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Validity and reliability of the Ocular Motor Nerve Palsy Scale

Neural Regeneration Research 2018年第10期13卷 1851-1856页

作者： ling-yun zhou Chang Su Tie-Juan Liu Xue-Mei Li Ocular Motility Disorder Treatment & Rehabilitation Center Department of AcupunctureFirst Affiliated Hospital of Harbin Medical University

Objective and accurate assessment of the degree of ocular motor nerve palsy is helpful not only in the evaluation of prognosis, but also for the screening of treatment methods. However, there is currently no comprehensive measure of its severity. In this study, we designed the Ocular Motor Nerve Palsy Scale and investigated its validity and reliability. Six experts were invited to grade and evaluate the scale. The study recruited 106 patients with a definite diagnosis of unilateral isolated ocular motor nerve palsy. Three physicians evaluated the patients using the scale. One of the three physicians evaluated the patients again after 24 hours. The content validity index（CVI） and factor analysis were used to analyze the scale＇s construct validity. The intraclass correlation coefficient and Cronbach＇s alpha were used to evaluate the inter-rater and test-retest reliability and the internal consistency. The CVI results（I-CVI = 1.0, S-CVI = 0.9, Pc = 0.016, K＊ = 1） indicated good content validity. Factor analysis extracted two common factors that accounted for 85.2% of the variance. Furthermore, the load value of each component was above 0.8, indicating good construct validity. The Ocular Motor Nerve Palsy Scale was found to be highly reliable, with an inter-rater reliability intraclass correlation coefficient of 0.965（P 0.01）, a test-retest reliability intraclass correlation coefficient of 0.976（P 0.01）, and Cronbach＇s alpha values of 0.63–0.70. In conclusion, the Ocular Motor Nerve Palsy Scale with good validity and reliability can be used to quantify the severity of ocular motor nerve palsy. This study was registered at Chinese Clinical Trial Registry（registration number： Chi CTR-OOC-17010702）.

关键词： nerve regeneration Ocular Motor Nerve Palsy Scale oculomotor nerve paralysis abducens nerve paralysis trochlear nerve paralysis validity reliability internal consistency diplopia eyeball movement disorder ptosis neural regeneration

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Adult reference values of the computerized diplopia test

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1646-1650页

作者： ling-yun zhou Tie-Juan Liu Xue-Mei Li Ocular Motility Disorder Treatment Centre the First Affiliated Hospital of Harbin Medical University

AIM： To estimate the adult reference values for measured deviations by a computerized diplopia test and testify the ***： Totally 391 participants were recruited and taken the computerized diplopia test. The plots and amplitude of deviations were recorded. The differences in different gender, age and visual acuity groups were analyzed respectively. Of 30 subjects were enrolled to testify the interobserver reliability. Another 46 subjects（including 26 normal subjects and 20 patients） were taken the test and theirs deviations were recorded to testify the validity of the reference ***： The max horizontal and vertical deviations were 2.55° and 0.76° with normal corrected visual acuity while 3.88° and 1.46° for subjects with poor corrected vision. The differences between age groups was insignificant（Z =3.615, 4.758; P =0.461, 0.313 for horizontal and vertical respectively）. The max horizontal deviation of female was smaller than male（Z =-2.177; P =0.029）,but the difference in max vertical deviation was insignificant（Z =-1.296; P =0.195）. The mean difference between observers were both-0.1°, with 95% confidence limits（CI） of-1.4° and 1.6° in max horizontal deviations while-2.1° and 1.8° in max vertical deviation. The mean deviation of 26 normal subjects was 1.02° ±0.84° for horizontal and 0.47° ±0.30° for vertical which both within the range of reference values. The mean deviation of 20 patients was 13.51°±11.69° for horizontal and 8.34°±8.58°for vertical which both beyond the reference ***： The max amplitude of horizontal and vertical deviation is pointed as the numerical parameters of computerized diplopia test. The reference values are different between normal corrected visual acuity and poor corrected vision. These values may useful for evaluating patients with diplopia in veriety conditions during clinical practice.

关键词： computerized diplopia test referencevalues amplitude of deviations

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Early warning and clinical outcome prediction of acute-onchronic hepatitis B liver failure

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World Journal of Gastroenterology 2015年第42期21卷 11964-11973页

作者： En-Qiang Chen Fan Zeng ling-yun zhou Hong Tang Center of Infectious Diseases West China Hospital of Sichuan University Division of Infectious Diseases State Key Laboratory of Biotherapy Sichuan University

Hepatitis B virus(HBV) associated acute-on-chronic liver failure(ACLF) is an increasingly recognized fatal liver disease encompassing a severe acute exacerbation of liver function in patients with chronic hepatitis B(CHB). Despite the introduction of an artificial liver support system and antiviral therapy, the short-term prognosis of HBV-ACLF is still extremely poor unless emergency liver transplantation is performed. In such a situation, stopping or slowing the progression of CHB to ACLF at an early stage is the most effective way of reducing the morbidity and mortality of HBV-ACLF. It is well-known that the occurrence and progression of HBV-ACLF is associated with many factors, and the outcomes of HBV-ACLF patients can be significantly improved if timely and appropriate interventions are provided. In this review, we highlight recent developments in early warning and clinical outcome prediction in patients with HBV-ACLF and provide an outlook for future research in this field.

关键词： Chronic hepatitis B Acute exacerbation Acute-on-ch

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A new interpretation and quantitative method for diplopia test： 304 cases of ocular motor nerve palsy for clinical test and verify

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1768-1770页

作者： ling-yun zhou Tie-Juan Liu Xue-Mei Li Chang Su Xiao-Jie Ji Ming Zhao Ocular Motility Disorder Treatment & Rehabilitation Center Acupuncture Department the First Affiliated Hospital of Harbin Medical University Harbin 150001 HeilongjiangProvince China

We introduce a new interpretation and quantitative method for computerized diplopia test. By comparing this new method to the Hess screen test, we validate its applicability among 304 patients with ocular motor nerve palsy. This new method shows great assistant value as the Hess screen test in making accurate diagnosis and quantitative evaluation the severity of diplopia. Furthermore, it is more convenient and suitable for daily clinical use.

关键词： diplopia test interpreting and scoring method Hess charts ocular motor nerve palsy max angle of diplopia

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Effects of Intraorbital Electroacupuncture on Diabetic Abducens Nerve Palsy

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Chinese Medical Journal 2017年第14期130卷 1741-1742页

作者： ling-yun zhou Tie-Juan Liu Xue-Mei Li Chang Su Jin zhou Ocular Motility Disorder Treatment Centre The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Hematology The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Diabetic abducens nerve palsy main symptoms include ocular motility disorders and *** disease is mainly caused by severe vascular *** is a serious impact on patient＇s quality of life and mental ***,there is no effective means of intervention for eye movement disorders and diplopia,the patients could only expect for neural self-repair.[1] Our team invented intraorbital electroacupuncture （IEA） therapy to repair abducens nerve affected by *** the meantime,we applied it into clinical practice and achieved great success.

关键词： Acupuncture Diabetic Abducens Nerve Palsy Diplopia Deviation Eyeball Movement

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Advancing gravitational theory through the tetrahedral constellation gravitational wave observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 197-198页

作者： yun-Yong Wang zhou-Jian Cao Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing102206China

The Tetrahedral Constellation Gravitational Wave Observatory(TEGO)[1]represents a significant leap forward in gravitational wave detection,advancing our understanding of gravitational *** introducing a fourth spacecraft to form a tetrahedral configuration,TEGO enhances traditional triangular setups,enabling the simultaneous sensitivity to all six gravitational wave polarization modes,including those not predicted by general relativity.

关键词： wave polarization theory

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Intraorbital Electroacupuncture Therapy for Thyroid-associated Ophthalmopathy

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Chinese Medical Journal 2017年第15期130卷 1884-1885页

作者： ling-yun zhou Chang Su Xue-Mei Li Tie-Juan Liu Ming Zhao Department of Acupuncture and Moxibustion The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

To the Editor：Intraorbital electroacupuncture （IEA） therapy is highly effective in treating ocular motility disorders,but it has only rarely been used to treat thyroid-associated ophthalmopathy （TAO）.Herein,we report one successful case.A 54-year-old Chinese man was diagnosed with hyperthyroidism 4 years ago and received I[3] ***,the result was *** had to keep taking antithyroid drugs （ATDs）.His palpebral edema gradually worsened and he developed visual impairment during the ATD *** therapy was administered to relieve his ***,his condition worsened after a reduction in the glucocorticoid dosage.

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Tensor Decomposition-assisted Multiview Subgroup Analysis

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Acta Mathematica Sinica,English Series 2025年第2期41卷 588-618页

作者： Xun Zhao ling zhou Weijia Zhang Huazhen Lin Center of Statistical Research and School of Statistics New Cornerstone Science LaboratorySouthwestern University of Finance and EconomicsChengdu 610064P.R.China Department of Financial and Actuarial Mathematics Xi'an Jiaotong-Liverpool UniversitySuzhou 215123P.R.China

To learn the subgroup structure generated by multidimensional interaction, we propose a novel multiview subgroup integration technique based on tensor decomposition. Compared to the traditional subgroup analysis that can only handle single-view heterogeneity, our proposed method achieves a greater level of homogeneity within the subgroups, leading to enhanced interpretability and predictive power. For computational readiness of the proposed method, we build an algorithm that incorporates pairwise shrinkage-encouraging penalties and ADMM techniques. Theoretically, we establish the asymptotic consistency and normality of the proposed estimators. Extensive simulation studies and real data analysis demonstrate that our proposal outperforms other methods in terms of prediction accuracy and grouping consistency. In addition, the analysis based on the proposed method indicates that intergenerational care significantly increases the risk of chronic diseases associated with diet and fatigue in all provinces while only reducing the risk of emotion-related chronic diseases in the eastern coastal and central regions of China.

关键词： Multiview subgroup analysis tensor decomposition data integration ADMM algorithm

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Efficacy of intraorbital electroacupuncture for diabetic abducens nerve palsy： study protocol for a prospective single-center randomized controlled trial

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Neural Regeneration Research 2017年第5期12卷 826-830页

作者： ling-yun zhou Xue-mei Li Tie-juan Liu Xiao-jie Ji Ming Zhao Chang Su Ji-chao Liu Jiang-yun Sun Ocular Motility Disorder Treatment & Rehabilitation Center Department of Acupuncture the First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang Province China

Abducens nerve palsy（ANP） is commonly seen in patients with diabetes mellitus. The validity of acupuncture as a traditional Chinese medicine method in peripheral nerve repair is well established. However, its efficacy in randomized controlled trials remains unclear. Herein, we designed a protocol for a prospective, single-center, randomized controlled trial to investigate the effect of intraorbital electroacupuncture on diabetic ANP. We plan to recruit 60 patients with diabetic ANP, and randomly divide them into treatment and control groups. Patients in both groups will continue their glucose-lowering therapy. A neural nutrition drug will be given to both groups for six weeks. The treatment group will also receive intraorbital electroacupuncture therapy. We will assess efficacy of treatment, eyeball movement, diplopia deviation and the levels of fasting blood-glucose and glycosylated hemoglobin before treatment at 2, 4, and 6 weeks after treatment. The efficacy and recurrence will be investigated during follow-up（1 month after intervention）. This protocol was registered at Chinese Clinical Trial Registry on 16 January 2015（Chi CTR-IPR-15005836）. This study was approved by the Ethics Committee of First Affiliated Hospital of Harbin Medical University of China（approval number： 201452）. All protocols will be in accordance with Declaration of Helsinki, formulated by the World Medical Association. Written informed consent will be provided by participants. We envisage that the results of this clinical trial will provide evidence for promoting clinical use of this new therapy for management of ANP.

关键词： nerve regeneration sixth cranial nerve peripheral nerve injury electroacupuncture diabetes mellitus eyeball movement diplopia rehabilitation ocular motility disorder intervention randomized controlled trail neural regeneration

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Rehabilitation of Abducens Nerve Palsy after Cholesteatoma Resection at Cerebellopontine Angle by Intraorbital Electroacupuncture

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Chinese Medical Journal 2017年第13期130卷 1625-1626页

作者： ling-yun zhou Xue-Mei Li Tie-Juan Liu Xiao-Jie Ji Ming Zhao Chang Su Harbin Med Univ Affiliated Hosp 1 Dept Acupuncture & Moxibust 199 Dongdazhi St Harbin 150001 Heilongjiang Peoples R China

To the Editor： A 20-year-old man reported with a complaint of diplopia for 10 days after a resection of cholesteatoma at left cerebellopontine angle （CPA）. One and half months before the surgery, the patient suddenly had a shock and unbearable pain on his left cheek with no obvious incentives. The patient did not have facial hypoesthesia, hearing loss, diplopia, and other symptoms such as nausea and vomiting. Two weeks later, the pain became deteriorated, was induced easily by touching or washing face,

关键词： Abducens Nerve Palsy Cholesteatoma Resection Cerebellopontine Angle

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