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Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction

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Neural Regeneration Research 2022年第9期17卷 2036-2042页

作者： Ya Zheng Dan Zhao Dong-Dong Xue Ye-Ran Mao ling-yun cao Ye Zhang Guang-Yue Zhu Qi Yang Dong-Sheng Xu Department of Rehabilitation Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Hepatobiliary Surgery Hebei General HospitalShijiazhuangHebei ProvinceChina Department of Rehabilitation Baoshan BranchShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina Rehabilitation Engineering Research Center for Integrated Traditional Chinese and Western Medicine Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina

Following a spinal cord injury,there are usually a number of neural pathways that remain intact in the spinal *** residual nerve fibers are important,as they could be used to reconstruct the neural circuits that enable motor *** group previously designed a novel magnetic stimulation protocol,targeting the motor cortex and the spinal nerve roots,that led to significant improvements in locomotor function in patients with a chronic incomplete spinal cord ***,we investigated how nerve root magnetic stimulation contributes to improved locomotor function using a rat model of spinal cord *** underwent surgery to clamp the spinal cord at T10;three days later,the rats were treated with repetitive magnetic stimulation(5 Hz,25 pulses/train,20 pulse trains)targeting the nerve roots at the L5-L6 *** treatment was repeated five times a week over a period of three *** found that the nerve root magnetic stimulation improved the locomotor function and enhanced nerve conduction in the injured spinal *** addition,the nerve root magnetic stimulation promoted the recovery of synaptic ultrastructure in the sensorimotor ***,the results suggest that nerve root magnetic stimulation may be an effective,noninvasive method for mobilizing the residual spinal cord pathways to promote the recovery of locomotor function.

关键词： evoked potentials H-reflex motor activity nerve conduction neural plasticity rehabilitation sensorimotor cortex spinal cord injury synapses transcranial magnetic stimulation

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Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury:a resting-state functional MRI study

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Neural Regeneration Research 2023年第2期18卷 410-415页

作者： Cheng-Cheng Sun Yu-Wen Zhang Xiang-Xin Xing Qi Yang ling-yun cao Yu-Feng Cheng Jing-Wang Zhao Shao-Ting Zhou Dan-Dan Cheng Ye Zhang Xu-yun Hua He Wang Dong-Sheng Xu Department of Rehabilitation Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina Institute of Rehabilitation Medicine School of Rehabilitation ScienceShanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Rehabilitation Tongren HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Rehabilitation Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Department of Traumatology and Orthopedics Yueyang HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Yangzhi Rehabilitation HospitalTongji UniversityShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina

Modified constraint-induced movement therapy(mCIMT)has shown beneficial effects on motor function improvement after brain injury,but the exact mechanism remains *** this study,amplitude of low frequency fluctuation(ALFF)metrics measured by resting-state functional magnetic resonance imaging was obtained to investigate the efficacy and mechanism of mCIMT in a control co rtical impact(CCI)rat model simulating traumatic brain *** 3 days after control co rtical impact model establishment,we found that the mean ALFF(mALFF)signals were decreased in the left motor cortex,somatosensory co rtex,insula cortex and the right motor co rtex,and were increased in the right corpus *** 3 weeks of an 8-hour daily mClMT treatment,the mALFF values were significantly increased in the bilateral hemispheres compared with those at 3 days *** mALFF signal valu es of left corpus callosum,left somatosensory cortex,right medial prefro ntal cortex,right motor co rtex,left postero dorsal hippocampus,left motor cortex,right corpus callosum,and right somatosensory cortex were increased in the mCIMT group compared with the control cortical impact ***,we identified brain regions with significantly decreased mALFF valu es at 3 days *** correlation coefficients with the right forelimb sliding score indicated that the improvement in motor function of the affected upper limb was associated with an increase in mALFF values in these brain *** findings suggest that functional co rtical plasticity changes after brain injury,and that mCIMT is an effective method to improve affected upper limb motor function by promoting bilateral hemispheric co rtical *** values correlate with behavio ral changes and can potentially be used as biomarkers to assess dynamic cortical plasticity after traumatic brain injury.

