei Zhang Yan-Yun Ma Wei-Heng Shi Dong-Hai Lin Shi-Gang Sun School of Energy and Materials Shanghai Engineering Research Center of Advanced Thermal Functional MaterialsShanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai201209China State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing401331China Center of Advanced Energy Technology and Electrochemistry Institute of Advanced Interdisciplinary StudiesChongqing UniversityChongqing400044China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA19104USA

Metal-organic frameworks(MOFs)h ave attracted widespread attention due to their large surface area and porous *** designing the nanostructures of MOFs to promote their application in ethanol electrooxidation is still a ***,a novel Cu-NCNs(Cu-nitrogen-doped carbon nanotubes)support was synthesized by pyrolysis of melamine(MEL)and Cu-ZIF-8 together,and then,Pd-Au nanoalloys were loaded by sodium borohydride reduction method to prepare PdAu@Cu-NCNs *** generating mesoporous carbon with high specific surface area and favorable electron and mass transport can be used as a potential excellent carrier for PdAu *** addition,the balance of catalyst composition and surface structure was tuned by controlling the content of Pd and ***,the best-performed Pd_(2)Au_(2)@Cu-NCN-1000-2(where 1000 means the carrier calcination temperature,and 2 means the calcination constant temperature time)catalyst exhibits better long-term stability and electrochemical activity for ethanol oxidation in alkaline media(4.80 A·mg^(-1)),which is 5.05 times higher than that of commercial Pd/C(0.95 A·mg^(-1)).Therefore,this work is beneficial to further promoting the application of MOFs in direct ethanol fuel cells(DEFCs)and can be used as inspiration for the design of more efficient catalyst support structures.

关键词： Metal-organic frameworks(MOFs) N-doped Mesoporous carbon PdAu Ethanol electrooxidation

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Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza *** Carthamus tinctorius L.

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 44-54页

作者： Linying Zhong ling Dong Jing Sun Jie Yang Zhiying Yu ping He Bo Zhu Yuxin Zhu Siyuan Li Wenjuan Xu School of Life Sciences Bejing University of Chinese MedicineBeijing 102488China School of Chinese Materia Medica Beijing University of Chinese MedicineBejing 102488China

Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(***,Dan Shen)and *** L.(***,Hong Hua)as an herb pair through network pharmacology and subsequent experimental ***:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of *** and *** as herb *** docking was used to verify the binding of the components of these herbs and their potential *** H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination *** blot was performed to detect the protein expression of these ***:Network pharmacology analysis revealed 5 pathways and 8 core targets of *** and *** in myocardial *** of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling *** achieved vascular tone mainly by regulating the target genes of the HIF-1 *** an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective *** docking verified the strong binding of Myric,Sal.B,and Ctan to *** blot further showed that the active ingredients synergistically upregulated the protein expressionof ***:The pharmacodynamic transmission analysis revealed that the active ingredients of *** and *** can synergistically resist ischemia through various targets and *** study provides a methodological reference for interpreting traditional Chinese medicine compatibility.

关键词： S.miltiorrhiza-C.tinctorius herb pair Compatibilitymechanism Networkpharmacology Multipletargeteffect Myocardial protection

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Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

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Journal of Integrative Medicine 2024年第1期22卷 72-82页

作者： Jing-shun Meng Yun He Heng-bin Yang Li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu Chang-quan ling Shanghai University of Traditional Chinese Medicine Shanghai 201203China Oncology Department of Traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Faculty of Traditional Chinese Medicine Naval Medical UniversityShanghai 200043China State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology(Ministry of Education) School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Yantai Fuheng Biological Technology Co. Ltd.YantaiShandong Province 264006China. Department of Clinical Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

Objective Melittin and its derivatives have been characterized to establish effective gene delivery *** capability of facilitating endosomal release enhances the nanoparticles-based gene ***,little investigation has been conducted to explore its potential application in the context of viral *** Various melittin-derived peptides were inserted into the loop VIII of the capsid proteins of recombinant adeno-associated virus *** vectors carrying either gfp or fluc genes were subjected to qPCR assays and transduction assays of HEK293T cells to investigate the efficiency of vector production and gene *** addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 ***,the intricate details of the vector-mediated transduction mechanisms were revealed by specific pharmacological inhibitors of every stage of the rAAV2 intracellular life *** A total of 76 melittin-related peptides were compiled from existing *** them,cMA2,Melt13,p5RHH and aAR3 were found to significantly enhance the gene delivery efficiency of rAAV2 *** p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to ***,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 *** importantly,p5RHH-rAAV8 vectors also demonstrated increased hepatic transduction in vivo in C57BL/6 *** The incorporation of melittin analogues into the rAAV capsids results in a significant improvement in rAAV-mediated transgene *** further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.

