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Ypsilandrosides U-Y,five new steroidal saponins from Ypsilandra thibetica

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Natural Products and Bioprospecting 2022年第1期12卷 211-219页

作者： Wen-Tao Gao ling-ling yu Jing Xie Long-Gao Xiao Shi-Juan Zhang Wen-Yi Ma Huan Yan Hai-Yang Liu College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming 650500China State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides,named ypsilandrosides U-X(1-4),and one new cholestanol glycoside,named ypsilandroside Y(5).Their structures have been established by extensive spectroscopic data and chemical *** them,compound 4 is a rare spirostanol glycoside which possesses a novel 5(6→7)abeo-steroidal aglycone,while compound 1 is a first spiro-stanol bisdesmoside attached to C-3 and C-12,respectively,isolated from the genus *** induced platelet aggregation activity of the isolates was tested.

关键词： Ypsilandra thibetica Melanthiaceae Ypsilandrosides U-Y Spirostanol saponins Cholestanol saponins

Independent and joint association of physical activity and sedentary behavior on all-cause mortality

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Chinese Medical Journal 2021年第23期134卷 2857-2864页

作者： Wei Zhou Wei Yan Tao Wang ling-Juan Zhu Yan Xu Jun Zhao ling-ling yu Hui-Hui Bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center NanchangJiangxi 330006China Chronic Disease Prevention and Control Institute Jiangxi Province Center for Disease Control and PreventionNanchangJiangxi 330006China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China.

Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese *** aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern ***:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 *** self-reported PA and SB were collected via the ***–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause ***:A total of 11,744 eligible participants were included in the *** an average of 5.4 years of follow-up,796 deaths *** risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause *** with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.

关键词： Physical activity Sedentary behavior All-cause mortality Joint association

How to select gastric cancer patients suitable for immunotherapy?

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Clinical Research Communications 2023年第4期6卷 10-11页

作者： ling-ling yu Guo-Jun Zhang Bao Zhang Hai-yue yu Guo-Liang Zheng Department of Integrated Chinese and Western Medicine Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042China Department of Pathophysiology College of Basic Medicine ScienceChina Medical UniversityShenyang 110122China Department of Gastric Surgery Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042China

Stomach cancer is the fourth leading cause of cancer-related deaths worldwide[1].There are approximately one million new cases of gastric cancer worldwide each year,with about 45%occurring in China[1].In China,the number of deaths from gastric cancer ranks second among all tumors each year[2],the majority of patients are diagnosed at an advanced or late stage,making them ineligible for surgical *** of these patients can regain the opportunity for surgery through conversion therapy,while more patients can only receive comprehensive treatment with cytotoxic drugs,anti-metabolite drugs,DNA-targeting drugs,and targeted drugs[3].

关键词： drugs patients cancer

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping yu Emily Choi Michael QJiang ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Mechanistic investigation of the saponin components of Trillium tschonoskii and the anti-gastric cancer effects based on inhibiting Ras signaling

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Mechanistic investigation of the saponin components of Trill...

Acute Appendicitis in the Early Stage after Orthotopic Liver Transplantation

中国化学会第十届全国天然有机化学学术会议

作者： ling-ling yu yuan-Bao Ai Wei Liu Shi-Gang Li School of Medicine China Three Gorges University

＜正＞AIM:To identify the main antitumor compounds of Trillium tschonoskii as well as to investigate its antitumor activity and the ***:Activity leading isolation to find out the main antitumor compounds and test their inhibited proliferation of tumor cells in vitro and in ***:（1）The total saponins of *** could inhibit proliferation of tumor

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Chinese Medical Journal 2017年第10期130卷 1253-1254页

作者： Jun-Feng Huang Jie-Fei Ma yu Gong ling-ling yu Chun-Xiao Cui Liu-Xiao Yang Jian Zhou Du-Ming Zhu Ting Wang Department of Intensive Care Medicine Zhonqshan Hospital Fudan University Shanghai 200032 China Department of Liver Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

Acute appendicitis is one of the most common surgical diseases in the general population, but it rarely happens after orthotopic liver transplantation （OLT）, The impaired immune function in these patients usually predisposes them to a delay in diagnosis owing to an atypical presentation, which might increase complications including death. It is reported that acute appendicitis after liver transplantation happens mostly after postoperative day （POD） 14. Herein, we presented two cases of acute appendicitis after OLT happened within POD 14.

关键词： Appendicitis Immunosuppression Liver Transplantation

跨界书写与共同主体性建构——以殖民地时期在华韩国流亡文学为中心

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吉林大学社会科学学报 2023年第3期63卷 218-234,240页

作者：金柄珉梁玉玲延边大学延吉133000 延边大学朝汉文学院延吉133000

殖民地时期在华韩国流亡文学中的共同主体性,经历了建构与解构、解构与重构的历史进程。在华韩国流亡文人的个体生命自觉和民族主体性是建构共同主体性的根本前提,而在中国的现代语境则始终是其重要的变数。因为中韩志士面临着共同的反... 详细信息

殖民地时期在华韩国流亡文学中的共同主体性,经历了建构与解构、解构与重构的历史进程。在华韩国流亡文人的个体生命自觉和民族主体性是建构共同主体性的根本前提,而在中国的现代语境则始终是其重要的变数。因为中韩志士面临着共同的反帝反封建的历史使命,在华韩国流亡文学逐渐表现出交互主体与共同主体性建构的特质。这一建构过程大致经过两个阶段:一是辛亥革命和大革命时期,为探索阶段与初步形成阶段,积累了多方面的历史经验。二是全面抗战时期,为成熟与全面发展阶段,主要表现在中韩志士作为共同主体参加中国抗战,进而建构交互主体与共同主体性;在文学活动方面表现为同一主题的共同书写以及戏剧文学的创作与共同演出等。在华韩国流亡文学中的交互主体、共同主体性的建构过程呈现出中韩命运共同体的文化亲和性、互动交融性以及共存发展性等特点。

关键词：韩国流亡文学跨界书写中国语境共同主体性

采用二流式算法的GOCI／AOT反演方法及其应用

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浙江大学学报（工学版） 2016年第12期50卷 2424-2432页

作者：姚玲玲张霄宇江彬彬浙江大学地球科学学院空气污染与健康研究中心浙江杭州310027

针对静止海洋水色传感器(GOCI)2.1μm短波红外通道缺失和高太阳天顶角的特点,采用二流式算法,并考虑气溶胶的折射率、地球曲率等因素,重新计算地表反射率、表观反射率以及反演GOCI气溶胶光学厚度(AOT).结果表明:参数重新计算后的GOCI\AO... 详细信息

针对静止海洋水色传感器(GOCI)2.1μm短波红外通道缺失和高太阳天顶角的特点,采用二流式算法,并考虑气溶胶的折射率、地球曲率等因素,重新计算地表反射率、表观反射率以及反演GOCI气溶胶光学厚度(AOT).结果表明:参数重新计算后的GOCI\AOT反演精度明显增高;根据目前广泛使用的实测AOT(440nm)>1.00霾判定阈值,采用线性内插方法,建议GOCI\AOT以AOT(555nm)>0.81作为霾判定阈值;中分辨率成像光谱仪(MODIS)是业务化的极轨卫星,GOCI\AOT整体略大于MODIS\AOT,拟合精度R2=0.82.以2015年11月27日至同年12月2日华北地区发生的霾事件为例,结合具有大范围观测能力的MODIS卫星,多源遥感监测方法有效地反映了该霾事件的动态发展过程.

关键词：静止海洋水色传感器(GOCI) 气溶胶光学厚度(AOT) 二流式算法霾事件动态观测

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紫外光照亲水性聚碳酸酯的合成及性能

高分子学报 2019年第11期50卷 1202-1207页

作者：于伶伶程瑞华童钰涛刘柏平华东理工大学化学工程联合国家重点实验室上海200237 华南农业大学材料与能源学院广州510642

采用2-{[(2-硝基苯基)甲氧基]甲基}环氧乙烷(单体a)与二氧化碳(CO2)、环氧丙烷(PO)在SalenCo(Ⅲ)Cl/双(三苯基正膦基)氯化铵(PPNCl)催化下三元共聚,紫外(UV)光照脱除保护基,成功合成羟基官能化聚碳酸酯(PPC-OH).采用红外光谱、核磁共振... 详细信息

采用2-{[(2-硝基苯基)甲氧基]甲基}环氧乙烷(单体a)与二氧化碳(CO2)、环氧丙烷(PO)在SalenCo(Ⅲ)Cl/双(三苯基正膦基)氯化铵(PPNCl)催化下三元共聚,紫外(UV)光照脱除保护基,成功合成羟基官能化聚碳酸酯(PPC-OH).采用红外光谱、核磁共振、凝胶渗透色谱、接触角测量仪等对产物表征,结果表明:单体a成功引入聚碳酸酯骨架;SalenCo(Ⅲ)Cl催化剂表现出高催化活性、高选择性以及对第三单体良好的耐受性,聚合物碳酸酯单元含量>98%,首尾相连结构>99%,分子量分布极窄,CO2和环氧化物完美交替共聚.通过UV光照成功脱除羟基保护基生成PPC-OH,主链骨架无降解;单体a加入量至6%时,PPC-OH羟基含量增加至19.4%,水接触角由78.3°减小至57.6°,亲水性得到明显改善.

关键词：羟基官能化聚碳酸酯二氧化碳亲水性三元共聚 SalenCo(Ⅲ)Cl催化剂