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Construction of a niche-specific spinal white matter-like tissue to promote directional axon regeneration and myelination for rat spinal cord injury repair

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Bioactive Materials 2022年第5期7卷 15-31页

作者： Bi-Qin Lai Yu-Rong Bai Wei-Tao Han Bao Zhang Shu Liu Jia-Hui Sun Jia-Lin Liu Ge Li Xiang Zeng Ying Ding Yuan-Huan Ma ling Zhang Zheng-Hong Chen Jun Wang Yuan Xiong Jin-Hua Wu Qi Quan ling-yan xing Hong-Bo Zhang Yuan-Shan Zeng Key Laboratory for Stem Cells and Tissue Engineering(Sun Yat-sen University) Ministry of EducationGuangzhou510080China Department of Histology and Embryology Zhongshan School of MedicineSunYat-sen UniversityGuangzhou510080China Institute of Spinal Cord Injury Sun Yat-sen UniversityGuangzhou510120China Co-innovation Center of Neuroregeneration Nantong UniversityNantong226001China Department of Anatomy Anhui Medical UniversityHefei230032China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou510080China Department of Geriatrics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Physiotherapy Department Guangdong Work Injury Rehabilitation HospitalGuangzhouChina Department of Orthopedic Surgery Key Laboratory of Musculoskeletal Trauma&War Injuries PLABeijing Key Lab of Regenerative Medicine in OrthopedicsThe 4th Medical CentreChinese PLA General HospitalBeijingChina

Directional axon regeneration and remyelination are crucial for repair of spinal cord injury(SCI),but existing treatments do not effectively promote those ***,we propose a strategy for construction of niche-specific spinal white matter-like tissue(WMLT)using decellularized optic nerve(DON)loaded with neurotrophin-3(NT-3)-overexpressing oligodendrocyte precursor cells.A rat model with a white matter defect in the dorsal spinal cord of the T10 segment was *** WMLT transplantation group showed significant improvement in coordinated motor functions compared with the control *** transplants integrated well with host spinal cord white matter,effectively addressing several barriers to directional axonal regeneration and myelination during SCI *** WMLT,laminin was found to promote development of oligodendroglial lineage(OL)cells by binding to laminin ***,laminin could also guide linear axon regeneration via interactions with specific integrins on the axon *** WMLT developed here utilizes the unique microstructure and bioactive matrix of DON to create a niche rich in laminin,NT-3 and OL cells to achieve significant structural repair of *** protocol can help to promote research on repair of nerve injury and construction of neural tissues and organoids that form specific cell niches.

关键词： Extracellular matrix Oligodendroglial lineage cells White matter-like tissue Directional axon regeneration Spinal cord injury

基于DMSP/OLS夜间灯光影像的省际经济发展水平评估模型研究

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应用科学学报 2017年第5期35卷 647-657页

作者：马丹程辉毛艳玲邢世和福建农林大学资源与环境学院福州350002 山东女子学院旅游学院济南250300

采用2001年、2004年、2007年的DMSP/OLS夜间灯光数据提取中国31个省市的夜间灯光强度图,引入相对亮度和相对面积,通过相关分析和主成分分析法,构建了灯光指数和统计指数.以2001年、2004年的灯光指数与统计指数为样本,以2007年数据为检验... 详细信息

采用2001年、2004年、2007年的DMSP/OLS夜间灯光数据提取中国31个省市的夜间灯光强度图,引入相对亮度和相对面积,通过相关分析和主成分分析法,构建了灯光指数和统计指数.以2001年、2004年的灯光指数与统计指数为样本,以2007年数据为检验值,建立线性回归模型,可决系数为0.872.最后,以灯光指数对中国省际经济发展水平空间格局进行分析.结果表明,引入相对亮度和相对面积构建的灯光指数能较准确地反映中国省际经济发展综合水平的时空格局变化.

关键词： DMSP/OLS 国民生产总值夜间灯光指数回归分析主成分分析

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Influences of stroma development on Roegneria kamoji reveals occurrence and dispersal of chemical signals in the hosts

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Influences of stroma development on Roegneria kamoji reveals...

