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磁性微球在循环肿瘤细胞和病毒以及核酸分离富集和检测分析中的应用进展

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分析化学 2024年第6期52卷 778-788页

作者：郭玲香周健平杨涛东南大学化学化工学院东南大学智能材料研究院

磁性微球是一种多用途复合材料，通常以纤维素、壳聚糖、二氧化硅以及聚苯乙烯等生物兼容性好的材料为包覆载体，通过表面的活性基团（—OH、—COOH、—NH2和—SH等）负载荧光分子、抗体和核酸等，可以特异性识别癌细胞、病毒和遗传物... 详细信息

磁性微球是一种多用途复合材料，通常以纤维素、壳聚糖、二氧化硅以及聚苯乙烯等生物兼容性好的材料为包覆载体，通过表面的活性基团（—OH、—COOH、—NH2和—SH等）负载荧光分子、抗体和核酸等，可以特异性识别癌细胞、病毒和遗传物质。借助其自身优异的磁响应特性，磁性微球可实现快速分离和富集，在免疫分析、细胞分离以及环境检测等领域具有广阔的应用前景；磁性微球还可与微流控芯片等结合，构建高通量检测平台。本文介绍了近5年来磁性微球在循环肿瘤细胞检测、病毒抗原抗体和核酸检测等前沿分析领域中的应用进展，并讨论了以磁性微球以及以其为载体开发的检测分析试剂盒的商业化前景。

关键词：磁性微球循环肿瘤细胞病毒抗原核酸检测评述

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China Life Sciences 2024年

作者： Xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo ling Chen Zheng-Jie Wang Yu Yu Tian Xia Xue-Min Zhang Ai-ling Li tao Zhou Hong Cai tao Li Nanhu Laboratory National Center of Biomedical Analysis School of Basic Medical Sciences Fudan University Department of Basic Medical Sciences School of Medicine Tsinghua University

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid （CSF） flow by beating their motile cilia coordinately. The ependymal denudation or ciliary dysfunction causes hydrocephalus. Here, we report that the deficiency of regulator of Gprotein signaling 22 （RGS22） results in severe congenital hydrocephalus in both mice and rats. Interestingly, RGS22 is specifically expressed in ependymal cells within the brain. Using conditional knock-out mice, we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus. Mechanistically, we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis. This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor （LPAR） signaling under Rgs22–/–condition, as the LPAR blockade effectively alleviates hydrocephalus in Rgs22–/–rats. Therefore, our findings unveil a previously unrecognized role of RGS22 in the central nervous system, and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

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笑气滥用致周围神经损害二例

中国现代神经疾病杂志 2024年第5期24卷 365-369页

作者：董美学胡玲李涛武汉大学人民医院湖北省人民医院神经内科 400030

例1男性,26岁,主因渐进性四肢乏力10天,于2022年5月5日入院。患者入院前10天无明显诱因出现四肢乏力,以下肢为著,伴行走不稳、双下肢麻木,上肢无法长时间持物,便秘、小便正常,当地医院考虑周围神经损害,予甲钴胺0.50 mg/d静脉滴注对症治... 详细信息

例1男性,26岁,主因渐进性四肢乏力10天,于2022年5月5日入院。患者入院前10天无明显诱因出现四肢乏力,以下肢为著,伴行走不稳、双下肢麻木,上肢无法长时间持物,便秘、小便正常,当地医院考虑周围神经损害,予甲钴胺0.50 mg/d静脉滴注对症治疗3天,症状无缓解,遂至我院就诊,门诊以“周围神经病”收入院。患者自发病以来,精神、睡眠、饮食尚可。患者3个月前开始吸食笑气,每日约10罐(7.50 g/罐);吸烟10年,约20支/d;双下肢阵发性抽搐5年,未予重视;个人史及家族史无特殊。入院后体格检查:体温36.3℃,心率79次/min,呼吸18次/min,血压116/72 mm Hg(1 mm Hg=0.133 kPa),心、肺、腹部检查无异常。

关键词：氧化亚氮周围神经系统疾病病例报告

深化产教融合创新现代学徒制人才培养模式研究——以安徽省铜陵市为例

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宿州教育学院学报 2024年第3期27卷 46-51页

作者：凌涛铜陵职业技术学院安徽铜陵244061

以安徽省铜陵市为例,阐述了创新现代学徒制人才培养模式的必要性与可行性,分析了创新现代学徒制人才培养模式存在的问题,探讨了创新现代学徒制人才培养模式的路径策略,展望了创新现代学徒制人才培养模式的预期成效。这将有效推动校企合... 详细信息

以安徽省铜陵市为例,阐述了创新现代学徒制人才培养模式的必要性与可行性,分析了创新现代学徒制人才培养模式存在的问题,探讨了创新现代学徒制人才培养模式的路径策略,展望了创新现代学徒制人才培养模式的预期成效。这将有效推动校企合作人才培养工作,也将有效促进市域产教联合体的发展,为地方产业转型升级和创新发展培养更多的高级技能型人才。

关键词：产教融合现代学徒制铜陵市

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山东省系列标准地图编制与在线服务应用研究

山东国土资源 2024年第8期40卷 48-53页

作者：陶玲山东省地图院山东济南250014

标准地图是利用权威地理信息资料、依据区域界线标准画法编制而成的地图,在规范使用地图和减少“问题地图”发生方面起到积极作用,得到社会各界广泛应用。本文以山东省为例,提出了系列标准地图设计、编制、发布和在线应用等一体化技术方... 详细信息

标准地图是利用权威地理信息资料、依据区域界线标准画法编制而成的地图,在规范使用地图和减少“问题地图”发生方面起到积极作用,得到社会各界广泛应用。本文以山东省为例,提出了系列标准地图设计、编制、发布和在线应用等一体化技术方法,实现了多区域多主题版本多尺度标准地图产品免费浏览、下载和在线自助制图,可同时为社会各界提供标准地图产品级和定制化服务,建立了省域标准地图服务新模式,提高了省域标准地图的系统性、丰富性和服务便捷性和定制化。

关键词：标准地图多区域多版本多开本在线服务

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大力推进功能MRI技术在腮腺疾病影像诊断中的应用

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中华放射学杂志 2024年第5期58卷 471-473页

作者：杨功鑫朱凌陶晓峰上海交通大学医学院附属第九人民医院放射科上海200011

近年来,多种MRI技术迅速发展,在腮腺疾病影像诊断中的应用是当前研究的热点。该文分析了MRI技术在腮腺疾病影像研究中的研究现状和应用情况,探讨了当前腮腺疾病影像研究中面临的挑战,包括技术限制、临床应用和数据分析等方面的问题,并... 详细信息

近年来,多种MRI技术迅速发展,在腮腺疾病影像诊断中的应用是当前研究的热点。该文分析了MRI技术在腮腺疾病影像研究中的研究现状和应用情况,探讨了当前腮腺疾病影像研究中面临的挑战,包括技术限制、临床应用和数据分析等方面的问题,并提出了未来研究的发展方向。最后强调了MRI新技术、新方法在腮腺疾病影像学研究中的重要性和潜力。

关键词：腮腺磁共振成像应用现状

Drug-coated balloon angioplasty for the treatment of intracranial arterial stenosis in a young stroke patient:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3956-3960页

作者： Peng-Cheng Zhu ling-Feng Shu Qing-Hai Dai Hong-Tu Tan Jia-Bin Wang tao Wu Department of Intervention Encephalopathy CenterThe First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina The First Clinical Medical College Henan University of Traditional Chinese MedicineZhengzhou 450046Henan ProvinceChina

BACKGROUND Intracranial arterial narrowing is a significant factor leading to brief episodes of reduced blood flow to the brain,known as transient ischemic attacks,or fullblown *** atherosclerosis is commonly associated with intracranial arterial narrowing,it is frequently of a non-atherosclerotic nature in younger *** SUMMARY Here,we present the case of a young stroke patient with narrowing of the middle cerebral artery(MCA),characterized as non-atherosclerotic lesions,who experienced an ischemic stroke despite receiving standard drug *** patient underwent digital subtraction angiography(DSA)to assess the entire network of blood vessels in the brain,revealing significant narrowing(approximately 80%)in the M1 segment of the right ***,the patient underwent Drug-Coated Balloon Angioplasty to treat the stenosis in the right MCA's M1 ***-up DSA confirmed the resolution of stenosis in this *** the remaining branches showed satisfactory blood flow,the vessel wall exhibited irregularities.A review of DSA conducted six months later showed no evident stenosis in the right MCA,with a smooth vessel *** The use of drug-coated balloon angioplasty demonstrated favorable outcomes in repairing and reshaping the blood vessel wall in young ***,it may be considered a promising treatment option for similar cases.

关键词： Intracranial arterial stenosis Middle cerebral artery Drug-coated balloon Young stroke Case report

Data-Driven Direct Adaptive Risk-Sensitive Control of Stochastic Systems

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Journal of Systems Science & Complexity 2024年第4期37卷 1446-1469页

作者： QIAO Nan LI tao School of Mathematical Sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

The authors propose a data-driven direct adaptive control law based on the adaptive dynamic programming(ADP) algorithm for continuous-time stochastic linear systems with partially unknown system dynamics and infinite horizon quadratic risk-sensitive *** authors use online data of the system to iteratively solve the generalized algebraic Riccati equation(GARE) and to learn the optimal control law *** the case with measurable system noises,the authors show that the adaptive control law approximates the optimal control law as time goes *** the case with unmeasurable system noises,the authors use the least-square solution calculated only from the measurable data instead of the real solution of the regression equation to iteratively solve the *** authors also study the influences of the intensity of the system noises,the intensity of the exploration noises,the initial iterative matrix,and the sampling period on the convergence of the ADP ***,the authors present two numerical simulation examples to demonstrate the effectiveness of the proposed algorithms.

关键词： Adaptive dynamic programming direct adaptive control generalized algebraic Riccati equation risk-sensitive control

Effective Capacity of URLLC over Parallel Fading Channels with Imperfect Channel State Information

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China Communications 2024年第5期21卷 45-63页

作者： Peng Hongsen tao Meixia Department of Electronic Engineering and the Cooperative Medianet Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China

This paper investigates the effective capacity of a point-to-point ultra-reliable low latency communication(URLLC)transmission over multiple parallel sub-channels at finite blocklength(FBL)with imperfect channel state information(CSI).Based on reasonable assumptions and approximations,we derive the effective capacity as a function of the pilot length,decoding error probability,transmit power and the sub-channel *** we reveal significant impact of the above parameters on the effective capacity.A closed-form lower bound of the effective capacity is derived and an alternating optimization based algorithm is proposed to find the optimal pilot length and decoding error *** results validate our theoretical analysis and show that the closedform lower bound is very *** addition,through the simulations of the optimized effective capacity,insights for pilot length and decoding error probability optimization are provided to evaluate the optimal parameters in realistic systems.

关键词： effective capacity finite blocklength regime imperfect CSI parallel fading channels URLLC