关键词： Melittin Recombinant adeno-associated virus Capsid engineering Transduction efficiency

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Simulating a Chern Insulator with𝐶C=±2 on Synthetic Floquet Lattice

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Chinese Physics Letters 2024年第9期41卷 1-8页

作者： ling-Xiao Lei Wei-Chen Wang Guang-Yao Huang Shun Hu Xi Cao Xin-Fang Zhang Ming-Tang Deng ping-Xing Chen Institute for Quantum Science and Technology College of ScienceNational University of Defense TechnologyChangsha 410073China Institute for Quantum Information&State Key Laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Greatwall Quantum Laboratory Changsha 410006China Hefei National Laboratory Hefei 230088China

The synthetic Floquet lattice,generated by multiple strong drives with mutually incommensurate frequencies,provides a powerful platform for quantum simulation of topological *** this study,we propose a 4-band tight-binding model of the Chern insulator with a Chern number𝐶=±2 by coupling two layers of the half Bernevig–Hughes–Zhang lattice and subsequently mapping it onto the Floquet lattice to simulate its topological *** determine the Chern number of our Floquet-version model,we extend the energy pumping method proposed by Martin et al.[2017 ***.X 7041008]and the topological oscillation method introduced by Boyers et al.[2020 ***.125160505],followed by numerical simulations for both *** simulation results demonstrate the successful extraction of the Chern number using either of these methods,providing an excellent prediction of the phase diagram that closely aligns with the theoretical one derived from the original bilayer half Bernevig–Hughes–Zhang ***,we briefly discuss a potential experimental implementation for our *** work demonstrates significant potential for simulating complex topological matter using quantum computing platforms,thereby paving the way for constructing a more universal simulator for non-interacting topological quantum states and advancing our understanding of these intriguing phenomena.

关键词： properties. topological quantum

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Role of hsa_circ_0007482 in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： Li-Yun Zhang Xin Liu Shuo Zheng Wen-Qun Xi Xue-ping Wu Dan-Yao Nie Hui-ling Hu Jian-Tao Wang Xin-Hua Liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482 on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482 expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482,along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2(Bcl-2),and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482 expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(Pdiscernible positive correlations detected between the expression of hsa_circ_0007482 and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

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Quantifying the natural growth rate of hepatocellular carcinoma:A real-world retrospective study in southwestern China

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World Journal of Hepatology 2024年第5期16卷 800-808页

作者： Li Tu Hong Xie Qi Li ping-Gui Lei Pei-ling Zhao Fan Yang Chi Gong Yuan-Lin Yao Shi Zhou Department of General Practice The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Clinical Medicine Soochow UniversitySuzhou 215123Jiangsu ProvinceChina Department of Radiology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Clinical Laboratory Center The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Key Laboratory of Biology and Medical Engineering Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Radiology Yanhe Tujia Autonomous County People's HospitalTongren 565300Guizhou ProvinceChina Department of Radiology The Qiandongnan Miao and Dong Autonomous Prefecture People's HospitalKaili 556000Guizhou ProvinceChina Department of Interventional Radiology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND In recent years,approximately half of the newly diagnosed cases and mortalities attributed to hepatocellular carcinoma(HCC)have been reported in *** the high incidence of HCC,there remains a paucity of data regarding the natural growth pattern and the determination of optimal surveillance intervals specific to the Chinese *** To quantify the natural tumor growth pattern of HCC in regional *** A retrospective analysis was performed on patients from a single institution in Southwest China who had undergone two or more serial dynamic computed tomography or magnetic resonance imaging scans between 2014 and 2020,without having received any anti-cancer *** growth was assessed using tumor volume doubling time(TVDT)and tumor growth rate(TGR),with volumes measured manually by experienced *** univariate linear regression and descriptive analysis were applied to explore associations between growth rates and clinical *** This study identifies the median TVDT for HCC as 163.4 d,interquartile range(IQR)72.1 to 302.3 d,with a daily TGR of 0.42%(IQR 0.206%-0.97%).HCC growth patterns reveal that about one-third of tumors grow indolently with TVDT exceeding 270 d,another one-third of tumors exhibit rapid growth with TVDT under 90 d,and the remaining tumors show intermediate growth rates,with TVDT ranging between 3 to 9 *** The identified TGRs support biannual surveillance and follow-up for HCC patients in certain regions of *** the observed heterogeneity in HCC growth,further investigation is warranted.