CaO-FeO-SiO_2-Al_2O_3/Na_2O/TiO_2渣系与碳饱和铁水间磷分配行为

2012年中国菌物学会学术年会

作者： Lu Tao Ji yan-ling Li xing-hui Wang Zhi-wei~* (College of Life Sciences Nanjing Agricultural University Nanjing China 210095)

＜正＞Epichloae endophytes including Neotyphodium *** Epichloe *** highly host specific fungal symbionts（endophytes） of cool-season *** most cases,they systemically infect and colonize in all aerial parts of host *** these 2 endophyte species had recorded in Roegneria kamoji（Ohwi） Kent et Chen, their biological functions are still *** a sexual fungal endophyte involved in the host,the influences of stroma development of Epichloe yangzii Li et Wang to morphological properties of the host was focused in present study. Fungal endophytes infected *** plants including stromatal producing and stromatal nonproducing plants were collected in a particular site located in Jiangpu,Nanjing,*** of *** appeared white,cereous,smooth and wet at first in early April,then turned to yellow,dry and rough within about 7 to 8 wk, collapsed and became white or gray at last in late *** procedures of hyphae staining,fungal isolation,fungal identification and plant measurement,differences between stromatal plants and non-stromatal plants on tillering and heading of the plants,thickness and length of the culms,numbers,length and senescence of the leaves were investigated *** indicated that all endophyte strains from both stromatal and non-stromatal plants were ***,all symbiota investigated in this study should be ***/*** complexes. TILLER NUMBERS of stromatal plants and non-stromatal plants were 59.8±4.3 and 41.5±*** PERCENTAGES,CULM THICKNESS,CULM LENGTHS,LEAF NUMBERS,LEAF SENESCENCE PERCENTAGE of stromatal culm on stromatal plant（SS culm）,non-stromatal culm on stromatal plant（NS culm） and non-stromatal culm on non-stromatal plant（NN culm） were 0,100%and 99.15%;2.0±0.4,2.1±0.4 and 2.7±0.4 mm;303.8±90.4,608.3.9±166.6 and 933.2±92.0 mm;6,6 and 6;48.3%,41.7%and 71.7%respectively. The stroma development of *** promote the growth of the flag leaf,delay senescence of plant leaves on bot

关键词： stroma Epichloe yangzii Roegneria kamoji

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钢铁 2017年第2期52卷 18-23页

作者：李显鹏高金涛张延玲邢磊磊邹亮北京科技大学钢铁冶金新技术国家重点实验室北京100083

为了研究Al_2O_3、Na_2O和TiO_2作为铁水预处理渣的助熔剂对铁水预处理脱磷的影响,借助Fact Sage热力学软件绘制了CaO-FeO-SiO_2渣系1 573 K液相区。随着Al_2O_3和Na_2O质量分数的增加,该渣系液相区明显扩大,TiO_2对渣系液相区影响不大... 详细信息

为了研究Al_2O_3、Na_2O和TiO_2作为铁水预处理渣的助熔剂对铁水预处理脱磷的影响,借助Fact Sage热力学软件绘制了CaO-FeO-SiO_2渣系1 573 K液相区。随着Al_2O_3和Na_2O质量分数的增加,该渣系液相区明显扩大,TiO_2对渣系液相区影响不大。实验室研究采用纯铁箔替代碳饱和铁水进行热力学平衡试验,间接测定了1 573 K时铁水预处理脱磷渣与碳饱和铁水间的平衡磷分配比。结果表明,渣铁磷分配比随渣中Al_2O_3和TiO_2质量分数的增加而减小,TiO_2对磷分配比的影响相对较小;渣铁磷分配比随渣中Na_2O质量分数和碱度的增加而增加,Na_2O可显著提高渣的脱磷能力;渣铁磷分配比随渣中FeO质量分数的增加先增加后减小,最合适的FeO质量分数为35%~40%。

关键词：磷分配比碳饱和铁水 CaO-FeO-SiO2 液相区

Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 329-355页

作者： Yufeng xing Ye Yuan Gen Li Institute of Solid Mechanics Beihang University(BUAA)Beijing100191China

The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical *** taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue ***,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are *** is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.

关键词： Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method

Loss Aware Feature Attention Mechanism for Class and Feature Imbalance Issue

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Computers, Materials & Continua 2025年第1期82卷 751-775页

作者： Yuewei Wu Ruiling Fu Tongtong xing Fulian Yin College of Information and Communication Engineering Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

In the Internet era,recommendation systems play a crucial role in helping users find relevant information from large *** imbalance is known to severely affect data quality,and therefore reduce the performance of recommendation *** to the imbalance,machine learning algorithms tend to classify inputs into the positive(majority)class every time to achieve high prediction *** can be categorized such as by features and classes,but most studies consider only class *** this paper,we propose a recommendation system that can integrate multiple networks to adapt to a large number of imbalanced features and can deal with highly skewed and imbalanced datasets through a loss *** propose a loss aware feature attention mechanism(LAFAM)to solve the issue of feature *** network incorporates an attention mechanism and uses multiple sub-networks to classify and learn *** better results,the network can learn the weights of sub-networks and assign higher weights to important *** propose suppression loss to address class imbalance,which favors negative loss by penalizing positive loss,and pays more attention to sample points near the decision *** on two large-scale datasets verify that the performance of the proposed system is greatly improved compared to baseline methods.

关键词： Imbalanced data deep learning e-commerce recommendation loss function big data analysis

Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing LIU Wei ZHU Di LI xing HU Liang SONG Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution