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Rising above:exploring the therapeutic potential of natural product-based compounds in human cancer treatment

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Traditional Medicine Research 2025年第3期10卷 56-74页

作者： Li-Yan Yang Shi-Zeng Lei Wen-Jing Xu yu-Xin Lai ying-ying Zhang ying Wang Zhong-Lei Wang School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Green Natural Products and Pharmaceutical Intermediates in Colleges and Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu 273165China School of Pharmaceutical Sciences Key Laboratory of Bioorganic PhosphorusChemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China

Tumors,due to their diversity and heterogeneity,pose a significant threat to human *** resistance is a prevalent and grave issue in clinical treatment,resulting in treatment failure and cancer *** resistance renders conventional drug therapies ineffective,presenting a substantial challenge to human health and medical *** natural products as potential sources for anti-cancer drugs could lead to the development of innovative and efficacious cancer *** article aims to investigate the health implications of natural products(such as paclitaxel,podophyllotoxin,homoharringtonine,camptothecin,and vinblastine)in the discovery of anti-cancer drugs while discussing the methods and progress made in researching novel anti-cancer drugs derived from natural *** paper discusses the diversity,intricate structures,and target affinity of natural products along with their structural modification techniques,combination therapies utilization possibilities with prodrugs or ***,considering the escalating multidrug resistance observed in tumors nowadays;certain natural products offer new insights and approaches for discovering effective anti-tumor drugs that are crucial for addressing global public health *** challenges faced by natural products during drug development including issues related to bioavailability toxicity concerns as well as limited resources are examined *** opportunities current issues along with future challenges are highlighted aiming at facilitating the clinical translation of original anti-cancer drugs using natural products.

关键词： tumors multidrug resistance natural products camptothecin future challenges

Exploratory growth and characterization of CaNdAl_(3)O_(7) single crystal with nonsymmetric structure in tetragonal family

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Journal of Rare Earths 2025年第1期43卷 153-161,I0006页

作者： Xiangkang Peng Fapeng yu State Key Laboratory of Crystal Materials Institute of Crystal MaterialsShandong UniversityJinan250100China

The new component of melilite type crystal CaNdAl_(3)O_(7)(CNA)was grown by the Czochralski pulling *** crystal structure analysis was *** is found that the CNA crystal belongs to the tetragonal system with P-421m space *** cell parameters a=b=0.77461 nm and c=0.51089 *** density and Mohs hardness of CNA crystal are 4.08 g/cm^(3) and 5.45,*** specific heat of the crystal is 0.57-0.77 J/(g·K)in the temperature range of 30-300℃.X-ray photoelectron spectro scopy(XPS)shows that the crystal has stable atomic valence states and chemical *** vibration state of polyhedra groups in the crystal was measured by Raman spectra,and the piezoelectric response was analyzed based on the calculated results for the polyhedra polarization dipole *** relative dielectric permittivity of the CNA crystal at room temperature was determined to be 11.80 and the electrical resistivity was measured to be on the order of 5×10^(6)Ω·cm at 800℃.

关键词： Piezoelectric Melilite Crystal growth High-temperature Czochralski Rareearths

Correlations of the expression of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-ling yu Ming-yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCF^(FBXW7),p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCF^(FBXW7)(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCF^(FBXW7) and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCF^(FBXW7),thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCF^(FBXW7) Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Passive-state preparation for quantum secure direct communication

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Science China(Physics,Mechanics & Astronomy) 2025年第04期Mechanics & Astronomy) .卷 39-48页

作者： Jia-Wei ying Jin-yu Wang yu-Xiang Xiao Shi-Pu Gu Xing-Fu Wang Wei Zhong Ming-Ming Du Xi-yun Li Shu-Ting Shen An-Lei Zhang Lan Zhou yu-Bo Sheng College of Electronic and Optical Engineering and College of Flexible Electronics (Future Technology) Nanjing University of Posts and Telecommunications Institute of Quantum Information and Technology Nanjing University of Posts and Telecommunications College of Science Nanjing University of Posts and Telecommunications

Quantum secure direct communication（QSDC） can transmit the secret message directly. Single-photon-based QSDC protocol requires the active modulation of the quantum state of the source, potentially introducing various side-channel vulnerabilities. In this paper, we propose a passive-state preparation QSDC protocol. By utilizing a passive-state preparation method, we remove the need for active modulation, thus eliminating the side-channel risks associated with the source encoder. To evaluate the performance of the protocol, we develop a system model and improve the decoy state method. Through parameter optimization,we identify the optimal secrecy message capacity for various communication distances and compare it with active modulation QSDC. At a communication distance of 10（15） km, the secrecy message capacity of passive-state preparation QSDC reaches3.894 × 10-4（3.715 × 10-5） bit/pulse, achieving 95.3%（91.5%） of the active case's performance. Meanwhile, we consider the resource consumption and optimize the secrecy message transmission rate of passive-state preparation QSDC. Using a coherent light source with a frequency of 10～6Hz, at communication distances of 5, 10, and 15 km, the secrecy message transmission rates for passive-state preparation QSDC reach 2.370 × 10～2, 4.218 × 10, and 2.504 bit/s, respectively.

