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New insights into the mechanism of surfactant enhanced oil recovery:Micellar solubilization and in-situ emulsification

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Petroleum Science 2022年第2期19卷 870-881页

作者： Xue-Zhi Zhao Guang-Zhi Liao ling-yan gong Huo-Xin Luan Quan-Sheng Chen Wei-Dong Liu Dong Liu Yu-Jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065People's Republic of China PetroChina Exploration&Production Company Beijing100007People's Republic of China Research Institute of Experiment and Detection Xinjiang Oilfield Branch CompanyPetroChinaKaramay834000People's Republic of China Research Institute of Petroleum Exploration&Development PetroChina Company LimitedBeijing100083People's Republic of China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang621000People's Republic of China

Reducing the oil-water interfacial tension(IFT)to ultra-low is believed the primary mechanism for surfactant-based enhanced oil recovery(EOR)***,field trials have shown that low concentration surfactant flooding can also improve oil recovery without ultra-low *** clarify the mechanism behind,the currently-used surfactant,naphthenic arylsulfonate(NAS),was used to unravel its function during surfactant flooding from the horizon of micron-and *** solubilization capacity of NAS micelle to petroleum fractions was evaluated through light absorbance strategy,smallangle neutron scattering,dynamic light scattering and transmission electron *** was found that micellar solubilization plays a significant role during the surfactant ***-situ emulsification was visualized in microfluidics with three types of microchips,respectively.A series of displacement tests were carried out with NAS solution pumping into oil-saturated *** results show that in-situ emulsification improve oil recovery mainly through blocking and entrainment *** from this work aid in understanding the interaction between surfactant solution and petroleum fractions at low surfactant concentration,which is helpful for design surfactant-based displacing system for EOR process.

关键词： Enhanced oil recovery Surfactant flooding Micellar solubilization Microfluidics In-situ emulsification

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Analysis on application law of dampness-removing traditional Chinese medicines in treatment of coronavirus disease 2019

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Chinese Herbal Medicines 2021年第4期13卷 518-524页

作者： Er-wei Hao Zi-xia Su yan-ling gong Zheng-cai Du Xue yang Chun-tao Huang Xiao-tao Hou Jia-gang Deng Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Guangxi University of Chinese MedicineNanning 530001China Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues Guangxi University of Chinese MedicineNanning 530200China Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases Guangxi University of Chinese MedicineNanning 530001China Guangxi International Zhuang Medical Hospital Guangxi University of Chinese MedicineNanning 530201China

Objective:Coronavirus Disease 2019(COVID-19)has been diagnosed as an epidemic disease characterized by cold and dampness pathogens in TCM *** to many Chinese medicines with different functions were used in the treatment of COVID-19,it is very important to find the law of application of dampremoving traditional Chinese medicine with high frequency application,with view to providing a reference for the use and research of Chinese medicine to further control the ***:The publicly released diagnosis and treatment programs issued by the National Health Commission and Health Commission of provinces,autonomous regions and municipalities,and Chinese herbs prescription information in these were collected,a database was established,and Excel and Graphpad 8.0 software were used to analyze the frequency of use of various Chinese medicines,the frequency and property characters including five flavors(bitter,pungent,sweet,sour,and salty)and four natures(warm,hot,cool,and cold)and channel tropisms of Chinese medicine for removing ***:A total of 137 prescriptions of Chinese medicine for treating COVID-19 were collected,including178 TCMs showing functions of resolving phlegm,relieving cough and asthma,resolving dampness,clearing damp and inducing dieresis,clearing heat,tonifying deficiency,and relieving exterior syndrome,in which the TCMs with the first four functions that we called the dampness-removing TCMs,accounted for 35.78%.Also a number of TCMs in the rest functions showed *** first four functions were divided into subfunctions including aromatic resolving dampness,clearing heat and drying dampness,drying dampness and tonifying spleen qi,drying dampness and removing phlegm,inducing diuresis and relieving swelling,inducing diuresis and relieving exterior *** them,the most frequently used TCMs was Ephedrae Herba,followed by Citri Reticulatae Pericarpium,Pogostemonis Herba,Pinelliae Rhizoma,Poria,Scutellariae Radix,and

关键词： application law COVID-19 dampness-removing traditional Chinese medicine

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin yan You Zheng gong yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-Liang gong Hong-Jie Zhang yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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小鼠海马锥体细胞树突棘形态的电镜三维重建

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生物物理学报 2003年第1期19卷 18-22页

作者：杨光龚锴蒋五玲公衍道张秀芳赵南明清华大学生物科学与技术系

大多数神经元的复杂三维结构是很难直接观察的。激光扫描共聚焦显微镜技术结合染料标记技术可以重建神经元的三维形态,但精细结构的识别需要电子显微镜。利用透射电子显微镜技术,可以得到连续超薄组织切片的高分辨率图像,结合计算机支... 详细信息

大多数神经元的复杂三维结构是很难直接观察的。激光扫描共聚焦显微镜技术结合染料标记技术可以重建神经元的三维形态,但精细结构的识别需要电子显微镜。利用透射电子显微镜技术,可以得到连续超薄组织切片的高分辨率图像,结合计算机支持的三维重建技术就可进一步获得神经细胞精细结构的三维信息。通过电镜三维重建技术对未成熟和成熟小鼠海马锥体细胞树突棘的形态进行了观察和分析,并对其关键步骤的操作技巧进行了重点说明。实验结果为进一步利用成像技术研究树突棘的结构、功能和可塑性提供了重要信息。

