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Effect of liver inflammation on accuracy of FibroScan device in assessing liver fibrosis stage in patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2021年第7期27卷 641-653页

作者： ling-ling huang Xue-Ping Yu Ju-Lan Li Hui-Ming Lin Na-ling Kang Jia-Ji Jiang Yue-Yong Zhu Yu-Rui Liu Da-Wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Hospital of Quanzhou Affiliated to Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Fujian Key Laboratory of Precision Medicine for Cancer Fujian Key Laboratory of Laboratory MedicineThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina

BACKGROUND Transient elastography(FibroScan)is a new and non-invasive test,which has been widely recommended by the guidelines of chronic hepatitis B virus(HBV)management for assessing hepatic fibrosis ***,some confounders may affect the diagnostic accuracy of the FibroScan device in fibrosis *** To evaluate the diagnostic value of the FibroScan device and the effect of hepatic inflammation on the accuracy of FibroScan in assessing the stage of liver fibrosis in patients with HBV *** The data of 416 patients with chronic HBV infection who accepted FibroScan,liver biopsy,clinical,and biological examination were collected from two hospitals *** operating characteristic(ROC)curves were used to analyze the diagnostic performance of FibroScan for assessing the stage of liver *** discordance in fibrosis staging by FibroScan and pathological scores was statistically *** regression and ROC analyses were used to analyze the accuracy of FibroScan in assessing the stage of fibrosis in patients with different degrees of liver inflammation.A non-invasive model was constructed to predict the risk of misdiagnosis of fibrosis stage using *** In the overall cohort,the optimal diagnostic values of liver stiffness measurement(LSM)using FibroScan for significant fibrosis(≥F2),severe fibrosis(≥F3),and cirrhosis(F4)were 7.3 kPa[area under the curve(AUC)=0.863],9.7 kPa(AUC=0.911),and 11.3 kPa(AUC=0.918),*** rate of misdiagnosis of fibrosis stage using FibroScan was 34.1%(142/416 patients).The group of patients who showed discordance between fibrosis staging using FibroScan and pathological scores had significantly higher alanine aminotransferase and aspartate aminotransferase levels,and a higher proportion of moderate to severe hepatic inflammation,compared with the group of patients who showed concordance in fibrosis staging between the two *** inflammation activity over 2(O

关键词： Liver stiffness measurement Fibrosis stage Liver inflammation Hepatitis B virus FibroScan Predictive model

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Success rates of in vitro fertilization versus intracytoplasmic sperm injection in men with serum anti-sperm antibodies:a consecutive cohort study

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Asian Journal of Andrology 2019年第5期21卷 473-477页

作者： Shao-Ming Lu Xiao Li Shi-Li Wang Xiao-Li Yang Yan-Zhen Xu ling-ling huang Jiao-Long Liu Fei-Fei Cai Zi-Jiang Chen Center for Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong UniversityNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsThe Key laboratory for Reproductive Endocrinology of Ministry of EducationJinan 250000China Maternal and Child Health Care Hospital Rizhao 276800China The Medical Scientific Research Center of Guangxi Medical University Nanning 53000China Department of Obstetrics The First Affiliated Hospital of Guangxi Medical UniversityNanning 53000China

Antisperm antibodies(ASAs)are assumed to be a possible causative factor for male infertility,with ASAs detected in 5%-15%of infertile men but in only l%-2%of fertile *** remains unclear whether ASAs have an adverse effect on the outcome of in v/tro fertilization(IVF)or intracytoplasmic sperm injection(ICSI).This study investigated differences in the rates of fertilization,pregnancy,and live births associated with serum ASA-positive and ASA-negative men following IVF or *** hundred and fifty-four consecutive infertile couples undergoing IVF(n=399)or ICSI(n=155)were *** two-sample two-sided t-test and Chi-square or Fisher's exact test was used for statistical *** rates of fertilization(41.7%vs 54.8%,P=0.03),good embryos(18.9%vs 35.2%,P=0.00),pregnancy(38.5%vs 59.4%,P=0.00),and live births(25.8%vs 42.5%,P=0.00)were observed in men of the IVF group with a positive serum ASA than in those with a negative *** positivity/negativity correlated with pregnancy rates(P=0.021,odds ratio[OR]:0.630,95%confidence interval[Cl]:0.425-0.932)and live birth rates(P=0.010,OR:1.409,95%Cl:1.084-1.831)after controlling for the female serum follicle-stimulating hormone level and the couple's ages at *** coupled with ASA-positive men had lower live birth rates with IVF than with ICSI(25.8%and 47.4%,respectively;P=0.07).Women coupled with ASA-positive men had lower rates of pregnancy and live births following IVF than those coupled with ASA-negative men but had a similar outcome with ICSI.

关键词： intracytoplasmic sperm injection in vitro fertilization pregnancy outcome serum antisperm antibodies

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Quantum metasurface holography

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Photonics Research 2022年第11期10卷 2607-2613页

作者： JIA-ZHI YANG RUI-ZHE ZHAO ZHE MENG JIAN LI QING-YUAN WU ling-ling huang AN-NING ZHANG Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements(MOE) School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Engineering Research Center of Mixed Reality and Advanced Display School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China

Metasurface holography has great application potential in the fields of optical display, optical storage, and security. Traditional metasurface holography uses the well-designed subwavelength structure to modulate the incident laser beam. Although many researches about laser metasurface holography have been realized,metasurface holography based on quantum light sources is rare. Here, we realized quantum metasurface holography through single-photon and multichannel polarization multiplexing metasurfaces, and we compared the quantum results with laser results.

关键词： quantum surface rare

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Liver Stiffness Measurement can Predict Liver Inflammation in Chronic Hepatitis B Patients with Normal Alanine Transaminase

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 817-826页

作者： ling-ling huang Xue-Ping Yu Qing-Fa Ruan Yan-Xue Lin Huan Li Wen Jin Rui-Feng Liu Yan-Lan Liang Yu-Rui Liu Yue-Yong Zhu Jia-Ji Jiang Ri-Cheng Mao Da-Wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated hospitalFujian Medical UniversityFuzhouFujianChina Department of Infectious Diseases The First Hospital of Quanzhou Affiliated to Fujian Medical UniversityQuanzhouFujianChina Hepatology Center Xiamen Hospital of Traditional Chinese MedicineXiamenFujianChina Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalFudan UniversityShanghaiChina Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina Hepatology Fujian Medical University Xiamen Humanity HospitalXiamenFujianChina

Background and Aims:To determine whether liver stiffness measurement(LSM)indicates liver inflammation in chronic hepatitis B(CHB)with different upper limits of normal(ULNs)for alanine aminotransferase(ALT).Methods:We grouped 439 CHB patients using different ULNs for ALT:cohort I,≤40 U/L(439 subjects);cohort II,≤35/25 U/L(males/females;330 subjects);and cohort III,≤30/19 U/L(males/females;231 subjects).Furthermore,84 and 96 CHB patients with normal ALT(≤40 U/L)formed the external and prospective validation groups,respectively We evaluated the correlation between LSM and biopsy-confirmed liver inflammation,and determined diagnostic accuracy using area under the curve(AUC).A noninvasive LSM-based model was developed using multivariate logistic ***:Fibrosis-adjusted LSM values significantly increased with increasing *** AUCs of LSM in cohorts I,II,and III were 0.799,0.796,and 0.814,respectively,for significant inflammation(A≥2)and 0.779,0.767,and 0.770,respectively,for severe inflammation(A=3).Cutoff LSM values in all cohorts for A≥2and A=3 were 6.3 and 7.5 kPa,***,external,and prospective validations showed high diagnostic accuracy of LSM for A≥2 and A=3,and no significant differences in AUCs among the four *** and globulin independently predicted A≥*** AUC of an LSM-globulin model for A≥2 exceeded those of globulin,ALT,and AST,but was similar to that of ***:LSM predicted liver inflammation and guided the indication of antiviral therapy for CHB in patients with normal ALT.

关键词： Hepatitis B virus Liver inflammation Fibrosis Liver stiffness measurement Alanine aminotransferase

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Effects of traditional Chinese medicine XinJiErKang formula on 2K1C hypertensive rats Role of Oxidative Stress and Endothelial Dysfunction

Effects of traditional Chinese medicine XinJiErKang formula ...

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安徽省药理学会2012年学术年会

作者： Ting-ting Yu ling-ling huang Han-chun Chen Xing-hui Wang Shan Gao Department of Pharmacology Key Laboratory of Antiinflammatory and Immunopharmacology of Education MinistryBasic Medical CollegeAnhui Medical University Department of Neurosurgery Suzhou Kowloon HospitalShanghai Jiaotong University School of Medicine

Ethnopharmacological relevance XinJiErKang(XJEK),a Chinese herbal formula,is identified as an effective preparation to remedy coronary heart disease and *** of the study The aim of this investigation is to reveal the anti-hypertensive effects of XJEK via gavage administration in terms of oxidative stress and vascular endothelial function on 2 kidney, 1-clip(2K1C) hypertensive *** and methods The 2K1C model of hypertension was used to investigate the potential antihypertensive effects of *** of the renal artery resulted in gradual elevation of the systolic blood pressure(SBP) which reached a plateau after 4 weeks of *** of hypertensive rats(20mmHg higher than basic systolic blood pressure) with XJEK(6,12,24 g/kg/day) and fosinopril(15 mg/kg/day) respectively by intragastric administration started 4 weeks after surgery and continued for 4 *** sham-operated(Sh-Op) controls received drinking *** was monitored weekly using tail-cuff *** the end of 8 wk,left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),rate of rise of left ventricular pressure(±dp/dtmax) were *** myocardial hypertrophy index was expressed as heart weight/body weight (HW/BW),the histological changes were investigated by HE and Van Gieson stain. Endothelium-dependent relaxations due to acetylcholine were observed in isolated rat thoracic aortic ring *** dismutase(SOD)activity,malondialdehyde(MDA) and nitric oxide(NO) content in serum,contents of hydroxyproline(Hyp) in the ventricular tissue were assayed by xanthin oxidase method,thiobarbituric acid(TBA) method,Griess method and alkaline hydrolysis method,*** method was use to detect serum angiotensinⅡ(AngⅡ) *** XJEK therapy potently improved cardiac function, inhibited myocardial hypertrophy,improved cardiac pathology change,decreased the myocardial cross-section area(CSA),collagen volume

关键词： xidative stress Endothelial dysfunction Antioxidant Renovascular Hypertension Cardiac remodeling

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试论科技法与知识产权法之关系及其在高校教学体系中之设置

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科技与法律 2008年第6期 3-7页

作者：马忠法黄玲玲复旦大学法学院知识产权研究中心华东政法大学

科技法与知识产权法关系密切、区别明显,又多有交叉重叠,且在促进国家经济发展过程中互为补充。高校教学体系应当平衡二者关系。在当前知识产权法作为法学类核心课程之一的情形下,应当继续重视科技法学科建设和教育工作,恢复和保有其应... 详细信息

科技法与知识产权法关系密切、区别明显,又多有交叉重叠,且在促进国家经济发展过程中互为补充。高校教学体系应当平衡二者关系。在当前知识产权法作为法学类核心课程之一的情形下,应当继续重视科技法学科建设和教育工作,恢复和保有其应有的教学地位。

关键词：科技法知识产权法高校教学体系科技法教学知识产权法教学

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急性下呼吸道感染患儿人冠状病毒感染状况研究

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中华医院感染学杂志 2017年第12期27卷 2813-2816页

作者：单淑琴夏科君干冬梅华玲玲黄静宁波市妇女儿童医院儿内科浙江宁波315000

目的探讨住院急性下呼吸道感染患儿人冠状病毒感染状况,为临床防治提供理论依据。方法选择2013年1月-2015年12月医院就诊急性下呼吸道感染的患儿3140例,36例单纯人冠状病毒(HCoV)感染患儿为研究组,在其余3012例非人冠状病毒感染患儿中... 详细信息

目的探讨住院急性下呼吸道感染患儿人冠状病毒感染状况,为临床防治提供理论依据。方法选择2013年1月-2015年12月医院就诊急性下呼吸道感染的患儿3140例,36例单纯人冠状病毒(HCoV)感染患儿为研究组,在其余3012例非人冠状病毒感染患儿中选择与研究组一般资料无差异的患儿60例为对照组;采集所有患儿入院1d内的鼻咽吸取物或者鼻咽拭子标本1份,并于72小时内送检;对3140例下呼吸道感染患儿中人冠状病毒感染情况及临床特征进行分析。结果 3140例患儿共检出流感病毒224例,呼吸道合胞病毒652例,多瘤病毒KI173例,多瘤病毒WU 192例,人偏肺病毒257例,人冠状病毒128例,副流感病毒572例,腺病毒358例,鼻病毒584例其中人冠状病毒感染阳性率为4.08%,单纯感染患儿36例,其中HCoV-HKUI、HCoV-OC43、HCoV-229E、HCoV-NL63、HCoV-EMC、SARS-CoV分别为6例,12例、6例、6例、3例、3例;研究组患儿咳嗽、呼吸衰竭、腹泻、发热、喘息和低氧血症比例显著高于对照组(P<0.05);27例患儿出现吸气相湿啰音和双肺呼气相喘鸣音,30例患儿胸部影像学表现支气管炎,3例为喉气管炎,3例为毛细支气管炎,9例患儿表现出肺部实变影,24例患儿表现出过度通气现象。结论下呼吸道感染患儿人冠状病毒感染,咳嗽为首发症状,同时伴随呼吸急促、喘息,多数伴随发热,肺部听诊表现呼气相高调喘鸣声和细湿罗音,部分患儿伴有腹泻症状。对于临床诊断为以上症状的儿童,应该积极采取措施,对患者感染病毒进行检测,进行针对性治疗。

关键词：急性下呼吸道感染儿童人冠状病毒感染

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高危妊娠孕产妇抑郁、育儿胜任感和社会支持的相关性研究

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中国优生与遗传杂志 2017年第10期25卷 62-65页

作者：翁雪玲瞿佳黄淑婷高玲玲黄嘉骏中山大学孙逸仙纪念医院广州510080 中山大学护理学院兰州大学医学院兰州730000

目的探讨高危妊娠孕产妇抑郁、育儿胜任感和社会支持从妊娠晚期至产后3-5天的变化及其相关性。方法采用爱丁堡产后抑郁量表、中文版育儿胜任感量表、领悟社会支持量表对180名高危妊娠孕产妇于妊娠晚期及产后3-5天进行调查。结果高危妊... 详细信息

目的探讨高危妊娠孕产妇抑郁、育儿胜任感和社会支持从妊娠晚期至产后3-5天的变化及其相关性。方法采用爱丁堡产后抑郁量表、中文版育儿胜任感量表、领悟社会支持量表对180名高危妊娠孕产妇于妊娠晚期及产后3-5天进行调查。结果高危妊娠孕产妇妊娠晚期抑郁得分为(8.29±4.17)分,育儿胜任感量表总分为(74.14±9.39)分,领悟社会支持得分为(61.83±9.56)分;产后早期抑郁得分为(8.95±5.29)分,育儿胜任感量表总分为(76.44±10.34)分,领悟社会支持总分为(64.47±8.01)分;高危孕产妇妊娠晚期与产后3-5天育儿胜任感及社会支持得分差异有统计学意义(P<0.05),抑郁得分差异无统计学意义(P=0.20)。高危妊娠孕产妇妊娠晚期与产后早期抑郁、育儿胜任感和社会支持均存在不同程度相关性(r=-0.490~0.774,P<0.05)。结论高危妊娠孕产妇妊娠晚期以及产后抑郁症状及母亲角色适应有待改善,医护工作者应鼓励家庭参与育儿活动,提高孕产妇社会支持水平,进而促进孕产妇母亲角色适应,改善产后抑郁状况。

关键词：妊娠,高危围产期育儿胜任感社会支持

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掺镱氟锆酸盐玻璃光纤反斯托克斯荧光制冷初探

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武汉大学学报（理学版） 2001年第4期47卷 453-455页

作者：吴科钟家柽龚楚清周小昝菱黄玲李承芳武汉大学红外材料研究室湖北武汉430072 武汉大学物理科学与技术学院湖北武汉430072

用高纯原料制备了掺镱 1% ,2 % ,3 % m ol的氟锆酸盐玻璃 ,并研制了有芯皮料的氟锆酸盐光纤预制棒 ,拉制了光纤 ,并对它们的吸收谱进行了研究 ,初步探索了它们反斯托克斯荧光制冷机理 .

关键词：掺镱氟锆酸盐玻璃反斯托克斯荧光制冷机理吸收谱荧光制冷多模光纤

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用二苯并-18-冠-6萃取光度法测钾

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化学试剂 1985年第1期 9-10页

作者：周稚仙王凌黄玲申俊英郑州大学化学系郑州市环保监测站

18-冠-6对钾离子具有选择络合的特性,已用于钾的萃取光度或萤光光度测定,有的已将此法用于血清及水等样品中钾的测定~[1～3]。由于二苯并-18-冠-6的价格较低,而且熔点高、水溶性小、易于回收,如能代替18-冠-6,将更有利于冠醚类试剂的推... 详细信息

18-冠-6对钾离子具有选择络合的特性,已用于钾的萃取光度或萤光光度测定,有的已将此法用于血清及水等样品中钾的测定~[1～3]。由于二苯并-18-冠-6的价格较低,而且熔点高、水溶性小、易于回收,如能代替18-冠-6,将更有利于冠醚类试剂的推广应用。近年来国外有这方面的报导,但存在着选择性差或有色试剂不易获得等向题~[4,5]。我们用二苯并-18-冠-6代替文献[1]所用的18-冠-6,以溴甲酚绿作

关键词：缓冲溶液 pH ppm 冠醚试剂环醚二苯并缔合物钾离子比耳定律醋酸锉

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