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Effects of electro-acupuncture on Noxa and caspase-3 expression in hippocampal CA1 region of a vascular dementia rat model

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Neural Regeneration Research 2008年第8期3卷 826-831页

作者： Yanzhen zhu Qiang Wu ling Lin Department of Integrative Medicine Fujian University of Traditional Chinese Medicine Fuzhou 350108 Fujian Province. China Department of Acupuncture and Moxibustion Fujian University of Traditional Chinese Medicine Fuzhou 350108 Fujian Province. China The Room for Confocal Laser Scanning Microscope Fujian Medical University Fuzhou 350004 Fujian Province China

BACKGROUND：Noxa, a pro-apoptotic member of the Bcl-2 protein family, has been shown to induce the mitochondrial pathway of apoptosis and to mediate hypoxic cell death in a rat model of cerebral ischemia. This suggests that Noxa could participate in apoptosis during vascular dementia （VD）. OBJECTIVE： To detect Noxa and caspase-3 expression after electro-acupuncture in VD rats to further validate the mechanism of electro-acupuncture-induced effects in the treatment of VD. DESIGN, TIME AND SETTING： A randomized, controlled study was performed at the Center for the Neurobiology of Fujian Medical University between January 2006 and March 2007. MATERIALS： A total of forty adult, male, Sprague Dawley rats were included in this study. The following equipment was used： confocal laser scanning microscope （Sp5, Leica, Germany）, water maze （Bejing Suntendy Science and Technology Co., Ltd., China）, and SDZ-II electronic acupuncture treatment instruments （Suzhou Medical Appliance Factory, China）. METHODS： Thirty-eight rats with sufficient learning and memory abilities were selected by Morris water maze criteria. Twelve rats received sham-surgery; the remaining 26 rats were used to establish a VD model by bilateral occlusion of the common carotid arteries. The rats that survived the occlusion procedure were randomly assigned into an electro-acupuncture group （n = 11） and a VD model group （n = 12）. MAIN OUTCOME MEASURES： Neuropathological changes were observed with hematoxylin-eosin staining of the hippocampus and expression of Noxa and caspase-3 in the hippocampal CA1 region was analyzed by confocal laser scanning microscope following immunofluorescence staining. RESULTS： Expressions of Noxa and caspase-3 in the electro-acupuncture group and sham-operated group were less than in the VD model group （P 〈 0.01）. Electro-acupuncture reduced the amount of apoptotic neurons in hippocampal CA1 area of rats with VD. The average latency in the Morris water maze test was significantly short

关键词： apoptosis caspase-3 electro-acupuncture Noxa vascular dementia

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Tensor semantic model for an audio classification system

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Science China(Information Sciences) 2013年第6期56卷 106-114页

作者： XING ling MA Qiang zhu Min School of Information Engineering Southwest University of Science and Technology

Audio resources are a very important part of multimedia *** classification effect of audio is directly related to the service mode of personal resource management *** present,vector features have been widely used in audio classification ***,some semantic correlations among different audio information can not be completely expressed by simple vector *** are multidimensional matrices,and their mathematical expansion and application can express multi-semantic *** tensor uniform content locator(TUCL) is proposed as a means of expressing the semantic information of audio,and a three-order tensor semantic space is constructed according to the semantic *** semantic dispersion(TSD) can aggregate some audio resources with the same semantics and,at the same time,its automatic classification can be accomplished by calculating the *** order to effectively utilize TSD classification information,a radial basis function tensor neural network(RBFTNN) is constructed and used to train an intelligent learning *** results show that the tensor model can significantly improve the classification precision under multi-semantic classification requests within an information resource management system.

关键词： audio classification tensor semantic dispersion tensor uniform content locator

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NEW HYDRAULIC ACTUATOR'S POSITION SERVOCONTROL STRATEGY

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Chinese Journal of Mechanical Engineering 2007年第5期20卷 46-53页

作者： KE Zunrong zhu Yuquan ling Xuan School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074. China

A new hydraulic actuator-hydraulic muscle （HM） is described, and the actuator＇s features and applications are analyzed, then a position servocontrol system in which HM is main actuator is set up. The mathematical model of the system is built up and several control strategies are discussed. Based on the mathematical model, simulation research and experimental investigation with subsection PID control, neural network self-adaptive PID control and single neuron self-adaptive PID control adopted respectively are carried out, and the results indicate that compared with PID control, neural network self-adaptive PID control and single neuron self-adaptive PID control don＇t need controlled system＇s accurate model and have fast response, high control accuracy and strong robustness, they are very suitable for HM position servo control system.

