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Autophagy Elicits Neuroprotection at the Subacute Phase of Transient Cerebral Ischaemia but Has Few Effects on Neurological Outcomes After Permanent Ischaemic Stroke in Rats

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Current Medical Science 2021年第4期41卷 803-814页

作者： Tao guo Yi-hao DENG ling-ling DONG Lu REN Hong-yun HE Department of Basic Medicine Medical SchoolKunming University of Science and TechnologyKunming 650500China

Objective Autophagy was prominently activated by cerebral *** study was to investigate the exact role of autophagy in ischaemic *** Two rat models of transient middle cerebral artery occlusion(tMCAO)and permanent MCAO(pMCAO)were *** brain tissues in the penumbra were obtained to observe the dynamic variations of autophagy activity with Beclin1 and LC3 antibodies by Western *** the characteristic time points,when autophagy activity was markedly elevated or reduced,the autophagy activation signaling was intervened with rapamycin and 3-methyladenine,***,key proteins in the autopahgic/lysosomal pathway were detected with the antibodies of LC3,p62,ubiquitin,LAMP-1 and cathepsin ***,TTC staining,neurological score and immunofluorescence were performed to evaluate brain infarct volume,neurological deficit and neuron survival,*** Both Beclin1 and LC3 expression levels were remarkably altered at 6 h,12 h,2 days and 7 days after ***,the dynamic changes of autophagy activity following pMCAO were identical to those after *** autophagy induction nor autophagy inhibition was able to ameliorate the pMCAO-induced neurological injury due to lysosomal dysfunction,as indicated by low levels of LAMP-1 and cathepsin B,accompanied with the accumulation of LC3-II,ubiquitin and insoluble ***,autophagy induction elicited overt neuroprotection at 2 and 7 days after tMCAO,and this neuroprotection might be elicited by the enhancement of autophagy *** Our study suggests that autophagy confers neuroprotection at the subacute phase of tMCAO but has few effects on neurological outcomes after pMCAO.

关键词： permanent cerebral stroke transient cerebral ischaemia autophagy induction autophagy inhibition neuroprotection

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Nanograting‑Based Dynamic Structural Colors Using Heterogeneous Materials

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Nano-Micro Letters 2025年第3期17卷 138-151页

作者： Jingang Wang Haibo Yu Jianchen Zheng Yuzhao Zhang Hongji guo Ye Qiu Xiaoduo Wang Yongliang Yang Lianqing Liu State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Dynamic structuralcolors can change in response todifferent environmental *** ability remains effectiveeven when the size of the speciesresponsible for the structural coloris reduced to a few micrometers,providing a promising sensingmechanism for solving microenvironmentalsensing problems inmicro-robotics and ***, the lack of dynamicstructural colors that can encoderapidly, easily integrate, and accuratelyreflect changes in physical quantities hinders their use in microscale sensing applications. Herein, we present a 2.5-dimensionaldynamic structural color based on nanogratings of heterogeneous materials, which were obtained by interweaving a pH-responsive hydrogelwith an IP-L photoresist. Transverse gratings printed with pH-responsive hydrogels elongated the period of longitudinal grating in the swollenstate, resulting in pH-tuned structural colors at a 45° incidence. Moreover, the patterned encoding and array printing of dynamic structuralcolors were achieved using grayscale stripe images to accurately encode the periods and heights of the nanogrid structures. Overall, dynamicstructural color networks exhibit promising potential for applications in information encryption and in situ sensing for microfluidic chips.

关键词： Dynamic structural colors Four-dimensional printing pH-responsive Nanogrid Heterogeneous materials

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Polarization-encoded neural networks with simplified grating patch

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Science China Technological Sciences 2025年

作者： Chengyan ZHONG Xiang WANG lingfei LI Yuanchi CUI Lei XIAO Dawei SONG Junxiong guo Wen HUANG Yufeng guo Yu LIU College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University Nanjing Mumusili Technology Co. LTD School of Integrated Circuits Tsinghua University Institute of Advanced Study School of Electronic Information and Electrical Engineering Chengdu University State Key Laboratory of Electronic Thin Films and Integrated Devices School of Integrated Circuit Science and EngineeringUniversity of Electronic Science and Technology of China

