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Highly coupled off-resonance lattice design in diffraction-limited light sources

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第9期35卷 1-11页

作者： Gong, Yi-Hao Tian, Shun-Qiang Liu, Xin-Zhong Xuan, Shou-Zhi Tan, Li-Yuan mao, ling-long Chinese Acad Sci Shanghai Shanghai Adv Res Inst Shanghai Synchrotron Radiat Facil Shanghai 201204 Peoples R China Chinese Acad Sci Shanghai Shanghai Inst Appl Phys Shanghai 201800 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

The round-beam operation presents many benefits for scientific experiments regarding synchrotron radiation and the weakening influences of intra-beam scattering in diffraction-limited synchrotron light sources. A round-beam generation method based on the global setting of skew quadrupoles and the application of a non-dominated sorting genetic algorithm was proposed in this study. Two schemes, including large-emittance coupling introduced via betatron coupling and vertical dispersion, were explored in a candidate lattice for an upgrade-proposal of the Shanghai synchrotron radiation facility. Emittance variations with lattice imperfections and their influence on the beam dynamics of beam optic distortions were investigated. The results demonstrated that a precise coupling control ranging from 10 to 100% was achieved under low optical distortion, whereas full-coupling generation and its robustness were achieved by our proposed method by adjusting the skew quadrupole components located in the dispersion-free sections. The Touschek lifetime increased by a factor of 2-2.5.

关键词： Diffraction-limited storage ring (DLSR) Shanghai synchrotron radiation facility upgrade (SSRF-U) Round beam Off-resonance coupling EMITTANCE OPTICS

Heat stress induced hepatocyte apoptosis in largemouth bass Micropterus salmoides via IRE1α/TRAF2/ASK1/JNK pathway

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Journal of Oceanology and Limnology 2024年第3期42卷 988-1000页

作者： Xuqian ZHAO Wenjia mao Zijie LIN Qufei ling School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow UniversitySuzhou 215000China

Heat stress(HS)has been shown to adversely affect fish livers and can lead to extensive *** investigate the relationship between endoplasmic reticulum(ER)stress and HS-induced apoptosis in fish livers,we isolated and cultured primary hepatocytes of largemouth bass,Micropterus salmoides by trypsin method,then established an in-vitro model of liver cells under HS(35℃).The contents of lactic dehydrogenase(LDH)and hydrogen peroxide(H2O2)were determined to evaluate the effects of HS on hepatocyte injury and oxidative ***-qPCR was performed to discover the key genes in unfolded protein response(UPR)pathways involved at different HS *** inhibitor 4-PBA and IRE1αinhibitor 4μ8C were used to further investigate the effects of HS on IRE1αapoptosis pathway in *** show that HS led to significant increases in the release of LDH,the content of H2O2,and the expressions of oxidative protein folding genes(ero1αand pdi)under HS,suggesting severe hepatocyte injury and oxidative stress happened in heat-stressed largemouth bass *** continuous activation of IRE1αpathway genes(grp78,grp94,atf6,perk,eif2a,atf4,chop,ire1α,traf2,ask1,jnk1,and jnk2)indicated that HS led significantly to ER *** particular,the mRNA expression levels of ER stress-related genes(grp78,grp94,atf6,perk,ire1α,chop,jnk1,and jnk2)in the high temperature(HT)+4-PBA group and the HT+4μ8C group were significantly down-regulated under *** 4μ8C treatment,the expression levels of apoptosis-related genes(caspase-2,caspase-3,caspase-6,caspase-7,caspase-8,caspase-9,and caspase-10)and LDH content were significantly decreased,whereas the cell survival rate was significantly increased when given 4-PBA or 4μ8C *** findings demonstrate that HS could induce liver apoptosis of largemouth bass through the IRE1αpathway,which may act as a key switch mediating liver apoptosis of largemouth bass under HS.

关键词： heat stress Micropterus salmoides endoplasmic reticulum stress apoptosis oxidative stress

One bird,multiple stones:The race to find a gene of dominant negative effect in wheat

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The Crop Journal 2024年第4期12卷 951-952页

作者： long mao State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

In the current issue of The Crop Journal,Chen et al.[1]reports map-based cloning of a wheat gene that showed temperaturedependent pleiotropic effects on multiple traits including plant height,leaf shape,spike and grain morphology,and accordingly was named WPA1 for Wheat Plant Architecture *** mutant was first observed among EMS-treated plants and repeatedly appeared in multiple occasions.

关键词： Wheat bird repeatedly

A framework of force of information influence and application for C4KISR system

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Journal of Systems Engineering and Electronics 2024年第2期35卷 430-443页

作者： mao Shaojie DIAO Lianwang SUN Yu WANG Heng YI Kan XU Xin mao Xiaobin ZHANG Kecheng SHENG long Science and Technology on Information Systems Engineering Laboratory The 28th Research Institute of China Electronics Technology Group CorporationNanjing 210007China Unit 94860 of the PLA Nanjing 210008China

The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.

关键词： information warfare command control communications computer kill intelligence surveillance reconnaissance(C4KISR)system information circulation force of information influence information entropy

Impacts of multi-foulings on salinity gradient energy conversion process in negatively charged conical nanochannels

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Science China(Technological Sciences) 2024年第6期67卷 1714-1726页

作者： mao RuiJie CHEN Xi ZHOU RuHong long Rui LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Membrane fouling inevitably occurs during nanofluidic reverse ***,the impact of multi-fouling on the energy conversion performance of negatively charged conical nanochannels under asymmetrical configurations is systematically *** results reveal that in Configuration I,where a high-concentration solution is applied at the tip side,at small concentration ratios,multiple foulings reduce the electric *** Configuration II,where a low-concentration solution is applied at the tip side,multiple foulings near the base side contribute to the electric *** fouling that formed near the lowconcentration entrance diminished the electric power and energy conversion ***-fouling lowered the electrical power consumption by 69.27%and 99.94%in Configurations I and II,*** Configuration I,the electric power first increased with increasing fouling surface charge density,reached its maximum value,and thereafter *** Configuration II,the electric power first decreased with increasing fouling surface charge density,reached its minimum value,and thereafter *** negative or positive charge densities of fouling contribute to the electric power and energy conversion efficiency.

关键词： conical nanochannel fouling nanofluidic reverse electrodialysis salinity gradient energy

Design and Application of an S-band Fast Radio Bursts Search Pipeline for the Nanshan 26 m Radio Telescope

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Research in Astronomy and Astrophysics 2024年第7期24卷 111-117页

作者： Yan-ling Liu mao-Zheng Chen Jian Li Jian-Ping Yuan Rai Yuen Zhi-Yong Liu Hao Yan Wen-long Du Nan-Nan Zhai Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Microwave Technology Urumqi 830011China University of Chinese Academy of Sciences Beijing 100049China

Fast radio bursts(FRBs)are among the most studied radio transients in astrophysics,but their origin and radiation mechanism are still *** is a challenge to search for FRB events in a huge amount of observational data with high speed and high *** the rapid advancement of the FRB research process,FRB searching has changed from archive data mining to either long-term monitoring of the repeating FRBs or all-sky surveys with specialized ***,establishing a highly efficient and high quality FRB search pipeline is the primary task in FRB *** learning techniques provide new ideas for FRB search *** have detected radio bursts from FRB 20201124A in the L-band observational data of the Nanshan 26 m radio telescope(NSRT-26m)using the constructed deep learning based search pipeline named dispersed dynamic spectra search(DDSS).Afterwards,we further retrained the deep learning model and applied the DDSS framework to S-band *** this paper,we present the FRB observation system and search pipeline using the S-band *** carried out search experiments,and successfully detected the radio bursts from the magnetar SGR J1935+2145and FRB *** experimental results show that the search pipeline can complete the search efficiently and output the search results with high accuracy.

关键词： radio continuum general-methods data analysis-methods observational

Reconstruction of Postinfarcted Cardiac Functions Through Injection of Tanshinone IIA@ Reactive Oxygen Species-Sensitive Microspheres Encapsulated in a Thermoreversible Hydrogel

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Energy & Environmental Materials 2024年第2期7卷 191-203页

作者： ling Yu Yubin Liang Lei Gao Peipei Chen Zhiqiang Yu Minzhou Zhang Aleksander Hinek Shuai mao Second Clinical College Guangzhou University of Chinese Medicine Department of Critical Care Medicine Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Branch of National Clinical Research Centre for Chinese Medicine Cardiology Department of Radiation Medicine and Applied Sciences University of California San Diego Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Research Affiliated Dongguan Hospital Southern Medical University Translational Medicine Hospital for Sick Children