关键词： Hydraulic muscle (HM) Position servocontrol Control strategies Subsection PID control Neural network self-adaptive PID control Single neuron self-adaptive PID control

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g-Besselian Frames in Hilbert Spaces

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2117-2130页

作者： Ming ling DING Yu Can zhu College of Computer and Information Fujian Agriculture and Forestry University Fuzhou 350002 P. R. China Department of Mathematics Fuzhou University Fuzhou 350108 P. R. China

In this paper, we introduce the concept of a g-Besselian frame in a Hilbert space and discuss the relations between a g-Besselian frame and a Besselian frame. We also give some characterizations of g-Besselian frames. In the end of this paper, we discuss the stability of g-Besselian frames. Our results show that the relations and the characterizations between a g-Besselian frame and a Besselian frame are different from the corresponding results of g-frames and frames.

关键词： g-frame Besselian frame g-Besselian frame stability

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Sevoflurane effects on cyclic adenosine monophosphate response element binding protein,phosphorylated cyclic adenosine monophosphate response element binding protein,and Livin expression in the cortex and hippocampus of a vascular cognitive impairment rat

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Neural Regeneration Research 2009年第7期4卷 523-529页

作者： Bin Wu ling Dan Xianlin zhu Department of Anesthesiology First Affiliated Hospital Chongqing Medical University Chongqing 400016 China Department of Anesthesiology Second Affiliated Hospital Chongqing Medical University Chongqing 400010 China

BACKGROUND： Neuronal necrosis and apoptosis play important roles in the pathophysiology of cerebral ischemia and resulting cognitive impairment. However, inhibition of neuronal necrosis and apoptosis has been shown to attenuate cognitive impairment following cerebral ischemia. OBJECTIVE： To investigate the effects of sevoflurane on cyclic adenosine monophosphate response element binding protein （CREB）, phosphorylated CREB （pCREB）, and Livin expression in the cortex and hippocampus of a rat model of vascular cognitive impairment.DESIGN, TIME AND SETTING： A randomized, controlled experiment was performed in the Chongqing Key Laboratory of Neurology between June 2007 and July 2008.MATERIALS： Sevoflurane was provided by Abbott Laboratory, UK; Morris water maze was provided by Chinese Academy of Medical Sciences, China; goat anti-rat CREB, goat anti-rat pCREB and goat anti-rat Livin antibodies were provided by Biosource International, USA. METHODS： A total of 42 female, Wistar rats were randomly assigned to the following groups： sham operation, vascular cognitive impairment, and sevoflurane treatment. The vascular cognitive impairment rat model was established by permanent bilateral occlusion of both common carotid arteries, and 1.0 MAC sevoflurane was immediately administered by inhalation for 2 hours. MAIN OUTCOME MEASURES： CREB, pCREB, and Livin expression was measured in the cortex and hippocampus by Western blot and reverse transcription-polymerase chain reaction. Behavior was evaluated with Morris water maze. RESULTS： CREB, pCREB, and Livin expression in the sevoflurane treatment group was significantly greater than the vascular cognitive impairment group （P 〈 0.01）. However, expression of CREB and pCREB was significantly less in the sevoflurane treatment and vascular cognitive impairment groups, compared with the sham operation group （P 〈 0.01）. Livin expression in the sevoflurane treatment and vascular cognitive impairment groups was significantly gre

关键词： vascular cognitive impairment sevoflurane cyclic adenosine monophosphate response element binding protein Livin

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Scalar transport by propagation of an internal solitary wave over a slope-shelf

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Journal of Hydrodynamics 2019年第2期31卷 317-325页

作者： Jin Xu ling-ling Wang Hong-wu Tang zhu Hai John James Reginald Williams State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hobai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China School of Engineering and Materials Science Queen Mary University of LondonLondonUK

Internal solitary waves(ISWs)of depression are commonly found in the coastal environment and are believed to re-suspend sediments in coastal regions where the waves *** this research,the direct numerical simulation is used to study the scalar transport induced by the ISWs of depression propagating over a slope-shelf *** scalar in this paper is considered to represent the concentrations of very fine suspended solids or *** are observed from the numerical results at the bottom boundary layer on the slope during the ISW shoaling process,resulting in a scalar *** in cident ISWs of depression are observed to produce a waveform inversion on the *** scalar transport from a slope to a shelf is the consequence of the combined vortices at the bottom boundary layer and the overturning of the ISWs of depression,and the latter was commonly ignored in previous *** study shows that the ISW-induced scalar transport consists of the following four stages:the slip transport,the wash transport,the vortex transport,and the secondary transport.A dimensionless time scales of the four stages are calculated,and the beginning times of the wash transport and the secondary transport are found to be uncorrelated with the slope gradients,taking values of 1.26,4,respectively.