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Conversion-type cathode materials for high energy density solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 409-425页

作者： yuhao Ma Shihong Qing Hongyu Liu Chuntao Ma yuan yu Chuang yu Liping Wang School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Solid-state lithium batteries(SSLBs)are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes(SSEs),as well as state-of-the-art progress in various promising cathodes(e.g.,FeS_(2),CuS,FeF_(3),FeF_(2),and S)in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSEs and halide SSEs have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Conversion-type cathode Lithium-free cathode Solid-state electrolyte Solid-state lithium battery High energy density

Antimicrobial resistance crisis:could artificial intelligence be the solution?

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Military Medical Research 2025年第1期12卷 72-95页

作者： Guang-yu Liu Dan yu Mei-Mei Fan Xu Zhang Ze-yu Jin Christoph Tang Xiao-Fen Liu Department of Immunology and Pathogen Biology School of Basic Medical SciencesHangzhou Normal UniversityKey Laboratory of Aging and Cancer Biology of Zhejiang ProvinceKey Laboratory of Inflammation and Immunoregulation of HangzhouHangzhou Normal UniversityHangzhou 311121China National Key Discipline of Pediatrics Key Laboratory of Major Diseases in Children Ministry of Education Laboratory of DermatologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Robert and Arlene Kogod Center on Aging Mayo ClinicRochesterMN 55905USA Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Sir William Dunn School of Pathology University of OxfordOxford OX13REUK Institute of Antibiotics Huashan HospitalFudan UniversityKey Laboratory of Clinical Pharmacology of AntibioticsNational Health Commission of the People’s Republic of ChinaNational Clinical Research Centre for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China

Antimicrobial resistance is a global public health threat,and the World Health Organization(WHO)has announced a priority list of the most threatening pathogens against which novel antibiotics need to be *** discovery and introduction of novel antibiotics are time-consuming and *** to WHO’s report of antibacterial agents in clinical development,only 18 novel antibiotics have been approved since ***,novel antibiotics are critically *** intelligence(AI)has been rapidly applied to drug development since its recent technical breakthrough and has dramatically improved the efficiency of the discovery of novel ***,we first summarized recently marketed novel antibiotics,and antibiotic candidates in clinical *** addition,we systematically reviewed the involvement of AI in antibacterial drug development and utilization,including small molecules,antimicrobial peptides,phage therapy,essential oils,as well as resistance mechanism prediction,and antibiotic stewardship.

关键词： Antibiotic Artificial intelligence(AI) Clinical development Machine learning(ML) Antimicrobial peptide Phage therapy Antibiotic stewardship

New Taub-NUT black holes with massive spin-2 hair

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 51-58页

作者： yu-Qi Chen Hai-Shan Liu Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China

We consider Einstein gravity extended with quadratic curvature invariants,within which the well-known Ricci-flat Taub-NUT black hole remains a *** analysis of the unstable Lichnerowicz modes in the Taub-NUT background enables us to identify the mass and NUT parameters(m,n)where new Taub-NUT black holes can *** then adopt numerical techniques to construct these new Taub-NUT black holes,which bifurcate away from the Ricci-flat *** the Ricci-flat Taub-NUT,there can exist two new black holes for an appropriate given temperature,making it a total of three if we include the Ricci-flat one.

关键词： higher derivative gravity black hole solution Taub-NUT spacetime

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数字经济测度：地区、行业与企业层面的视角

中国管理科学 2025年第1期33卷 124-139页

作者：方颖余兴锦厦门大学王亚南经济研究院厦门大学大数据金融交叉实验室

本文从地区、行业和企业层面对数字经济测度的研究现状进行全面综述，并在此基础上提出一种基于多区域投入产出表构建地区产业数字化投入指数的方法，进一步通过构建区域间数字经济要素关联矩阵分析地区数字经济要素汇聚和溢出效应。研... 详细信息

本文从地区、行业和企业层面对数字经济测度的研究现状进行全面综述，并在此基础上提出一种基于多区域投入产出表构建地区产业数字化投入指数的方法，进一步通过构建区域间数字经济要素关联矩阵分析地区数字经济要素汇聚和溢出效应。研究发现，各地区的产业数字化投入在样本期内普遍增长，但东部发达地区与内陆和欠发达地区之间存在较大差异，后者产业数字化投入水平较低但增长迅猛，显示出较大的数字化转型潜力，有望缩小与东部地区的差距；数字化投入指数呈第三产业>第二产业>第一产业的普遍现象，信息依赖度高的行业表现突出，而传统制造业、资源型行业及部分服务业数字化投入水平则相对较低；东部沿海地区尤其是广东和江苏在数字经济网络中扮演核心角色，显示出强大的经济溢出和汇聚能力，而中西部地区则表现为较强的汇聚能力。本文研究为新质生产力的测度提供理论借鉴和方法支持，同时，有助于政策制定者更准确地把握数字经济的发展态势，并据此制定相应的政策以缩减区域间数字鸿沟。

关键词：数字经济测度地区产业数字化投入指数数字鸿沟

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors