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疟原虫有性生殖传播阻断疫苗的研究进展

中国寄生虫学与寄生虫病杂志 2024年第3期42卷 399-406页

作者：王蓉徐洁朱晓彤中国医科大学第二临床学院辽宁沈阳110122 中国医科大学药学院辽宁沈阳110122 中国医科大学免疫学教研室辽宁沈阳110122

疟疾仍是一项重大的全球卫生挑战。现阶段由于药物和相关技术的应用,一定程度上减少了疾病的负担,但发病率和死亡率仍然非常高。随着耐药性的广泛出现,亟需探索和研制新的防疟根本策略,有效控制和阻断疟疾的传播。针对有性生殖阶段的传... 详细信息

疟疾仍是一项重大的全球卫生挑战。现阶段由于药物和相关技术的应用,一定程度上减少了疾病的负担,但发病率和死亡率仍然非常高。随着耐药性的广泛出现,亟需探索和研制新的防疟根本策略,有效控制和阻断疟疾的传播。针对有性生殖阶段的传播阻断疫苗(TBV)是一个很好的选择,其旨在控制疟原虫从人类宿主传播到蚊媒媒介。TBV的研制受到了国内外研究者的重视,被认为是防治疟疾的新技术之一。本文总结了TBV的研究和开发,以及候选抗原的发现和进展,为TBV的进一步研究提供理论参考。

关键词：疟疾疟原虫传播阻断疫苗候选抗原

Pricing strategy in the product and service market

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Journal of Management Science and Engineering 2021年第2期6卷 211-234页

作者： Yu Xia Jiaping Xie Weijun zhu ling Liang School of Business Nanjing University of Information Science&Technology219 Ningliu RoadNanjingJiangsu210044China School of International Business Administration Shanghai University of Finance&Economics777 Guoding RoadShanghai200433China Tourism and Event Management School Shanghai University of International Business and Economics1900 Wenxiang RoadShanghai201620China

Existing studies have mainly focused on pricing in either primary markets or ***,in practice,prices in primary markets and aftermarkets are closely *** study examines the joint pricing strategy in both primary markets and aftermarkets based on customer utility and establishes a pricing model for profit-maximization *** results show that overpricing in the aftermarket is caused by customer myopia,while the motivation of the firm to avoid customer myopia depends on its pricing strategy.A quantityeprice contract in the aftermarket is designed to raise the firm’s profit.

关键词： Aftermarket service Customer myopia Product service system

Signature of Superconductivity in Pressurized La_(4)Ni_(3)O_(10)

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Chinese Physics Letters 2024年第1期41卷 77-84页

作者：李庆张英杰项浙宁张宇航祝熙宇闻海虎 National Laboratory of Solid State Microstructures and Department of Physics Center for Superconducting Physics and MaterialsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The discovery of high-temperature superconductivity near 80K in bilayer nickelate La_(3)Ni_(2)O_(7)under high pressures has renewed the exploration of superconducting nickelate in bulk *** extension of superconductivity in other nickelates in a broader family is also ***,we report the experimental observation of superconducting signature in trilayer nickelate La_(4)Ni_(3)O_(10)under high *** using a modified solgel method and post-annealing treatment under high oxygen pressure,we successfully obtained polycrystalline La_(4)Ni_(3)O_(10)samples with different transport behaviors at ambient *** we performed high-pressure electrical resistance measurements on these samples in a diamond-anvil-cell ***,the signature of possible superconducting transition with a maximum transition temperature(T_(c))of about 20K under high pressures is observed,as evidenced by a clear drop of resistance and the suppression of resistance drops under magnetic *** the resistance drop is sample-dependent and relatively small,it appears in all of our measured *** argue that the observed superconducting signal is most likely to originate from the main phase of La_(4)Ni_(3)O_(10).Our findings will motivate the exploration of superconductivity in a broader family of nickelates and shed light on the understanding of the underlying mechanisms of high-T_(c) superconductivity in nickelates.

关键词： materials superconductivity signature

鸟分支杆菌致支气管扩张症合并感染的药物治疗与监护一例

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临床药物治疗杂志 2024年第3期22卷 83-85页

作者：祝晓雨王静宜陈瑞玲首都医科大学附属北京天坛医院药学部北京100070 西南医科大学附属中医医院静脉用药调配中心四川泸州646000

本文报道1例鸟分支杆菌致支气管扩张症合并感染患者,在缺乏药物敏感性试验指导的情况下,临床药师参与药物治疗及药学监护过程。临床药师结合患者的既往史、诊疗史、疾病生理特点及当前病情,通过循证协助选择初始治疗方案;从用药安全性... 详细信息

本文报道1例鸟分支杆菌致支气管扩张症合并感染患者,在缺乏药物敏感性试验指导的情况下,临床药师参与药物治疗及药学监护过程。临床药师结合患者的既往史、诊疗史、疾病生理特点及当前病情,通过循证协助选择初始治疗方案;从用药安全性、有效性、用药注意事项和用药依从性等方面实施药学监护;在初始治疗有效性不显著时,根据药物的药动学和药效学特点调整药物治疗建议,医师采纳并实施。经治疗患者临床效果良好,顺利出院。

关键词：非结核分枝杆菌鸟分枝杆菌复合群肺部感染临床药学服务

“腾笼换鸟”:高校布局调整与区县产业协调发展

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北京大学教育评论 2024年第1期22卷 41-59,189页

作者：林璐朱琼哈巍北京大学教育经济研究所北京100871

本文借助中国高等教育扩招浪潮下新建高校或校区的准实验,考察高校区域布局调整对区县产业协调发展的影响。本文发现,新建高校或校区对所在区县的新企业数量带来了消极影响,但对新企业的产业结构高级化水平起到了显著的积极影响,由此发... 详细信息