关键词： Internal solitary waves slope-shelf scalar transport wave inversion dimensionless time scale

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Comparative proteomic study and functional analysis of translationally controlled tumor protein in rice roots under Hg^(2+) stress

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Journal of Environmental Sciences 2012年第12期24卷 2149-2158页

作者： Feijuan Wang Yongshen Shang ling Yang Cheng zhu College of Life Sciences Zhejiang UniversityHangzhou 310058China College of Life Sciences China Jiliang UniversityHangzhou 310018China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004China

So far, very little is known about mercury stress-induced intercellular metabolic changes in rice roots at the proteome level. To investigate the response of rice roots to mercury stress, changes in protein expression in rice roots were analyzed using a comparative proteomics approach. Six-leaf stage rice seedlings were treated with 50 μmol/L HgC12 for 3 hr; 29 protein spots showed a significant changes in abundance under stress when compared with the Hg2＋-tolerant rice mutant and wild type （Zhonghua 11）. Furthermore, all these protein spots were identified by mass spectrometry to match 27 diverse protein species. The identified proteins were involved in several processes, including stress response, redox homeostasis, signal transduction, regulation and metabolism; some were found to be cellular structure proteins and a few were unknown. Among the up-regulated proteins, OsTCTP （translationally controlled tumor protein） was chosen to perform hetereologous expression in yeast which was presumed to participate in the Hg2~ tolerance of rice, providing evidence for its role in alleviating Hg2~ damage. Among the many tests, we found that OsTCTP-overexpressed yeast strains were more resistant to Hg2＋ than wild-type yeast. Thus, we propose that OsTCTP contributes to Hg2＋ resistance. Here we present, for the first time, the functional characterization of OsTCTP in connection with Hg2＋ stress in plants.

关键词： 2-DE mercury stress rice roots OsTCTP heteroexpression

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Deducing the Intonation of Chinese Characters in Suzhou-Zhongzhou Dialect by Its Singing Technique in Kunqu:A New Probe into Ancient Chinese Phonology

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Language and Semiotic Studies 2020年第2期6卷 65-80页

作者： ling zhu the Center of Intercultural Studies Soochow UniversityChina

Kunqu is a comprehensive art which is considered to be an epitome of the achievements of Chinese *** was unanimously selected by UNESCO from the first round of entrants for the category of"Oral and Intangible Heritage of Humanity",with emphasis on its heritage value as embodied in language,literature,music,singing technique,dance,performance,set design,makeup,and more,and has been given the status of living fossil by artists both in China and *** on the relationship between the intonation of Chinese characters and singing techniques,especially the criterion in Kunqu that the"singing technique follows the intonation of a Chinese character",we attempt to deduce the intonation of Chinese characters in the Suzhou-Zhongzhou dialect based on its singing ***,we deduce the archaic intonations of Chinese characters by the exclusive singing techniques in Kunqu for the purpose of exploring a new approach to Chinese phonology of the Ming and Qing dynasties from an interdisciplinary perspective of artistic criterion and linguistics.

关键词： Kunqu singing technique Chinese phonology heritage value interdisciplinary research

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From China to the world:Science China Chemistry celebrates the International Year of Chemistry

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Science China Chemistry 2012年第1期55卷 195-200页

作者： zhu XiaoWen XUE Zi-ling Science China Press 16 Donghuangchenggen North StreetBeijing 100717China Department of Chemistry University of TennesseeKnoxvilleTennessee 37996-1600USA

1 Introduction Science China Chemistry is considered the best and most comprehensive chemistry journal in *** primary mission is to communicate the results of basic and innovative chemistry research. The subject areas... 详细信息

关键词：化学研究中国科学国际世界物理化学有机化学无机化学

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Effects of Rural Medical Financial Assistance in China

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China & World Economy 2007年第2期15卷 16-28页

作者： ling zhu Chinese Academy of Social Sciences Beijing China

This paper presents research results from the evaluation of the Medical Financial Assistance （MFA） program, supported by the Worm Bank, to extremely poor rural residents. It is found that MFA can help to improve the ability of the poor to make use of medical services, and especially their ability to receive services from township clinics. The present study also shows that adoption of the MFA mechanism helps to reduce the impact of disease on the economies of poor families, and prevents the poor afflicted with serious illnesses from being marginalized. However, as the beneficiaries often suffer from serious, complicated and lasting illnesses, the fnancial assistance is often insignificant in relation to medical eapenses. Furthermore, the MFA plays no significant role in restoring a patient＇s income-earning ability.

关键词： financial assistance poverty reduction rural medical

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