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Enhanced oral drug delivery by mimicking natural amino acid and oligopeptide absorption route

Nano Research 2025年第2期18卷 525-540页

作者： Ruinan Wu Xiaoxing Fan Licheng Wu Liyun Xing Jinxia kong Zhou Zhou Jingyuan Wen Lian Li Yuan Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China School of Pharmacy Faculty of Medical and Health SciencesUniversity of AucklandAuckland 1023New Zealand

Oral delivery of protein and peptide drugs presents considerable challenges due to their susceptibility to digestive enzymes in gastrointestinal(Gl)tract and low efficiency of transepithelial ***,inspired by efficient absorption of protein-based nutrients,we constructed several kinds of oral drug delivery systems by mimicking natural amino acid and oligopeptide absorption *** kinds of amino acids and two kinds of oligopeptides were chosen as targeting ligands to mediate transportation of orally administered nanoparticles(NPs).Liraglutide(Lira),a kind of glucagon like peptide-1(GLP-1)receptor agonist,was used as model *** functionalized NPs could protect Lira from enzymatic degradation in Gl ***,compared with amino acid-modified NPs,oligopeptide-modified NPs exhibited greater transepithelial transport efficiency and were primarily absorbed in the proximal small intestine due to the high expression and transportation mediated by proton coupled oligopeptide transporter 1(PEPT1).These Lira-loaded NPs could effectively control the blood glucose level,reduce plasma lipid level,and repair tissue damage on type 2 diabetic mice and even showed comparable hypoglycemic effects of subcutaneous injection(s.c.)free *** study demonstrates the potential of mimicking natural oligopeptide absorption route to enhance oral delivery of protein and peptide drugs.

关键词： oral drug delivery amino acid absorption route oligopeptide absorption route liraglutide

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The transcriptome of MHV-infected RAW264.7 cells offers an alternative model for macrophage innate immunity research

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Animal Models and Experimental Medicine 2025年第1期8卷 57-66页

作者： Yun Liu Ting-Ting Feng Wei Tong Zhi Guo Xia Li Qi kong Zhi-Guang Xiang Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences(CAMS)and Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingP.R.China

Background:Macrophages are the primary innate immune cells encountered by the invading coronaviruses,and their abilities to initiate inflammatory reactions,to main-tain the immunity homeostasis by differential polarization,to train the innate immune system by epigenic modification have been reported in laboratory animal ***:In the current in vitro research,murine macrophage RAW 264.7 cell were infected by mouse hepatitis virus,a coronavirus existed in *** 3-,6-,12-,24-,and 48-h post infection(hpi.),the attached cells were washed with PBS and harvested in Trizol *** The harvest is subjected to transcriptome ***:The transcriptome analysis showed the immediate(3 hpi.)up regulation of DEGs related to inflammation,like Il1b and *** related to M2 differential po-larization,like Irf4 showed up regulation at 24 hpi.,the late term after viral *** addition,DEGs related to metabolism and histone modification,like Ezh2 were de-tected,which might correlate with the trained immunity of ***:The current in vitro viral infection study showed the key innated im-munity character of macrophages,which suggested the replacement value of viral infection cells model,to reduce the animal usage in preclinical research.

关键词： coronavirus innate immunity macrophage transcriptome

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儿童噪声下言语感知能力评估研究进展

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中国听力语言康复科学杂志 2025年第1期23卷 61-65页

作者：邱黄玲孔令志北京语言大学语言康复学院北京100083

现代社会噪声污染越来越严重,对儿童来说,即使在教室中也充斥着噪声,严重影响其言语感知能力及学习与健康。因此,了解并评估儿童在噪声下言语感知能力的发展水平非常重要,可以及时发现并诊断儿童的听觉感知缺陷。现有的评估方法和结果不... 详细信息

现代社会噪声污染越来越严重,对儿童来说,即使在教室中也充斥着噪声,严重影响其言语感知能力及学习与健康。因此,了解并评估儿童在噪声下言语感知能力的发展水平非常重要,可以及时发现并诊断儿童的听觉感知缺陷。现有的评估方法和结果不一,给临床工作人员带来极大不便。故本文以听觉感知发展理论为基础,对儿童噪声下言语感知能力评估常使用的目标材料、噪声材料和评估方法进行综述,以期为儿童噪声下言语感知能力提供完善、合适的评估。