关键词： Hepatocellular carcinoma Natural tumor growth pattern Tumor volume doubling time Tumor growth rate Realworld retrospective study

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Correlation between TEX14 and ADAM17 expressions in colorectal cancer tissues of elderly patients and neoplasm staging,invasion,and metastasis

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World Journal of Clinical Cases 2024年第24期12卷 5492-5501页

作者： Gun Chen ling-Hua Cong Chi-Jiang Gu ping Li Department of Pathology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Department of Gastrointestinal Surgery The Affiliated People’s Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one of the most frequently encountered malignant tumors in clinical *** encoded by the testis-expressed gene 14(TEX14)are imperative for spermatogenesis,necessitating intercellular bridges between germ *** expression of TEX14 has also been associated with the proliferation and differentiation of certain tumor *** A disintegrin and metalloprotease 17(ADAM17)is known as a membrane-bound protease that regulates cellular activities and signal transduction by hydrolyzing various substrate proteins on the cell *** hypothesize that TEX14 and ADAM17 may serve as potential biomarkers influencing the staging,invasion,and metastasis of *** To probe the correlation between TEX17 and ADAM17 profiles in the CRC tissues of elderly patients and their association with CRC staging,invasion,and *** We gathered data from 86 elderly patients diagnosed pathologically with CRC between April 2020 and December *** each patient,one sample of cancer tissue and one sample of adjacent normal tissue were ***-time fluorescence quantitative PCR measured the mRNA profiles of TEX14 and *** ascertained the positivity rates of TEX14 and ADAM17 *** pathological features of neoplasm staging,invasion,and metastasis were collected,and the association between TEX14 and ADAM17 expressions and clinical pathology was *** The mRNA and expression profiles of TEX14 and ADAM17 were significantly elevated in CRC *** positivity rates of TEX14 and ADAM17 proteins in CRC tissues were 70.93%and 77.91%,*** were no significant differences in age,sex,pathological type,and tumor diameter between TEX14 and ADAM17-positive and-negative *** with higher tumor differentiation degree,deeper infiltration and TNM stages ranging from III to IV exhibited higher positivity rates of TEX14 and *** with lymph node me

关键词： Elderly patients Colorectal cancer TEX14 ADAM17 Staging Invasion Metastasis

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Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

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Animal Models and Experimental Medicine 2024年第1期7卷 56-70页

作者： Shang Wang Yi Yan Jian Zhang ping Yuan Ci-Jun Luo Hong-ling Qiu Hui-Ting Li Jian Xu Lan Wang Tian-Lan Li Rong Jiang Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Heart Center and Shanghai Institute of Pediatric Congenital Heart disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Respiratory and Critical Care Medicine The 416 Hospital of Nuclear IndustryThe Second Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoChina

Background:The maintenance dosage of selexipag is categorized as low,medium or *** order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and ***:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were ***:Thirteen studies were *** led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good *** treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage *** finding is important for guiding individualized treatments.

关键词： individualized treatments meta-analysis prostacyclin receptor agonist risk stratification systematic review

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Breast cancer and rectal cancer associated with Lynch syndrome:A case report

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World Journal of Clinical Oncology 2024年第9期15卷 1215-1221页

作者： Pei-Fang Qin ling Yang Jun-ping Hu Jing-Yue Zhang Department of Laboratory Medicine The People Hospital of GuigangGuigang 537100Guangxi Zhuang Autonomous RegionChina

BACKGROUND The development mechanisms of Lynch syndrome(LS)-related breast cancer(BC)and rectal cancer are complex and variable,leading to personalized variations in diagnosis and treatment *** SUMMARY This paper presents a comprehensive review of clinical diagnosis and treatment data from a patient with LS-associated BC and rectal ***,screening data and management guidelines,as well as relevant literature on LS,are included in this *** study summarizes the molecular pathogenesis,clinicopathological features,and screening and management protocols for LS-associated BC and rectal *** Implementing early screening,prevention,and timely diagnosis and treatment measures is expected to reduce mitigate the incidence and mortality of LS-related BC and rectal cancer.

关键词： Lynch syndrome Breast cancer Rectal cancer Mismatch repair gene Case reports

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