本文借助中国高等教育扩招浪潮下新建高校或校区的准实验,考察高校区域布局调整对区县产业协调发展的影响。本文发现,新建高校或校区对所在区县的新企业数量带来了消极影响,但对新企业的产业结构高级化水平起到了显著的积极影响,由此发挥出促进地方产业“腾笼换鸟”的功能。在区域协调发展方面,新建高校或校区在距离省会城市中心较远的地区同样发挥出了促进当地新企业产业结构高级化的功能。从全国跨区域比较来看,新建高校或校区具有“放大”区位劣势的效应,非东部地区的院校或校区对当地新企业产业结构高级化的促进作用较弱。应积极发挥高校通过影响产业布局促进地方产业结构转型升级的作用,实现地方高校特色办学与产业特色发展相结合,推动区域高等教育与经济建设协调发展。

关键词：产业布局高等教育准实验产业结构升级区域协调发展

维普期刊数据库博看期刊

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金融科技发展与银行提质增效研究

金融论坛 2024年第1期29卷 25-34页

作者：朱小能李雄一上海财经大学金融学院、上海国际金融与经济研究院上海200433 上海财经大学金融学院上海200433

本文运用文本挖掘方法构建银行金融科技发展指标,基于2011-2020年469家商业银行面板数据,研究金融科技发展与银行提质增效的多维关系。研究表明:银行发展金融科技,通过提升金融服务能力和经营管理水平增加经营效益,提升信贷风险管控水... 详细信息

本文运用文本挖掘方法构建银行金融科技发展指标,基于2011-2020年469家商业银行面板数据,研究金融科技发展与银行提质增效的多维关系。研究表明:银行发展金融科技,通过提升金融服务能力和经营管理水平增加经营效益,提升信贷风险管控水平优化银行成本效率,从而实现银行提质增效。通过异质性分析发现,银行金融科技对大型银行营业收入和经营成本的影响略为迟缓,但是大型银行运用金融科技优化经营绩效的整体效果更为突出。

关键词：金融科技提质增效银行数字化转型文本挖掘

Crystal face dependent intrinsic wettability of metal oxide surfaces

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National Science Review 2021年第1期8卷 109-116页

作者： Zhongpeng zhu Zhenwei Yu Frank F.yun Deng Pan Ye Tian Lei Jiang Xiaolin Wang Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of Sciences Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang University Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of Wollongong

Knowledge of intrinsic wettability at solid/liquid interfaces at the molecular level perspective is significant in understanding crucial progress in some fields, such as electrochemistry, molecular biology and earth science. It is generally believed that surface wettability is determined by the surface chemical component and surface topography. However, when taking molecular structures and interactions into consideration,many intriguing phenomena would enrich or even redress our understanding of surface wettability. From the perspective of interfacial water molecule structures, here, we discovered that the intrinsic wettability of crystal metal oxide is not only dependent on the chemical components but also critically dependent on the crystal faces. For example, the （1■02） crystal face of α-Al;O;is intrinsically hydrophobic with a water contact angle near 90°, while another three crystal faces are intrinsically hydrophilic with water contact angles <65°. Based on surface energy analysis, it is found that the total surface energy, polar component and Lewis base portion of the hydrophobic crystal face are all smaller than the other three hydrophilic crystal faces indicating that they have different surface states. DFT simulation further revealed that the adsorbed interfacial water molecules on each crystal face hold various orientations. Herein, the third crucial factor for surface wettability from the perspective of the molecular level is presented, that is the orientations of adsorbed interfacial water molecules apart from the macro-level chemical component and surface topography. This study may serve as a source of inspiration for improving wetting theoretical models and designing controllable wettability at the molecular/atomic level.

关键词： anisotropic wettability α-Al2O3 interfacial water layer surface energy DFT simulation

Oscillation Criteria for Impulsive Hyperbolic Equations of Neutral Type

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Chinese Quarterly Journal of Mathematics 2006年第2期21卷 176-184页

作者： zhu Xian-yang LI Yong-kun LU ling-hong Department of Mathematics Yunnan University Kunming 650091 China Department of Mathematics Shanghai University Shanghai 200436 China

Oscillation properties of the solutions of impulsive hyperbolic equations are investigated by the method of differential inequalities.

关键词： oscillation hyperbolic equation impulsive boundary value problem

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数字化医疗在儿童术后疼痛管理中的应用前景

协和医学杂志 2024年第2期15卷 279-284页

作者：陈斐张羽冠朱波国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院麻醉科北京100021 中国医学科学院北京协和医院麻醉科北京100730

近年来,随着数字化医疗在医学麻醉领域应用逐渐广泛,其在儿童术后疼痛管理中的作用日益受到关注。数字化医疗不仅为儿童术后疼痛的术前预测、术后监测评估及治疗管理提供了新思路,同时为麻醉医生制定最佳术后疼痛管理策略提供了新方案... 详细信息

近年来,随着数字化医疗在医学麻醉领域应用逐渐广泛,其在儿童术后疼痛管理中的作用日益受到关注。数字化医疗不仅为儿童术后疼痛的术前预测、术后监测评估及治疗管理提供了新思路,同时为麻醉医生制定最佳术后疼痛管理策略提供了新方案。本文通过回顾数字化医疗及其在临床麻醉中的应用,对该疗法在儿童术后疼痛管理方面的应用前景进行综述,以期加深临床医师的认知。

关键词：数字化医疗临床麻醉小儿术后疼痛疼痛治疗