关键词：听力测试噪声儿童言语感知

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A major facilitator superfamily transporter PlMFS1 contributes to growth,oosporogenesis,and pathogenesis of Peronophythora litchii

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Horticultural Plant Journal 2025年第1期11卷 189-198页

作者： Pinggen Xi Tianfang Guan Xiyuan Liu Xiaofeng Li Ziyuan Dou Liyun Shi Jiamin Huang Liqun Jiang Junjian Situ Minhui Li Guanghui kong Zide Jiang Guangdong Province Key Laboratory of Microbial Signals and Disease Control/Department of Plant Pathology South China Agricultural UniversityGuangzhouGuangdong 510642China Rice Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of New Technology in Rice BreedingGuangzhouGuangdong 510640China

Major facilitator superfamily(MFS)transporters are secondary active membrane transporters that play an important role in solute interchange and energy *** litchii causes the most destructive disease on lichi,litchi downy ***90 was reported as a key oosporogenesis ***,we identified an MFS transporter gene PlMFS1,which is up-regulated during oospore formation at the late infection stage,while down-regulated in the PlM90 *** investigate PlMFS1 function,we generated PlMFS1knockout mutants using CRISPR/Cas9-mediated genome editing *** with the wild-type strain SHS3,PlMFS1 deletion impaired mycelium growth,zoospore release,oospore production and ***,PlMFS1 deletion significantly affected *** utilization of fructose,lactose and maltose,and may be the PlMFS1 mechanism involved in mycelial ***1 gene deletion also led to deceased laccase activity,laccase-encoding gene downregulation and impaired *** *** our knowledge,this is the first report of an MFS transporter involved in sugar utilization,sexual reproduction,asexual reproduction and pathogenesis in oomycetes.

关键词： Peronophythora litchii Major facilitator superfamily Oospore Pathogenicity

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Biotransformation of 4-Hydroxybenzen Derivatives by Hairy Root Cultures of Polygonum multiflorum Thunb

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Journal of Integrative Plant Biology 2007年第2期49卷 207-212页

作者： Chun-Yan Yan rong-Min Yu Zhang Zhang ling-Yi kong Department of Natural Medicinal Chemistry College of Traditional Chinese Medicines China Pharmaceutical University Nanjing 210038 China Department of Natural Medicinal Chemistry and Pharmacognosy College of Pharmacy Jinan University Guangzhou 510632 China

The biotransformation of four 4-hydroxybenzen derivatives （1,4-benzenediol （compound 1）, 4-hydroxybenzaldehyde （compound 2）, 4-hydroxybenzyl alcohol （compound 3） and 4-hydroxybenzoic acid （compound 4）） by the hairy root cultures of Polygonum multiflorum Thunb. as a new biocatalyst was investigated. It was found that the substrates were transformed to their corresponding glucosides, 4-hydroxyphenyl β-D-glucopyranoside （arbutin, compound la）, 4-hydroxymethylphenyl β-D-glucopyranoside （gastrodin, compounds 2a, 3a） and 4-carboxyphenyl α-D- glucopyranoside （compound 4a）, respectively. In the meantime, the hairy roots of P. multiflorum were able to stereoselectively and regioselectively glucosylate phenolic hydroxyl groups of compounds 1-4, but the cultures could not glucosylate the aldehyde group of compound 2 or the benzyllc hydroxyl group of compound 3, and no glucosyl esterification of carboxyl groups of compound 4 was detected. On the other hand, the result also showed that the hairy roots of P. multiflorum were able to reduce the 4-hydroxybenzaldehyde to its corresponding alcohol. This is the first report that substrate 4 has been converted into its α-D-glucopyranoside by a plant biotransformα- tion system.

关键词： 4-hydroxybenzen derivatives arbutin biotransformation gastrodin hairy root cultures Polygonum multiflorum.

