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Sea-level variation/change and thermal contribution in the Bering Sea

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Acta Oceanologica Sinica 2005年第6期24卷 36-45页

作者： ZUO Juncheng ZHANG Jianli DU ling li Peiliang li Lei College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China

The long-term sea-level trend in the Bering Sea is obtained by the analysisof TOPEX/Poseidon altimeter data, including the data of two tide gauges. The averaged sea-level inthe Bering Sea rises at a rate of 2.47 mm/a from 1992 to 2002. The mean sea-level is falling in themost part of the Bering Sea, especially in its central basin, and it is rising in the northeasternpart of the Bering Sea. During the 1998/99 change, the sea-level anomaly differences exhibit asignificant sea-level anomaly fall in the deep basin of the Bering Sea, which is roughly in the sameposition where a prominent SST fall exists. The maximal fall of sea-level is about 10 cm in thesouthwestern part of the Bering Sea, and the maximal fall of about 2℃ in the SST also appeared inthe same region as the sea level did. The steric sea-level change due to temperature variations isdiscussed. The results are compared with the TOPEX/Poseidon altimeter data at the different spatialscales. It is indicated that the seasonal amplitude of the steric height is about 35% of theobserved TOPEX/Poseidon amplitude, which is much smaller than the 83% in the mid-latitudes area. Thesystematic difference between the TOPEX/Poseidon data with the range of about 7.5 cm and thethermal contribution with the range of about 2.5 cm is about 5 cm. This indicates that the thermaleffect on the sea level is not as important as the case in the mid-latitudes area. In the BeringSea, the phase of the steric height leads the observed sea level by about three months.

关键词： sea-level variation steric bering sea

Differentiation of hepatocytoid cell induced from whole-bone-marrow method isolated rat myeloid mesenchymal stem cells

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World Journal of Gastroenterology 2006年第30期12卷 4866-4869页

作者： Wei li Su-Nan liu Duan-De Luo Lei Zhao ling-Lan Zeng Shu-ling Zhang Shu-li li Department of Infectious Disease Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

AIM： To explore the expansion and differentiation of hepatocytoid cell induced from myeloid mesenchymal stem cell （MSC） in vib＇o, in order to find suitable resource of hepatocytes for bioartiflcial liver or liver transplantation. METHODS： The rat myeloid MSC was isolated and divided into three groups which were cultured by Friedensteion method, and then were induced by culture fluid, culture fluid plus cholestatic serum and culture fluid plus hepatocyte growth factor （HGF）, respectively. Hepatocytoid cell as well as expression of CK18 and AFP was observed by immunohistochemistry. RESULTS： After the induction for 21 d, hepatocytoid cell was observed, and its expression of CK18 and AFP was detected by immunohistochemistry in MSC cultured with cholestatic serum. Furthermore, on the 35^th d, albumin mRNA was expressed in the cell, suggesting the inducing effect was similar to that by HGF.CONCLUSION： Rat myeloid MSC can differentiate into hepatocyte lineage under appropriate condition. This method is easy to operate.

关键词： Mesenchyme stem cell Hepatocytoid cell Expansion Differentiation Induction

Expression of hepatocyte nuclear factor 4 alpha,wingless-related integration site,andβ-catenin in clinical gastric cancer

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World Journal of Clinical Cases 2022年第21期10卷 7242-7255页

作者： Qian Hu ling-li li Ze Peng Ping Yi Department of Integrated Traditional Chinese and Western Medicine Institute of Integrated Traditional Chinese and Western MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Gastric cancer(GC)is the second most common cause of cancer-related deaths *** nuclear factor 4 alpha(HNF4α)that belongs to the nuclear hormone receptor superfamily,is overexpressed in GC tissues,and might be involved in the development of GC by regulating its downstream winglessrelated integration site(WNT)/β-catenin *** To clarify the expression of HNF4α/WNT5a/β-catenin signaling proteins in clinical GC *** We immunohistochemically stained pathological blocks of GC and matched paracancerous *** intensity of HNF4α,WNT5a andβ-catenin staining in the tumor cells was determined according to cell rates and staining *** correlations between GC and HNF4α,WNT5a,andβ-catenin expression using chisquare and paired chi-square *** between double-positive HNF4αand WNT5a expression and types of gastric tumor tissues were assessed using regression *** between HNF4αand WNT5a expression at the RNA level in GC tissues found in the TCGA database were analyzed using Pearson correlation *** We found more abundant HNF4αand WNT5a proteins in GC,especially in mucinous adenocarcinoma and mixed GC than in adjacent tissues(P<0.001).Low and high levels of cytoplasmicβ-catenin respectively expressed in GC and adjacent tissues(P<0.001)were not significantly associated with pathological *** The expressions of HNF4αand WNT5a could serve as early diagnostic biomarkers for GC.

关键词： β-catenin Biomarker Gastric cancer Hepatocyte nuclear factor 4 alpha Wingless-related integration site

Arabidopsis Sucrose Transporter SUT4 Interacts with Cytochrome b5-2 to Regulate Seed Germination in Response to Sucrose and Glucose

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Molecular Plant 2012年第5期5卷 1029-1041页

作者： Yan li ling-li li Ren-Chun Fan Chang-Cao Peng Hai-li Sun Sai-Yong Zhu Xiao-Fang Wang ling-Yun Zhang Da-Peng Zhang College of Biological Sciences China Agricultural University Beijing 100094 China Key Laboratory of Forest Silviculture and Conservation of the Ministry of Education Beijing Forestry University Beijing 100083 China Systems Biology and Bioinformatics Laboratory of the Ministry of Education School of Life Sciences Tsinghua University Beijing 100084 China

It remains unknown whether a sucrose transporter mediates sugar signaling. Here, we report that the Arabidopsis （Arabidopsis thaliana） sucrose transporter SUT4 interacts with five members of the Arabidopsis cytochrome b5 （Cyb5） family, and sucrose represses the interaction between SUT4 and a Cyb5 member Cyb5-2/A. We observed that down- regulation of SUT4 and three cytochrome b5 members （Cyb5-2, Cyb5-4, and Cyb5-6） confers the sucrose- and glucose- insensitive phenotypes in the sucrose/glucose-induced inhibition of seed germination. The sut4 cybS-2 double mutant displays slightly stronger sucrose/glucose-insensitive phenotypes than either the sut4 or cyb5-2 single mutant. We showed that the SUT4/Cyb5-2-mediated signaling in the sucrose/glucose-induced inhibition of seed germination does not require ABA or the currently known ABI2/ABI4/ABI5-mediated signaling pathway（s）. These data provide evidence that the sucrose transporter SUT4 interacts with Cyb5 to positively mediate sucrose and glucose signaling in the sucrose/ glucose-induced inhibition of seed germination.

关键词： sucrose transporter SUT4 cytochrome b5 seed germination sucrose signaling Arabidopsis thaliana.

Easily misdiagnosed complex Klippel-Trenaunay syndrome: A case report

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World Journal of Clinical Cases 2023年第4期11卷 922-930页

作者： ling-li li Rui Xie Fu-Qing li Cheng Huang Bi-Guang Tuo Hui-Chao Wu Department of Gastroenterology Digestive Disease HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND Klippel-Trenaunay syndrome(KTS) is a congenital vascular malformation with a complicated etiology. It is sporadic and clinically rare in occurrence. The typical characteristics are capillary malformation(also known as port-wine stain),varicose veins and malformations, and bony and/or soft tissue hypertrophy with or without lymphatic malformation, which are known as the “classic clinical triad”. Herein, a rare case of KTS characterized by crossed-bilateral limb hypertrophy accompanied by intermittent hematochezia and hematuria is *** SUMMARY We described a 37-year-old female with KTS. She was admitted to our hospital owing to the gradual enlargement of the left lower extremity along with intermittent hematochezia and hematuria. The patient was diagnosed to have hemorrhoid bleeding by other hospitals and treated with conventional hemostatic drugs, but continued to have intermittent gastrointestinal bleeding and hematuria. Therefore, she visited our hospital to seek further treatment. During hospitalization, relevant imaging and laboratory examinations and colonoscopy were performed. In combination with the patient’s history and relevant examinations, we considered that the patient had a complex form of KTS. We recommended a combined diagnosis and treatment from the vascular, interventional,anorectal, and other departments, although she declined any further treatment for financial *** The clinical manifestations of KTS are extensive and diverse and chiefly include the typical triad. However, Vascular malformations of KTS can also involve several parts and systems such as digestive and urogenital systems. Therefore, the atypical manifestations and rare complications necessitate the clinician’s attention and are not to be ignored.

关键词： Gross hematuria Hematochezia Klippel-Trenaunay syndrome limb hypertrophy Vascular malformation Case report

Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 842-857页

作者： ling-li li Ze Peng Qian Hu li-Jun Xu Xin Zou Dong-Mei Huang Ping Yi Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430045Hubei ProvinceChina Department of Integrated Traditional Chinese and Western Medicine West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Gastric cancer is the third deadliest cancer in the world and ranks second in incidence and mortality of cancers in *** advances in prevention,diagnosis,and therapy,the absolute number of cases is increasing every year due to aging and the growth of high-risk populations,and gastric cancer is still a leading cause of cancer-related *** cancer is a consequence of the complex interaction of microbial agents,with environmental and host factors,resulting in the dysregulation of multiple oncogenic and tumor-suppressing signaling *** efforts have been made to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic ***,a monoclonal antibody against the HER2 receptor,is approved in the first-line treatment of patients with HER2+tumors,which accounts for 13%-23%of the gastric cancer ***,a monoclonal antibody against VEGFR2,is currently recommended in patients progressing after first-line *** clinical trials have also tested novel agents for advanced gastric cancer but mostly with dis-appointing results,such as anti-EGFR and anti-MET monoclonal ***,it is still of great significance to screen specific molecular targets for gastric cancer and drugs directed against the molecular *** To investigate the effect and mechanism of berberine against tumor growth in gastric cancer xenograft models and to explore the role of hepatocyte nuclear factor 4α(HNF4α)-WNT5a/β-catenin pathways played in the antitumor effects of *** MGC803 and SGC7901 subcutaneous xenograft models were *** control group was intragastrically administrated with normal saline,and the berberine group was administrated intragastrically with 100 mg/kg/d *** body weight of nude mice during the experiment was measured to assess whether berberine has any adver

关键词： Berberine Gastric cancer Xenograft models Hepatocyte nuclear factor 4α WNT5a

Knockout of three aminopeptidase N genes does not affect susceptibility of Helicoverpa armigera larvae to Bacillus thuringiensis Cry1A and Cry2A toxins

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Insect Science 2020年第3期27卷 440-448页

作者： Jing Wang Ya-Yun Zuo ling-li li Hui Wang Shao-Yan liu Yi-Hua Yang Yi-Dong Wu College of Plant Protection Nanjing Agricultural UniversityNanjingChina

Bacillus thuringiensis(Bt)insecticidal toxins have been globally utilized for control of agricultural insects through spraying or transgenic *** of Bt toxins to special receptors on midgut epithelial cells of target insects is a key step in the mode of *** studies suggested aminopeptidase N1(APN1)as a receptor or putative receptor in several lepidopteran insects including Helicoverpa armigera through evidence from RNA interefence‐based gene silencing *** the current study we tested the role of APNs in the mode of action of Bt toxins using clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR‐associated protein 9‐mediated gene *** APN genes(HaAPN1,HaAPN2 and HaAPN5)were individually knocked out in a susceptible strain(SCD)of *** to establish three homozygous knockout *** in vitro binding studies indicated binding of Cry1Ac or Cry2Ab to midgut brush border membrane vesicles was not obviously affected by APN *** results showed that none of the three knockouts had significant changes in susceptibility to Cry1A or Cry2A toxins when compared with the SCD *** suggests that the three HaAPN genes we tested may not be critical in the mode of action of Cry1A or Cry2A toxins in ***.

关键词： aminopeptidase N Bacillus thuringiensis CRISPR/Cas9 Helicoverpa armigera receptor

Preparation and Ethanol Sensing Properties of ZnO Nanofibers

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Chemical Research in Chinese Universities 2011年第5期27卷 720-723页

作者： FENG Cai-hui RUAN Sheng-ping ZHU ling-hui li Chao li Wei CHEN Wei-you CHEN li-hua ZHANG Xin-dong State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changehun 130012 P. R. China

ZnO nanofibers with an average diameter of about 90 nm were prepared by an electrospinning method combined with a calcination process. The as-electrospun nanofibers before and after calcination were characterized by means of differential thermal analysis（DTA）, thermal gravimetric analysis（TGA）, X-ray diffraction（XRD） and scanning electron microscopy（SEM）. The fibers after calcination at 600 °C belong to the hexagonal wurtzite structure. The sensor based on ZnO nanofibers exhibited excellent ethanol sensing properties at 206 °C such as good linear dependence in the low concentration（1―100 μL/L）, high response, and good selectivity. Fast response（less than 2 s） and recovery（about 16 s） were also observed in our investigations.

关键词： Electrospinning method ZnO Nanofiber Ethanol Gas sensor

Trehalose and trehalose-hydrolyzing enzyme in the haemolymph of Locusta rnigratoria infected with Metarhizium anisopliae strain CQMa102

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Insect Science 2007年第4期14卷 277-282页

作者： HUA ZHAO ZHONG-KANG WANG YOU-PING YIN YAN-ling li ZHEN-LUN li GUO-XIONG PENG YU-XIAN XIA GeneticEngineeringResearchCenter CollegeofBioengineeringChongqingUniversityChongqingChina

Topical application of the Metarhizium anisopliae var. acridum specialist strain CQMa 102 to the locust Locusta migratoria manilensis results in changes of the concentrations of trehalose and glucose in the haemolymph. Micrographs of the locust haemolymph shows Metarhizium anisopliae can effectivly penetrate the external skeleton of locust and after 2 days infection, the hyphae body will appear in the haemolymph of infected insects. The time in decrease of trehalose concentration coincided with that in increase of trehalose-hydrolysing enzyme activity in the haemolymph of the fungus-infected insects. Overlay gel analysis indicated there was considerably more trehalose-hydrolysing activity in the haemolymph of locusts infected by fungus than in controls. A comparable isoform was identified in in vitro culture of the fungus, suggesting a fungal origin for the in vivo enzyme. Haemolymph trehalose decreased significantly during mycosis of locusts by M. anisopliae. All these results suggested that this fungus may take advantage of competing nutrient utilization against the insect by its trehalose-hydrolyzing enzyme secretion. It may provide fundamental knowledge for fungal pathogenesis.

关键词： Metarhizium anisopliae Locusta migratoria manilensis trehalose-hydrolysingenzymes trehalose glucose mycosis