关键词：透射电子显微镜连续超薄切片三维重建树突棘

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting yang Danfeng gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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Unconventional photon blockade induced by the self-Kerr and cross-Kerr nonlinearities

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Frontiers of physics 2023年第1期18卷 185-191页

作者： ling-Juan Feng Li yan Shang-Qing gong School of Sciences Shanghai Institute of TechnologyShanghai 201418China School of Physics and Electronic Engineering Heze UniversityHeze 274015China School of Physics East China University of Science and TechnologyShanghai 200237China

We study the use of the self-Kerr and cross-Kerr nonlinearities to realize strong photon blockade in a weakly driven,four-mode optomechanical *** to the Born–Oppenheimer approximation,we obtain the cavity self-Kerr coupling and the inter-cavity cross-Kerr coupling,adiabatically separated from the mechanical *** minimizing the second-order correlation function,we find out the optimal parameter conditions for the unconventional photon *** the optimal conditions,the strong photon blockade can appear in the strong or weak nonlinearities.

关键词： unconventional photon blockade cross-Kerr nonlinearity self-Kerr nonlinearity optomechanical system

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通心络胶囊治疗冠心病心绞痛临床疗效观察

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中国实用内科杂志 2008年第S2期28卷 59-60页

作者：康建华郭莉娜李玲妹公言增胡毅敏武警北京市总队医院门诊部北京100027

目的观察通心络胶囊治疗冠心病心绞痛的临床疗效。方法选择符合标准的稳定性心绞痛患者98例作为观察对象,随机分为两组,分别采用通心络胶囊和消心痛治疗,疗程4周。治疗(通心络胶囊)组50例,对照(消心痛)组48例,观察抗心绞痛和缺血性心电... 详细信息

目的观察通心络胶囊治疗冠心病心绞痛的临床疗效。方法选择符合标准的稳定性心绞痛患者98例作为观察对象,随机分为两组,分别采用通心络胶囊和消心痛治疗,疗程4周。治疗(通心络胶囊)组50例,对照(消心痛)组48例,观察抗心绞痛和缺血性心电图变化。结果治疗组抗心绞痛显效率为70.0%(35例),对照组45.8%(22例),两组差异比较具有统计学意义(P<0.05);治疗组心电图改善显效率48.0%(24例),对照组为22.9%(11例),两组差异比较也具有显著意义(P<0.05)。结论通心络胶囊治疗冠心病心绞痛疗效可靠。

关键词：稳定性心绞痛通心络胶囊消心痛

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Universal adversarial examples and perturbations for quantum classifiers

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National Science Review 2022年第6期9卷 48-55页

作者： Weiyuan gong Dong-ling Deng Center for Quantum Information Institute for Interdisciplinary Information Sciences (ⅢS) Tsinghua University Shanghai Qi Zhi Institute

Quantum machine learning explores the interplay between machine learning and quantum physics, which may lead to unprecedented perspectives for both fields. In fact, recent works have shown strong evidence that quantum computers could outperform classical computers in solving certain notable machine learning tasks. Yet, quantum learning systems may also suffer from the vulnerability problem: adding a tiny carefully crafted perturbation to the legitimate input data would cause the systems to make incorrect predictions at a notably high confidence level. In this paper, we study the universality of adversarial examples and perturbations for quantum classifiers. Through concrete examples involving classifications of real-life images and quantum phases of matter, we show that there exist universal adversarial examples that can fool a set of different quantum classifiers. We prove that, for a set of k classifiers with each receiving input data of n qubits, an O(ln [k]/2~n) increase of the perturbation strength is enough to ensure a moderate universal adversarial risk. In addition, for a given quantum classifier, we show that there exist universal adversarial perturbations, which can be added to different legitimate samples to make them adversarial examples for the classifier. Our results reveal the universality perspective of adversarial attacks for quantum machine learning systems, which would be crucial for practical applications of both near-term and future quantum technologies in solving machine learning problems.

关键词： quantum machine learning quantum classifiers adversarial examples measure concentration quantum no-free-lunch theorem

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Cyclic oxidation behavior of Ni_(3)Al-based single crystal alloy IC21

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Rare Metals 2023年第5期42卷 1656-1662页

作者： Tian-Tian yang Xin Zhou Shu-Suo Li yan-ling Pei Sheng-Kai gong School of Materials Science and Engineering Beihang UniversityBeijing100191China

In this study,the cyclic oxidation tests of the Ni3Al-based single-crystal super alloy IC21 were carried out at 800,900,950,1000,1050 and 1100℃in *** present study shows that the complex oxide scale on the surface of the alloy is made up of an outer columnar NiO layer,an intermediate mixture of NiO and NiAl2O4layer with a small amount of Mo oxides and an inner continuous layer ofα-Al_(2)O_(3).The cyclic oxidation kinetics curves show that oxidation resistance at 800,900,950,1000 and1050℃seems to follow a similar law and is better than that at 1100℃.The overall weight changes at 1100℃follows a parabolic *** and severe rumpling of the oxide scale are observed on the surface of the alloy at1100℃,revealing the occurrence of disastrous oxidation.

关键词： Ni_(3)Al Thermal cycling Oxidation Microstructure

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