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DOPO配位金属基衍生物的制备及其对环氧树脂的阻燃作用

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塑料工业 2025年第1期53卷 64-69页

作者：荣光辉何亮潮李曼平孔庆红中国石油长庆油田分公司第九采油厂宁夏银川750000 江苏大学环境与安全工程学院江苏镇江212013 中国石油长庆油田分公司第五采油厂陕西西安710200

为了提高环氧树脂(EP)的阻燃性,本研究将P/N协效和催化成炭相结合,通过水杨醛与对苯二胺反应生成水杨醛基席夫碱,进一步与9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物(DOPO)通过加成反应得到衍生物(SPPO),SPPO与通过Fe3+、Bi3+配位作用生成... 详细信息

为了提高环氧树脂(EP)的阻燃性,本研究将P/N协效和催化成炭相结合,通过水杨醛与对苯二胺反应生成水杨醛基席夫碱,进一步与9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物(DOPO)通过加成反应得到衍生物(SPPO),SPPO与通过Fe3+、Bi3+配位作用生成水杨醛基席夫碱金属配合物(SPPO-Fe和SPPO-Bi),制备EP/SPPO-Fe和EP/SPPO-Bi复合材料。结果显示,EP/6%SPPO-Fe、EP/6%SPPO-Bi复合材料的垂直燃烧达到UL94 V-1等级;与纯EP相比,极限氧指数(LOI)分别提升至29.3%和28.4%,热分析结果显示残炭率分别增加了11.7和23.4个百分点;锥形量热仪测试结果表明热释放速率峰值(PHRR)降低33.6%和34.8%;总热释放量(THR)降低17.3%和14.2%;TSP降低35.4%和38.9%。EP复合材料阻燃性能的提升主要得益于P、N元素与金属离子Fe3+、Bi3+之间的协同阻燃效应;金属离子卓越的催化成炭能力提升了残炭率、降低了烟气释放;致密炭层增强物理阻隔效应,进一步阻止可燃气体的逸出、氧气的进入以及热量的释放,提高EP复合材料的阻燃性。

关键词：环氧树脂 9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物衍生物阻燃性席夫碱金属配合物

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不平衡电网下三相PWM整流器模型预测控制及纹波抑制方法

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电力系统及其自动化学报 2025年第1期37卷 54-63页

作者：胡裕峰叶鹤松孔亮许榕国网江西省电力有限公司九江供电分公司九江332000

针对三相电网不平衡故障下的电压型PWM整流器的直流电压二次纹波和网侧电流谐波,研究了一种纹波抑制方法。基于传统的双闭环控制结构,提出电网不对称故障下参考电流计算方法。利用模型预测控制取代电流环PI控制,结合PWM调制环节固定开... 详细信息

针对三相电网不平衡故障下的电压型PWM整流器的直流电压二次纹波和网侧电流谐波,研究了一种纹波抑制方法。基于传统的双闭环控制结构,提出电网不对称故障下参考电流计算方法。利用模型预测控制取代电流环PI控制,结合PWM调制环节固定开关频率,根据电流预测模型和电流误差最小原则,不仅减小了网侧电流谐波和直流母线侧电压纹波,而且降低了平均开关次数进而减少了器件损耗。通过建立的交流侧110 V、直流侧300 V、输出功率0.7 k W的实验平台进行了实验验证,表明该系统具有良好的稳态性能。仿真结果和实验结果验证了所提出控制方法的有效性以及理论分析的正确性。

关键词：三相不平衡三相PWM整流器模型预测控制

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Post-silking leaf senescence is delayed in low-N-tolerant maize cultivars under low N fertilization

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Crop Journal 2025年第1期13卷 246-256页

作者： Wei, Gui Wang, Xinglong Wu, Yawei Liu, Fan Lan, Tianqiong Liu, Qinlin Lyu, Chengcheng kong, Fanlei Yuan, Jichao College of Agronomy Sichuan Agricultural University Sichuan Chengdu 611130 China Key Laboratory of Crop Ecophysiology and Farming System in Southwest China Ministry of Agriculture Sichuan Chengdu 611130 China Crop Ecophysiology and Cultivation Key Laboratory of Sichuan Province Sichuan Chengdu 611130 China

