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Effect of Sintering Temperature on the Microstructure and Mechanical Properties of Nanocrystalline Cemented Carbide

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 664-672页

作者：陈先富刘颖 ye Jinwen WANG Lu School of Materials Science and Engineering Sichuan UniversityChengdu 610065China Key Laboratory of Advanced Special Ma-terial&Technology Ministry of EducationChengdu 610065China

WC-Co nanocrystalline nitrogen-containing cemented carbides were prepared by vacuum sintering and low pressure *** sintering processes of Cr_(2)(C,N)doped nano WC-Co powders were studied by using thermogravimetric analysis(TGA)and differential scanning calorimetry(DSC).The effect of sintering temperature on the microstructure and mechanical properties of nanocrystalline cemented carbide was studied by scanning electron microscope(SEM),high resolution transmission electron microscope(HRTEM)and mechanical property *** results showed that the nano WC grains began to grow in the solid phase sintering stage.A high-performance nano-nitrogen-containing cemented carbide with uniform microstructure and good interfacial bonding can be obtained by increasing the sintering temperature to 1380℃.It has a transverse rupture strength(TRS)of 5057 MPa and a hardness of 1956 HV30.

关键词： nano nitrogen cemented carbide sintering temperature microstructure mechanical properties

Clinical prediction of insufficient vaults after implantable collamer lens implantation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1300-1306页

作者： Jun Zhu Dan Cheng Xue-ying Zhu Fen-Fen Li ye Yang Yu-Feng ye National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)***:The participants underwent ICL surger... 详细信息

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(yes)and 36 patients(63 eyes)were in the low and normal vault groups,*** implantation procedures were uneventful with no cataract formation in the early postoperative *** sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after *** 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in ***:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these *** the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.

关键词： insufficient vault implantable collamer lens ciliary body posterior chamber

Serrated flow behavior of GH536 superalloy under different loading rates at room temperature

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Rare Metals 2024年第5期43卷 2317-2323页

作者： Wen-Xiang Gao Dong Ma Li-Li Zhao Fan ye ling Shao Su-Jun Wu School of Materials Science and Technology Beihang UniversityBeijing100091China

Serrated flow phenomenon has been widely observed among different metals due to the potential influence on their *** tensile tests of nickel-based superalloy GH536 were carried out at loading rates of 0.06,0.60,3.60,and 36.00 mm·min^(-1)at room temperature,*** tensile stress-strain curves demonstrate repetitive and discontinuous yielding behavior,namely serrated *** is observed that the stress-strain curves were dominated by type B serration,and original annealing twin boundaries(TBs)were distorted to various degrees under comparatively different lower tensile *** contrast,the TBs almost disappear,and the type B serrations become smoother and regular under the higher loading *** phenomenon can be attributed to the interactions between TBs and dislocations during tensile *** effects of the mobile and immobile dislocations illustrate the unsteady amplitude of serrations observed in stress-strain *** electron microscope images of tested pieces reveal the interaction of dislocation and TB,with dislocation tangling around the TBs.

关键词： Nickel-based superalloy Serrations Twin boundaries Deformation mechanism

Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

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World Journal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu Li-Bo Zhang Yi-Yi Luo ling Wang ye-Pin Zhang Pei-Qi Chen Xue-ying Ba Jian Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

BACKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,ELISA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

Effect of three-step homogenization on microstructure and properties of 7N01 aluminum alloys

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Transactions of Nonferrous Metals Society of China 2018年第5期28卷 829-838页

作者： Hua-qiang LIN ling-ying ye Lin SUN Tao XIAO Sheng-dan LIU Yun-lai DENG Xin-ming ZHANG National Engineering Research Center for High-Speed EMU CRRC Qingdao Sifang Co. Ltd. Qingdao 266000 China School of Materials Science and Engineering Central South University Changsha 410083 China Light Alloy Research Institute Central South University Changsha 410083 China

The effect of different homogenization treatments on the microstructure and properties of the 7N01 aluminum alloy was investigated using hardness measurements, electrical conductivity measurements, tensile and slow strain rate tests, electron probe microanalysis, optical microscopy, scanning electron microscopy, and transmission electron microscopy. The results revealed that three-step homogenization improved the uniformity of Zr distribution by eliminating segregation of the main alloying elements. During the second homogenization step at 350 °C for 10 h, coarse and strip-like equilibrium η phases formed which assisted the nucleation of Al3Zr dispersoids and reduced the width of the precipitate-free zone of A13Zr dispersoids. As a result, coarse recrystallization was greatly reduced after homogenization at 200 °C, 2 h ＋ 350 °C, 10 h ＋ 470 °C, 12 h, which contributed to improving the overall properties of the 7N01 aluminum alloys.

关键词： 7N01 aluminum alloy three-step homogenization microstzucture mechanical properties stress corrosion cracking

Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration

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International Journal of Oral Science 2024年第2期16卷 306-321页

作者： Jiayi Wu Feifei Li Peng Yu Changhao Yu Chuyi Han Yitian Wang Fanyuan Yu ling ye State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal *** extensive studies on mineralized parenchymal tissue rebuilding,regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances *** knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic *** to date,the absence of promising therapeutic biomaterials/scaffolds *** reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of *** address these issues,in this study,we systematically investigated the cellular fate determinations and transcriptomic mechanisms by distinct types of commonly used calvarial *** data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.A feasible scaffold,polylactic acid electrospinning membrane(PLA),was next identified to precisely control mesenchymal ingrowth and self-renewal to rebuild non-osteogenic suture-like tissue at the defect center,meanwhile supporting proper osteointegration with defect bony ***,transcriptome analysis and cellular mechanisms underlying the well-orchestrated cell fate determination of PLA were *** study for the first time cellularly decoded the fate regulations of scaffolds in suture-bony composite defect healing,offering clinicians potential choices for regenerating such complicated injuries.

关键词： injuries healing suture

Anisotropic swelling pressures of compacted GMZ bentonite infiltrated with salt solutions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3772-3785页

作者： Jing Ma Yong-Gui Chen ling-Yan Jia Wei-Min ye Dong-Bei Wu Qiong Wang Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai200092China State Key Laboratory of Disaster Reduction in Civil Engineering College of Civil EngineeringTongji UniversityShanghai200092China School of Chemical Science and Engineering Tongji UniversityShanghai200092China

In the high-level radioactive waste(HLW)deep geological repository,bentonite is compacted uniaxially,and then arranged vertically in engineered *** assembly scheme induces the initial anisotropy,and with hydration,it develops more evidently under chemical *** investigate the anisotropic swelling of compacted Gaomiaozi(GMZ)bentonite and the further response to saline effects,a series of constant-volume swelling pressure tests were *** showed that dry density enhanced the bentonite swelling and raised the final anisotropy,whereas saline inhibited the bentonite swelling but still promoted the final *** final anisotropy coefficient(ratio of radial to axial pressure)obeyed the Boltzmann sigmoid attenuation function,decreasing with concentration and dry density,converging to a minimum value of *** staged evolution of anisotropy coefficient was discovered,that saline inhibited the rise of the anisotropy coefficient(Dd)in the isotropic process greater than the valley(d1)in the anisotropic process,leading to the final anisotropy *** isotropic stage amplified the impact of soil structure rearrangement on the macro-swelling pressure ***,a new method for predicting swelling pressures of compacted bentonite was proposed,by expanding the equations of Gouy-Chapman theory with a dissipative wedge *** evolutionary function was constructed,revealing the correlation between the occurrence time and the pressure value due to the structure rearrangement and the former crystalline ***,a design reference for dry density was given,based on the chemical conditions around the pre-site in Beishan,*** anisotropy promoted by saline would cause a greater drop of radial pressure,making the previous threshold on axial swelling fail.

关键词： HLW deep geological repository Compacted GMZ bentonite Anisotropic swelling pressure Multi-scale structure Saline effect

Carboniferous integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1071-1106页

作者： Keyi HU Xiangdong WANG Wenqi WANG yingfan SONG Xunyan ye Lu LI Yukun SHI Sunrong YANG ying LI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China

During the Carboniferous Period,the Qinghai-Tibetan Plateau and its surrounding areas were located in quite different paleogeographic positions with various sedimentary and biological *** is important to systematically compile and summarize the Carboniferous strata and biotas of the Qinghai-Tibetan Plateau and its surrounding areas,to establish an integrated stratigraphic framework for correlation,and to reconstruct the paleogeography for correctly understanding the breakup of the Gondwana Continent and the evolution of the Paleo-Tethys Ocean in the Late *** Carboniferous of the Qinghai-Tibetan Plateau and its surrounding areas can be subdivided into the Gondwanan,Cimmerian,and Tethyan *** Gondwanan-type Carboniferous are distributed in the North Himalayan,Kangmar-Lhunze,and Zanda-Zumba regions of the South Tibet Subprovince and northern India-Pakistan Area,where only the Mississippian is developed and the biota is of Gondwanan *** Cimmerian-type Carboniferous,which are found in the Baoshan,Tengchong,Coqen-Xainza,LhasaZayu,Nagqu-Biru,and South Qiangtang regions,as well as Shan-Thai and South Afghanistan-Pamir areas,also represent only the Mississippian strata,but their biota is characterized by mixed characters of European,South China,Australian,and North American *** Tethyan-type Carboniferous are distributed in the Tanggula Mountains,Hoh Xil-Bayanhar,ChamdoHengduanshan,Tiekelike,West Kunlun,Karakorum,East Kunlun-Central Qinling,and Qilian regions,where the Carboniferous succession is well developed,and the biota is of warm-water Tethyan *** biostratigraphical correlation of the Gondwanan-type and Cimmerian-type Carboniferous is based mainly on conodonts and additionally on brachiopods and rugose *** Mississippian of the Tethyan-type Carboniferous is correlated mainly by using rugose corals and brachiopods,whereas in the Pennsylvanian foraminifera(fusuline)and conodonts are regarded as primary fossil groups,subord

关键词： Qinghai-Tibetan Plateau Carboniferous Lithostratigraphy Biota Stratigraphic correlation

A systematic review of the efficacy of traditional Chinese medicine retention enema in the treatment of ulcerative colitis

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Journal of Integrative Nursing 2024年第1期6卷 55-61页

作者： Jiaji LI ling TANG ye LI Jingjin XU Jing ZHANG School of Nursing Beijing University of Chinese MedicineBeijingChina Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina

The objective of this study is to summarize the efficacy and safety of traditional Chinese medicine(TCM)enema in the treatment of ulcerative colitis(UC).The randomized controlled trials on TCM enema intervention in the treatment of UC were searched in seven databases:PubMed,Embase,Web of Science,CBM,CNKI,Wanfang Database,and VIP Database from January 1,2013 to June 6,2022,and the data were analyzed using RevMan 5.3 software.A total of 18 studies involving 1514 UC patients were *** analysis results showed that compared with conventional Western medicine,Chinese medicine enema had a significant effect on UC,and the clinical effective rate of the experimental group using Chinese medicine enema was 4.45 times that of the control group using conventional Western medicine(odds ratio=4.45,95%confidence interval[3.27,6.06]).Therefore,Chinese medicine enema is effective in the treatment of UC,and can significantly reduce related symptoms.

关键词： Meta‑analysis retention enema systematic review traditional Chinese medicine ulcerative colitis