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Lesions of mediodorsal thalamic nucleus reverse abnormal firing of the medial prefrontal cortex neurons in parkinsonian rats

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Neural Regeneration Research 2019年第9期14卷 1635-1642页

作者： ling-ling fan Bo Deng Jun-Bao Yan Zhi-Hong Hu Ai-Hong Ren Dong-Wei Yang Department of Physiology Medical College Henan University of Science and Technology

The dysfunction of the medial prefrontal cortex is associated with affective disorders and non-motor features in Parkinson’s ***,the exact role of the mediodorsal thalamic nucleus in the function of the prefrontal cortex remains *** study the possible effects of the mediodorsal thalamic nucleus on the neurological function of the medial prefrontal cortex,a model of Parkinson’s disease was established by injecting 8μg 6-hydroxydopamine into the substantia nigra compacta of *** 1 or 3 weeks,0.3μg ibotenic acid was injected into the mediodorsal thalamic nucleus of the *** 3 or 5 weeks after the initial injury,neuronal discharge in medial prefrontal cortex of rat brain was determined *** numbers of dopamine-positive neurons and tyrosine hydroxylase immunoreactivity in substantia nigra compacta and ventral tegmental area were detected by immunohistochemical *** demonstrated that after injury,the immunoreactivity of dopamine neurons and tyrosine hydroxylase decreased in the substantia nigra compacta and ventral tegmental areas of *** with normal medial prefrontal cortical neurons,at 3 and 5 weeks after substantia nigra compacta injury,the discharge frequency of pyramidal neurons increased and the discharge pattern of these neurons tended to be a burst-discharge,with an increased discharge *** discharge frequency of interneurons decreased and the discharge pattern also tended to be a burst-discharge,but the discharge interval was only higher at 3 *** 3 weeks after the combined lesions,the discharge frequency,discharge pattern and discharge interval were restored to a normal level in pyramidal neurons and interneurons in medial prefrontal *** findings have confirmed that mediodorsal thalamic nucleus is involved in regulating neuronal activities of the medial prefrontal *** changes in the function of the mediodorsal thalamic nucleus may be associated with the abnorma

关键词： nerve regeneration Parkinson's disease mediodorsal thalamic nucleus medial prefrontal cortex pyramidal neurons interneurons discharge neural regeneration

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First total synthesis of natural products cajanolactone A and cajanonic acid A

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Chinese Chemical Letters 2014年第5期25卷 749-751页

作者： Wen-Zhang Chen ling-ling fan Hai-Tao Xiao Ying Zhou Wan Xiao Jian-Ta Wang Lei Tang School of Pharmacy Guiyang Medical University School of Pharmacy Guizhou University

First total synthesis of cajanolactone A and cajanonic acid A has been achieved through steps of anion–anion condensations,cyclization,Williams etherification,selective demethylation,1 3-sigmatropic rearrangement and... 详细信息

关键词： Total synthesis Cajanolactone A Cajanonic acid A

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Effects of quercetin on hyper-proliferation of gastric mucosal cells in rats treated with chronic oral ethanol through the reactive oxygen species-nitric oxide pathway

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World Journal of Gastroenterology 2008年第20期14卷 3242-3248页

作者： Jing-Li Liu Jun Du ling-ling fan Xiao-Yan Liu Luo Gu Ying-Bin Ge Department of Physiology Nanjing Medical UniversityNanjing 210029 Jiangsu Province China Department of Physiology Henan Universityof Science and Technology Luoyang 471003 Henan ProvinceChina