Myocardial damage resulting from acute myocardial infarction often leads to progressive heart failure and sudden death, highlighting the urgent clinical need for effective therapies. Recently, tanshinone IIA has been identified as a promising therapeutic agent for myocardial infarction. However, efficient delivery remains a major issue that limits clinical translation. To address this problem, an injectable thermosensitive poly(lactic acid-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(lactic acid-co-glycolic acid) gel(PLGA-PEG-PLGA) system encapsulating tanshinone IIA-loaded reactive oxygen species-sensitive microspheres(Gel-MS/tanshinone IIA) has been designed and synthesized in this study. The thermosensitive hydrogel exhibits good mechanical properties after reaching body temperature. Microspheres initially immobilized by the gel exhibit excellent reactive oxygen speciestriggered release properties in a high-reactive oxygen species environment after myocardial infarction onset. As a result, encapsulated tanshinone IIA is effectively released into the infarcted myocardium, where it exerts local antipyroptotic and anti-inflammatory effects. Importantly, the combined advantages of this technique contribute to the mitigation of left ventricular remodeling and the restoration of cardiac function following tanshinone ***, this novel, precision-guided intra-tissue therapeutic system allows for customized local release of tanshinone IIA, presenting a promising alternative treatment strategy aimed at inducing beneficial ventricular remodeling in the post-infarct heart.

关键词： myocardial infarction ROS-sensitive polymer tanshinone IIA thermoreversible hydrogel ventricular remodeling

Differential expression of miRNAs and mRNAs in the livers of largemouth bass Micropterus salmoides under heat stress

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Journal of Oceanology and Limnology 2024年第2期42卷 594-608页

作者： Xuqian ZHAO Zijie LIN Caijuan LI Hao ZHU lingling LI Wenjia mao Qufei ling School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow UniversitySuzhou 215000China

Global warming threatens freshwater ecosystems and compromises fish *** elucidate the role of miRNAs in the livers of heat stressed largemouth bass,juvenile fish was subject to heat stress under 37°*** mRNA-seq and miRNA-seq were conducted on the liver tissues under control and heat stress *** gene expression analysis and enrichment analysis were performed on mRNA and miRNA expression profiles.A total of 406 differentially expressed genes(DEGs)were discovered,of which 212 were up-regulated and 194 were *** of the DEGs were significantly implicated in the regulation of“protein processing in endoplasmic reticulum”,“proteasome”,“steroid biosynthesis”,and“ornithine decarboxylase inhibitor activity”*** addition,47 differentially expressed miRNAs(DEMs)were identified in largemouth bass livers under heat stress,including 21 up-regulated and 25 down-regulated miRNAs.A negatively regulated miRNA-mRNA network including 12 miRNAs and 19 mRNAs was constructed with DEMs involved in“protein degradation”,“calcium ion regulation”,“cell apoptosis”,and“lipid metabolism”.Moreover,this study indicated novel-miR-144 activated the IRE1 signaling pathway by targeting txndc5 to induce liver apoptosis in largemouth bass under heat *** study revealed the involvement of miRNA regulation in largemouth bass in response to heat stress.

关键词： heat stress largemouth bass miRNA-mRNA interaction

Aptasensing biosynthesized phosphatidylserine with a AuNPs nanozyme-based colorimetric aptasensor

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Food Science and Human Wellness 2024年第2期13卷 823-829页

作者： Sai Wang Rui Ma Chengqiang Li ling Zhang Haiyang Zhang Xuehan Li Xiangzhao mao Qingdao Key Laboratory of Food Biotechnology College of Food Science and EngineeringOcean University of ChinaQingdao 266404China Key Laboratory of Biological Processing of Aquatic Products China National Light IndustryQingdao 266404China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Sensitive monitoring of the target products during the biosynthesis process is crucial,and facile analytical approaches are urgently ***,phosphatidylserine(PS)was chosen as the model target,a colorimetric aptasensor was developed for the rapid quantitation in biosynthesis samples.A chimeric aptamer was constructed with two homogeneous original PS *** recognition between the chimeric aptamer and PS results in the desorption of aptamer from the surface of the AuNPs nanozyme,and the peroxidase-like enzymatic activity of the AuNPs nanozyme was weakened in a relationship with the different *** developed aptasensor performed well when applied for analyzing PS in biosynthesis *** aptasensor offers good sensitivity and selectivity,under optimal conditions,achieving monitoring and quantitation of PS in the range of 2.5-80.0μmol/L,with a limit of detection at 536.2 nmol/***,the aptasensor provides good accuracy,with comparison rates of 98.17%-106.40%,when compared with the *** study provides a good reference for monitoring other biosynthesized products and promoting the development of aptamers and aptasensors in real-world applications.

关键词： Phosphatidylserine Chimeric aptamer AuNPs nanozyme Colorimetric aptasensor