A four-year field experiment was conducted with two cultivars and four N rate to investigate the spatio-temporal characteristics of leaf senescence in maize after silking and its response to N fertilizer rates on them, as well as to reveal the differences in post-silking chlorophyll degradation between low-N-tolerant cultivars. The results showed that the order of leaf senescence after silking in maize was lower leaf > upper leaf > ear leaf, leaf tip > middle > base. Increasing N fertilizer down-regulated the expression of ZmCLH2 and ZmPPH in the leaves at 10–30 d after silking, reducing CLH and PPH activities, thereby delaying the leaf senescence. These effects were more prominent in low-N-sensitive cultivar Xianyu 508 (XY508) than in low-N-tolerant cultivar Zhenghong 311 (ZH311), especially in the lower leaves and leaf tip. Under low N condition, leaf yellowing and chlorophyll degradation occurred later and slower in ZH311 than in XY508. This resulted in a higher post-silking dry matter accumulation and grain yield in ZH311, which may be one of the important physiological bases of low nitrogen tolerant cultivars. Future research should focus on developing low-N-tolerant maize cultivars with slower leaf senescence near the ear after silking. © 2024

关键词： Chlorophyll degradation Low-N-tolerant maize variety Nitrogen fertilizer Spatio-temporal characteristics

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Alkaline leaching mechanism of MSWI bottom ash:the pivotal role of Si(Al)chemical bonding environments

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Science China(Technological Sciences) 2025年第2期68卷 73-85页

作者： Ningning SHAO Zekun JIAO Weipeng FENG Yu JIN Fanlong kong Zhijun DONG Zuotai ZHANG Institute of Technology for Marine Civil Engineering Shenzhen Institute of Information Technology(SZIIT)Shenzhen 518172China School of Environmental Science and Engineering Key Laboratory of Municipal Solid Waste Recycling Technology and Management of Shenzhen CitySouthern University of Science and Technology(SUSTech)Shenzhen 518055China Guizhou NASH Ecological Technology Co. LTDGuiyang 550016China

Municipal solid waste incineration bottom ash(MSWIBA)is a complex assemblage of aluminosilicate materials encompassing diverse solid ***,its complexity poses great challenges to their resource *** the sake of the alkali activation use of MSWIBA,this work focused on the characterizations and alkaline leaching experiments of various classified MSWIBA after *** the different categories of MSWIBA,waste glass(BA-G)and other unidentified slags(BA-O)were identified as potential precursors for alkali activation *** alkaline leaching experiments proved that alkaline concentration,reaction temperature,reaction time,and raw material classification influenced the leaching process and *** these,the Si/Al chemical bonding environments from the material type played a pivotal *** the materials had Q_(n)(n>2)as the primary bonding structure,steric hindrance by the chain frameworks affected the alkali dissolution process,resulting in gradual disintegration from the outer layers *** the materials dominated by Q1 frameworks,OH-could penetrate the frameworks,leading to their rapid depolymerization and outward ***,the Si/Al bonding environment played a crucial role in alkaline dissolution,providing theoretical guidance for classifying the alkali-activation utilization of MSWIBA and other aluminosilicate solid wastes.

关键词： municipal solid waste incineration bottom ash classification alkaline leaching chemical bonding environments mechanism

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Trajectory planning and tracking control for vehicles with tire blowout in complex traffic flows

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Science China(Information Sciences) 2025年第03期68卷 220-241页

作者： Dongsheng YANG Di LIU Bing HAN Guoxiang LU lingan kong Chaosheng HUANG Jun LI School of Vehicle and Mobility Tsinghua University BYD Auto Industry Company Limited

This article focuses on the trajectory planning and tracking control of autonomous vehicles with tire blowouts in complex traffic flows. First, a lane change decision method for obstacle avoidance is developed based on coordinate system transformation projection. Second, combining this decision method, a lattice algorithm is developed with the kinematic constraint of the vehicle with a tire blowout to plan the trajectory in real-time. Third, the trajectory tracking control is decoupled longitudinally and laterally in the Frenet coordinate system. The existence of the optimal solution can be ensured by constructing a longitudinal speed control optimization problem and solving explicitly based on the Pontryagin maximum principle. Lateral displacement control problems are constructed and solved quickly by using the back-stepping method, in which Lyapunov stability can be demonstrated. Finally, the effectiveness of the proposed methods was verified through co-simulation.

关键词： complex traffic trajectory planning domain transformation decoupling quick solution tire blowout

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