关键词： amplitude of low frequency fluctuation cortical plasticity functional magnetic resonance imaging modified constraint-induced movement therapy traumatic brain injury

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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隧道式余热锅炉对流管束角焊缝漏水原因分析及对策

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工业锅炉 2016年第5期 42-43页

作者：王凌云曹习功郑州锅炉股份有限公司河南郑州450001

隧道式余热锅炉的对流管束角焊缝漏水原因复杂,对角焊缝漏水机理分析,通过一定的措施控制隧道式余热锅炉对流管束角焊缝的焊接质量,并对其进行热处理,可以解决对流管束角焊缝漏水的问题。

关键词：隧道式余热锅炉对流管束角焊缝附加应力泄露热处理

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Preparation and Biological Evaluation of Heat-press Glass Ceramics

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Chinese Journal of Biomedical Engineering(English Edition) 2003年第2期12卷 66-71页

作者： FENG ling-yun1,cao Xian-ying1,YAN Yu-hua1,LI Shi-pu,WANG Jia-wei21 Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070,China 2 Dental Hospital, Wuhan University, Wuhan 430070,China

Castable glass ceramics based on SiO 2-Al 2O 3-K 2O-Na 2O system were prepared. The structure and physical properties of this material were tested and analyzed by x-ray, SEM and other methods. It was show that the major crystalline phase is leucite(KalSi 2O 6) and compressive and flexible strength is 420 MPa and 102 MPa respectively. Its character is almost similar to natural dental enamel. This material is an ideal dental repair material. The biological tests show that this material has a good biocompatibility and prospectives for developing.

关键词： heat-press glass ceramics leucite biocompatibility

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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基于代理与仿真技术的远程故障诊断系统

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系统仿真学报 2004年第9期16卷 1961-1965页

作者：韩彦岭陈云曹守启方明伦上海大学CIMS和机器人中心上海200072

从资源共享、知识集成的角度,探讨服务与诊断技术向远程化、智能化方向发展的必要性和涉及的问题,将多代理技术、仿真技术应用于远程服务与故障诊断研究领域。研究基于多代理的远程服务与故障诊断系统(RSFDS)的工作模式及体系结构,构建... 详细信息

从资源共享、知识集成的角度,探讨服务与诊断技术向远程化、智能化方向发展的必要性和涉及的问题,将多代理技术、仿真技术应用于远程服务与故障诊断研究领域。研究基于多代理的远程服务与故障诊断系统(RSFDS)的工作模式及体系结构,构建基于多代理的RSFDS系统模型,包括概念模型和结构模型,详细论述面向服务与故障诊断的Agent功能结构及基于仿真技术的系统实现与应用策略,给出印刷机械设备远程服务与故障诊断应用实例。

关键词：故障诊断多代理分析与仿真远程服务决策空间

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Chiral emission and Purcell enhancement in a hybrid plasmonic-photonic microresonator

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Light(Science & Applications) 2020年第1期9卷 1961-1962页

作者： Qi-Tao cao You-ling Chen yun-Feng Xiao Frontiers Science Center for Nano-optoelectronics&School of Physics Peking UniversityBeijing 100871China State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

A high-Q hybrid plasmonic-photonic microresonator,which consists of a dielectric microdisk hybridized with a plasmonic nanoantenna dimer,enables an enlarged local density of states of the optical field and chiral prop... 详细信息

关键词： cavity plasmon Chiral

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Trapping photons with optical black hole

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Light(Science & Applications) 2023年第4期12卷 507-508页

作者： You-ling Chen Qi-Tao cao yun-Feng Xiao State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Frontiers Science Center for Nano-optoelectronics&School of Physics Peking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006 ShanxiChina

An optical black-hole cavity based on transformation optics enables Q-factor enhancement and strong field confinement,by eliminating the intrinsic radiation loss of the conventional whispering-gallery modes,holding po... 详细信息

关键词： optics eliminating enable

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Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan cao Zhiqun He Chunjun Liang Mingxing Chen Jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

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