AIM： To investigate the effect of quercetin （3,3,4,5, 7-pentahydroxy flavone）, a major flavonoid in human diet, on hyper-proliferation of gastric mucosal cells in rats treated with chronic oral ethanol. METHODS： Forty male Sprague-Dawley rats, weighing 200-250 g, were randomly divided into control group （tap wateradlibitum）, ethanol treatment group （6 mL/L ethanol）, quercetin treatment group （intragastric gavage with 100 mg/kg of quercetin per day）, and ethanol plus quercetin treatment group （quercetin and 6 mL/L ethanol）. Expression levels of proliferating cell nuclear antigen （PCNA）and Cyclin D1 were detected by Western blot to assay gastric mucosal cell proliferation in rats. To demonstrate the influence of quercetin on the production of extra-cellular reactive oxygen species/ nitrogen species （ROS/RNS） in rats, changes in levels of thiobarbituric acid reactive substance （TBARS）, protein carbonyl, nitrite and nitrate （NOx） and nitrotyrosine （NT） were determined. The activity of inducible nitric oxide synthase （NOS） including iNOS and nNOS was also detected by Western ***：Compared to control animals, cell proliferation in the gastric mucosa of animals subjected to ethanol treatment for 7 days was significant increased （increased to 290% for PCNA density P 〈 0.05, increased to 150 for Cyclin D1 density P 〈 0.05 and 21.6 ± 0.8 vs 42.3 ± 0.7 for PCNA positive cells per view field）, accompanied by an increase in ROS generation （1.298 ± 0.135 μmol vs 1.772 ± 0.078 μmol for TBARS P 〈 0.05; 4.36 ± 0.39 μmol vs 7.48 ± 0.40 μmol for carbonyl contents P 〈 0.05） and decrease in NO generation （11.334 ± 0.467 μmol vs 7.978 ± 0.334 μmol P 〈 0.01 for NOx; 8.986 ± 1.351 μmol vs 6.854 ± 0.460 μmol for nitrotyrosine P 〈 0.01） and nNOS activity （decreased to 43% P 〈 0.05）. This function was abolished by the co-administration of quercetin. CONCLUSION： The antioxidant action of quercetin relies, in part, on its ability to stimulate nNOS and enhance production of NO that would

关键词： Quercetin Cell proliferation Reactiveoxygen species Nitric oxide Gastric mucosa Ethanol

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Effect of ECAP process on liquid distribution of AZ80M alloy during semi-solid isothermal heat treatment

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Transactions of Nonferrous Metals Society of China 2021年第6期31卷 1599-1611页

作者： ling-ling fan Ming-yang ZHOU Yang-yang GUO Yu-wen-xi ZHANG Gao-feng QUAN Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

Two kinds of semi-solid samples of AZ80−0.2Y−0.15Ca(wt.%)(AZ80M)magnesium alloy were prepared by semi-solid isothermal heat treatment of materials with and without equal channel angular pressing(ECAP)*** microstructures of initial and semi-solid treated samples were compared and *** results showed a significant difference in the liquid phase distribution between three-pass ECAP processed(3P)and as-received samples during the isothermal heating *** semi-solid 3P sample showed a more uniform liquid distribution due to its smaller dihedral ***,the coarsening processes of solid grains of as-received and 3P samples were dominated by the coalescence and Ostwald ripening mechanism,*** difference of coarsening processes was mainly related to the proportion of the high-angle grain boundaries in materials,which further affected the evolution behavior of the liquid pools.

关键词： AZ80M equal channel angular pressing semi-solid microstructure liquid phase distribution coarsening mechanism

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Effect of yttrium and calcium additions on electrochemical behaviors and discharge performance of AZ80 anodes for Mg-air battery

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Transactions of Nonferrous Metals Society of China 2022年第8期32卷 2510-2526页

作者： Yu-wen-xi ZHANG Lu HAN Lin-bao REN ling-ling fan Yang-yang GUO Ming-yang ZHOU Gao-feng QUAN Key Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Center for Advancing Materials Performance from the Nanoscale State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Xi’an Rare Metal Materials Institute Co. Ltd.Xi’an 710049China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

The effects of yttrium(Y)and yttrium+calcium(Y+Ca)additions on the electrochemical properties and discharge performance of the as-extruded Mg−8Al−0.5Zn−0.2Mn(AZ80)anodes for Mg−air batteries were *** results show that the addition of 0.2 wt.%Y increased the corrosion resistance and discharge activity of AZ80 *** was attributed to the fine and sphericalβ-Mg_17)Al_(12) phases dispersing evenly in AZ80+0.2Y alloy,which suppressed the localized corrosion and severe“chunk effect”,and facilitated the rapid activation ofα-*** addition of 0.2 wt.%Y and 0.15 wt.%Ca generated grain refinement and a reduction of theβ-Mg_17)Al_(12) phase,resulting in a further enhancement in discharge ***,the incorporation of Ca in Mg_17)Al_(12) and Al_(2)Y compounds compromised the corrosion resistance and anodic efficiency of AZ80+0.2Y+0.15Ca ***,AZ80+0.2Y anode exhibited excellent overall discharge performance,with the peak discharge capacity and anodic efficiency of 1525 mA·h·g^(−1) and 67%at 80 mA/cm^(2),13%and 14%higher than those of AZ80 anode,respectively.

关键词： Mg-air battery Mg-Al-Zn anode discharge performance electrochemical behavior

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Loss of NB-3 Aggravates Cerebral Ischemia by Impairing Neuron Survival and Neurite Growth

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生理通讯 2014年第3期33卷 70-77页

作者： Xin Huang Jia Sun Tong Zhao Kuiwu Wu Kazutada Watanabe Zhi-Cheng Xiao ling-ling Zhu Ming fan Department of Brain protection and Plasticity Institute of Basic Medical Sciences No.2 7 Taiping Road Beo'ing 100850 China

2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参加评选，会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过... 详细信息

2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参加评选，会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过专家对参评者论文和现场报告的综合评判，评出一等奖、二等奖、三等奖、特别奖、最佳表达奖、最佳答辩奖和最佳图表奖共11名。从2013年第6期开始，《生理通讯》将陆续转载获奖者的参评论文各一篇，以飨读者。

关键词：生理学论文研究成果基金

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表面抗菌功能涂层的构建及在生物医用材料中的应用研究

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高分子学报 2021年第3期52卷 253-271页

作者：范玲玲黎槟瑞张浩伟方艳南京工业大学材料化学工程国家重点实验室生物与制药工程学院南京211816

近年来,生物医用材料在使用过程中产生的医源性感染问题层出不穷,对人们健康和生命造成严重威胁.表面抗菌涂层构建是解决该类医源性感染问题最有效的策略之一.目前,按照作用机制和功能不同将表面抗菌涂层分为接触式抗菌涂层、抗黏附抑... 详细信息

近年来,生物医用材料在使用过程中产生的医源性感染问题层出不穷,对人们健康和生命造成严重威胁.表面抗菌涂层构建是解决该类医源性感染问题最有效的策略之一.目前,按照作用机制和功能不同将表面抗菌涂层分为接触式抗菌涂层、抗黏附抑菌涂层、抗黏附杀菌涂层以及智能抗菌涂层.表面抗菌涂层的构建不仅赋予了生物医用材料抗菌性能,有效解决了上述医源性感染问题,还可以提高材料的生物相容性,赋予其抗黏附、抗氧化、生物识别、传感等功能.本文旨在对目前表面抗菌涂层的种类、构建方法以及其在生物医用材料领域中的应用做一全面论述,为进一步开发高性能表面抗菌涂层并扩展其应用提供新思路.

关键词：表面改性抗黏附抗菌涂层生物医用材料

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The regulation of carotid body in the process of anti-hypoxia injury on the CHL1-null mice

The regulation of carotid body in the process of anti-hypoxi...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia SUN,Xin HUANG,ling-ling ZHU~*,Ming fan Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China

Objective Close homolog of L1(also known as neural cell adhesion molecule L1-like protein,CHLl) is a cell adhesion molecule which plays an important role in organism repair of *** recent years there has been evidence of the relation between CHL1 and nervous system *** the role of CHL1 protein in hypoxia injury has not been *** present study is to explore the impact of CHL1 deficiency on the tolerance of mice to acute hypoxia and the Phenotype and Protein Expression of Mouse Carotid *** The hypoxia toleration of CHL1 and CHL1 mice was evaluated by survival time in a normobaric hypoxia *** blot assays were used for measurement of protein expression in carotid *** and Immunofluorescence staining were used for showing morphological structure of carotid ***(1) CHL1 gene deletion increases tolerance to acute hypoxia in the mouse.(2) The total volume,number of TH+ cells and TH protein expression are increased in CHL1 carotid *** CHL1 gene deficiency of mice could change the morphology and function of carotid body,which could explain the enhanced tolerance of CHL1 mice to hypoxia.

关键词： CHLl carotid body hypoxia

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Keratograph 5M评估玻璃体切除手术对眼表的影响

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国际眼科杂志 2020年第11期20卷 1847-1852页

作者：范玲玲范仕剑高健刘伦廖荣丰安徽医科大学第一附属医院眼科安徽省合肥市230022 安徽医科大学第一附属医院实验室安徽省合肥市230022

目的:该研究旨在应用Keratograph 5M评估玻璃体切除手术(PPV)对眼表的影响。方法:本研究纳入23G玻璃体切除手术的患者30例30眼。分别于手术前、手术后1、2、4、8及12wk行眼表疾病指数(OSDI)问卷评分,采集眼表参数包括泪河高度(TMH)、非... 详细信息

目的:该研究旨在应用Keratograph 5M评估玻璃体切除手术(PPV)对眼表的影响。方法:本研究纳入23G玻璃体切除手术的患者30例30眼。分别于手术前、手术后1、2、4、8及12wk行眼表疾病指数(OSDI)问卷评分,采集眼表参数包括泪河高度(TMH)、非侵入性泪膜破裂时间(NITBUT)和眼红指数,并进一步分析各临床参数之间的相关性。结果:玻璃体切除术后4wk内,畏光、异物感较术前显著增加,但是手术后8、12wk降至术前水平;术后1wk眼胀不适较前显著增加,但术后2、4、8及12wk与术前无显著差异。OSDI评分在术后4wk内显著增加,但在术后8wk及12wk降至术前水平。TMH在术后2wk较前增高,但与术前相比差异无统计学意义。首次NITBUT和平均NITBUT在术后8wk内显著缩短,但术后12wk延长至术前水平。眼红指数在术后4wk内显著增加,但术后8wk降至术前水平。首次NITBUT和平均NITBUT在每次随访时间点均呈显著正相关,TMH与平均NITBUT在术后1wk呈显著正相关。结论:Keratograph 5M可作为评估玻璃体切除手术对眼表影响的一种可靠方法。玻璃体切除手术可引起早期眼表症状及体征的改变,但是这些改变在手术后12wk内将逐渐恢复到术前水平。

关键词：眼表综合分析仪泪膜玻璃体切除手术干眼综合征

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The potential antioxidant effects of 5-hydroxymethyl-2-furaldehyde

The potential antioxidant effects of 5-hydroxymethyl-2-fural...

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2008北京国际生理科学学术大会

作者： ZHANG Jian-Hong,WU Li-Ying,LI Xiang,HUANG Xin,ZHAO Tong,ZHU ling-ling,fan Ming Institute of Basic Medical Sciences,27 Taiping Road,Beijing 100850,China

It is known that hydrogen peroxide(HO)is one of the main reactive oxygen species(ROS)that can cause lipid peroxidation,DNA damage and also can stimulate cytochrome C release from mitochondria which is the cue for cell death in many ***/Ref-1 is an essential enzyme in the repair of DNA damage caused by oxidative and alkylation *** importantly,APE/Ref-1 also functions as a redox factor maintaining transcription factors in active reduced ***,it is not well defined that the role of 5-hydroxymethyl-2-furaldehyde (5-HMF)in antioxidant injury and the underlying mechanism is also *** investigate the antioxidant effects of 5-HMF,we first measured the effects of 5-HMF on cell *** viability was assessed with ***-8 reduction assay has been used to reflect the number of viable *** result showed that the percentage of viable PC 12 cells after exposure to HO significantly decreased,while 5-HMF attenuated the decrease *** order to investigate the underlying mechanism of the protective role of 5-HMF against oxidation injury,we tested the effects of 5-HMF on APE/Ref-1 expression by immunocytochemical staining and Western blot,since APE is a crucial protein in repairing DNA damage induced by *** results indicated that the expression of APE decreased after treatment with HO,however,50μg/mL and 100μg/mL of 5-HMF inhibited the decrease of APE *** to above results,we suppose that the maintaining of APE/Ref-1 proteins by 5-HMF may result in a higher viability of PC12 cells after exposure to *** together,we determine that 5-HMF has the potential antioxidant effects and the antioxidant effects of 5-HMF is correlated with maintaining the expression of APE/Ref-1 in oxidative *** the near future,5-HMF that regulates APE/Ref-1 expression may be applied in the treatment of diseases induced by oxidative damage.

关键词： 5-HMF APE/Ref-1 antioxidant effects

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