Optical neural networks (ONNs) offer a promising solution for high-performance, energy-efficient artificial intelligence hardware by leveraging the parallelism and speed of light. However, the large-scale implementation of ONNs remains challenging due to the bulky footprint and complex control of optical synapses. In this work, we propose and simulate a plasmonic polarized synaptic architecture that overcomes the diffraction limit and enables ultra-compact ONNs. By tuning the polarization state of incident light, the optical transmittance through each plasmonic unit can be dynamically adjusted to represent a synaptic weight. Our plasmonic structures, with features as small as 40 nm, operate well below this limit in the visible spectrum (400–750 nm). Compared with diffraction and interference-based circuit designs, our proposed method achieves a substantial reduction in synaptic density by factors of 150000-fold and 1500-fold, respectively. Furthermore, we successfully demonstrate a proof-of-concept plasmonic ONN applied to the Canadian Institute for Advanced Research—10classes (CIFAR-10) dataset using a Visual Geometry Group network with 16 layers (VGG16) model. After training for 80epochs, the network achieves an accuracy of 93%. The polarization-tunable plasmonics paves the way towards scalable ONNs for next-generation artificial intelligence (AI) accelerators and smart sensors.

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Mission and challenges of higher education: an interview with G.Q. Max Lu, the president of the University of Surrey

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National Science Review 2020年第6期7卷 1108-1113页

作者： ling Wang Zhengtang guo the Institute of Geology and Geophysics Chinese Academy of Sciences

The University of Surrey (referred to as Surrey hereafter) is one of the renowned universities in the UK that was established on 9 September1966 with the grant of its Royal Charter and its roots go back to Battersea Polytechnic Institute, founded in 1891. Surrey is the research hub of small satellites, mobile telecommunication and artificial intelligence in Europe. In 2016, Surrey was named as ‘Univer-

关键词： Biographies

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Literature study on traditional Chinese medicine syndromes after renal transplantation

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World Journal of Transplantation 2025年第1期15卷 150-155页

作者： yun-Peng guo ling-Xue Bao Yu-Yang Wang Quan Wen Gai Hang Bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Urology Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,*** have not been effectively *** study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying *** To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical *** The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically *** Following the established inclusion and exclusion criteria,13 studies were selected for ***-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM ***,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the *** Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent *** is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

关键词： Kidney transplantation Syndrome Literature analysis Traditional Chinese medicine Systematic review

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Exploration and analysis of the composition and mechanism of efficacy of camel milk

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Food Bioscience 2023年第3期53卷 85-95页

作者： Chen Liu ling-Xiao Liu Jie Yang yun-guo Liu Shandong(Linyi)Institute of Modern Agriculture Zhejiang UniversityLinyi276000China College of Life Sciences Linyi UniversityLinyi276005China Linyi Academy of Agricultural Sciences Linyi276005China College of Life Science and Technology Xinjiang UniversityUrumqi830046China

Camel milk is a high-quality milk with high nutritional value and health *** milk contains a variety of nutrients such as fat,protein,vitamins,lactose,*** milk production and quality of camels is influenced by their size,age and feeding *** camel milk is consumed,it is supplemented with nutrients,and after digestion and absorption in the body,it produces a large amount of angiotensin converting enzyme(ACE)inhibitory peptides and DPPV inhibitory peptides,which can also assist in the treatment of hypertension,diabetes,immunity,delay kidney and liver damage,without toxic side effects to the *** has also been found that the various biological activities of camel milk may be related to its *** review provides a comprehensive overview of the components of camel milk,its adjuvant therapeutic effects on diseases,and presents the high quality value of camel milk through the research literature.

关键词： Camel milk Nutrition Peptides Diabetes Hypertension

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Ammonia-induced CuO/13X for H_(2)S removal from simulated blast furnace gas at low temperature

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Green Energy & Environment 2025年第1期10卷 139-149页

作者： Erping Cao Yuhua Zheng Hao Zhang Jianshan Wang Yuran Li Tingyu Zhu Zhan-guo Zhang Guangwen Xu Yanbin Cui State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization PanGang Group Research Institute Co.Ltd.Panzhihua Sichuan617000China Shenyang University of Chemical Technology Shenyang110142China University of Chinese Academy of Sciences Beijing 100049China

Blast furnace gas(BFG)is an important by-product energy for the iron and steel industry and has been widely used for heating or electricity ***,the undesirable contaminants in BFG(especially H_(2)S)generate harmful environmental *** desulfurization of BFG is urgent for integrated steel plants due to the stringent ultra-low emission *** with other desulfurization materials,zeolite-based adsorbents represent a viable option with low costs and long service *** this study,an ammonia-induced CuO modified 13X adsorbent(NH3–CuO/13X)was prepared for H_(2)S removal from simulated BFG at low *** XRD,H_(2)-TPR and TEM analysis proved that smaller CuO particles were formed and the dispersion of Cu on the surface of 13X zeolite was improved via the induction of *** on H_(2)S adsorption performance of the adsorbent was carried out using simulated BFG,and the results showed that NH3–CuO/13X-3 has better breakthrough sulfur capacity,which was more than twice the sulfur capacity of CuO/*** is proposed that the enhanced desulfurization performance of NH3–CuO/13X is attributed to an abundant pore of 13X,and combined action of 13X and *** work provided an effective way to improve the sulfur capacity of zeolite-based adsorbents via impregnation method by ammonia induction.

关键词： Blast furnace gas Desulfurization Ammonia-induced CuO 13X zeolite

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Effect of Sleeve Plunge Depth on Interface/Mechanical Characteristics in Refill Friction Stir Spot Welded Joint

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Acta Metallurgica Sinica(English Letters) 2020年第4期33卷 551-560页

作者： Guang-Da Sun Li Zhou Ren-Xiao Zhang ling-yun Luo Hao Xu Hong-yun Zhao Ning guo Di Zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Shandong Provincial Key Laboratory of Special Welding Technology Harbin Institute of Technology at WeihaiWeihai 264209China State Key Laboratory of Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

Refill friction stir spot welding was employed to produce 6061-T6 aluminum alloy joints with different sleeve plunge *** interface characteristics of joint-line remnant and hook are investigated by optical and scanning electron *** joint-line remnant consists of primary bonding region and secondary bonding region,and two types of hook can be identified as downward hook and upward *** shear results demonstrate that joint-line remnant and hook make interaction effects on tensile shear *** optimal joint is achieved when sleeve plunge depth was 2.0 mm with the corresponding failure load of 8673.4 *** different types of fracture mode are exhibited in joints produced at different sleeve plunge depths,which are closely related with the morphology of interface characteristics.

关键词： Refill friction stir spot welding Interface characteristics Mechanical properties Fracture behavior

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Li,Na,and Cs-based metal-organic frameworks for room temperature phosphorescence applications

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Science China Chemistry 2025年

作者： Jiaqi Ma Rui Feng Yanyuan Jia Mingshi Zhang Shuo guo College of Chemistry and Chemical Engineering Inner Mongolia University School of Materials Science and Engineering Smart Sensing Interdisciplinary Science Center Nankai University & TKL of Metal and Molecule Based Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University Department of Chemistry and Biochemistry University of California San Diego

The conventional design of metal-organic frameworks (MOFs) with room-temperature phosphorescence (RTP) mostly relies on using heavy metals,as the heavy atom effect can effectively increase the efficiency of intersystem crossing (ISC) to get a better phosphorescence *** the first time,we reported the highly efficient RTP of a lithium-based MOF IMU-101 with a lifetime (τ) of 299 ms and a quantum yield (QY) of 4.91%.In addition,MOFs IMU-102 and IMU-103,with sodium and cesium as metal nodes,were successfully *** phosphorescence properties of this series of alkali metal MOFs were systematically studied and *** crystallography and computational calculation show that the mechanism for achieving RTP for this material lies in the ultrashort coordination bond of Li,which enables the reduction of non-radiative ***-101,as a cheap and environmentally friendly room-temperature phosphorescent material,has been further developed into composite polymer inks and bulk *** makes them promising for applications in anti-counterfeiting and information encryption.

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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